Patents Assigned to Pharmaceutical Industry Technology and Development Center
-
Patent number: 11759471Abstract: The present invention is concerned with a modified release pharmaceutical composition comprising an effective amount of at least one antipsychotic agent so that the antipsychotic agent(s) are released in such a manner to better accord with physiological and chronotherapeutic requirements of patients.Type: GrantFiled: April 10, 2020Date of Patent: September 19, 2023Assignee: MEDICAL AND PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTERInventors: Shih-Ku Lin, Chih-Chiang Yang, Tse-Ching Lin, Lai-Cheng Chin, Pei Hsuan Ho
-
Patent number: 10940113Abstract: A pharmaceutical composition for colon targeting, a method for treating a colon-related disease using the same and a preparation method thereof are disclosed. The pharmaceutical composition of the present disclosure comprises: a core matrix comprising a cross-linked hydrogel and an active ingredient, wherein the active ingredient is dispersed in the cross-linked hydrogel, and a content of the active ingredient is 65 wt % to 95 wt % based on a total weight of the core matrix.Type: GrantFiled: February 22, 2018Date of Patent: March 9, 2021Assignee: MEDICAL AND PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTERInventors: Chih-Chiang Yang, Wen-Che Wang, Chiao-Ling Hsu
-
Publication number: 20190388340Abstract: Disclosed herein is an oral dosage formulation suitable for treating a neurodegenerative disorder. The oral dosage formulation contains both sustained-release and immediate-release drugs. The sustained-release drug in the oral dosage formulation is memantine, and the immediate-release drug in the oral dosage formulation is donepezil and/or memantine, and the formulation is characterized in having a pH-independent dissolution profile of memantine at a pH range from about 1.0 to about 7.0.Type: ApplicationFiled: June 20, 2019Publication date: December 26, 2019Applicants: Center Laboratories, Inc., Medical and Pharmaceutical Industry Technology and Development CenterInventors: Meng-Ju LEE, Shu-Hsien CHANG, Chih-Chiang YANG, Yuan-Chih LE, Tse-Ching LIN, Ko-Chiang CHEN, Lai-Cheng CHIN, Tai-Yin KE, Pei-Ying LIAO
-
Publication number: 20150306167Abstract: Disclosed herein is the use of an extract from Alpinia spp. for the preparation of a medicament for the treatment of irritable bowel syndrome (IBS). The extract is prepared by extracting fresh and/or dried fruits of Alpinia spp. plant with a solvent such as a supercritical fluid, water, 10-95% (v/v) ethanol, acetone, ethyl acetate or n-hexane, to obtain an extract suitable for the preparation of IBS medicaments. In some embodiments, active compounds with anti-abnormal defecation activity and/or analgesia effect are isolated from the water extract of Alpinia spp.; these compounds are therefore potential lead compounds for use as medicaments for treating IBS.Type: ApplicationFiled: December 30, 2013Publication date: October 29, 2015Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Jui-Ching CHEN, Che-Yi LIN, Chih-Sheng HUNG, Pei-Fan WU, Fen CHEN
-
Patent number: 9144590Abstract: Disclosed herein is the use of an extract from an Aster species for the preparation of a medicament for the treatment of opioid-induced constipation. The extract is extracted from fresh and/or dried roots and rhizomes of a Tatarian aster (Aster tartaricus) plant, in which the extraction uses water or 40-95% (v/v) ethanol as an extractant to obtain an extraction mixture. In some embodiments, the extraction mixture is then eluted with water followed by at least one eluent.Type: GrantFiled: December 23, 2011Date of Patent: September 29, 2015Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Jui-Ching Chen, Che-Yi Lin, Chien-Chang Wu, Cheng-Po Huang, Yuan-Ling Ku, Yueh-Chu Chen, Yu-Hsuan Lin, Chih-Sheng Hung
-
Publication number: 20140314867Abstract: A vitamin K2 microsphere. The microsphere includes a poly(lactide-co-glycolide) acid (PLGA) particle, in which the Mw of PLGA is between 1000 and 300000, and the molar ratio between the lactide repeat units and the glycolide repeate unit is 1-9:9-1; and one or more vitamin K2 molecules are embedded in the PLGA particle, wherein the vitamin K2 is present in an amount of 0.005-75 wt %, based on the weight of the microsphere. Also disclosed are a method of preparing the vitamin K2 microsphere, a method of treating osteoporosis using this microsphere, and a pharmaceutical composition containing the microsphere.Type: ApplicationFiled: April 22, 2014Publication date: October 23, 2014Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Shu-Wen Whu, Chung-Chih Cheng, Chih-Chiang Yang
-
Patent number: 8470379Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: GrantFiled: October 25, 2010Date of Patent: June 25, 2013Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
-
Patent number: 8257759Abstract: An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of the Morus australis Poir extract as an active component. The effective Morus australis Poir extract is prepared by extracting the root-bark of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.Type: GrantFiled: December 25, 2008Date of Patent: September 4, 2012Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Yuan-Ling Ku, Chien-Jen Shih, Hsiao-Chu Huang, Chun-Hung Kuo, Yi-Chen Lin, Yueh-Chu Chen, Feng-Nien Ko
-
Patent number: 8226981Abstract: A method of preparing a taste-masking oral dosage form is provided. The method includes providing a first solution comprising a pharmaceutically active ingredient and a starch, providing a second solution comprising a hydrophilic polymer and a surfactant, blending the first and second solution to form a plurality of microparticles by a granulating process, wherein the microparticle is a co-crystal structure comprising the pharmaceutically active ingredient and the starch, and performing a compression-molding process to form the tablet.Type: GrantFiled: September 5, 2007Date of Patent: July 24, 2012Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Chih-Chiang Yang, Wen-Che Wang, Hui-Yu Chen
-
Patent number: 8071142Abstract: An extract prepared from the root barks of Morus australis Poir.Type: GrantFiled: December 29, 2008Date of Patent: December 6, 2011Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Yuan-Ling Ku, Shih-Tsun Liang, Yu-Hsuan Lin, Liang-Hua Chen, Ying-Yu Kuo, Feng-Nien Ko
-
Publication number: 20110038966Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: ApplicationFiled: October 25, 2010Publication date: February 17, 2011Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien KO, Mo-Chi CHENG, Cheng-Ko LIU, Jen-Wei CHEN, Fen CHEN, Chao-Chi YEI
-
Patent number: 7842318Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: GrantFiled: October 18, 2007Date of Patent: November 30, 2010Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
-
Publication number: 20100292257Abstract: The present invention discloses new uses of 2-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one in providing an analgesic effect in a patient, treating passive cutaneous anaphylaxis in a patient, and in eliciting a histamine H1 receptor antagonism effect in a patient to treat a disease or disorder, such as allergy.Type: ApplicationFiled: July 26, 2010Publication date: November 18, 2010Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien KO, Yuan-Ling Ku
-
Patent number: 7771745Abstract: The present invention provides a method for making a fast dissolving tablet. The method includes the steps of (a) preparing a first solution containing a hydrophilic polymer and a starch; (b) preparing a second solution containing a pharmaceutically active ingredient and a surfactant; (c) blending the first and the second solution together to form a plurality of granule powders by granulation; (d) mixing the granule powders with excipients; and (e) applying a compression-molding process to form the fast dissolving tablet.Type: GrantFiled: May 3, 2004Date of Patent: August 10, 2010Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Wen-Che Wang, Hui-Yu Chen, Chih-Chiang Yang
-
Publication number: 20100166898Abstract: An extract prepared from the root barks of Morus australis Poir.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Yuan-Ling Ku, Shih-Tsun Liang, Yu-Hsuan Lin, Liang-Hua Chen, Ying-Yu Kuo
-
Publication number: 20100166890Abstract: An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of the Morus australis Poir extract as an active component. The effective Morus australis Poir extract is prepared by extracting the root-bark of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.Type: ApplicationFiled: December 25, 2008Publication date: July 1, 2010Applicant: Pharmaceutical Industry Technology and Development CenterInventors: Yuan-Ling Ku, Chien-Jen Shih, Hsiao-Chu Huang, Chun-Hung Kuo, Yi-Chen Lin, Yueh-Chu Chen
-
Patent number: 7645915Abstract: A composite dressing including a first polymeric layer, a second polymeric layer, a metal oxide, and a pharmaceutical active material is provided. The second polymeric layer is biocompatible and is disposed on a surface of the first polymeric layer. The metal oxide is distributed inside or on at least one surface of the first polymeric layer, while the pharmaceutical active material is distributed inside or on at least one surface of the second polymeric layer.Type: GrantFiled: December 11, 2007Date of Patent: January 12, 2010Assignees: Medical and Pharmaceutical Industry Technology and Development Center, National Applied Research LaboratoriesInventors: Ching-Cheng Huang, Su-Huei Lai, Yung-Sheng Lin, Ting-Kai Leung
-
Patent number: 7569238Abstract: An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.Type: GrantFiled: April 28, 2003Date of Patent: August 4, 2009Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Wei-Ja Wang, Cheng-Ko Liu, Pin-Fen Chen, Yu-Feng Han, Mai-Yu Lee
-
Patent number: 7531519Abstract: A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R? and R? independently are H or R1, provided that R, R? and R? are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.Type: GrantFiled: September 21, 2006Date of Patent: May 12, 2009Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Mo-Chi Cheng, Feng-Nien Ko, Tian-Shung Wu
-
Publication number: 20090104293Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: ApplicationFiled: October 18, 2007Publication date: April 23, 2009Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei