Abstract: The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.
Type:
Application
Filed:
May 20, 2004
Publication date:
October 28, 2004
Applicant:
Pharmaceutical Industry Technology and Development Center, a Taiwan corporation
Abstract: The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.
Type:
Grant
Filed:
May 6, 2002
Date of Patent:
October 5, 2004
Assignee:
Pharmaceutical Industry Technology and Development
Center
Abstract: A method of preparing an extract which is potent in anti-fungal activity from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
Type:
Application
Filed:
May 14, 2003
Publication date:
October 30, 2003
Applicant:
Pharmaceutical Industry Technology and Development Center
Inventors:
Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
Abstract: The present invention provides a oral capsule preparation, comprising a capsule prepared from a drug or the alkaline salt thereof, an oily compound or the alkaline salt thereof, an emulsifier and a polycarbon alcohol, together with an enteric coating disposed on the outer layer of the capsule; wherein said emulsifier is a composition of C6-18 organic fatty acid and an organic amine, or the mixture thereof. The invention also provides a method of preparing the oral capsule preparation of the invention.
Type:
Grant
Filed:
June 29, 2001
Date of Patent:
September 30, 2003
Assignee:
Pharmaceutical Industry Technology and Development
Center
Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
Type:
Application
Filed:
January 3, 2003
Publication date:
July 17, 2003
Applicant:
Pharmaceutical Industry Technology and Development Center
Abstract: A pharmaceutical composition useful in treating psychosis contains a therapeutically effective amount of 2-[piperidinyl]methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one as an active ingredient.
Type:
Application
Filed:
May 13, 2002
Publication date:
July 17, 2003
Applicant:
Pharmaceutical Industry Technology and Development Center
Abstract: The invention discloses a pharmaceutical composition for preventing and/or treating peptic ulcer, including American ginseng or the extract thereof, and a method for preparing American ginseng extract, said method including extracting American ginseng with water or ethanol aqueous solution, and then ultrafiltrating, dialyzing, precipitating with ethanol, or performing reverse phase chromatography to obtain various fractions of extract with anti-peptic ulcer effect.
Type:
Application
Filed:
May 6, 2002
Publication date:
December 12, 2002
Applicant:
Pharmaceutical Industry Technology and Development Center, a Taiwan
Abstract: The present invention discloses a novel 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives (formula I), with a process for their preparation, and with pharmaceutical compositions containing them as the active ingredient for the treatment of bacterial infections and/or renal cancer diseases.
Type:
Grant
Filed:
November 15, 2001
Date of Patent:
December 10, 2002
Assignee:
Pharmaceutical Industry Technology and Development
Center
Inventors:
Cherng-Chyi Tzeng, Yeh-Long Chen, Feng-Nien Ko
Abstract: The invention discloses an extract containing puccoon and Chinese angelica, and a formula and preparation method of an ointment containing the extract. The extract is used for treating burns and scalds and is characterized by superior shelf-life. The puccoon and Chinese angelica are extracted with an organic solvent having a polarity of between 0.35 and 0.95, which are then filtrated, concentrated and mixed with a physiologically acceptable carrier or excipient.
Type:
Grant
Filed:
August 3, 2000
Date of Patent:
October 22, 2002
Assignee:
Pharmaceutical Industry Technology and Development
Center
Inventors:
Ce-Shing Sheu, Yi-Ching Wu, Jun-Hung Kuo
Abstract: A method of preparing an extract which is potent in anti-fungal activity from Zingiber officinale, includes the following steps: preparing a crude liquid from rhizomes of ginger by extraction with an organic solvent or supercritical CO2, or by distillation with steam; introducing the crude liquid to a reverse phase chromatography column, and eluting the column with water, a first eluent and a second eluent having a polarity weaker than that of the first eluent but stronger than that of chloroform, so that a first eluate resulting from elution of the first eluent and a second eluate resulting from elution of the second eluent are obtained; removing the first eluent and the second eluent from the first eluate and the second eluate by evaporation, respectively, so that a first concentrated eluate and a second concentrated eluate are obtained as the potent extract.
Type:
Application
Filed:
June 22, 2001
Publication date:
April 18, 2002
Applicant:
Pharmaceutical Industry Technology and development Center
Inventors:
Tian-Shung Wu, Sheng-Chu Kuo, Che-Ming Teng, Feng-Nien Ko
Abstract: The invention discloses a process for producing Guilu Erxian Gao used as a tonic medicine, comprising the steps of: (a) extracting medicinal materials comprising tortoise plastron and buckhorn with an edible acid to obtain an extract; (b) dialyzing the extract; (c) decocting ginseng and medlar and filtrating to obtain a filtrate; and (d) concentrating the mixtures of dialyzed extract and the filtrate to form a gel-like solid.
Type:
Grant
Filed:
July 7, 2000
Date of Patent:
April 16, 2002
Assignee:
Pharmaceutical Industry Technology and Development
Center
Inventors:
Shu-Ching Wang, Shih-Yu Lee, Jenn-Ru Shaw, Wei-Min Lee