Patents Assigned to Pharmaceutical Solutions, Inc.
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Patent number: 8383577Abstract: Methods, formulations and kits are described that allow for the controlled release of octreotide, e.g., octreotide acetate, in a subject.Type: GrantFiled: April 29, 2011Date of Patent: February 26, 2013Assignee: Endo Pharmaceuticals Solutions, Inc.Inventors: Petr Kuzma, Stefanie Decker, Harry Quandt
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Patent number: 8357389Abstract: This invention is related to the use of polyurethane based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs. The drug delivery device for releasing one or more drugs at controlled rates for an extended period of time to produce local or systemic pharmacological effects comprises: 1. a reservoir, said reservoir comprising; 2. at least one active ingredient; and, optionally, 3. at least one pharmaceutically acceptable carrier; a polyurethane based polymer completely surrounding the reservoir.Type: GrantFiled: August 31, 2010Date of Patent: January 22, 2013Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Sheng-hung Kuo, Petr Kuzma
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Patent number: 8343528Abstract: This invention is related to the use of polyurethane based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs. The drug delivery device for releasing one or more drugs at controlled rates for an extended period of time to produce local or systemic pharmacological effects comprises: 1. a reservoir, said reservoir comprising; 2. at least one active ingredient; and, optionally, 3. at least one pharmaceutically acceptable carrier; a polyurethane based polymer completely surrounding the reservoir.Type: GrantFiled: October 19, 2010Date of Patent: January 1, 2013Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Sheng-hung Kuo, Petr Kuzma
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Patent number: 8303977Abstract: This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs.Type: GrantFiled: October 26, 2010Date of Patent: November 6, 2012Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Petr Kuzma, Harry Quandt
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Publication number: 20120245118Abstract: Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.Type: ApplicationFiled: June 6, 2012Publication date: September 27, 2012Applicant: Endo Pharmaceuticals Solutions Inc.Inventors: John J. Murphy, Kay Jorgenson D'Orlando
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Patent number: 8273721Abstract: Novel methods useful for treating a patient with bladder cancer such as superficial bladder cancer includes administering to the patient a therapeutically effective amount of valrubicin and trospium chloride.Type: GrantFiled: March 4, 2009Date of Patent: September 25, 2012Assignee: Endo Pharmaceuticals Solutions Inc.Inventor: James E. Shipley
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Patent number: 8242132Abstract: Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.Type: GrantFiled: December 20, 2010Date of Patent: August 14, 2012Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: John J. Murphy, Kay Jorgenson D'Orlando
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Publication number: 20120203645Abstract: A computer-enabled method for dynamic, automated application of taxes to veterinary pharmaceutical and other animal-related product items for sale by a central product provider and subsequent recovery of historically accurate taxes as applied by the central product provider for automated tax crediting and distribution to veterinary hospitals for later remittance to taxing authorities. Member account details, per-item and per-invoice tax records are accessed, created and stored in computer memory, and during purchase an invoice record is created with a snapshot of an invoice ID, per-item base prices, per-item taxes and per-invoice taxes. After a sale is completed, including payment of the invoice with a customer's credit card wallet information, the invoice is retrieved and taxes on the invoice are automatically credited and distributed to various veterinary hospitals.Type: ApplicationFiled: February 9, 2011Publication date: August 9, 2012Applicant: STRATEGIC PHARMACEUTICAL SOLUTIONS, INC.Inventors: DONALD C. SUTTER, KURT D. GREEN, THOMAS A. FRIAR, ANDREW J. BANE
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Publication number: 20120203678Abstract: A computer-enabled method and system for dynamic, automated pricing of veterinary pharmaceutical and other animal-related product items by a central product provider, wherein the method allows subsequent recovery of historical pricing information by the central product provider computer for subsequent sale proceeds sharing with a veterinary hospital, comprising the steps of: asynchronously creating and storing member account details, asynchronously retrieving from vendors and storing pricing and other information for a plurality of product item records, asynchronously maintaining and storing a plurality of per-product-item fee records and proceed split percentage information, providing to veterinary hospitals responsive item product information for one or more items selected and creating and temporarily storing a snapshot for subsequent optional recall of product item record pricing, per-item and per-invoice fee information, and making selected item product information available for display.Type: ApplicationFiled: February 8, 2011Publication date: August 9, 2012Applicant: STRATEGIC PHARMACEUTICAL SOLUTIONS, INC.Inventors: DONALD C. SUTTER, KURT D. GREEN, THOMAS A. FRIAR, ANDREW J. BANE
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Publication number: 20120203671Abstract: A computer-enabled method for efficiently displaying automatically generated, customizable views of a master product item catalog of veterinary pharmaceutical and other animal-related product item records provided by a centralized pharmacy to a large number of veterinarians, veterinary hospitals and customers, the views comprising administrator views, hospital staff views and user views, the views being selectively excludable and modifiable by each hospital administrator via an exception-type customization and hospital manageable database, access to which is provided for each hospital on the central pharmacy's server, each hospital being enabled to provide customers and staff of the hospital access to its customized catalog via point-of-sale and e-commerce points of access over the Internet or other network.Type: ApplicationFiled: February 8, 2011Publication date: August 9, 2012Applicant: STRATEGIC PHARMACEUTICAL SOLUTIONS, INC.Inventors: DONALD C. SUTTER, KURT D. GREEN, THOMAS A. FRIAR, ANDREW J. BANE
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Patent number: 8206734Abstract: This invention is related to the use of polyurethane based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs. The drug delivery device for releasing one or more drugs at controlled rates for an extended period of time to produce local or systemic pharmacological effects comprises: 1. a reservoir, said reservoir comprising; 2. at least one active ingredient; and, optionally, 3. at least one pharmaceutically acceptable carrier; a polyurethane based polymer completely surrounding the reservoir.Type: GrantFiled: August 31, 2010Date of Patent: June 26, 2012Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Sheng-hung Kuo, Petr Kuzma
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Patent number: 8071537Abstract: Described herein are implantable devices, formulations and methods of making implantable devices for the release of a polypeptide from an implantable device, and methods of use thereof.Type: GrantFiled: June 24, 2009Date of Patent: December 6, 2011Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Petr Kuzma, Stefanie Decker, Harry Quandt
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Patent number: 8062652Abstract: The present invention is directed to the controlled delivery of gonadotropin-releasing hormone (GnRH) agonists, preferably from a polymeric material that is implanted in the body. More specifically, the present invention relates to compositions comprised of a GnRH agonist, preferably histrelin, in a polymeric material that results in a desired and controlled delivery of a therapeutically effective amount of GnRH agonist over an extended period of time in order to treat central precocious puberty (CPP).Type: GrantFiled: June 17, 2005Date of Patent: November 22, 2011Assignee: Endo Pharmaceuticals Solutions Inc.Inventor: Petr Kuzma
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Publication number: 20110196804Abstract: A computer-enabled method and system for generating a script for veterinary pharmaceutical and other animal-related product transactions comprising aggregation of participant data, including animal hospital data, veterinarian data, client data and animal data into the script, adding treatment regimen data to one or more orders associated with the script in accordance with the veterinarian's treatment plan, to enable determination of the initial date to begin filling the product, quantity of product, the number of fills and frequency to enable automatic generation of a series of autoship records including projected dates for shipping the orders to the animal owner upon verification of funds available, to print usage instructions, Rx labels, product information, shipping labels and packing slips, and to send notification emails to the animal owner and confirmation emails to the animal hospital.Type: ApplicationFiled: February 10, 2010Publication date: August 11, 2011Applicant: STRATEGIC PHARMACEUTICAL SOLUTIONS, INC.Inventors: Donald C. Sutter, Kurt D. Green, Thomas A. Friar, Andrew J. Bane, Sara C. Davis
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Patent number: 7960335Abstract: Methods, formulations and kits are described that allow for the controlled release of octreotide, e.g., octreotide acetate, in a subject.Type: GrantFiled: June 24, 2009Date of Patent: June 14, 2011Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Petr Kuzma, Stefanie Decker, Harry Quandt
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Patent number: 7858638Abstract: Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.Type: GrantFiled: February 1, 2005Date of Patent: December 28, 2010Assignee: Endo Pharmaceuticals Solutions, Inc.Inventors: John J. Murphy, Kay Jorgenson D'Orlando
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Patent number: 7858110Abstract: This invention is related to the use of polyurethane-based polymer as a drug delivery device to deliver biologically active compounds at a constant rate for an extended period of time and methods of manufactures thereof. The device is very biocompatible and biostable, and is useful as an implant in patients (humans and animals) for the delivery of appropriate bioactive substances to tissues or organs.Type: GrantFiled: September 30, 2008Date of Patent: December 28, 2010Assignee: Endo Pharmaceuticals Solutions, Inc.Inventors: Petr Kuzma, Harry Quandt
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Patent number: 7850639Abstract: A device for inserting implantable objects beneath the skin of a patient includes a handle for grasping the device and a base connected to the handle. The base comprises a post, a cannula, and a flexible actuator positioned in an angled track. The cannula is positioned coaxially around and is longitudinally slidable over the post from an extended position, where an implantable object is retained in the cannula, to a retracted position, where the implantable object is released from the cannula. A flexible actuator positioned on an angled track in the base is slidably engaged with a boss on the cannula and is used to move the cannula from an extended position to a retracted position to release the implantable object from the cannula; the actuator flexes between a locked and an unlocked position. The angled track provides for control of the release of the implantable object.Type: GrantFiled: March 31, 2009Date of Patent: December 14, 2010Assignee: Endo Pharmaceuticals Solutions, Inc.Inventors: Matthew L. Rue, David S. Tierney
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Patent number: 7803773Abstract: A formulation of octreotide or pharmaceutically acceptable salts thereof, which provides controlled release of a therapeutically effective amount of octreotide for a period of at least about two months. Methods of treating acromegaly, decreasing growth hormone, decreasing IGF-1, and treating conditions associated with carcinoid tumors and VIPomas by administering a controlled release formulation of octreotide are provided herein.Type: GrantFiled: September 29, 2008Date of Patent: September 28, 2010Assignee: Endo Pharmaceuticals Solutions Inc.Inventors: Petr Kuzma, Stefanie Decker
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Patent number: 7759334Abstract: A solid mixture or aqueous solution of amoxicillin antibacterial agent with a material that aids in its dissolution in water to render it ingestive and palatable.Type: GrantFiled: June 27, 2007Date of Patent: July 20, 2010Assignee: Pharmaceutical Solutions, Inc.Inventors: Michael A. Strobel, Pat Soderlund, Jr.