Patents Assigned to Pharmacia AB
  • Patent number: 6559120
    Abstract: A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phi p I epitope clones (28, 34, 41, 42, 43, 45, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114), with the amino acid sequences defined in SEQ ID NOS: 5, 7, 9 and 12-28, and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phi p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114). Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: May 6, 2003
    Assignee: Pharmacia AB
    Inventors: Tanja Ball, Susanne Vrtala, Wolfgang Sperr, Peter Valent, Markus Susani, Dietrich Kraft, Rudolf Valenta, Sylvia Laffer
  • Patent number: 6558395
    Abstract: A device for deforming and ejecting a deformable intraocular lens for insertion into a small incision in an eye, the device comprising a) a housing, b) a lens transporting duct in a front part of the housing defining a duct axis, the duct having a front end with a cross-section adapted to the lens in deformed state with small maximum dimensions transversal to the duct axis, a rear lens-receiving end with a cross-section adapted for the lens in un-deformed state, or less deformed state, than at the front end, with larger maximum dimensions lateral to the duct axis than at the front end and an intermediate convergent duct part between the front and rear ends with a varying cross-section shape, having decreasing maximum dimensions lateral to the duct axis when moving from rear to front in the duct and c) a plunger operative to displace the lens in the duct at least in the forward direction.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: May 6, 2003
    Assignee: Pharmacia AB
    Inventors: Birger Hjertman, Jonas Fridholm, Hans Himbert, Carl-Göran Crafoord
  • Patent number: 6547755
    Abstract: A delivery device including a) a housing, b) a container for a fluid arranged in the housing, the container having an opening, c) a delivery conduit connected in fluid communication with the opening, the conduit having a front end in flow respect distal from the container and a rear end in flow respect proximal to the container, the front end and the rear end defining an axis therebetween and a forward direction and a rearward direction, and d) a pump arranged to deliver fluid at least in a direction from the container through the conduit, the device comprising, a sensor able to change state in at least one respect in response to a predetermined proximity of an object to the sensor in a sensing direction, a converter, separate from or integral with the sensor, converting at least one of the sensor states into an electromagnetic signal, and a processor, receiving the electromagnetic signal and delivering a control signal to an operational component of the device.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: April 15, 2003
    Assignee: Pharmacia AB
    Inventors: Barbara Lippe, Anders Holte, Hans Himbert, Birger Hjertman, Bohdan Pavlu, Magnus Westermark, Ranier Bosse, Markus Adam
  • Patent number: 6537795
    Abstract: A method for selecting streptococcus strains capable of producing hyaluronic acid with molecular weight exceeding six million includes the steps of cultivating strains of streptococci individually in culture medium which is free of metal ions which promote degradation of hyaluronic acid and which does not release from the reactor metal ions which promote the degradation of hyaluronic acid; and selecting a supercapsulated strain of a streptococcus, supercapsulated members thereof having a mucoid morphology and being capable of forming capsules having a diameter of greater than 4 &mgr;m.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: March 25, 2003
    Assignee: Pharmacia AB
    Inventor: Sten Ståhl
  • Patent number: 6528322
    Abstract: The invention relates to a method for qualitative, semi-quantitative or quantitative determination of at least two analytes in an aqueous sample containing or suspected of containing the analytes, which method comprises the steps of: (i) providing a flow matrix comprising a separation zone extending in a first dimension thereof, and a detection zone extending in the first dimension in a spaced parallel relationship with the separation zone, the detection zone comprising an immobilized reagent capable of capturing the analytes through biospecific interaction therewith, (ii) applying the sample to the flow matrix at or upstream of the separation zone, (iii) initiating a first essentially aqueous fluid flow in the flow matrix along the separation zone in the first dimension to transport the analytes through the separation zone to be separated therein, (iv) interrupting the first fluid flow and initiating a second essentially aqueous fluid flow in a second dimension of the flow matrix substantially transverse
    Type: Grant
    Filed: August 4, 2000
    Date of Patent: March 4, 2003
    Assignee: Pharmacia AB
    Inventors: Jan Carlsson, Maria Lönnberg
  • Patent number: 6517864
    Abstract: Device for transdermal administration of tolterodine, optionally encompassing salts, prodrugs and metabolites thereof, optionally together with pharmaceutically acceptable carrier(s) to a human being or an animal in order to achieve an effect against overactive bladder. Use of a compound having an effect against overactive bladder comprising tolterodine, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable carrier(s), for the manufacture of a composition to be administered transdermally for achieving an effect against overactive bladder. Method for achieving an effect against overactive bladder in a living body by transdermal administration of a compound comprising tolterodine, optionally encompassing salts, prodrugs and metabolites thereof, and optionally together with pharmaceutically acceptable carrier(s).
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: February 11, 2003
    Assignee: Pharmacia AB
    Inventors: Lene Orup Jacobsen, Bo Kreilgard, Ulla Hoeck, Helle Kristensen
  • Patent number: 6514498
    Abstract: A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, referably TCRV&bgr;, and T cell activation has been replaced by another amino acid residue while retaining the ability to activate a subset of T cells. In a preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens. A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs.
    Type: Grant
    Filed: August 12, 1996
    Date of Patent: February 4, 2003
    Assignee: Pharmacia AB
    Inventors: Per Antonsson, Per Björk, Mikael Dohlsten, Johan Hansson, Göran Forsberg, Lars Abrahmsén, Terje Kalland
  • Patent number: 6506425
    Abstract: Method for marking an object where the object is placed in a package whereby a pattern in said package is caused to make a marking in said object. Objects being marked with the above method. The invention is especially useful for marking solid or semi-solid formulations of drugs, candy and food-stuff. Specifically the invention is useful to mark nicotine-containing chewing gums. Other solid or semi-solid objects can equally well be marked using the present invention.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: January 14, 2003
    Assignee: Pharmacia AB
    Inventor: Stig Gustafsson
  • Patent number: 6495329
    Abstract: The present invention relates to a method for determinating cytokine receptor, especially growth hormone receptor (GHR), activation, by the use of an antibody capable of discriminating between an activated and an inactive cytokine receptor conformation, especially GHR or growth hormone binding protein (GHBP) conformation, the method comprising: contacting the antibody and the cytokine receptor to form a complex, contacting a candidate ligand to the complex, measuring the antibody binding to inactive cytokine receptor and thereby discriminating between an activated and an inactive conformation. The invention also relates to an antibody directed to the hinge spanning subdomains I and II of the growth hormone receptor extracellular region and which is capable of discriminating between an activated and an inactive receptor conformation. The invention also relates to the use of the antibody for e.g.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: December 17, 2002
    Assignees: Pharmacia AB, Consejo Superior de Investigaciones
    Inventors: Carlos Martinez Alonso, José Mario Mellado Garcia, Leonor Kremer Baron, José Miguel Rodriguez Frade
  • Publication number: 20020137692
    Abstract: Novel compositions comprising a potassium channel opener, such as minoxidil, and a protein kinase C inhibitor, such as procyanidin B2 are presented, as are kits containing a first composition comprising a potassium channel opener and a second composition comprising a protein kinase C inhibitor. Also presented are methods for using the novel compositions for treating and preventing hair loss in a region of a patient.
    Type: Application
    Filed: January 29, 2002
    Publication date: September 26, 2002
    Applicant: Pharmacia AB
    Inventors: Jan Rundegren, Bo Kreilgaard
  • Patent number: 6423040
    Abstract: An eye fluid applicator. A hand grip part has a distal end and a proximal end. The distal end and the proximal end define an axis therebetween, a distal direction, and a proximal direction along the axis. A container includes a bottle part and a delivery orifice for delivery of a stream or drops. The orifice defines a fluid delivery axis and a fluid delivery direction from the bottle through the orifice along the fluid delivery axis. The container orifice is arranged closer to the proximal end of the container than the distal end. An eye cup part has a rim and a cavity. The rim defines a contact plane, a contact axis normal to the contact plane, and a contact direction along the contact axis from the cavity toward the rim. The eye cup is arranged at the orifice. The proximal direction of the hand grip and the contact direction of the eye cup form an acute angle therebetween.
    Type: Grant
    Filed: June 2, 1998
    Date of Patent: July 23, 2002
    Assignee: Pharmacia AB
    Inventors: Maria Benktzon, Henric Bjarke, Carl-Göran Crafoord, Hans Himbert, Stig Mannberg, Ann-Marie Svensson, Jonas Törnsten
  • Patent number: 6398771
    Abstract: A flexible transparent container for improved storage of oxygen sensitive parenterally administerable agents comprising an inner, primary container enclosed in a substantially oxygen impermeable outer envelope with an oxygen absorber, capable of consuming essentially all residual oxygen after the outer envelope is sealed, and for sufficient period also the oxygen penetrating said envelope. The inner container is made of a polypropylene containing flexible polymeric material compatible with lipophilic agents capable of forming both permanent and peelable seals, while the envelope is made of a substantially water impermeable flexible multilayered polymeric material comprising a first outer substantially water impermeable polymeric film with oxygen barrier forming capacity, assembled with a second, inner polymeric film with a supplementary oxygen barrier forming capacity. The container essentially maintains its characteristics after being subjected to sterilization by steam or radiation.
    Type: Grant
    Filed: October 19, 1999
    Date of Patent: June 4, 2002
    Assignee: Pharmacia AB
    Inventors: Bo Gustafsson, Stefan Lundmark, Kjell Berglund, Cathrine Brooling, Otto Skolling
  • Patent number: 6399387
    Abstract: The present invention relates to new color compositions which are especially suitable to be used in oxygen indicators. The compositions comprise iron(II), an agent containing pyrogallol entities and an organic acid.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: June 4, 2002
    Assignee: Pharmacia AB
    Inventors: Åke Stenholm, Lars Karlsson, Anders Löfgren, Bo Nyström, Otto Skolling
  • Patent number: 6399734
    Abstract: The present invention relates to photocurable siloxane polymers having functional acryl groups, useful in the preparation of intraocular lenses (IOLs). The polymers are siloxane copolymers, wherein the siloxane can be selected from the group consisting of diphenyl siloxane, phenylalkyl siloxane, dialkyl siloxane, and trifluoroalkyl alkyl siloxane. The invention also relates to methods for producing the said siloxane polymers, as well as to producing accommodating lenses in vivo, which means that the tens is formed in the capsular bag of the eye.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: June 4, 2002
    Assignee: Pharmacia AB
    Inventors: Kenneth A. Hodd, Sverker Norrby
  • Patent number: 6391414
    Abstract: The invention relates to an article of manufacture comprising a partial or complete tubular primary part defining a tube axis and having an at least partially curved circumferential wall at least partially encircling the axis; said wall comprising a joint edge, defining a) a joint line along said edge on said wall, b) a joint plane drawn to contain said joint line, c) a joining direction having at least a direction component perpendicular to said joint line and said joint plane, d) a locking plane at least partially at the surface or within a section through said wall in which both said joint line and said joining direction lies and e) a normal direction being perpendicular to said joint plane; and at least one locking structure, the improvement comprising that the locking structure includes at least one positive or negative hook structure in said locking plane, extending in the joining direction away from the joint line and having an undercut in the locking plane and that the hook structure is exposed from a
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: May 21, 2002
    Assignee: Pharmacia AB
    Inventors: Birger Hjertman, Rudolf Cseke
  • Patent number: 6392223
    Abstract: A tilt sensing device and method for its operation, the device being of the type comprising (a) a housing, (b) a radiation transmitter and a radiation receiver arranged in or at the housing to form a beam path therebetween, (c) a radiation obstructing or deflecting body movable in relation to the beam path and (d) a rest surface for the body defining at least two possible rest positions for the body can move by gravity at defined tilt angles for the device and which rest positions are selected to give a detectable output difference from the radiation receiver depending on which of the rest positions is occupied by the body. The size of the movable body, expressed as the diameter of a sphere of corresponding volume, is less than 10 mm. Operation of the device includes monitoring the output from the receiver to obtain an amplitude versus time function and processing data from the function to obtain a modified signal.
    Type: Grant
    Filed: June 28, 1999
    Date of Patent: May 21, 2002
    Assignee: Pharmacia AB
    Inventors: Birger Hjertman, Anders Holte
  • Publication number: 20020052490
    Abstract: A recombinant DNA molecule comprising a nucleotide sequence (I) which codes for a polypeptide displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in FIG. 2 and preferably being derived from grasses or monocotyledonic plants, or a nucleotide sequence (II) which hybridizes with such a nucleotide sequence (I) under conditions of high stringency. Polypeptides displaying the antigenicity of one, two or more of the Phl p I epitope clones (28, 34, 41, 42, 43, 50, 52, 64, 80, 85, 86, 95, 97, 98, 103, 108, 109, 113, 114) with the amino acid sequences defined in FIG. 2 +L. Recombinant expression vectors containing the recombinant molecule and host cells transformed with the vector. Diagnostic methods based on utilizing the polypeptides in immunoassays for humoral antibodies and cellular reactions.
    Type: Application
    Filed: March 20, 2001
    Publication date: May 2, 2002
    Applicant: PHARMACIA AB
    Inventors: Tanja Ball, Susanne Vrtala, Wolfgang Sperr, Peter Valent, Markus Susani, Dietrich Kraft, Rudolf Valenta, Sylvia Laffer
  • Patent number: 6371939
    Abstract: An autoinjector for replaceable containers of syringe type, comprising a barrel of axially roughly constant cross-section, a front opening with or for an injection needle and at least one movable rear piston, optionally with a plunger connected thereto, inserted in the barrel for the displacement of a container content, the autoinjector comprising a) a housing, b) a container carrier, arranged for reception of the container and arranged movably in relation to the housing in container axial direction between a rear, needle-covering, position and a forward, needle-exposing, position, c) an autopenetration mechanism, comprising at least a penetration head and a penetration drive, the penetration head being arranged for movement of the barrel or carrier in the forward direction and the penetration drive being operable to apply force between the housing and the penetration head, d) an autoinjection mechanism, comprising at least an injection head and an injection drive, the injection head being arranged for moveme
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: April 16, 2002
    Assignee: Pharmacia AB
    Inventors: Thomas Bergens, Mikael Amark
  • Patent number: D467414
    Type: Grant
    Filed: April 15, 2002
    Date of Patent: December 24, 2002
    Assignee: Pharmacia AB
    Inventors: Bohdan Pavlu, Daniel Höglund, Jonas Fridholm, Hans Himbert, Ulrika Vejbrink
  • Patent number: D471976
    Type: Grant
    Filed: December 26, 2001
    Date of Patent: March 18, 2003
    Assignee: Pharmacia AB
    Inventors: Bohdan Pavlu, Carl-Göran Crafoord, Jonas Fridholm, Hans Himbert, Ulrika Vejbrink, Daniel Höglund