Patents Assigned to Pharmacia Italia S.p.A.
  • Publication number: 20110166077
    Abstract: The present invention provides the use of acryloyl distamycin derivatives, in particular ?-bromo- or ?-chloro-acryloyl distamycin derivatives, in combination with radiotherapy, for the treatment of tumors.
    Type: Application
    Filed: October 1, 2004
    Publication date: July 7, 2011
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Maria Geroni, Jennifer Tursi, Camilla Fowst
  • Publication number: 20070142415
    Abstract: Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5 and R6 are as defined in the specification or a pharmaceutically acceptable salt or solvate thereof, compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 19, 2005
    Publication date: June 21, 2007
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Ermes Vanotti, Barbara Forte, Katia Martina, Maria Menichincheri, Alessandra Cirla, Paolo Orsini
  • Publication number: 20070142414
    Abstract: Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 21, 2007
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Ermes Vanotti, Maria Menichincheri, Paolo Orsini, Alessandra Scolaro, Mario Varasi
  • Publication number: 20070112020
    Abstract: The present invention is directed to compounds of the formula or pharmaceutically acceptable salts, prodrug, solvate or optical isomer thereof, pharmaceutical compositions containing same and use thereof for treating diseases linked to disregulated cell proliferation or to disregulated protein kinase.
    Type: Application
    Filed: November 11, 2005
    Publication date: May 17, 2007
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Ermes Vanotti, Francesco Angelucci, Alberto Bargiotti, Maria Brasca, Antonella Ermoli, Maria Menichincheri
  • Publication number: 20060276471
    Abstract: Pyrrolo[3,4-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: August 11, 2006
    Publication date: December 7, 2006
    Applicant: Pfizer Italia S.r.l. (formerly Pharmacia Italia S.p.A.)
    Inventors: Daniele Fancelli, Barbara Forte, Jurgen Moll, Mario Varasi, Paola Vianello
  • Publication number: 20060205814
    Abstract: The present invention concerns a method of therapeutic prevention and treatment of a heart disease chosen from cardiac insufficiency and heart failure including the administration of an essential fatty acid containing a mixture of eicosapentaenoic acid ethyl ester (EPA) and docosahexaenoic acid ethyl ester (DHA), either alone or in combination with another therapeutic agent.
    Type: Application
    Filed: January 17, 2006
    Publication date: September 14, 2006
    Applicant: Pharmacia Italia S.P.A.
    Inventors: Francesco Granata, Franco Pamparana, Eduardo Stragliotto
  • Publication number: 20060160874
    Abstract: Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: January 18, 2005
    Publication date: July 20, 2006
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Roberto Tonani, Simona Bindi, Daniele Fancelli, Valeria Pittala', Matteo D' Anello
  • Publication number: 20060106083
    Abstract: Compounds which are indazole derivatives and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them, as well as combinatorial libraries of indazole derivatives, as set forth in the specification, are disclosed; these compounds or compositions may be useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
    Type: Application
    Filed: November 17, 2004
    Publication date: May 18, 2006
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Katia Martina, Wolfgang Brill
  • Patent number: 7034049
    Abstract: Compounds which are 3-amino-pyrazole derivatives represented by formula (I) wherein R is C3–C6 cycloalkyl group optionally substituted by a straight or branched C1–C6 alkyl or arylalkyl group; R1 is a straight or branched C1–C6 alkyl, C2–C4 alkenyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, arylalkyl, arylcarbonyl, aryloxyalkyl or arylalkenyl group, each of which may be optionally further substituted as indicated in the description; or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: April 25, 2006
    Assignees: Pharmacia Italia S.p.A., Pharmacia & Upjohn Company LLC
    Inventors: Paolo Pevarello, Paolo Orsini, Gabriella Traquandi, Mario Varasi, Edward L. Fritzen, Martha A. Warpehoski, Betsy S. Pierce, Maria Grabriella Brasca
  • Patent number: 7030089
    Abstract: Compounds which are ?-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: April 18, 2006
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Maria Cristina Geroni, Paolo Cozzi, Italo Beria
  • Publication number: 20060046993
    Abstract: This invention relates to a novel crystalline polymorphic form of irinotecan hydrochloride. A process for preparing this novel polymorphic form, pharmaceutical compositions comprising it as an active ingredient and the use of the same and its pharmaceutical compositions as a therapeutic agent is also within the scope of the present invention.
    Type: Application
    Filed: September 1, 2004
    Publication date: March 2, 2006
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Romualdo Forino, Natale Barbugian, Massimo Zampieri, Attilio Tomasi
  • Patent number: 7005285
    Abstract: The present invention provides a human polypeptide homolog of P21-activated kinase (PAK) polynucleotides which identify and encode PAK5 serine/threonine kinase. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of PAK5 agonists/antagonists, useful for the treatment of human diseases and conditions.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: February 28, 2006
    Assignee: Pharmacia & Italia S.P.A.
    Inventors: Mats Dahlberg, Jurgen Moll, Arturo Galvani
  • Patent number: 6974828
    Abstract: Novel propanoic acid derivatives are integrin receptor antagonists or inhibitors, in particular of the avb3 integrin receptor. The compounds of the invention are for instance useful for the treatment of solid tumors by inhibition of angiogenic growth of tumor vessel network, thus promoting tumor regression, inhibition of metastatic spread, thus avoiding cancer metastases, inhibition of bone resorption, thus controlling osteoporosis, inhibition of smooth muscle cells migration into neointima, thus blocking restenosis after percutaneous coronary angioplasty and the treatment of other pathological conditions mediated by cell adhesion, cell migration or angiogenesis such e.g. diabetic retinopaty, rheumatoid arthritis and inflammation.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: December 13, 2005
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Tiziano Bandiera, Paola Vianello, Paolo Cozzi, Arturo Galvani
  • Patent number: 6969592
    Abstract: The present invention relates to the field of cancer treatment and, more particularly, it relates to a method for predicting the sensitivity towards chemotherapy of a patient, by measuring glutathione (GSH) blood levels of the said patient undergoing chemotherapeutic treatment.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: November 29, 2005
    Assignees: Pharmacia Italia S.p.A., Pharmacia & Upjohn Company LLC
    Inventors: Camilla Fowst, Maria Christina Rosa Geroni, Jennifer Margaret Tursi, Franzanne Vreeland
  • Publication number: 20050256151
    Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
    Type: Application
    Filed: December 23, 2004
    Publication date: November 17, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Barbara Salom, Matteo D'Anello, Maria Brasca, Patrizia Giordano, Katia Martina, Francesco Angelucci, Frederick Brookfield, William Trigg, Edward Boyd, Jonathan Larard
  • Patent number: 6951951
    Abstract: A process for preparing distamycin derivatives possessing antitumor activity, by starting from distamycin A itself, is described.
    Type: Grant
    Filed: June 14, 2001
    Date of Patent: October 4, 2005
    Assignee: Pharmacia Italia S.p.A.
    Inventors: Italo Beria, Paolo Cozzi, Nicola Mongelli, Fabrizio Orzi
  • Publication number: 20050209269
    Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
    Type: Application
    Filed: December 23, 2004
    Publication date: September 22, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Barbara Salom, Matteo D'Anello, Maria Brasca, Patrizia Giordano, Katia Martina, Dania Tesei, Frederick Brookfield, William Trigg, Edward Boyd, Jonathan Larard
  • Publication number: 20050187209
    Abstract: Thieno[2,3-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: February 3, 2005
    Publication date: August 25, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Daniele Fancelli, Paola Vianello, Mario Varasi, Simona Bindi, Sergio Vioglio, Dania Tesei
  • Publication number: 20050143315
    Abstract: The present invention provides the use of acryloyl distamycin derivatives, in particular ?-bromo- or ?-chloro-acryloyl distamycin derivatives, in combination with radiotherapy, for the treatment of tumors.
    Type: Application
    Filed: October 1, 2004
    Publication date: June 30, 2005
    Applicant: Pharmacia Italia S.p.A.
    Inventors: Maria Geroni, Jennifer Tursi, Camilla Fowst
  • Publication number: 20050143927
    Abstract: The present invention relates to a method for estimating or predicting anti-tumor activity of a compound and for estimating or predicting the tumor growth in mammals; the estimation comprises a) measuring the tumor weight in time; b) measuring the concentration of the compound in time; c) calculating kinetic parameters of the tumor growth: -a parameter (L0), representative of the portion of tumor cells present at the instant t0=0 that succeeds in taking root and in starting tumor cells proliferation in the mammals; -an index (?0) of the production rate of tumor cells during an exponential phase of tumor growth; -an index (?1) of tumor cells mass produced in the time unit during a linear phase of the tumor growth; and pharmacodynamic parameters: -an index (K1) of tumor cells death rate; -an index (K2) of the potency of the compound; and d) calculating tumor growth curves.
    Type: Application
    Filed: September 15, 2004
    Publication date: June 30, 2005
    Applicants: Pharmacia Italia S.p.A., Universita Degli Studi Di Pavia
    Inventors: Cristiano Cammia, Giuseppe DeNicolao, Italo Poggesi, Maurizio Rocchetti