Abstract: An apparatus for a controlled delivery of a liquid preparation from a cylindrical liquid container, which has a liquid outlet at its front end and a movable wall, which acts like a piston at its rear end is provided. The driving force acting on the movable wall for expelling the liquid from the container is generated by means of a piston rod in connection with a piston, which by the action of the atmospheric pressure is urged into a space where a vacuum has been established. The amount delivered can be varied according to different modes by providing an auxiliary force which acts on the piston during the initial stage of its movement into the vacuum space.

Abstract: The invention relates to the use of a new type of peptide antagonists at glutamate receptors and a subtype of glutamate receptors (NMDA (N-methyl-D-aspartate)) for the manufacture of a medicament to influence the glutamate receptor and the NMDA-receptor controlled cells such as neurons or glial cells in the central nervous system.

Abstract: Porous cellulose matrices with a defined particle size and a significantly higher porosity (i.e. pore volume) than conventional formulations, such as pellet formulations containing cellulose and binders are prepared. The cellulose is mechanically treated with low adhesion to the process equipment during a controlled gradual addition of an aqueous based fluid, optionally containing a surface-active ingredient, into regular particles, which are finally dried to obtain dry porous cellulose matrices. The so obtained matrices can be used as carriers for bioactive substances in multiple-unit preparations or tablets.

Abstract: The invention relates to the use of growth hormone (GH) or effective analogues thereof for the manufacture of a medicament intended for preoperative administration in order to reduce protein loss, especially for the manufacture of a medicament for the preparation of a patient for surgery or other elective situation where catabolism may be induced.

Abstract: The invention relates to solutions containing IGF-1 or any functional analogue thereof in which pH is 5.5 to 6.5, preferably 5.7 to 6.2. The amount of phosphate as buffer substance should be in a concentration of less than 50 mmol/L Preferably the formulation is an aqueous solution of IGF-1 and phosphate as buffer substance in a concentration of 5 to 50 mmole or more preferably 5-20 mmol/L, e.g. 10 mmol/L. The solution should be isotonic. The solution gives a reduced pain upon subcutaneous injection. The invention also relates to a process for preparation of the formulation by mixing IGF-1 or any functional analogue thereof with a buffer substance giving pH 5.5 to 6.5 and an isotonic agent. It also relates to a method for treatment of a patient in need of IGF-1 or any functional analogue thereof by administering the claimed formulation.

Abstract: An apparatus for controlled delivery of a liquid consists of a delivery unit which comprises a liquid container (3) having at least one movable wall (12) and a liquid outlet which is provided with a flow restriction, and a power unit which comprises a second container (21) which also has at least one movable wall (29) and wherein a vacuum may be established, and a mechanical coupling (31) between the movable wall (12) of the liquid container(3) and the movable wall (29) of the second container (21). The delivery unit and the power unit are connected together coaxially when the apparatus is prepared for delivery, and in this connecting together, the movable wall (29) of the second container is displaced by means of the mechanical coupling (31) such that the vacuum is established.

Abstract: Molecular cloning and expression of a prostaglandin F2.alpha. receptor which is linked to the signal transduction pathways via guanine nucleotide binding regulatory (G) proteins and measured by, for example, cAMP, IP.sub.3 or intracellular calcium. By constructing cell lines that express a prostaglandin F2.alpha., receptor, the affinities and efficacies of agonist and antagonist drugs with the receptor can be assessed. A recombinant DNA construct includes a vector and a DNA fragment encoding a prostaglandin F2.alpha. receptor. A host cell is transformed with a recombinant DNA construct, so that the DNA fragment is expressed and a prostaglandin F2.alpha., receptor is produced. Suitable host systems include eukaryotic and prokaryotic cells, especially mamalian cells such as rat or human. Additionally, for diagnostic purposes, antibodies to a prostaglandin F2.alpha. receptor can be prepared by producing all or a portion of the receptor protein and injecting these into various types of mammals.

Abstract: The present invention relates to omega-3-fatty acid containing preparations for the treatment of Disseminated Intravascular Coagulation (DIC) and symptoms related to DIC, as well as such preparations for reducing a pathological increase in pulmonary artery pressure (PAP). The preparations may be in the form of emulsions, or aerosols for inhalation, of an oil or phospholipids or other derivatives or salts of omega-3-fatty acids of marine and/or vegetable origin with a significant content of omega-3-fatty acids. The preparations may also be in tablet or capsule form for oral use.

Abstract: A piston (11) to be used in displacing a liquid inside a cylindrical chamber, such as in an injection cartridge of the dual-chamber type, has at least one of its end surfaces (12) shaped convex such that said end surface or surfaces (12) are essentially planar when the piston has been arranged inside the barrel of said cartridge. Preferably both pistons in the cartridge have such a shape, their planar surfaces facing each other.

Abstract: An autoclavable multi-layer film formed of thermoplastic materials capable of being processed into hollow shapes and useful for packaging oxygen sensitive materials. The film includes sequential layers A--B--C--D--C--B'--A', wherein the film may optionally not include layer A or A' and the corresponding layer B or B'. A and A' are layers substantially water and water vapor resistant, wherein at least one of the layers A and A' is made of polyolefins, polyethylene terephthalates, or co-polymers of polyethylene terephthalates. B and B' are layers adhesively bonding layers A and A' with layers C. C is a layer of a moisture absorbing polymer substantially impermeable to oxygen. The polymer is selected from the group consisting of aromatic polyamides and co-polymers of aromatic polyamides. D is a layer of a polyethylene-vinyl alcohol with a molar ethylene concentration between 0% and 80%.

Abstract: An injection device is provided for the infinitely variable metering and administering of a liquid preparation from a multi-dose injection cartridge having a rear piston which may be moved forward by means of a piston rod. The longitudinal movement of the piston rod is governed by two couplings arranged along the piston rod and each being capable of releasably gripping the piston rod by a locking device. The piston rod has a wedge-shaped cross section and each of the couplings includes a clamping shoe which has a wedge-shaped groove, the cross section of which is adapted to that of the piston rod, and locking device, by which the piston rod and each clamping shoe may be releasably clamped together to lock the piston rod in the groove of said clamping shoe.

Abstract: A method for treatment of a patient for obtaining an increased concentration of a factor selected from the group consisting of growth hormone, insulin-like growth factor (IGF-I) and IGFBP-3 in cerebrospinal fluid by administration of growth hormone or analogues thereof to a patient in need of said treatment.

Abstract: A process for manufacturing crystals of growth hormone (GH) comprising the steps of:i) mixing GH with an aqueous solution comprising a buffer and a chemical compound with the general formula (1):Ar--?--CR.sub.1 R.sub.2 --!n--?--C R.sub.3 R.sub.4 --!m--C R.sub.5 R.sub.6 --OH (1)in which Ar is phenyl, alkyl-substituted phenyl, naphthyl, or alkyl-substituted naphthyl, R.sub.1 to R.sub.6 is H, OH or alkyl and n and m is 0 or 1;ii) incubating; andiii) isolating the crystals is provided. The crystals are in the form of needles, trigonal forms, cubes or parallelepipeds with a length of at least 20 microns.

Abstract: The present invention relates to omega-3-fatty acid containing preparations for the treatment of Disseminated Intravascular Coagulation (DIC) and symptoms related to DIC, as well as such preparations for reducing a pathological increase in pulmonary artery pressure (PAP). The preparations may be in the form of emulsions, or aerosols for inhalation, of an oil or phospholipids or other derivatives or salts of omega-3-fatty acids of marine and/or vegetable origin with a significant content of omega-3-fatty acids. The preparations may also be in tablet or capsule form for oral use.

Abstract: A piston rod device for use in an injection device for an injection cartridge is provided with a single or multiple thread (3) along a predetermined portion of its length, after which the thread (3) changes into a longitudinal groove (5) for each thread, such that a turning movement of the piston rod will turn into an axial movement after the predetermined length. The thread (3) is shaped as one or more helicoidal grooves in the surface of the piston rod (1), the grooves (3) turning into longitudinal grooves (5) after the predetermined length. A nut element (6) cooperates with the thread (3), and its device for cooperating consists of at least one radial inwardly directed projection (10) for each thread, the projection (10) or projections guiding the piston rod (1) by the groove or grooves forming the thread (3).

Abstract: The invention relates to an expression system giving high extracellular production of apolipoprotein AI-M (Milano) using E. coli and comprises a plasmid carrying an origin of replication, an inducible promoter sequence, a DNA sequence coding for a signal peptide, a DNA sequence coding for apolipoprotein AI-M, and a transcription terminator. The invention also relates to a method of producing apolipoprotein AI-M using the expression system.

Abstract: An injection cartridge (1) of the dual-chamber type having a bypass connection (12) between its two chambers (9, 10) which is arranged such that the interior wall of the cartridge is modified in a predetermined area in such a way that the movable wall (11) between the two chambers does not seal completely against the interior wall in said area. The modification of the wall is arranged as a plurality of lands and grooves (12) which have a direction that is inclined in relation to the longitudinal axis of the cartridge barrel.

Abstract: The present invention relates to pharmaceutical compositions containing heparin or heparin fragments or their derivatives in combination with one or more glycerol esters of at least one fatty acid as single absorption enhancer. The compositions are useful for oral administration, for administration through mucous membranes or for transdermal administration. The compositions will when necessary contain further physiologically acceptable additives, such as diluents and/or carriers, suitable for the adaptation to oral, buccal, rectal, sublingual, nasal, subcutaneous or transdermal administration. The composition according to the invention provide excellent absorption and bioavailability without employing additional enhancers or promoters.

Abstract: The present invention relates to a composition comprising exogenous human or animal IGF-I or IGF-II or both or effective analogs thereof comprising foodstuff for oral administration wherein the foodstuff is selected from the group consisting of artificial milk, natural milk and colostrum.

Abstract: Provided is a closed fluid distribution system with manifold devices for aseptically distributing fluids in conduits from a controlled atmosphere zone for production of the fluids to collapsible storage containers located outside the zone. The manifold device facilitates filling of a plurality of containers with one or several compartments. The invention is especially advantageous when regarding that the system can be used for aseptically filling both one-, two- or three-compartment containers for storage, with possibilities of switching between the types of containers.