Abstract: The present invention is directed to the method and use of a helium containing gas for improving the physical stability of packaged sensitive products, especially those products which contain a fat emulsion.
Type:
Grant
Filed:
June 30, 1995
Date of Patent:
November 25, 1997
Assignee:
Pharmacia & Upjohn Aktiebolag
Inventors:
Yves Bourboulou, Micheline Boucheteil, Celine Philippon, Jean Tronchet
Abstract: An injection device is provided for a continuously variable metering and administering of a liquid preparation and having a holder device for a multi-dose injection cartridge, the rear piston of which may be moved forward by means of a piston rod. The piston rod is provided with releasable locking means having at least one longitudinal groove having a wedge-shaped cross section and at least one locking lug having a cross section adapted to that of the groove, and means for urging the locking lug into said grooves to lock the movement of the piston rod, or to release the locking lug from said groove to free the movement of said piston rod. At its rear end, the piston rod is connected to a spring device for moving the piston rod forward and to a device for determining the stroke of the piston rod when the preparation is administered.
Abstract: An acidic emulsion comprising a lipoid dispersed in an aqueous phase, a cationic sphingolipid, and a stabilizing amount of non-ionic surfactant and cholesterol is provided, along with the method of administering the emulsion.
Type:
Grant
Filed:
July 16, 1996
Date of Patent:
October 14, 1997
Assignees:
Pharmacia & Upjohn Aktiebolag, Eli Lilly and Company
Abstract: The invention relates to a lipid particle forming matrix, characterized by, that from a defined system of at least two lipid components chosen from classes of different polarity, in which at least one of the lipid components is bilayer forming, discrete lipid particles are formed spontaneously when interacting with aqueous systems. Preferably at least one of the lipid components is amphiphatic and polar and one is nonpolar. These discrete particles are formed spontaneously from the matrix without any chemical or physical treatment or initiation. The invention also relates to a process for producing the matrix and use thereof.
Type:
Grant
Filed:
May 13, 1994
Date of Patent:
September 9, 1997
Assignee:
Pharmacia & Upjohn Aktiebolag
Inventors:
Bengt Herslof, Alf Gunnar Martin Nicklasson
Abstract: A method for manufacturing an oral controlled release pharmaceutical preparation in the form of a capsule containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, comprising spray coating the morphine containing particles with a coating liquid and drying.
Type:
Grant
Filed:
April 21, 1995
Date of Patent:
August 12, 1997
Assignee:
Pharmacia & Upjohn Aktiebolag
Inventors:
Birgitta Olsson, Maritta Anneli Pesonen, Gert Ragnarsson
Abstract: An acid emulsion comprising a lipoid dispersed in an aqueous phase, a cationic sphingolipid, and a stabilizing amount of non-ionic surfactant and cholesterol is provided, along with the method of administering the emulsion.
Type:
Grant
Filed:
December 7, 1994
Date of Patent:
June 3, 1997
Assignees:
Pharmacia & Upjohn Aktiebolag, Eli Lilly and Company
Abstract: An oral controlled release pharmaceutical preparation in the form of a tablet, capsule or sachet containing a plurality of coated particles comprising a therapeutically effective amount of a salt of morphine coated with a barrier membrane providing a controlled, preferably pH-independent, release of morphine in that the serum concentration of morphine obtained is at least 50% of the maximum serum concentration during at least 12 hours after administration of a single dose, and providing a significantly reduced plasma concentration fluctuation compared to known morphine preparations. A method for the manufacture of such a preparation and the use of such preparations for the manufacture of an analgesic useful in the treatment of severe chronicle pain are also provided.
Type:
Grant
Filed:
March 16, 1994
Date of Patent:
March 25, 1997
Assignee:
Pharmacia & Upjohn Aktiebolag
Inventors:
Birgitta Olsson, Maritta A. Pesonen, Gert Ragnarsson