Patents Assigned to PHARMACOPHOTONICS, INC.
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Patent number: 11618825Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: GrantFiled: September 8, 2021Date of Patent: April 4, 2023Assignee: PHARMACOPHOTONICS, INC.Inventors: Ulf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Patent number: 11337629Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.Type: GrantFiled: November 22, 2019Date of Patent: May 24, 2022Assignee: PHARMACOPHOTONICS, INC.Inventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
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Publication number: 20210379206Abstract: A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard unmodified protein, colloid or crystalloid and a fluorescently-labeled protein, colloid or crystalloid of approximately the same molecular weight. The use of blood volume expanders to measure, adjust and maintain the level of blood volume in a patient also is described.Type: ApplicationFiled: April 30, 2021Publication date: December 9, 2021Applicant: PharmacoPhotonics, Inc. d/b/a FAST BioMedicalInventors: Ruben Sandoval, JR., Erinn Sheridan Reilly, Daniel Meier
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Patent number: 11130865Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: GrantFiled: December 6, 2019Date of Patent: September 28, 2021Assignee: PHARMACOPHOTONICS, INC.Inventors: Ulf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Patent number: 10994030Abstract: A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard unmodified protein, colloid or crystalloid and a fluorescently-labeled protein, colloid or crystalloid of approximately the same molecular weight. The use of blood volume expanders to measure, adjust and maintain the level of blood volume in a patient also is described.Type: GrantFiled: March 25, 2019Date of Patent: May 4, 2021Assignee: PHARMACOPHOTONICS, INC.Inventors: Ruben Sandoval, Jr., Erinn Sheridan Reilly, Daniel Meier
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Publication number: 20200174018Abstract: A method and system for selecting a treatment for a subject based on a value for the interstitial space volume of the subject utilizes plurality of sample data values representing concentrations of small and large markers in plurality of blood samples over time. The sample concentrations are utilized to predict a hypothetical peak concentration of the small marker prior to the dissipation of the markers during the test period. This hypothetical peak concentration and other sample values are utilized with either a bi-exponential or tri-exponential decay curve fitting algorithm to define a decay curve, the curve characteristics of which are then utilized to calculate values for glomerular filtration rate, a leakage rate of the small marker into interstitial space, and finally a value for the interstitial volume. The determined value for the interstitial volume can then be compared with number thresholds and decisions made for recommended therapy for the subject, if desired.Type: ApplicationFiled: October 7, 2019Publication date: June 4, 2020Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICALInventor: Daniel J. Meier
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Publication number: 20200109289Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: ApplicationFiled: December 6, 2019Publication date: April 9, 2020Applicant: PharmacoPhotonics, Inc. d/b/a FAST BioMedicalInventors: Ulf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Publication number: 20200100720Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.Type: ApplicationFiled: November 22, 2019Publication date: April 2, 2020Applicant: PharmacoPhotonics, Inc. d/b/a FAST BioMedicalInventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
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Patent number: 10571397Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.Type: GrantFiled: August 29, 2018Date of Patent: February 25, 2020Assignee: PHARMACOPHOTONICS, INC.Inventors: Ruben Sandoval, Jr., Erinn Reilly, Daniel Meier
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Patent number: 10501630Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: GrantFiled: April 9, 2018Date of Patent: December 10, 2019Assignee: PHARMACOPHOTONICS, INC.Inventors: Ulf J. Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
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Patent number: 10485469Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.Type: GrantFiled: July 25, 2016Date of Patent: November 26, 2019Assignee: PHARMACOPHOTONICS, INC.Inventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
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Patent number: 10279052Abstract: A method for measuring, adjusting and maintaining the level of blood volume in a patient is described. A blood volume expander composition includes, in combination, a standard umodified protein, colloid or crystalloid and a fluorescently-labeled protein colloid or crystalloid of approximately the same molecular weight. The use of blood volume expander to measure, adjust and maintain the level of blood volume in a patient also is described.Type: GrantFiled: February 6, 2015Date of Patent: May 7, 2019Assignee: Pharmacophotonics, Inc.Inventors: Ruben Sandoval, Jr., Erinn Sheridan Reilly, Daniel Meier
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Patent number: 10082465Abstract: Compositions and methods for increasing fluorescent signals generated by biomarkers are described. This serves to increase the accuracy of results when the biomarkers are used for the detection and diagnosis of physiological conditions, such as organ function and plasma volume.Type: GrantFiled: October 24, 2014Date of Patent: September 25, 2018Assignee: Pharmacophotonics, Inc.Inventors: Ruben Sandoval, Jr., Erinn Reilly, Daniel Meier
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Publication number: 20180256755Abstract: Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.Type: ApplicationFiled: November 29, 2017Publication date: September 13, 2018Applicant: PHARMACOPHOTONICS, INC.Inventors: Daniel Meier, Bruce Molitoris, Erinn Sheridan, Ruben Sandoval
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Publication number: 20180180622Abstract: Disclosed are methods for determining biometric indicators such as plasma volume, hematocrit and glomerular filtration rate, in mammalian subjects such as humans. The methods utilize a plurality of fluorescent tags having distinct fluorescent characteristics, which may be associated with a single static molecule, or wherein the static molecule is labeled with a fluorescent tag and a dynamic molecule is labeled with another fluorescent tag. One or more measurements of the intensities of the fluorescent emissions are taken subsequent to introduction of an injectate which contains the fluorescent tags, which can be taken using a probe or via a blood or plasma sample. Compositions and apparatuses for practicing the methods are also disclosed.Type: ApplicationFiled: June 24, 2016Publication date: June 28, 2018Applicant: PHARMACOPHOTONICS, INC. D/B/A FAST BIOMEDICALInventors: Daniel J. Meier, Ruben M. Sandoval, Jr., Erinn Reilly
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Publication number: 20180147302Abstract: Methods of measurement of biometric indicators in a mammalian subject are described. Biometric indicators of interest include hematocrit, plasma volume, volume of distribution, and glomerular filtration rate. The methods are especially applicable to subjects with rapid blood loss and to subjects with unstable hematocrits. Hematocrit may be measured by administering an injectate with a dynamic fluorescent marker and a static fluorescent marker, or a single static marker with two fluorescent tags, into the vascular system of the subject, and monitoring the emission intensities of the markers or fluorescent tags over a period of time. Hematocrit may then be calculated using a calibrated spectrometric analyzer by determining the raw ratio of the markers at T0, calculating the apparent hematocrit, and applying a correction factor.Type: ApplicationFiled: November 29, 2017Publication date: May 31, 2018Applicant: PHARMACOPHOTONICS, INC.Inventors: Daniel Meier, Bruce Molitoris, Erinn Sheridan, Ruben Sandoval
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Patent number: 9938410Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: GrantFiled: October 26, 2015Date of Patent: April 10, 2018Assignee: PHARMACOPHOTONICS, INC.Inventors: Ulf J. Bremberg, Erik Rinbgerg, Wei Berts, Anthony De Belder, James S. Strickland
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Patent number: 9814788Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.Type: GrantFiled: October 24, 2013Date of Patent: November 14, 2017Assignee: PHARMACOPHOTONICS, INC.Inventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
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Patent number: 9398876Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.Type: GrantFiled: December 13, 2012Date of Patent: July 26, 2016Assignee: Pharmacophotonics, Inc.Inventors: Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
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Patent number: 9169398Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.Type: GrantFiled: May 21, 2014Date of Patent: October 27, 2015Assignee: Pharmacophotonics, Inc.Inventors: Ulf Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland