Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
Type:
Application
Filed:
May 21, 2014
Publication date:
September 11, 2014
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS
Inventors:
Ulf BREMBERG, Erik RINGBERG, Wei BERTS, Anthony De BELDER, James S. STRICKLAND
Abstract: The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
Type:
Grant
Filed:
April 1, 2011
Date of Patent:
August 19, 2014
Assignee:
PharmacoPhotonics, Inc.
Inventors:
Ulf Bremberg, Erik Ringberg, Wei Berts, Anthony De Belder, James S. Strickland
Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.
Type:
Application
Filed:
March 13, 2014
Publication date:
July 10, 2014
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS
Inventors:
Bruce A. Molitoris, Exing Wang, Roben M. Sandoval, JR.
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Type:
Application
Filed:
October 24, 2013
Publication date:
February 20, 2014
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS
Inventors:
Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin
Abstract: A method for measuring a glomerular filtration rate of a mammalian subject comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the vascular system of the mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the glomerular filtration rate.
Type:
Grant
Filed:
November 15, 2010
Date of Patent:
November 26, 2013
Assignee:
Pharmacophotonics, Inc.
Inventors:
Exing Wang, Daniel Meier, Robert Bunch, Bruce Molitoris, Ruben Sandoval, Matthew Rubin, Erinn Sheridan
Abstract: A method for measuring a glomerular filtration rate in a mammalian kidney comprises a source of reporter and marker fluorescent molecules. The fluorescent molecules are introduced into the blood stream of a mammalian subject. Over a period of time, a measurement of the intensities of the reporter and marker fluorescent molecules is taken. A ratio is calculated to determine the health of the subject's kidney. This method measures volume of plasma distribution based on a fluorescence of a marker molecule relative to a fluorescence of a reporter molecule.
Type:
Application
Filed:
December 13, 2012
Publication date:
May 9, 2013
Applicant:
PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS
Inventor:
PHARMACOPHOTONICS, INC. D/B/A FAST DIAGNOSTICS
Abstract: The present invention is related generally to measurement of body fluid volumes in an animal subject. The body fluid volumes of interest include extracellular fluid volume (ECFV), total vascular plasma volume (TVPV) and interstitial fluid volume (IFV). The methods are especially beneficial for subjects suffering from renal failure and particularly those undergoing renal dialysis. ECFV can be measured by administering a first molecule which is non-metabolized and permeable to vessel walls of the vascular system wherein the first molecule is distributed within the total vascular space as well as the interstitial space. TVPV can be measured by administering a second molecule which is non-metabolized and impermeable to vessel walls of the vascular system wherein the second molecule is distributed within only the vascular space. IFV can then be calculated using the equation IFV=ECFV?TVPV.
Type:
Application
Filed:
April 29, 2010
Publication date:
November 1, 2012
Applicant:
PHARMACOPHOTONICS, INC.
Inventors:
Bruce A. Molitoris, Exing Wang, Ruben M. Sandoval
Abstract: The present invention is directed to a self-penetrating percutaneous optical sensing device for obtaining and transmitting optical signal from intravascular fluid in a blood vessel, the device comprising: (a) an elongated hollow rigid sensor sheath 20 having a proximal end 21, a distal end 22 and a central channel extending along the sensor sheath, wherein the distal end 22 of the sensor sheath 20 is sufficiently sharpened to puncture a cutaneous barrier and the sensor sheath 20 has a sufficient length to allow the sensor sheath 20 to penetrate into intravascular space of a blood vessel; (b) a flexible optical fiber 30 having a proximal end and a distal end situated coherently within the central channel of the sensor sheath 20 wherein the sensor sheath 20 covers a portion of the distal end of the flexible optical fiber 30 and wherein the distal end of the flexible optical fiber 30 aligns with the distal end 22 of the sensor sheath 20; and (c) an optical sensor 40 connected to the distal end of the flexible op