Patents Assigned to Photogen, Inc.
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Publication number: 20030133940Abstract: New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues.Type: ApplicationFiled: December 30, 2002Publication date: July 17, 2003Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott
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Publication number: 20030125376Abstract: New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation.Type: ApplicationFiled: December 30, 2002Publication date: July 3, 2003Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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Patent number: 6541223Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: GrantFiled: March 9, 2001Date of Patent: April 1, 2003Assignee: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Patent number: 6525862Abstract: Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. In an illustrative embodiment, such modulation is achieved using a modulated light source, a modulation frequency reference, a detector, and a demodulator. The modulated light source may comprise a light source emitting an inherently modulated output; alternately, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured so as to impose a modulation in the output of light source. Methods for imaging using such modulation are also disclosed.Type: GrantFiled: February 8, 2001Date of Patent: February 25, 2003Assignee: Photogen, Inc.Inventors: Walter G. Fisher, Eric A. Wachter
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Patent number: 6519076Abstract: Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. In an illustrative embodiment, such modulation is achieved using a modulated light source, a modulation frequency reference, a detector, and a demodulator. The modulated light source may comprise a light source emitting an inherently modulated output; alternately, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured so as to impose a modulation in the output of light source. Methods for imagine using such modulation are also disclosed.Type: GrantFiled: January 10, 2002Date of Patent: February 11, 2003Assignee: Photogen, Inc.Inventors: Walter G. Fisher, Eric A. Wachter
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Patent number: 6495360Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: GrantFiled: April 6, 2000Date of Patent: December 17, 2002Assignee: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Patent number: 6493570Abstract: The present invention is directed to an apparatus and method of imaging and treatment using at least one photodynamic therapy (“PDT”) agent. In particular, the apparatus and method is for imaging and treating diseased tissue.Type: GrantFiled: November 2, 1998Date of Patent: December 10, 2002Assignee: Photogen, Inc.Inventors: H. Craig Dees, Timothy Scott
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Publication number: 20020161035Abstract: New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues.Type: ApplicationFiled: July 6, 2001Publication date: October 31, 2002Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott
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Patent number: 6468777Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: GrantFiled: March 9, 2001Date of Patent: October 22, 2002Assignee: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Patent number: 6451597Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: GrantFiled: March 9, 2001Date of Patent: September 17, 2002Assignee: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Publication number: 20020122236Abstract: Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. In an illustrative embodiment, such modulation is achieved using a modulated light source, a modulation frequency reference, a detector, and a demodulator. The modulated light source may comprise a light source emitting an inherently modulated output: alternately, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured so as to impose a modulation in the output of light source. Methods for imaging using such modulation are also disclosed.Type: ApplicationFiled: January 10, 2002Publication date: September 5, 2002Applicant: Photogen, Inc.Inventors: Walter G. Fisher, Eric A. Wachter
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Publication number: 20020107281Abstract: The present invention is directed to new methods, medicaments and pharmaceutical compositions and agents for improved cancer treatment that lower recurrence of the primary tumor by causing selective, acute destruction of tumor tissue and thereby exposing the immune system to large amounts of substantially non-denatured tumor material over a short period of time. This effectively vaccinates the host against tumor tissue, allowing the host's immune system to attack any residual tumor tissue, and thereby reduces the recurrence rate and metastasis to remote sites. In preferred embodiments, this enhancement is achieved through application of phototherapeutic or chemotherapeutic modalities that are capable of producing such an acute, necrotic effect on treated lesions without completely denaturing tumor antigens.Type: ApplicationFiled: September 14, 2001Publication date: August 8, 2002Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter
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Publication number: 20020033989Abstract: Methods and apparatus directed to using modulation to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems. In an illustrative embodiment, such modulation is achieved using a modulated light source, a modulation frequency reference, a detector, and a demodulator. The modulated light source may comprise a light source emitting an inherently modulated output; alternately, this modulated light source may comprise a separate optical modulator and a continuous wave, modulated, or pulsed light source configured so as to impose a modulation in the output of light source. Methods for imaging using such modulation are also disclosed.Type: ApplicationFiled: February 8, 2001Publication date: March 21, 2002Applicant: Photogen, Inc.Inventors: Walter G. Fisher, Eric A. Wachter
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Publication number: 20020001567Abstract: New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation.Type: ApplicationFiled: March 26, 2001Publication date: January 3, 2002Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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Patent number: 6331286Abstract: Methods of treating and imaging diseased tissue having the steps of administering a radiosensitizer agent proximate to or into the diseased tissue; and treating the diseased tissue with x-rays or other ionizing radiation so as to activate the radiosensitizer agent in the diseased tissue. Preferably, the radiosensitizer agent is a halogenated xanthene.Type: GrantFiled: December 21, 1998Date of Patent: December 18, 2001Assignee: Photogen, Inc.Inventors: H. Craig Dees, Timothy Scott, John T. Smolik, Eric A. Wachter
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Publication number: 20010044146Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: ApplicationFiled: March 9, 2001Publication date: November 22, 2001Applicant: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Publication number: 20010041361Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: ApplicationFiled: March 9, 2001Publication date: November 15, 2001Applicant: Photogen, IncInventors: H. Craig Dees, John Smolik
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Publication number: 20010041354Abstract: A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.Type: ApplicationFiled: March 9, 2001Publication date: November 15, 2001Applicant: Photogen, Inc.Inventors: H. Craig Dees, John Smolik
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Publication number: 20010022970Abstract: New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection.Type: ApplicationFiled: March 6, 2001Publication date: September 20, 2001Applicant: Photogen, Inc.Inventors: H. Craig Dees, Timothy C. Scott, Eric A. Wachter, Walter G. Fisher, John Smolik
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Patent number: 6042603Abstract: An apparatus for the treatment of a particular volume of plant or animal tissue by treating the plant or animal tissue with at least one photo-active molecular agent, wherein the particular volume of the plant or animal tissue retains at least a portion of the at least one photo-active molecular agent, and then treating the particular volume of the plant or animal tissue with light sufficient to promote a simultaneous two-photon excitation of at least one of the at least one photo-active molecular agent retained in the particular volume of the plant or animal tissue, wherein the at least one photo-active molecular agent becomes active in the particular volume of the plant or animal tissue.Type: GrantFiled: May 4, 1998Date of Patent: March 28, 2000Assignee: Photogen, Inc.Inventors: Walter G. Fisher, Eric A. Wachter, H. Craig Dees