Patents Assigned to Pierre Fabre S.A.
  • Patent number: 5030451
    Abstract: The present invention relates to topical compositions containing caffeine carboxylates with organic bases, which are useful as slenderizing agents and in the treatment of cellulitis, as well as their preparation.The heterogeneous topical compositions of the invention contain, as active principle, a caffeine carboxylic acid which has been salified with a cosmetologically-acceptable organic base, the active principle preferably being present in the form of microparticles or microgranules suspended in a hydroalcoholic gel.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: July 9, 1991
    Assignee: Pierre Fabre S.A.
    Inventors: Marie-Therese Trebosc, Gilbert Mouzin, Henri Cousse
  • Patent number: 4567288
    Abstract: The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: January 28, 1986
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Bernard Bonnaud, Marie Charveron, Francois Fauran
  • Patent number: 4539413
    Abstract: The present invention concerns a novel process for the production of new chemical compounds of the general formula: ##STR1## in which: R.sub.1 and R.sub.2 may be identical or different and represent a hydrogen or halogen atom or else a lower alkyl, lower alkoxy, nitro or acetyl group andR represents a lower alkyl or lower aralkyl group, such as benzyl.These compounds are useful in therapy for the treatment of hypertension and cardiac arrhythmia.The novel process involves reaction of a 2-hydroxymethyl-1,4-benzodioxan with epichlorohydrin to produce an intermediate glycidyl ether, which is then reacted with a primary amine to produce the final 3-amino-1-[(1,4-benzodioxan)-2-yl-methoxy]-2-propanol or an acid addition salt thereof.
    Type: Grant
    Filed: January 3, 1983
    Date of Patent: September 3, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Pol Vilain
  • Patent number: 4511566
    Abstract: The present invention concerns new 2-N-cycloalkylmethyl 3-oxo 5,6-diaryl as-triazines, their method of production, pharmaceutical compositions thereof, and their use as medicaments, for treating pain.The derivatives of 2-N-cycloalkylmethyl 3-oxo 5,6-diaryl as-triazine according to the invention have the general formula I ##STR1## in which Ar represents a phenyl, furyl, thienyl, or pyridyl group, which group may possibly be substituted by a lower C.sub.1 to C.sub.4 alkoxy radical, in particular by the methoxy radical, andn is a whole number having a value of 1 to 4.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: April 16, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Guy Pitet, Henri Cousse, Gilbert Mouzin
  • Patent number: 4510142
    Abstract: This invention relates to new derivatives of biphenyl alkyl carboxylates, to a process for the preparation thereof and the use thereof as medicaments.The new derivatives according to the present invention correspond to general formula (I): ##STR1## wherein X represents a hydrogen atom or a halogen atom,R represents a hydrogen atom or an alkyl group, andR.sub.1 represents the following groups: ##STR2## These compounds will notably be used in the treatment of obstinate pains and inflammatory syndromes.
    Type: Grant
    Filed: October 12, 1982
    Date of Patent: April 9, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Henry Cousse, Gilbert Mouzin, Jean-Pierre Tarayre, Jean-Pierre Rieu
  • Patent number: 4507318
    Abstract: The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: March 26, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Bernard Bonnaud, Marie Charveron, Francois Fauran
  • Patent number: 4501693
    Abstract: The present invention relates to a method of preparing bacterial membranous proteoglycans with an action which induces interferon from soluble membranous proteoglycans of a strain of gram-negative bacterium, wherein the soluble membranous proteoglycans of a strain of gram-negative bacterium are hydrolyzed by lysozyme and the proteoglycans with a molecular weight between 200,000 and 400,000 are separated from the hydrolysis product.The products obtained are useful as a medicament.
    Type: Grant
    Filed: March 3, 1983
    Date of Patent: February 26, 1985
    Assignee: Pierre Fabre S.A.
    Inventors: Lucien Dussourd d'Hinterland, Gerard Normier, Anne-Marie Pinel
  • Patent number: 4478836
    Abstract: The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxamides (Z) of general formula I: ##STR1## in which: R represents a hydrogen or halogen atom, a lower alkyl group, a lower alkoxy group, or a hydroxy. nitro or amino group;n represents the value 1 or 2;R.sub.1 and R.sub.2 represent a hydrogen atom, a lower alkyl group, an aryl or lower alkaryl group, possibly substituted, preferably in para position, by a halogen atom, preferably a chlorine atom;R.sub.1 and R.sub.2 may also form a heterocycle having 5 or 6 members with the adjacent nitrogen atom;R.sub.3 and R.sub.4 represent a hydrogen atom or a lower alkyl group;R.sub.3 and R.sub.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: October 23, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Bernard Bonnaud, Michel Morre, Antoine Stenger
  • Patent number: 4460575
    Abstract: The present invention relates to a vaccinal complex containing a specific antigen. This is a vaccinal complex characterized in that it is composed of bacterial ribosomal RNA or fragments of bacterial ribosomal RNA on which are coupled from 1 to 5% by weight of a specific antigen of bacterial serotype. This complex may be used as a vaccine.
    Type: Grant
    Filed: February 20, 1981
    Date of Patent: July 17, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Lucien D. d'Hinterland, Gerard Normier, Anne-Marie Pinel, Jacques Durand
  • Patent number: 4460109
    Abstract: This invention relates to a device for the distribution in regulable proportions of two pasty substances which are contained separately inside a deformable tube.The device comprises a distributor which is mounted so that it pivots inside a cylindrical casing which is integral with a cap fitted on the outlet orifice of the deformable tube. The casing comprises two outlets for the two pasty substances contained in the tube, and a common extrusion orifice.The invention is notably used for the distribution of sun care products comprising a pasty excipient and an active pasty substance.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: July 17, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Luc Ducros, Roger Navarro, Charles Kaeser
  • Patent number: 4456614
    Abstract: The present invention concerns chemical compounds of the general formula: ##STR1## in which: R.sub.1 and R.sub.2 may be identical or different and represent a hydrogen or halogen atom or else a lower alkyl, lower alkoxy, nitro or acetyl group andR represents a lower alkyl or lower aralkyl group, such as benzyl.These compounds are useful in therapy for the treatment of hypertension and cardiac arrhythmia.
    Type: Grant
    Filed: April 2, 1981
    Date of Patent: June 26, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Pol Vilain
  • Patent number: 4436749
    Abstract: A compound corresponding to formula (I): ##STR1## wherein X represents oxygen, sulphur or >N--R',R' representing hydrogen or an alkyl radical,R.sub.1 to R.sub.4, andR'.sub.1 to R'.sub.5 independently represent the following:a hydrogen or halogen atom,an alkyl, aryl, alkoxy, aryloxy or acyloxy radical,a hydroxy radical,an amino, mono-alkylamino or di-alkylamino radical,a hydroxyalkyl, aminoalkoxy, mono- or di-alkylaminoalkoxy radical,in the form of the d or l isomer, or in the form of a racemic mixture, is useful as a medicament.
    Type: Grant
    Filed: May 10, 1982
    Date of Patent: March 13, 1984
    Assignee: Pierre Fabre S.A.
    Inventors: Philippe Hatinguais, Jean-Francois Patoiseau, Gilbert Marcelon
  • Patent number: 4409241
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: September 20, 1982
    Date of Patent: October 11, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4397838
    Abstract: This invention relates to a process for the preparation of purified bacterial membranal proteoglycans. The process comprises at least one step in which crude proteoglycans are treated in aqueous medium with a base or a hypobromite, followed by elimination of the excess reactant and the insoluble residue, the purified proteoglycans being present in aqueous solution. The thus obtained purified proteoglycans may be used as immunity adjuvants in vaccines without causing side-effects such as pyrogenic reactions.
    Type: Grant
    Filed: July 6, 1981
    Date of Patent: August 9, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Lucien D. d'Hinterland, Gerard Normier, Anne-Marie Pinel, Jacques Durand
  • Patent number: 4389396
    Abstract: This invention relates to a non-specific immunostimulating preparation for the treatment of immunodeficits, such as those encountered in leprosy and cancer, characterized in that it contains as sole active principle one or more bacterial ribosomal RNA's extracted from the following strains:Klebsiella pneumoniaeSerratia marcescens
    Type: Grant
    Filed: August 18, 1981
    Date of Patent: June 21, 1983
    Assignee: Pierre Fabre, S.A.
    Inventors: Lucien Dussourd D'Hinterland, Gerard Normier, Anne-Marie Pinel, Jacques Durand
  • Patent number: 4382930
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: December 29, 1980
    Date of Patent: May 10, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4380667
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: September 19, 1979
    Date of Patent: April 19, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4370347
    Abstract: The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: January 25, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Gilbert Mouzin, Henri Cousse, Antoine Stenger
  • Patent number: 4349540
    Abstract: Vaccines which comprise in association the ribosomal fraction extracted from the bacterias against which a protection is wanted, and the peptidoglycanes extracted from the membranes of at least one of the bacteria previously used.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: September 14, 1982
    Assignee: Pierre Fabre S.A.
    Inventors: Lucien D. D'Hinterland, Hubert Serre, Gerard Normier
  • Patent number: RE31237
    Abstract: New derivatives of 2-benzoyl-4-nitro anilides, their preparation and their use as medicaments.The new chemical derivatives of the invention have the general formula ##STR1## in which R represents a linear or branched alkyl group, an alkenyl group, a cycloalkyl group or a benzyl group,R.sub.1 represents a hydrogen atom, an alkyl group or a hydroxy alkyl group,R.sub.2 represents a hydroxy-alkyl, alkenyl or alkynyl group, possibly substituted one or more times by an alkyl radical, or a cycloalkyl group having three to six carbon atoms;R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are attached, a nitrogen heterocycle containing possibly a second heteroatom selected from among oxygen and nitrogen;under the condition, however, that when R.sub.2 represents a hydroxy-alkyl group R.sub.1 may not be a hydrogen atom.Use as hypnotic agents for the treatment of insomnia.
    Type: Grant
    Filed: February 19, 1982
    Date of Patent: May 10, 1983
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin