Patents Assigned to Poli Industria Chimica
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Patent number: 7727751Abstract: The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence of Candida antarctica lipase, and in which the MPA esterification reaction is carried out in the presence of Candida antarctica lipase using the corresponding alcohol as the solvent.Type: GrantFiled: July 25, 2005Date of Patent: June 1, 2010Assignee: Poli Industria Chimica SpAInventors: Paride Grisenti, Paolo Prestileo
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Patent number: 7667056Abstract: The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (II) to give the intermediate of formula (III).Type: GrantFiled: July 31, 2003Date of Patent: February 23, 2010Assignee: Poli Industria Chimica S.p.A.Inventors: Paride Grisenti, Fabio Pecora, Elisa Verza, Massimo Leoni, Laura Bossi
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Publication number: 20080085542Abstract: The present invention relates to a process for the preparation of mycophenolate mofetil (MMF) in which an ester of mycophenolic acid (MPA) with a low-molecular-weight aliphatic alcohol is transesterified with N-(2-hydroxyethyl)morpholine in the presence of Candida antarctica lipase, and in which the MPA esterification reaction is carried out in the presence of Candida antarctica lipase using the corresponding alcohol as the solvent.Type: ApplicationFiled: July 25, 2005Publication date: April 10, 2008Applicant: POLI INDUSTRIA CHIMICA SPAInventors: Paride Grisenti, Paolo Prestileo
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Patent number: 6395901Abstract: Process for the preparation of compounds active in the treatment of Parkinson's disease, and such compounds, having general formula (VI) wherein R4 may be, independently, a linear, branched or cyclic, saturated or unsaturated C1-8 alkyl radical, such as, for example, the radicals methyl, ethyl, propyl, butyl, isobutyl, tert-butyl, pentyl, cyclopentyl, hexyl, cyclohexyl and octyl. The process utilizes as starting materials the compound of formula (I) wherein R1 represents a linear, branched or cyclic, saturated or unsaturated C1-8 alkyl residue.Type: GrantFiled: March 21, 2001Date of Patent: May 28, 2002Assignee: Poli Industria Chimica S.p A.Inventors: Alberto Mangia, Paride Grisenti
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Patent number: 6090957Abstract: The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R.sub.1 is=O and X is halo; and formula II: ##STR2## wherein R, and X are as defined above.Type: GrantFiled: October 1, 1998Date of Patent: July 18, 2000Assignee: Poli Industria Chimica S.p.A.Inventors: Ambrogio Magni, Paride Grisenti
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Patent number: 6043368Abstract: The present invention provides a method of preparing thieno[3,2-c]pyridine derivatives of formula I: ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl; lower alkylene phenyl; substituted lower alkylene phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro and halo; lower alkylene naphthyl, lower alkylene thienyl; lower alkylene diphenyl; lower alkylene-hydroxy-phenyl; substituted lower alkylene-hydroxy-phenyl wherein the phenyl is substituted from 1 to 3 times with lower alkyl, lower alkoxy, lower acyloxy, hydroxy, nitro, and halo; lower alkylene-hydroxy-naphthyl; lower alkylene-hydroxy-thienyl; lower alkylene-hydroxy-diphenyl, and R.sub.2 is H or lower alkylene. The method comprises reacting a compound of a formula II: ##STR2## with a cyclic dioxy or cyclic dithio in the presence of catalyst.Type: GrantFiled: September 4, 1996Date of Patent: March 28, 2000Assignee: Poli Industria Chimica, S.P.A.Inventors: Ambrogio Magni, Giovanni Signorelli
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Patent number: 5986142Abstract: The present invention provides a process for preparing compounds of Formula I: ##STR1## wherein R.sub.1 is methyl by reduction of a camphene intermediate with a reducing agent.Type: GrantFiled: September 23, 1997Date of Patent: November 16, 1999Assignee: Poli Industria Chimica SpAInventors: Ambrogio Magni, Giovanni Signorelli
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Patent number: 5891474Abstract: The present invention provides a method of achieving the time-specific delivery of a pharmaceutically active agent to a patient in need of the therapeutic effects of the pharmaceutically active agent. The method includes administering a pharmaceutical formulation comprising (a) a core including the pharmaceutically active agent to be delivered, and (b) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer. The swellable polymeric coating layer surrounding the core is provided by a new method which includes alternately (i) wetting the core with a binder solution, and (ii) coating the core with powdered polymeric particles a sufficient number of times to produce a time-specific dosage formulation having the desired thickness of swellable polymeric coating layer.Type: GrantFiled: January 29, 1997Date of Patent: April 6, 1999Assignee: Poli Industria Chimica, S.p.A.Inventors: Cesare Busetti, Tiziano Crimella
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Patent number: 5817803Abstract: The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R.sub.1 is .dbd.O and X is halo; and formula II: ##STR2## wherein R.sub.1 and X are as defined above.Type: GrantFiled: December 6, 1996Date of Patent: October 6, 1998Assignee: Poli Industria Chimica, S.p.A.Inventors: Ambrogio Magni, Paride Grisenti
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Patent number: 5808051Abstract: The present invention provides new process of preparing neuromuscular blocking agents. The process include preparing neuromuscular blocking agents using the compounds of formula I: ##STR1## wherein R.sub.1 is .dbd.O and X is halo; and formula II: ##STR2## wherein R.sub.1 and X are as defined above.Type: GrantFiled: October 27, 1997Date of Patent: September 15, 1998Assignee: Poli Industria Chimica, S.p.a.Inventors: Ambrogio Magni, Paride Grisenti
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Patent number: 5801020Abstract: A novel, cyclosporin-producing microbe is described. A process for the production of cyclosporin, comprising culturing the novel microbe and recovering the desired form of cyclosporin produced, is described.Type: GrantFiled: March 5, 1997Date of Patent: September 1, 1998Assignee: Poli Industria Chimica, S.p.A.Inventors: Enrico Casareto, Massimo Leoni, Enrico Ronzio, Ambrogio Magni
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Patent number: 5788987Abstract: The present invention provides methods of treating early morning pathologies using a time-specific controlled release dosage formulation which is administered prior to sleep, and which permits or achieves delivery of a pharmaceutically active agent effective for the treatment of the specific early morning pathology to be treated, at about the time of awakening. The time-specific controlled release dosage formulation comprises (1) a core including the pharmaceutically active agent(s) effective for the treatment of the early morning pathology, and (2) a swellable polymeric coating layer substantially surrounding the core. The swellable polymeric coating layer delays the release of the pharmaceutically active agent from the core for a predetermined period of time dependent upon the thickness of the swellable polymeric coating layer, to effect delivery of the pharmaceutically active agent at about the time of awakening.Type: GrantFiled: January 29, 1997Date of Patent: August 4, 1998Assignee: Poli Industria Chimica SpAInventors: Cesare Busetti, Tiziano Crimella
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Patent number: 5767112Abstract: The invention relates to pharmaceutical compositions for parenteral administration. The compositions comprise an amount of neuromuscular blocking agent effective to produce muscular relaxation, and at least one zwitterionic substance having an isoionic point not greater than 7. The zwitterionic substance is present in an amount of between about 2 and about 30 percent by weight, based on the weight of the composition. The resulting composition has a pH of less than 7.Type: GrantFiled: January 16, 1996Date of Patent: June 16, 1998Assignee: Poli Industria Chimica, S.p.A.Inventors: Stefano Poli, Tiziano Crimella, Ambrogio Magni, Luigi Moro
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Patent number: 5759566Abstract: Bioadhesive microemulsions or liposomic dispersions containing proteinaceous substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal route are described. This type of administration shows some considerable advantages of activity, tolerability, dosage individualization and drug stability.Type: GrantFiled: June 17, 1996Date of Patent: June 2, 1998Assignee: Poli Industria Chimica SpAInventors: Stefano Poli, Federico Mailland, Luigi Moro
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Patent number: 5747330Abstract: A novel, cyclosporin-producing microbe is described. A process for the production of cyclosporin, comprising culturing the novel microbe and recovering the desired form of cyclosporin produced, is described.Type: GrantFiled: June 5, 1996Date of Patent: May 5, 1998Assignee: Poli Industria ChimicaInventors: Enrico Casareto, Massimo Leoni, Enrico Ronzio, Ambrogio Magni
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Patent number: 5709797Abstract: The present invention provides a method for isolating cyclosporin by adsorption chromatography. The method comprises the steps of: (a) loading a crude solution containing a cyclosporin onto adsorption chromatography column containing an adsorption resin, (b) eluting the cyclosporin from the adsorption chromatography column, and (c) collecting the eluted cyclosporin. The step of eluting the cyclosporin is carried out by passing an eluting solvent through the column, which comprises a hydrophilic component and a lipophilic component, wherein the cyclosporin is separately eluted from other compounds by providing a hydrophilic/lipophilic balance in the eluting solvent that selectively desorbs the cyclosporin from the column.Type: GrantFiled: June 5, 1996Date of Patent: January 20, 1998Assignee: Poli Industria Chimica S.p.A.Inventors: Gianettore Bocchiola, Vittorio Buran, Ambrogio Magni
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Patent number: 5654000Abstract: Liquid bioadhesive microemulsions or liposomic dispersions containing proteinic substances, especially calcitonin, that allow the systemic, local or topical administration of drugs by transmucosal route are described. This type of administration shows some considerable advantages of activity, tolerability, dosage individualization and drug stability. The compositions contain proteinic substances, and a polyoxyethylene-polyoxypropylene thermosetting copolymer. At body temperature the viscosity of the compositions is increased and provides increase residence time at the administration site.Type: GrantFiled: July 17, 1996Date of Patent: August 5, 1997Assignee: Poli Industria Chimica S.p.A.Inventors: Stefano Poli, Federico Mailland, Luigi Moro
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Patent number: 5369131Abstract: A liquid pharmaceutical composition which can be administered as a foam by means of suitable supplying devices, without necessity of gas propeller, said composition consisting of:a) one or more natural or synthetic ionic or non ionic, acid, basic or neutral surfactants;b) a solvent or a solvent mixture;c) an active ingredient or a combination of active ingredients;d) optionally mucoadhesive or thermosetting polymers;e) optional adjuvants or excipients.Type: GrantFiled: May 20, 1993Date of Patent: November 29, 1994Assignee: Poli Industria Chimica S.p.A.Inventors: Stefano Poli, Germano Coppi, Cesare Busetti
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Patent number: 5254579Abstract: N-(5-thioxo-L-prolyl)-L-cysteine and derivatives thereof, having interesting mucolytic-expectorant, antioxidant (radical-scavenger), antielastase, antiemphysema, immunostimulating and hepatoprotective activities and a low toxicity are described, as well as processes for the preparation thereof and pharmaceutical formulations for the use in therapy.Type: GrantFiled: May 8, 1992Date of Patent: October 19, 1993Assignee: Poli Industria Chimica S.p.A.Inventors: Stefano Poli, Germano Coppi, Giovanni Signorelli
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Patent number: 5212160Abstract: 3-L-(5-thioxo-L-prolyl)thiazolidine-4-carboxylic acid and the derivatives thereof have valuable immunostimulating, antioxidant, antiradical and antiageing properties. They are prepared by thionating the corresponding 3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid derivatives or by condensing 5-thioxo-L-proline with the corresponding L-thiazolidine-4-carboxylic acid derivatives.Type: GrantFiled: January 16, 1991Date of Patent: May 18, 1993Assignee: Poli Industria Chimica S.p.A.Inventors: Stefano Poli, Lucio Del Corona, Germano Coppi