Patents Assigned to Portland State University
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Patent number: 9952231Abstract: Embodiments of methods and compounds for isolating and detecting lysophosphatidic acids (LPAs) are disclosed. Kits for performing the methods also are disclosed. LPAs are isolated from biological samples by liquid-liquid extraction followed by solid phase extraction. LPA species may be separated by HPLC, and the separated species may be identified and quantified. Also disclosed are embodiments of compounds capable of universally detecting a plurality of LPA species with substantially equivalent sensitivity. Embodiments of the disclosed compounds are useful for determination of total LPA concentration in a sample comprising a plurality of LPA species without separation of individual LPA species.Type: GrantFiled: March 14, 2014Date of Patent: April 24, 2018Assignee: Portland State UniversityInventors: Robert Strongin, Martha Sibrian-Vazquez, Jialu Wang, Lei Wang, Jorge O. Escobedo-Cordova
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Publication number: 20180071716Abstract: Embodiments of templated polymeric materials capable of binding lysophosphatidic acids (LPAs) are disclosed. Methods of making and using the templated polymeric materials also are disclosed. The disclosed templated polymeric materials are molecularly imprinted polymers that bind LPAs and facilitate the production of lysophosphatidic acid-enriched samples, for instance through extraction of lysophosphatidic acids from biological samples, such as plasma or serum samples.Type: ApplicationFiled: February 23, 2016Publication date: March 15, 2018Applicant: Portland State UniversityInventors: Robert M. Strongin, Martha Sibrian-Vazquez, Jialu Wang, Jorge O. Escobedo-Cordova
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Publication number: 20170247551Abstract: Disclosed embodiments concern a composition comprising a diatom frustule and two or more photocatalytic nanoparticles dispersed on the surface of the frustule. Also disclosed are embodiments of a method for making the composition. The nanoparticles are dispersed such that they are separate and not in physical contact with each other. An average distance between the nanoparticles may be from greater than 0 nm to 100 nm. The nanoparticles may comprise a dopant material. Paint compositions comprising the diatom frustule compositions are also contemplated. The diatom frustule composition may be useful for removing and/or degrading volatile organic compounds, such as those present in the atmosphere.Type: ApplicationFiled: May 17, 2017Publication date: August 31, 2017Applicant: Portland State UniversityInventors: Haiyan Li, Lester Lampert
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Patent number: 9709572Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: GrantFiled: November 24, 2015Date of Patent: July 18, 2017Assignee: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Publication number: 20170104584Abstract: Innovations in the construction and use of variable-input-length tweakable ciphers (“VILTCs”). In some cases, a VILTC uses an initialization vector that is protected from exposure outside an encryption/decryption system in order to provide enhanced security with efficient performance. For example, a system for encryption and/or decryption includes two fixed-input-length tweakable block ciphers (“FIL TBCs”) and a VILTC. The first FIL TBC is adapted to produce a fixed-length initialization vector. The VILTC is adapted to produce a variable-length output string using the fixed-length initialization vector as a tweak. The second FIL TBC is adapted to produce a fixed-length output string. In this way, the first FIL TBC and the second FIL TBC protect the fixed-length initialization vector from exposure outside the system. In other cases, a VILTC is used for a reliable and efficient implementation of authenticated encryption/decryption with associated data.Type: ApplicationFiled: December 28, 2016Publication date: April 13, 2017Applicant: Portland State UniversityInventors: Thomas E. Shrimpton, Robert S. Terashima
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Patent number: 9620365Abstract: Sub-50-nm structures are formed using sequential top-down and bottom up lithographies in conjunction with selective etching. The preferred rendition of the method involves: (a) rough lithographic patterning, (b) size/shape selected nanostructure deposition, (c) resist reflow around the nanostructures, and (d) selective removal/etching of the nanostructure.Type: GrantFiled: July 11, 2014Date of Patent: April 11, 2017Assignee: Portland State UniversityInventors: Shankar B. Rananavare, Moshood Kayode Morakinyo
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Publication number: 20170088697Abstract: Modified nano-clays and coating compositions including the modified nano-clays are disclosed. The coating compositions are useful for protecting objects such as outdoor sculptures and architectural elements made of metal or including metal components. In some embodiments, the modified nano-clay is Laponite that has been covalently modified with (tridecafluoro-1,1,2,2-tetrahydrooctyl) triethoxysilane and cation-exchanged with phosphorylcholine.Type: ApplicationFiled: September 28, 2016Publication date: March 30, 2017Applicant: Portland State UniversityInventors: Tami L. Clare, Natasja A. Swartz
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Patent number: 9597015Abstract: A method for estimating joint angles of a multi-segment limb from inertial sensor data accurately estimates and tracks the orientations of multiple segments of the limb as a function of time using data from a single inertial measurement unit worn at the distal end of the limb. Estimated joint angles are computed from measured inertial data as a function of time in a single step using a nonlinear state space estimator. The estimator preferably includes a tracking filter such as an unscented Kalman filter or particle filter. The nonlinear state space estimator incorporates state space evolution equations based on a kinematic model of the multi-segment limb.Type: GrantFiled: February 12, 2009Date of Patent: March 21, 2017Assignee: Portland State UniversityInventors: James Nathan McNames, Mahmoud El-Gohary, Sean Christopher Pearson
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Patent number: 9571270Abstract: Innovations in the construction and use of variable-input-length tweakable ciphers (“VILTCs”). In some cases, a VILTC uses an initialization vector that is protected from exposure outside an encryption/decryption system in order to provide enhanced security with efficient performance. For example, a system for encryption and/or decryption includes two fixed-input-length tweakable block ciphers (“FIL TBCs”) and a VILTC. The first FIL TBC is adapted to produce a fixed-length initialization vector. The VILTC is adapted to produce a variable-length output string using the fixed-length initialization vector as a tweak. The second FIL TBC is adapted to produce a fixed-length output string. In this way, the first FIL TBC and the second FIL TBC protect the fixed-length initialization vector from exposure outside the system. In other cases, a VILTC is used for a reliable and efficient implementation of authenticated encryption/decryption with associated data.Type: GrantFiled: November 20, 2014Date of Patent: February 14, 2017Assignee: Portland State UniversityInventors: Thomas E. Shrimpton, Robert S. Terashima
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Patent number: 9506929Abstract: Probes for selectively detecting compounds comprising a thiol group and an amino group (“thiols”) are disclosed. Exemplary thiols include cysteine, homocysteine, and glutathione. Embodiments of the disclosed probes produce a detectable change in absorbance spectrum and/or emission spectrum when reacted with one or more thiols in solution. Methods and kits for performing the detection also are disclosed. The probes have a general formula where each bond depicted as “” is a single or double bond; R1, R3-R6 and R8 independently are hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen; R2 is an ?,?-unsaturated aliphatic ester; R7 is oxygen, sulfur, hydrogen, hydroxyl, thiol, lower alkyl, carboxyalkyl, amino, alkoxy, or halogen, or R7 and R8 together form a cycloalkyl or aryl ring; X1 is CH2, S, NH, O, Se, Si(CH3)2, Ge(CH3)2, Sn(CH3)2, or C(CH3)2; and X2 is CH, CH2, N, NH, or CR9 where R9 is aryl.Type: GrantFiled: February 22, 2013Date of Patent: November 29, 2016Assignee: Portland State UniversityInventors: Robert M. Strongin, Yixing Guo, Lovemore Hakuna, Mark Allen Lowry, Jorge Omar Escobedo Córdova
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Patent number: 9493420Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).Type: GrantFiled: July 25, 2013Date of Patent: November 15, 2016Assignee: Portland State UniversityInventors: David H. Peyton, Steven Burgess
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Publication number: 20160303544Abstract: Disclosed herein are embodiments of a metallic composite that is made using embodiments of a facile, efficient method. Certain embodiments of the disclosed method of making the composite can comprise a one-step, room temperature synthetic procedure, and other embodiments can comprise a two-step synthetic procedure. Also disclosed herein are embodiments of a method of using the disclosed composite, such as for fluid purification via contaminant degradation, or in biological sensor applications.Type: ApplicationFiled: November 3, 2014Publication date: October 20, 2016Applicant: Portland State UniversityInventors: Jun Jiao, Wen Qian
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Publication number: 20160223558Abstract: Embodiments of compounds for selectively detecting an analyte are disclosed, along with methods and kits for detecting analytes with the compounds. The compounds are bridged viologen conjugates including at least one fluorophore according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together form a substituted or unsubstituted cycloalkyl or aryl.Type: ApplicationFiled: January 28, 2016Publication date: August 4, 2016Applicant: Portland State UniversityInventors: Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
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Publication number: 20160154001Abstract: Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together forms a substituted or unsubstituted cycloalkyl or aryl.Type: ApplicationFiled: December 15, 2015Publication date: June 2, 2016Applicant: Portland State UniversityInventors: Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
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Publication number: 20160123865Abstract: Embodiments of hydrogels for electrochemical sensing, electrodes comprising the hydrogels, and methods of making and using the hydrogels are disclosed. The disclosed hydrogel electrodes comprise a cross-linked poly(acrylic acid-co-2-acrylamido-2-methyl-1-propanesulfonic acid (poly(AA-AMPS)) hydrogel and an electrical contact.Type: ApplicationFiled: June 10, 2014Publication date: May 5, 2016Applicant: Portland State UniversityInventors: Tami Lasseter Clare, Alice H. England
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Patent number: 9301712Abstract: Disclosed embodiments include an apparatus for generating a plurality of movement impairment indices from one or more kinematic signals to characterize movement disorders. Additionally we disclose methods for generating a plurality of movement impairment indices from one or more kinematic signals obtained from one or more kinematic sensors, said methods implemented in a digital computer with one or more processors in order to characterize movement disorders based on spectral analysis, regularity metrics, and time-frequency analysis.Type: GrantFiled: July 28, 2009Date of Patent: April 5, 2016Assignees: PORTLAND STATE UNIVERSITY, APDM, INC.Inventors: James McNames, Pedro Mateo Riobo Aboy, Andrew Greenberg
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Publication number: 20160077103Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: ApplicationFiled: November 24, 2015Publication date: March 17, 2016Applicant: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Patent number: 9250246Abstract: Embodiments of near-infrared (NIR) dyes are disclosed, along with methods and kits for detecting analytes with the NIR dyes. The NIR dyes have a structure according to the general structure At least one of R1/R2, R2/R3, R3/R4, R5/R6, R6/R7, and/or R7/R8 together forms a substituted or unsubstituted cycloalkyl or aryl.Type: GrantFiled: June 29, 2012Date of Patent: February 2, 2016Assignee: Portland State UniversityInventors: Robert Michael Strongin, Martha Sibrian-Vazquez, Jorge Omar Escobedo-Cordova, Mark Allen Lowry
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Patent number: 9229007Abstract: Embodiments of probes for selectively detecting compounds having a thiol group and an amino group, e.g., cysteine and/or homocysteine, are disclosed, along with methods and kits for detecting the compounds in neutral media with the probes. The probes have a structure according to the general formula where R1-R4 independently are hydrogen hydroxyl, halogen, thiol, thioether, lower aliphatic, or lower alkoxy, x is an integer from 0 to 4, and each R5 independently is halogen, hydroxyl, thiol, thioether, lower aliphatic, or lower alkoxy. Embodiments of the disclosed probes are capable of undergoing condensation/cyclization reactions with cysteine and/or homocysteine. Cysteine and/or homocysteine can be selectively detected and identified by determining fluorescence emission of the probes at characteristic wavelengths.Type: GrantFiled: August 2, 2012Date of Patent: January 5, 2016Assignee: Portland State UniversityInventors: Robert Strongin, Xiaofeng Yang
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Patent number: 9222907Abstract: Sensors include nano-porous alumina membranes that are sensitized by immobilization of antibodies in the nano-pores. The nano-membranes can be sensitized to respond to a single target compound, or different portions of the nano-membrane can be differently sensitized. Capture of the target compound can be detected based on a spectral signature associated with electrical conductance in the nano-pores.Type: GrantFiled: April 2, 2013Date of Patent: December 29, 2015Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Portland State UniversityInventors: Shalini Prasad, Ravi Kiran Kondama Reddy