Abstract: Disclosed embodiments of the invention include a method, system, and apparatus to monitor cardiovascular signals such as arterial blood pressure (ABP), pulse oximetry (POX), and intracranial pressure (ICP). The system can be used to calculate and monitor useful clinical information such as heart rate, respiratory rate, pulse pressure variation (PPV), harmonic phases, pulse morphology, and for artifact removal. The method uses a statistical state-space model of cardiovascular signals and a generalized Kalman filter (EKF) to simultaneously estimate and track the cardiovascular parameters of interest such as the cardiac fundamental frequency and higher harmonics, respiratory fundamental frequency and higher harmonics, cardiac component harmonic amplitudes and phases, respiratory component harmonic amplitudes and phases, and PPV.

Abstract: Scanning probe microscopes include a probe tip coupled to a tuning fork or other acoustic resonator so as to apply a shear force when contacted to a specimen surface based on an applied acoustic signal. A secondary ultrasonic transducer is in acoustic communication with the specimen and a resonant structure. Probe tip-specimen displacement can be detected based on whispering gallery mode ultrasonic waves in the resonant structure using the secondary transducer, and such displacements maintained using feedback control based on whispering gallery mode acoustic wave magnitude.

Abstract: The disclosure provides modified chloroquine compounds having single ring or fused ring moieties. Also provided are pharmaceutical compositions comprising such compounds, methods of using such compounds to inhibit or treat diseases or conditions caused by chloroquine-resistant (CQR) and chloroquine-sensitive (CqS) malaria parasites and other CQ-susceptible microorganisms, and processes and intermediates useful for preparing such compounds.

Abstract: A method for identifying the redox activity of a subject compound is disclosed. The method can be performed aerobically and can include forming a mixture comprising a free-radical precursor and a compound to be tested, and converting the free-radical precursor into a free-radical anion and a free-radical cation. After the free radical cation and the free radical anion have been formed, the relative redox activity of the subject compound may cause a difference in the rate of photo-bleaching of the mixture and/or the rate of superoxide generation. These differences can be quantified and used to identify the redox activity of the subject compound. This sensitive technique for measuring redox activity can be used to screen compounds for various biological applications. Drugs also can be developed based on the relationship between redox activity and biological activity for particular biological applications.

Abstract: This disclosure provides a new class of compounds referred to as “reversed chloroquines” (RCQs), which are highly effective against CQR and CQS malaria parasites. RCQs are hybrid molecules, which include an antimalarial quinoline analog (such as chloroquine) moiety and a CQR reversal moiety. Exemplary RCQ chemical structures are provided. Also provided are pharmaceutical compositions including the disclosed RCQ compounds, and methods of using such compounds and compositions for the treatment of malaria and inhibition of CQR or CQS Plasmodium sp. (such as P. falciparum).

Abstract: A generalized software process simulation model is utilized to simulate software engineering processes and support project management and control. The simulation model takes advantage of generic software modeling blocks which represent differing stages or activities in a software development process and are represented in modeling environment. The generic software modeling blocks are also used to represent sub-processes and activities within higher-level processes. The blocks also provide dialog boxes which allow entering and adjustment of data and equations. Through manipulation of blocks and comparisons of simulations, a project manager can simulate and observe the outcome of different process decisions. Additional simulation capabilities are possible, as software engineering is one example of the technology.

Abstract: A global software development model instrument is described. The instrument utilizes a global system dynamics model, as well as one or more site-specific discrete event simulation and system dynamics models to model interactions within and between software development sites. Parameters, equations, and interactions between the model components are editable to allow for the simulation and comparison of various software development options and to provide for global software development research. Additional product development situations can be modeled as well, including hardware and systems engineering.

Abstract: A bi-directional software development process simulation model is described. The model simulates the stages of a software development process, using equations relating to defect injection and detection and parameters describing detection and injection rates. With forward development process simulation, predictions can be made for process outcomes. By simulating in the reverse direction, defect detection requirements can be found for each stage of the model to achieve a desired performance result. Outcome-based control levels are utilized with the model to better detect whether a process is out of control. By going between the forward and reverse simulation directions, control of the process can be fine-tuned as defect detection data is obtained during process execution. In addition to quality as measured by defects, other metrics can be simulated, including cost, time, and features; similarly other product development scenarios, such as hardware or systems engineering can also be modeled and simulated.

Abstract: Methods and systems for analyzing samples, such as gas samples, are described. One method comprises providing a gas sample, increasing pressure applied to the gas sample to compress the sample to a smaller volume and provide a pneumatically focused gas sample, and analyzing the pneumatically focused gas sample using any of a variety of analytical techniques. Also disclosed are systems for gas analysis, including systems for analysis of pneumatically focused, and thereby concentrated, gas samples and for analysis of particulate matter in gas samples. Analytical systems constructed within personal computer cases also are disclosed.

Abstract: Carbon nanotube (CNT) based devices include an actuator/switch that includes one or more fixed CNTs and a moveable CNT that can be urged toward or into contact with a selected fixed CNT with a magnetic field produced by a current in a control conductor. The control conductor can be formed of one or more CNTs, and the fixed and moveable CNTs can be retained by a support, and motion of the moveable CNT limited by a cavity defined in the support. In other examples, CNT FETS are used to form CNT transmission gates that are arranged to define circuits configured as multiplexers or to realize logical functions, addition, multiplication, or other operations such as Galois field arithmetic.

Abstract: Nanometrology device standards and methods for fabricating and using such devices in conjunction with scanning probe microscopes are described. The fabrication methods comprise: (1) epitaxial growth that produces nanometer sized islands of known morphology, structural, morphological and chemical stability in typical nanometrology environments, and large height-to-width nano-island aspect ratios, and (2) marking suitable crystallographic directions on the device for alignment with a scanning direction.

Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such “smart wells” because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

Abstract: A new class of enzymes that catalyze the conversion of a nitrile containing compound to the corresponding amine (such as a primary amine) are disclosed. Such enzymes are referred to herein as nitrile oxido-reductases. Methods of using the enzymes to reduce a nitrile to a amine, for example in vitro or in vivo, are provided. Such methods provide the first biocatalysis method for reducing nitrites to amines, and provides an alternative to currently used methods, which generally utilize harsh reaction conditions and the production of hazardous waste. While the hydrolysis of nitrites to amides and carboxylic acids via biocatalysis has found extensive use in industry, the lack of a known nitrile oxido-reductase has precluded the application of biocatalysis to nitrile reduction.

Abstract: Methods and systems for analyzing samples, such as gas samples, are described. One method comprises providing a gas sample, increasing pressure applied to the gas sample to compress the sample to a smaller volume and provide a pneumatically focused gas sample, and analyzing the pneumatically focused gas sample using any of a variety of analytical techniques. Also disclosed are systems for gas analysis, including systems for analysis of pneumatically focused, and thereby concentrated, gas samples and for analysis of particulate matter in gas samples. Analytical systems constructed within personal computer cases also are disclosed.

Abstract: A method is disclosed for directly synthesizing nanoscale structures, particularly in defined locations. The method overcomes problems in nanoscale manufacturing by enabling the direct fabrication of composites useful for constructing electronic devices. In one aspect of the method, nanotubes and arrays of nanotubes are synthesized directly at defined locations useful for constructing electronic devices.

Abstract: An active inductor circuit implemented in sub-micron CMOS semiconductor technology is usable at gigaHertz frequencies and includes an input node, a non-inverting transconductor circuit comprising a differential pair of NMOS transistors connected to the input node, an inverting transconductor circuit comprising an NMOS transistor connected to an output node of the non-inverting transconductor circuit and connected to the input node in a gyrator feedback configuration. Varactors coupled to the transconductor circuits tune the frequency and Q of the active inductor circuit.

Abstract: A method for analyzing a gas sample is described. The method comprises providing a gas sample, increasing pressure applied to the gas sample to compress the sample to a smaller volume and provide a pneumatically focused gas sample, and analyzing the pneumatically focused gas sample using any of a variety of analytical techniques. Pneumatic Focusing generally means increasing the pressure of the sample, column or cell to a pressure of from about 100 psi to about 15,000 psi, more typically from about 200 psi to about 2,000 psi. Examples including gas chromatography and absorption spectroscopy are illustrated herein. Numerous other examples could be given. The method is well suited for analyzing gaseous samples, such as ambient air samples, both continuously, and remotely, using computer control. Continuously sampling ambient air provides a method for real-time monitoring of air quality. Continuous monitoring allows for pollutant exposure and allows for the identification of emission sources.

Abstract: Methods and systems for analyzing samples, such as gas samples, are described. One method comprises providing a gas sample, increasing pressure applied to the gas sample to compress the sample to a smaller volume and provide a pneumatically focused gas sample, and analyzing the pneumatically focused gas sample using any of a variety of analytical techniques. Also disclosed are systems for gas analysis, including systems for analysis of pneumatically focused, and thereby concentrated, gas samples and for analysis of particulate matter in gas samples. Analytical systems constructed within personal computer cases also are disclosed.

Abstract: Methods of adhering polymeric materials to a substrate, either directly or through linker molecules, are disclosed. Structures, for example, microstructures, including microwells and arrays of microwells, may be readily formed using the methods. In some embodiments, microstructures formed completely from polymeric materials are provided, making it possible to tailor the chemical and physical properties of the microstructures. For example, microwells having a bottom comprising a polar polymeric material and well sides/top comprising a non-polar polymeric material are provided. Biochemical reagents may be easily delivered to such “smart wells” because the intrinsic attraction of the well bottom for the reagents and the intrinsic repulsion between the well sides/top combine to direct the reagents to the wells.

Abstract: There is disclosed a programmable analog or mixed analog/digital circuit. More particularly, this invention provides a circuit architecture that is flexible for a programmable electronic hardware device or for an analog circuit whose input and output signals are analog or multi-valued in nature, and primarily continuous in time. There is further disclosed a design for a current-mode integrator and sample-and-hold circuit, based upon Miller effect.