Abstract: An apparatus for dermal treatment of an active substance having certain physical properties having a flexible, wearable patch conformable to the contour of a skin surface and having: a first electrode adapted to communicate the active substance into the skin by application of an electrical current on the skin surface, a second electrode capable of closing an electrical circuit with the skin surface, a power source for providing a current and voltage connected through a conductive media to the first and second electrode, and an apparatus for substantially controlling penetration depth of the active substance by selecting at least one variable from a plurality of variables.

Abstract: The present invention provides a device and kit and method of use thereof for wound treatment of a subject. The device may include an electrically operated patch or other means of delivery of electrical current and a connected moist surface. Optionally, the device may include a composition comprising an active substance useful in wound treatment. Preferably, the means of delivery of electrical current includes a power source and a plurality of electrodes disposed in a suitable conformation on a base substrate layer, which readily facilitates electrical contact with the body area of the subject. Preferably, the kit may include a means of delivery of electrical current and a moist surface provided as separate components. The present invention further provides a thin and flexible device for galvanic treatment to treat wounds with electrical stimulation. Preferably, the device is made using a printing technique.

Abstract: Provided is a nail treatment device including an active delivery device for disposing on the nail and for promoting delivery of an active agent into the nail to treat a nail infection; and at least one means for preventing delivery of the active agent to the skin. Further provided is a method of treating a nail infection including applying onto an infected nail a nail treatment device including an active delivery device for promoting delivery of an active agent into the nail to treat a nail infection and at least one means for preventing delivery of the active agent to the skin.

Abstract: A method of forming an electrochemical cell is disclosed. The method comprises contacting a negative pole layer and a positive pole layer one with the other or with an optional layer interposed therebetween. The pole layers and the optional layer therebetween are selected to self-form an interfacial separator layer between the pole layers upon such contacting.

Abstract: The present invention provides a powered treatment device comprising at least one power source for supplying electrical energy to the device, and wherein at least one component of the power source is also configured as a power source treatment device electrode to facilitate electrical contact with a body region. In an embodiment wherein one component of the power source is configured as a power source treatment device electrode, the powered treatment device may further comprise at least one non-power source device electrode of opposite polarity from the power source treatment device electrode, wherein the at least one non-power source device electrode is electrically coupled to the at least one power source to facilitate electrical contact with a body area.

Abstract: The present invention provides a pharmaceutical composition comprising as the active agent a terbinafine compound, water, and at least one water-soluble or water-miscible nonionic surfactant, wherein the terbinafine compound has at least one form selected from the group consisting of free base form, acid addition salt form, ionic form, and combinations thereof; and wherein substantially no alcohol is present.

Abstract: Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.

Abstract: The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.

Abstract: An adhesive bandage is provided. The adhesive bandage includes: (a) an absorbent pad having an absorbent surface; (b) an adhesive tape attached to the absorbent pad, the adhesive tape being configured for attaching to a skin region so as to position the absorbent surface against a portion of the skin region; (c) a display being positioned on an outer surface of the adhesive bandage the display being configured and positioned so as to be viewable by an individual when the adhesive tape is attached to the skin region; and (d) a power source attached to or integrated with the adhesive tape, the power source being for powering the display, the display being for increasing an acceptability of use of the adhesive bandage by the individual when powered. Furthermore, the present invention provides an adhesive bandage with a display, the display being for displaying a skin condition value and for increasing an acceptability of use of the adhesive bandage by the individual when powered.

Abstract: Methods, apparatus, and kits for onychomycosis treatment are presented. In one embodiment, a kit for treatment includes an anti-fungal agent, in a composition, and an electrically powered patch. Exemplary embodiments of the patch include a first electrode, a power source having a first and second terminal, a second electrode coupled to the second terminal of the power source, and a base member supporting the first electrode, the second electrode, and the power source. Embodiments include those where the first and second electrode and power source are printed on the base member. Anti-fungal agents may be unionized while the composition includes an ionizing agent. Home use may be practiced, as embodiments include those in which the voltage or current of the power source cannot be adjusted by a user. Exemplary methods include the selection of a nail or diseased area to which treatment is desired and administering the kit as described.

Abstract: The invention is generally directed to a kit and patch for transdermal or intradermal delivery of at least one substance into the skin. The kit includes a dermal patch having an electrochemical cell with two electrodes and a retainer for retaining a conductive fluid which further includes an active substance. The conductive fluid can be deposited on at least one of the two electrodes. Alternatively, the conductive fluid can be applied topically to the skin.

Abstract: A method of forming an electrochemical cell is disclosed. The method comprises contacting a negative pole layer and a positive pole layer one with the other or with an optional layer interposed therebetween. The pole layers and the optional layer therebetween are selected so as to self-form an interfacial separator layer between the pole layers upon such contacting.

Abstract: The present invention is of an apparatus and method for enhancing skin, muscle and nerve stimulation and controlled delivery of an active substance to a subject's skin. Moreover, the present invention is of an apparatus, featuring a combination of a stimulating device and an exothermic heating source. Preferably, the stimulating device is an iontophoretic device, or an electrical stimulation device, such as, but not limited to TENS, IFC and GC devices or a combination thereof. The present invention also provides a method of using such an apparatus for enhancing skin, muscle and nerve stimulation. Furthermore, the present invention provides a method of use of such an apparatus for enhancing controlled delivery of an active substance.

Abstract: A kit, device and method for delivering an oxidizing agent onto and/or into the body are disclosed. Moreover, a dermal patch device, which delivers an oxidizing agent using iontophoresis and or electroosmosis onto and/or into the body is disclosed. Furthermore, use of a dermal patch device for treatment of a body area with an oxidizing agent is disclosed. The device may be a thin and flexible dermal patch. A method of using such a device/kit for treatment of a disorder of a body area with an oxidizing agent is also disclosed.

Abstract: The present invention is of an electrode comprising an electrode substrate, wherein the electrode substrate has an electrode side and a back side; a conductive material layer disposed on the back side of the electrode substrate; and an insoluble electroactive material disposed on the electrode side of the electrode substrate. The electrode substrate can be a conductive substrate or a non-conductive substrate. In an embodiment wherein the substrate is a non-conductive substrate, the electrode can include vias which extend from the electrode substrate backside to the electrode side of the substrate. In some embodiments, the electroactive material is zinc and the conductive material is silver. The present invention provides an electrode with improved current distribution and high capacity, which can provide higher current and/or higher voltage. In addition, the present invention provides a dermal patch, which includes a higher powered, high capacity electrode with uniform current distribution.

Abstract: A method of forming an electrochemical cell is disclosed. The method comprises contacting a negative pole layer and a positive pole layer one with the other or with an optional layer interposed therebetween. The pole layers and the optional layer therebetween are selected so as to self-form an interfacial separator layer between the pole layers upon such contacting.

Abstract: A method of forming an electrochemical cell is disclosed. The method comprises contacting a negative pole layer and a positive pole layer one with the other or with an optional layer interposed therebetween.

Abstract: A method of forming an electrochemical cell is disclosed. The method comprises contacting a negative pole layer and a positive pole layer one with the other or with an optional layer interposed therebetween. The pole layers and the optional layer therebetween are selected so as to self-form an interfacial separator layer between the pole layers upon such contacting.

Abstract: A functionally improved battery is disclosed. The battery includes a flexible thin layer open liquid state electrochemical cell and an electronic chip device integrally formed on or within the electrochemical cell. The cell includes a first layer of insoluble negative pole, a second layer of insoluble positive pole and a third layer of aqueous electrolyte. The third layer is disposed between the first and second layers. The third layer includes and includes a deliquescent material for keeping the cell wet, an electroactive soluble material for ionic conductivity and a watersoluble polymer for viscosity. The viscosity adheres the first and second layer to the third layer. The chip serves to improves a functionality of the battery.

Abstract: A flexible thin layer open liquid state electrochemical cell which can be used as a primary or rechargeable power supply for various miniaturized and portable electrically powered devices of compact design. The cell includes a wet electrolyte, yet maintains a fexible, thin and open configuration, thus devoid of accumulation of gases upon storage. The cell comprising a first layer of insoluble negative pole, a second layer of insoluble positive pole and a third layer of aqueous electrolyte, the third layer being disposed between the first and second layers and including a deliquescent material for keeping the open cell wet at all times; an electroactive soluble material for obtaining required ionic conductivity; and, a watersoluble polymer for obtaining a required viscosity for adhering the first and second layers to the third layer. The electrochemical cell of the present invention is preferably produced using a suitable printing technology.