Abstract: A medical practitioner can specify certain parameters for a procedure that involves delivering a therapeutic agent, while leaving other parameters open. The therapeutic agent can be sensitive to biomechanical forces (or other influences) associated with delivery. The procedure can involve regenerative medicine, for example delivering progenitor or stem cells to a diseased heart using a catheter, whereby unbridled transport in the catheter may compromise efficacy. The open parameters can influence efficacy of the agent and thus therapeutic outcome. A computer-based system can apply stored information, such as from databases, to narrow the possible values of the open parameters. From the narrowed possibilities, an optimization routine can determine suitable or optimized values for the open parameters. The determined values can manage biomechanical forces incurred by the therapeutic agent, thereby promoting efficacy and healing. The optimized parameters can guide the practitioner in the procedure.

Abstract: Embodiments include a method and apparatus for removably connecting a firearm, accessory, or tool to a surface, material, object, belt, vehicle, pocket, or tactical equipment. The apparatus may include a first connecting member operatively connectible to the firearm, accessory, or tool and a second connecting member operatively connectible to the surface, material, object, belt, vehicle, pocket, or tactical equipment. The first connecting member and second connecting member are capable of connection to one another to connect the firearm, accessory, or tool to the surface, material, object, belt, vehicle, pocket, or tactical equipment.

Abstract: A catheter for delivering a therapeutic agent to a target site of a human or animal subject can include a substantially flexible and biocompatible catheter body having a proximal end and a distal end. An eductor can be located at the distal end of the catheter body, and a first lumen within the catheter body for housing the therapeutic agent can be in fluid communication with the eductor. A second lumen, also in fluid communication with the first lumen, can extend from the proximal end of the catheter body towards the eductor and can have an output port at the distal end of the catheter body. The eductor can be operable to induce the therapeutic agent to flow from the first lumen out of the output port in response to fluid flowing through the second lumen.

Abstract: A physician, nurse, or other healthcare practitioner can deliver a therapeutic agent to a patient in a manner that maintains effectiveness of the therapeutic agent, via monitoring and controlling shear, stress, or other potentially detrimental effect. A gauge, meter, or other monitoring device can provide an indication of shear (or other effect) that the therapeutic agent is experiencing during delivery. The monitoring device can provide information relevant to delivering the therapeutic agent in a manner that maintains effectiveness, thereby guiding the practitioner during delivery. For example, the monitoring device can display an estimate of shear based on sensing flow rate or pressure. The therapeutic agent can comprise one or more therapeutic cells, such as progenitor cells or stem cells, or some other healing substance delivered via a cardiac catheter to the patient's cardiovascular tissue, for example.

Abstract: Embodiments include a method and apparatus for an integrated illumination device mount and for mounting the integrated illumination device and mount to a firearm or helmet. In some embodiments, the integrated illumination device mount is a low profile mount. In some embodiments, the integrated illumination device mount allows rigid mounting of an illumination device to a rail of a firearm. In other embodiments, the integrated illumination device allows pivotal mounting of the illumination device to a rail of a firearm. In yet other embodiments, the integrated illumination device mount allows pivotal mounting of the illumination device to a rail of a helmet.

Abstract: A temperature control device for use in a process reactor system with a bubbler having a container provided with a side wall. The device includes a vessel having an internal chamber adapted to receive the container of the bubbler. An enclosure member is extendable between the container of the bubbler and the vessel for enclosing the side wall of the container within the internal chamber. A temperature-changing device is coupled to the vessel for providing heat or cold to the internal chamber.

Abstract: Embodiments include a method and apparatus for removably connecting a firearm, accessory, or tool to a surface, material, object, belt, vehicle, pocket, or tactical equipment. The apparatus may include a first connecting member operatively connectible to the firearm, accessory, or tool and a second connecting member operatively connectible to the surface, material, object, belt, vehicle, pocket, or tactical equipment. The first connecting member and second connecting member are capable of connection to one another to connect the firearm, accessory, or tool to the surface, material, object, belt, vehicle, pocket, or tactical equipment.

Abstract: A speculum having a generally U-shaped frame with a pair of arms, each arm having a free end, a pair of cups, each cup coupled with the free end of one of the arms, and a pair of surfaces, each surface coupled with one of the cups and having a portion extending upward at an angle from the frame.

Abstract: A multi-spectrum emitting device is provided including one or more emitters configured to emit in a first spectrum and a second spectrum. Devices include a switching mechanism with at least two switching elements. The switching mechanism may be configured to require simultaneous activation of the at least two switching elements in order to change emissions from the first spectrum to the second spectrum. The first spectrum may be a non-visible light spectrum and the second spectrum may be a visible light spectrum. Devices may also include a tactile feedback mechanism that provides different tactile feedback for different emission modes of the device.

Abstract: Embodiments include a method and apparatus for mounting one or more accessories to a rail of a firearm. A mounting member may be utilized for attaching the one or more accessories to the rail. Embodiments further include a method and apparatus for protecting a user from a discharging portion of a firearm. Some embodiments include a foregrip having a gripping portion and a guarding portion which may be used for protecting the user. In some embodiments, the guarding portion has a larger outer diameter than the gripping portion so that the guarding portion acts as a stop for the user's body parts.

Abstract: An apparatus for use with a process liquid for controlling the temperature of a semiconductor-processing target comprises first and second tanks adapted for holding process liquid, at least one fluid level sensor carried by the first tank for monitoring the amount of process liquid in the first tank, and a valve coupled to one of the at least one fluid level sensor and configured to increases the flow of process liquid from the second tank to the target when the amount of process liquid in the first tank drops to a first predetermined amount. The first tank may include first and second compartments partially separated by a divider with a top whereby process liquid in the first compartment flows over the top of the divider into the second compartment.

Abstract: Embodiments include a method and apparatus for mounting one or more accessories to a rail of a firearm. A mounting member may be utilized for attaching the one or more accessories to the rail. Embodiments further include a method and apparatus for protecting a user from a discharging portion of a firearm. Some embodiments include a foregrip having a gripping portion and a guarding portion which may be used for protecting the user. In some embodiments, the guarding portion has a larger outer diameter than the gripping portion so that the guarding portion acts as a stop for the user's body parts.

Abstract: The invention relates to methods and systems for measuring and/or monitoring the chemical composition of a sample (e.g., a process stream), and/or detecting specific substances or compounds in a sample, using light spectroscopy such as absorption, emission and fluorescence spectroscopy. In certain embodiments, the invention relates to spectrometers with rotating narrow-band interference optical filter(s) to measure light intensity as a function of wavelength. More specifically, in certain embodiments, the invention relates to a spectrometer system with a rotatable filter assembly with a position detector rigidly attached thereto, and, in certain embodiments, the further use of various oversampling methods and techniques described herein, made particularly useful in conjunction with the rotatable filter assembly.

Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

Abstract: An image acquisition system and method employing multi-axis integration (MAI) may incorporate both optical axis integration (OAI) and time-delay integration (TDI) techniques. Disclosed MAI systems and methods may integrate image data in the z direction as the data are acquired, projecting the image data prior to deconvolution. Lateral translation of the image plane during the scan in the z direction may allow large areas to be imaged in a single scan sequence.

Abstract: A system and method employing photokinetic techniques in cell biology imaging applications are disclosed. Systems and methods of acquiring image data of an object may comprise: selectively inducing photoactivation of material at a site on the object; performing an optical axis integration scan; simultaneously executing a time delay integration scan sequence; and processing acquired image data in accordance with one or more desired analyses. Various methodologies and applications may include, inter alia, selective photobleaching of a site on the object, diffusion rate, velocity, and wave-front propagation analyses, multi-dimensional analyses of dispersion characteristics, biomolecular binding in cellular organelles, and photoactivation assisted systematic image segmentation for the study of cellular components.

Abstract: Expression profiling using DNA microarrays is an important new method for analyzing cellular physiology. In “spotted” microarrays, fluorescently labeled cDNA from experimental and control cells is hybridized to arrayed target DNA and the arrays imaged at two or more wavelengths. Statistical analysis is performed on microarray images and show that non-additive background, high intensity fluctuations across spots, and fabrication artifacts interfere with the accurate determination of intensity information. The probability density distributions generated by pixel-by-pixel analysis of images can be used to measure the precision with which spot intensities are determined. Simple weighting schemes based on these probability distributions are effective in improving significantly the quality of microarray data as it accumulates in a multi-experiment database. Error estimates from image-based metrics should be one component in an explicitly probabilistic scheme for the analysis of DNA microarray data.