Abstract: The system and method of the present invention rely on combining the Speakers+Room binaural Impulse Response(s) (SRbIR) with a special kind of crosstalk cancellation (XTC) filter—one that does not degrade or significantly alter the SRbIR's spectral and temporal characteristics that are required for effective head externalization. This unique combination leads to a 3D audio filter for headphones that allows the emulation of the sound of crosstalk-cancelled speakers through headphones, and allows for fixing the perceived soundstage in space using head tracking and thus solves the major problems for externalized and robust 3D audio rendering through headphones. Furthermore, by taking advantage of a well-documented psychoacoustic fact, this system and method can produce universal 3D audio filters that work for all listeners i.e. independent of the listener's head related transfer function (HRTF).

Abstract: The majority of clinically used antibiotics and anticancer agents are derived from bacterial small molecules. These molecules are produced by dedicated biosynthetic gene clusters, sets of genes that are responsible for the step-wise generation of the target small molecule. Recent investigations have indicated, to the surprise of many experts, that the majority of these biosynthetic genes are inactive or ‘silent’ for unknown reasons. Thus under typical bacterial culturing conditions, these genes are not expressed and consequently the bioactive small molecule products are not synthesized. Disclosed is a method for high throughput screening of elicitors of cryptic metabolites, a method for producing cryptic metabolites, and a new family of cryptic metabolites, the acybolins, as well as their complete structural elucidation.

Abstract: A multiplying analog to digital converter including an analog to digital converter (ADC) having a sample input and a feedback input and an ADC output configured with a feedback path configured to couple the ADC output to a digital to analog converter. A feedback attenuator is disposed in the feedback path, the feedback attenuator being configured to attenuate a feedback signal coupled to the feedback input, the feedback attenuator being configured to provide analog multiplication observed at the ADC output. A barrel shifter is configured to provide digital multiplication of the ADC output. The feedback attenuator may be configured as a divider network. The feedback attenuator may be configured to provide attenuation using only passive components. The feedback attenuator may be configured as a capacitive divider network. The feedback attenuator may be configured to provide attenuation ranging between 1 and 0.5.

Abstract: The present invention is related to solid state light emitting diodes (LEDs), photodetector/photovoltaic devices, displays, applications and methods for making the same. As demonstrated experimentally, the LEDs, as disclosed herein, have high light emission efficiency, high contrast, high brightness, low ambient light reflection, low light glare, and a tunable display viewing angle. The same LED disclosed here can be used as high efficiency displays and high efficiency photovoltaic device or photodetectors. This means that the same device, where used in array form, can be used as the display (LED operation mode) and power supply (photovoltaic device mode) and camera (photodetector and imaging mode).

Abstract: A 10-formyl-THF pathway for producing NADPH is useful in the diagnosis and treatment of cancer and metabolic disease, in the development of new antineoplastic agents and/or regimens, in the development of new methods for measuring metabolic pathway activity, and in the development of new therapeutics for treating metabolic disease.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: Disclosed is a detector for a positron imaging unit, comprises a hollow body with an inner cylindrical wall and an outer wall spaced apart from the inner cylindrical wall. The hollow body includes a scintillating material, suitable to emit photons once hit by a 511 keV Y-ray, and one or more pairs of photo-detecting units (e.g. comprising PMTs or SiPM) for detecting photons emitted by the scintillating material; each photo-detecting unit of a pair being placed at opposite ends of the inner cylindrical wall along a radial direction. The scintillating material has scintillation decay time ? lower than 10 ns, an atomic number greater than 10, and a high scintillation yield greater than 8,000 photons/MeV, and comprises a mixture of xenon and argon. An imaging unit including the detector and a method to estimate the differential of the dose of radiation provided in a subject to cancer cells and to surrounding tissues in the course of hadrotherapy is also disclosed.

Abstract: A chip multiprocessor includes a plurality of cores each having a translation lookaside buffer (TLB) and a prefetch buffer (PB). Each core is configured to determine a TLB miss on the core's TLB for a virtual page address and determine whether or not there is a PB hit on a PB entry in the PB for the virtual page address. If it is determined that there is a PB hit, the PB entry is added to the TLB. If it is determined that there is not a PB hit, the virtual page address is used to perform a page walk to determine a translation entry, the translation entry is added to the TLB and the translation entry is prefetched to each other one of the plurality of cores.

Abstract: The disclosure describes compstatin analogs and methods of using such analogs for the treatment of complement-related disease and disorder.

Abstract: Organic light emitting devices are disclosed which are comprised of a heterostructure for producing electroluminescence wherein the heterostructure is comprised of an emissive layer containing a phosphorescent dopant compound.

Abstract: A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m2/g to 2630 m2/g; and a method for producing the nanocomposite and uses thereof.

Abstract: Methods, kits, cartridges, and compounds related to generating chlorine dioxide by exposing ClO2? to at least one of an iron porphyrin catalyst or an iron porphyrazine catalyst are described.

Abstract: A system for simultaneous optical pathlength determination and remote chemical sensing of a sample disposed along an optical path. A modulated laser source configured for modulated light emission so that at least one spectral sideband with a sideband frequency is created, the modulated light emission is directed along the optical path and sideband frequency is varied over time. A detector is configured to detect transmitted light along the optical path and generate a detected light intensity signal. A frequency down-converter is configured to receive the detected light emission signal and generate a frequency down-converted light intensity signal. A demodulator is configured to demodulate the frequency of the down-converted light intensity signal and output an instantaneous frequency. A pathlength calculator is configured to determine an optical pathlength to the sample based on the instantaneous frequency.

Abstract: Mechanical energy harvesting is an increasingly important method of providing power to distributed sensor networks where physical connection to a power source is impractical. Conventional methods use vibrations to actuate a piezoelectric element, coil/magnet assembly, or capacitor plates, thereby generating an electric current. The low charge-density of these devices excludes their application in low frequency and static load sources, with the lowest frequency reported devices limited to 10 Hz. These frequency limitations can be overcome by exploiting the piezoelectrochemical effect, a similar but physically distinct effect from the piezoelectric effect whereby an applied mechanical load alters the thermodynamics of an electrochemical reaction to produce a voltage/current. Piezoelectrochemical energy harvesters are expected to produce orders of magnitude more energy per load cycle than piezoelectrics and comparable power capabilities.

Abstract: Compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. Pharmaceutical compositions comprising peptide sequences with high cytotoxicity to cancer cell lines are provided. A method for treating cancer is provided.

Abstract: Waveguides and electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising waveguides fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. The devices include electromagnetic splitters, filters, and sensors.

Abstract: Disclosed is a class of organic salts and electrolytes, generally for use with electrochemical devices. Some of these salts enable the transport of magnesium ions without the presence of any additives, such as halide ions. Precursors are generated using simple fluorinated alcohols as well as abundant reagents. These precursors, often dissolved in ethereal solvents, may be combined with an appropriate Lewis acid to result in solutions that are able to conduct ions and allow for reversible electrodeposition.

Abstract: The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type. A quorum sensing systems that regulates the expression of cell fate regulators is introduced into mammalian host cells, such as stem cells. The quorum sensing systems generally comprises vectors that express the components of a bacterial quorum sensing pathway, including proteins which catalyze the synthesis of an autoinducer and a gene encoding a regulatory partner of the autoinducer, and vectors in which genes encoding cell fate regulators are operably linked to a promoter induced by the autoinducer/regulatory partner complex.

Abstract: Fluorinated compounds are provided. Fluorinated compounds may be prepared by a method of halogenating a carbon containing compound having an sp3 C—H bond.

Abstract: Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the development of vaccine compositions, are disclosed. Vaccine compositions comprising CMV isolated from epithelial cells are also disclosed.