Patents Assigned to Princeton University
  • Publication number: 20180155532
    Abstract: A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m2/g to 2630 m2/g; and a method for producing the nanocomposite and uses thereof.
    Type: Application
    Filed: January 26, 2018
    Publication date: June 7, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Shuyang PAN, IIhan A. Aksay, Robert K. Prud'homme
  • Patent number: 9984450
    Abstract: A computer implemented method and apparatus for processing images comprises obtaining two or more images acquired by ultrasound. One or more operating parameters of the ultrasound probe (transducer) are varied so that the resulting images of a material or object under investigation differ with respect to intensity. Examples of parameters which may be varied include probe angle, frequencies, and even the time and/or resolution of the respective images. The method further comprises creating a new image by selectively subtracting one or more images from one or more others. In an embodiment, there are two images and one is partially subtracted from the other. If negative values are obtained as a result of the subtraction, such values are set to zero.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: May 29, 2018
    Assignee: The Trustees of Princeton University, Office of Technology and Trademark Licensing
    Inventors: Jason W. Fleischer, Jen-Tang Lu
  • Patent number: 9985251
    Abstract: The present invention is directed towards a thin-film device. In one embodiment, the thin film device comprises a scattering layer comprising a substrate, the substrate comprising a plurality of voids, and a device stock formed atop the scattering layer, wherein the plurality of voids have a high refractive index as compared to a refractive index of the substrate. Another embodiment of the present invention is directed towards a process for fabricating a thin-film device, the process comprising dissolving a precursor in an organic solvent to form a solution, coating the solution onto a substrate to form a film, immersing the film and the substrate into an antisolvent bath for a first period of time so as to form a plurality of air voids within the film, removing the film and substrate from the anti-solvent bath to dry and cure for a second period of time to create a porous film adhered to the substrate, the porous film and the substrate forming a scattering layer.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: May 29, 2018
    Assignee: The Trustees of Princeton University, Office of Technology and Trademark Licensing
    Inventors: Barry P. Rand, Tae-Wook Koh
  • Patent number: 9970117
    Abstract: A method for heterocycle catalyzed electrochemical reduction of a carbonyl compound is disclosed. The method generally includes steps (A) to (C). Step (A) may introduce the carbonyl compound into a solution of an electrolyte and a heterocycle catalyst in a divided electrochemical cell. The divided electrochemical cell may include an anode in a first cell compartment and a cathode in a second cell compartment. The cathode generally reduces the carbonyl compound to at least one aldehyde compound. Step (B) may vary which of the aldehyde compounds is produced by adjusting one or more of (i) a cathode material, (ii) the electrolyte, (iii) the heterocycle catalyst, (iv) a pH level and (v) an electrical potential. Step (C) may separate the aldehyde compounds from the solution.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 15, 2018
    Assignees: Princeton University, Avantium Knowledge Centre B.V.
    Inventors: Emily Barton Cole, Andrew B. Bocarsly
  • Publication number: 20180125066
    Abstract: The invention relates to compositions comprising QS modulating molecules attached to a surface via a linker. This QS modulator attached surface can then be used to modulate QS, biofilm production, biofilm streamer production and/or virulence factor production. The length of the linker that attaches the QS modulating molecule to the surface as well as the surface coverage density are features that impact QS modulation on surfaces. These QS modulator attached surfaces can be used to treat areas known to contain human pathogens notorious for causing hospital-acquired infections as well as fatal infections that occur outside of health care settings. Other surfaces that can be coated according to embodiments of the invention include abiotic materials, such as intravenous catheters, implants, medical devices, and cooling towers. Preferred microorganisms that can be treated with the compositions of the invention include, but are not limited to S. aureus and/or P. aeruginosa.
    Type: Application
    Filed: October 25, 2017
    Publication date: May 10, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Bonnie L. Bassler, Howard A. Stone, Min Young Kim, Thomas William Muir, Aishan Zhao
  • Patent number: 9966216
    Abstract: A new ultra-thin high-efficiency photoelectron source utilizing a metallic photonic resonant cavity having a photonic resonant cavity with a top metallic layer with a plurality of openings, each having an average dimension less than the wavelength of the excitation photons in vacuum, a bottom metallic layer and a photoelectron emission layer of semiconductor positioned between the top metallic layer and the bottom metallic.
    Type: Grant
    Filed: November 5, 2012
    Date of Patent: May 8, 2018
    Assignee: Princeton University
    Inventor: Stephen Y. Chou
  • Patent number: 9959883
    Abstract: The method and system for measuring low-noise acoustical impulse responses at high sampling rates of the present invention utilizes two exponential sine sweeps (ESSs) to measure the impulse responses. The first ESS is a quick sweep up to the Nyquist frequency to provide an estimate of the system response and sample the ambient noise. This measurement is used to algorithmically determine an appropriate pass-band of the system. A second, slower sweep through the pass-band alone is then executed and a corresponding band-pass filter is applied to the resulting output signal to suppress noise. The result is a measured impulse response with an improved signal-to-noise ratio and a much-reduced pre-response.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: May 1, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Edgar Y. Choueiri, Joseph Tylka, Rahulram Sridhar, Braxton Boren
  • Patent number: 9956179
    Abstract: This invention discloses a process for making nanoparticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule's solubility and stability in a nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient's body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: May 1, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Brian K. Johnson, Robert K. Prud'homme
  • Publication number: 20180109946
    Abstract: An implantable medical device (IMD) configured to communicate with an external device (ED). The ED supports two way RF communications and has a light source. The IMD includes a processor coupled to an optical detector, the processor is configured to verify that light is being received from the ED light source and that the ED is a trusted device, establishing a unidirectional optical channel from the ED to the IMD. An RF transceiver is coupled to the processor, the processor being configured permit two way RF communications with the ED only under a condition that the ED is verified as a trusted device. The processor may be configure to wake up periodically or aperiodically to check for the presence of light from the ED light source. The processor may be configured to detect a multi-bit message from the ED via the unidirectional optical channel. The multi-bit message may include a key.
    Type: Application
    Filed: October 3, 2017
    Publication date: April 19, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Arsalan Mosenia, Niraj K. Jha
  • Patent number: 9943490
    Abstract: The invention described herein relates to sterically stabilized colloidal constructs comprising preformed colloidal particles encapsulated within a polymeric shell. The constructs, which are controllably sized, are nanoparticles comprising hydrophobic elements, electrostatically charged particles with hydrophobic surfaces, hydrophobic inorganic nanostructures, and amphiphilic copolymers with hydrophobic domains and hydrophilic domains. The constructs are made by a process that allows for the simultaneous encapsulation of a preformed colloidal agent as well as a dissolved hydrophobic active within the core of the polymeric nanoparticle. Among the actives incorporated in various embodiments are organic fluorescent dyes, metal nanostructures and superparamagnetic materials for use in combined fluorescence, optical and magnetic resonance imaging applications, and hydrophobic drugs for therapeutic applications.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: April 17, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Robert K. Prud'homme, Marian Gindy, Ying Liu
  • Patent number: 9932587
    Abstract: The present invention relates generally to methods for identifying cancer patients with a poor prognosis, and to therapeutic modalities for improving prognosis by combating metastasis and abrogating chemoresistance in cancer cells. Embodiments of the present invention provide an objective means of prognostication regarding the long-term outcome of an incident of cancer, breast cancer in particular. Therapeutic modalities include immunotherapy and anti-sense therapy. Prognosis is determined by measuring the number of copies of the metadherin gene in the patient's cells.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: April 3, 2018
    Assignee: The Trustees Of Princeton University
    Inventors: Yibin Kang, Guohong Hu
  • Publication number: 20180078526
    Abstract: A structurally distinct and potent series of synthetic small molecule activators of Vibrio cholerae quorum sensing have been chemically synthesized. The small molecule activators reduce virulence in V. cholerae. Acyl pyrrole molecules displayed strong potency and stability, particularly 1-(1H-pyrrol-3-yl)decan-1-one.
    Type: Application
    Filed: November 29, 2017
    Publication date: March 22, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Bonnie L. Bassler, Lark J. Perez, Martin F. Semmelhack
  • Patent number: 9909989
    Abstract: Microstructures and nanostructures (100) consisting of a substrate (110), an array of pillars (120) capped by metallic disc (130), metallic dots (clusters or granules) (140) disposed on the sidewalls of the pillars, and a metallic backplane (150) that can interact to enhance a local electric field, the absorption of the light, and the radiation of the light are disclosed. Methods to fabricate the structures (100) are also disclosed. Applications of the structures to enhance the optical signals in the detection of molecules and other materials on a structure surface, such as fluorescence, photoluminescence and surface enhanced Raman Scattering (SERS) are also disclosed.
    Type: Grant
    Filed: September 30, 2015
    Date of Patent: March 6, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Stephen Y. Chou, Wendi Li
  • Patent number: 9911574
    Abstract: Provided among other things are a scanning electron microscope, scanning transmission electron microscope, focused ion beam microscope, ion beam micromachining device, or scanning probe nanofabrication device, wherein the microscope or device is configured to move a substrate and a scanning modality relative to one another with an enclosed sinusoidal trajectory, and methods of operation.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: March 6, 2018
    Assignee: The Trustees of Princeton University, Office of Technology and Trademark Licensing
    Inventors: Nan Yao, Wei Cai
  • Patent number: 9908995
    Abstract: A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m2/g to 2630 m2/g; and a method for producing the nanocomposite and uses thereof.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: March 6, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Shuyang Pan, Ilhan A. Aksay, Robert K. Prud'Homme
  • Publication number: 20180062393
    Abstract: A system and method for performing novel wind forecasting that is particularly accurate for forecasting over short-term time periods, e.g., over the next 1-5 hours. Such wind forecasting is particularly advantageous in wind energy applications. The disclosed method is anchored in a robust physical model of the wind variability in the atmospheric boundary layer (ABL). The disclosed method approach leverages a physical framework based on the unsteady dynamics of earth's atmosphere, and drives forecasting as a function of previously-observed atmospheric condition data observed at the same location for which a wind forecast is desired.
    Type: Application
    Filed: March 28, 2016
    Publication date: March 1, 2018
    Applicant: Trustees of Princeton University
    Inventors: Elie Bou-Zeid, Mostafa Momen
  • Publication number: 20180046313
    Abstract: A three dimensional touch sensing system having a touch surface configured to detect a touch input located above the touch surface is disclosed. The system includes a plurality of capacitive touch sensing electrodes disposed on the touch surface, each electrode having a baseline capacitance and a touch capacitance based on the touch input. An oscillating plane is disposed below the touch surface. A touch detector is configured to drive one of the touch sensing electrodes with an AC signal having a frequency that shifts from a baseline frequency to a touch frequency based on the change in electrode capacitance from the baseline capacitance to the touch capacitance. The touch detector is configured to drive the oscillating plane to the touch frequency.
    Type: Application
    Filed: July 7, 2017
    Publication date: February 15, 2018
    Applicant: The Trustees of Princeton University
    Inventors: Yingzhe Hu, Liechao Huang, Naveen Verma, Sigurd Wagner, James C. Sturm
  • Publication number: 20180037526
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Application
    Filed: February 9, 2016
    Publication date: February 8, 2018
    Applicant: The Trustees of Princeton University
    Inventors: John T. Groves, Xiongyi Huang
  • Patent number: 9885806
    Abstract: Waveguides and electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising electromagnetic cavities fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. Devices comprising waveguides fabricated in hyperuniform disordered materials with complete photonic bandgaps are provided. The devices include electromagnetic splitters, filters, and sensors.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: February 6, 2018
    Assignee: The Trustees of Princeton University
    Inventors: Paul J Steinhardt, Marian Florescu, Salvatore Torquato
  • Publication number: 20180032896
    Abstract: A quantum information processing system comprises a light source, a detector, at least one spatial light modulator and at least one optical lens. The light source is configured to provide a beam of entangled photons. The at least one optical lens is configured to project the resultant beam onto the spatial light modulator, either by direct imaging or by performing a full or partial optical Fourier transform. Said spatial light modulator includes a plurality of discrete pixels and is configured to select one or more of the plurality of discrete pixels to generate a resultant beam from said beam of entangled photons. The resultant beam from said spatial light modulator is projected onto the detector. For optical computation, such as search algorithms, the configuration and projections are repeated to find the optimal solution.
    Type: Application
    Filed: July 28, 2017
    Publication date: February 1, 2018
    Applicant: Trustees of Princeton University
    Inventors: Jason W. Fleischer, Chien-Hung Lu, Xiaohang Sun, Matthew Reichert, Hugo Defienne