Patents Assigned to Proteus
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Publication number: 20070185548Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070185537Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 9, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070179569Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: August 2, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Publication number: 20070173897Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: ApplicationFiled: March 29, 2007Publication date: July 26, 2007Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Patent number: 7238483Abstract: This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent (X) that can react either with a chemical group of unconsumed substrate (S) or with a chemical group of product (P) that is formed after an incubation period with the sample, the addition of a developer (R) that can react with reagent (X), and the detection of the transformation of developer (R).Type: GrantFiled: May 28, 2004Date of Patent: July 3, 2007Assignees: Proteus SA, Universite de BerneInventors: Jean-Louis Reymond, Denis Wahler
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Patent number: 7214189Abstract: Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.Type: GrantFiled: September 1, 2005Date of Patent: May 8, 2007Assignee: Proteus Biomedical, Inc.Inventor: Mark J. Zdeblick
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Publication number: 20070099257Abstract: This invention has as its object a method for releasing a product by subjecting a compound of Formula (II?): R?7R?8(HX)C1-C2(YH)R?9R?10 to a chemical oxidation that cleaves the bond C1-C2 to obtain the product. In the compound of Formula (II?): R?7 to R?10, which are identical or different, correspond to a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted functional group; X and Y, which are identical or different, are an oxygen atom, a sulfur atom, or an amine of Formula —NR11R12, wherein R11 is a hydrogen atom, an alkyl group, or a substituted or unsubstituted aryl group, and R12 is not a hydrogen atom. The invention also has as its object a method for releasing a product that comprises, before the chemical oxidation stage, a first step for preparing the compound of Formula (II?). The released product can be a volatile molecule or an active substance or else a specific product.Type: ApplicationFiled: November 20, 2006Publication date: May 3, 2007Applicants: Proteus, Universite de BerneInventors: Jean-Louis Reymond, Denis Wahler, Frabrizzio Badalassi, Hong-Khanh Nguyen
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Patent number: 7204798Abstract: Methods and systems of the present invention provide for measurement of various cardiac parameters. Methods generally involve causing a change in volume and/or pressure in a heart chamber, measuring the change, and calculating at least one cardiac parameter based on the change. Systems typically include at least one actuator, at least one sensor, and a catheter or other device for positioning at least partially in a heart chamber. In some embodiments, the system may also include a controller, such as a computer or other processor, an external actuator, an external sensor, and/or an ECG device. Methods and systems of the invention may be used to more accurately diagnose cardiac conditions in order to make more informed treatment decisions.Type: GrantFiled: January 23, 2004Date of Patent: April 17, 2007Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Joseph M. Ruggio
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Patent number: 7200439Abstract: Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.Type: GrantFiled: January 23, 2004Date of Patent: April 3, 2007Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Joseph M. Ruggio
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Patent number: 7163707Abstract: A process for cooking a food in oil and/or fat is provided. A dry protein mixture, a dry alkaline protein mixture, an aqueous alkaline protein mixture or an aqueous acidic protein is added to a food prior to cooking. The dry protein mixture, dry alkaline protein mixture, aqueous alkaline protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres. The amount of oil and/or fat absorbed by the food during cooking is substantially reduced.Type: GrantFiled: November 18, 2004Date of Patent: January 16, 2007Assignee: Proteus Industries, Inc.Inventors: Stephen D. Kelleher, Peter G. Williamson
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Patent number: 7160567Abstract: A peptide composition derived from a protein composition when added to uncooked food effects moisture retention during cooking of the food. The peptide composition is derived from a dry protein mixture or an aqueous acidic protein solution which, in turn, is derived from animal muscle tissue. The peptide composition is added to uncooked poultry, meat or fish prior to cooking. The dry protein mixture and aqueous acidic protein solution comprise myofibrillar proteins and sarcoplasmic proteins substantially free of myofibrils and sarcomeres.Type: GrantFiled: October 29, 2004Date of Patent: January 9, 2007Assignee: Proteus Industries, Inc.Inventors: Stephen D. Kelleher, Peter G. Williamson
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Patent number: 7090737Abstract: The present invention is directed to components of fiber-reinforced plastics which can also be used as load-bearing components in mechanical and automotive engineering. A construction for such components is created that can be used flexibly and enables a defined design of the components. A method is created for this purpose that makes it possible to design and produce such load-bearing components to specific requirements. The method can be automatable and can make highly replicable results possible. The components thus produced of a fiber-reinforced plastic can have low weight with high strength properties and can be economical to produce.Type: GrantFiled: August 30, 2002Date of Patent: August 15, 2006Assignee: Proteus GmbHInventor: Emil Lindenau
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Publication number: 20060166306Abstract: The present invention provides methods and composition for enhancing in vitro synthesis of biological macro-molecules in a call-free system where ATP is required as a primary energy source, wherein said cell-free system is enriched with ATP-sulfurylase The invention relates also to as cell-free systems and cell-free extracts enriched with ATP-sulfurylase for enhancing in vitro synthesis of any biological macromolecules.Type: ApplicationFiled: July 25, 2003Publication date: July 27, 2006Applicant: PROTEUS A.A.Inventors: Lyubov Ryabova, Jean-Michel Masson
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Patent number: 7073387Abstract: Implantable pressure sensors and methods for making and using the same. A feature of of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representable pressure sensors include the presence of a compliant member mounted on a substrate in a manner such that the compliant member has first and second opposing exposed surfaces and is positioned at least proximal to the said pressure sensor's neutral plane. The subject pressure sensors find use in a variety of applications.Type: GrantFiled: December 28, 2004Date of Patent: July 11, 2006Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Benedict James Costello
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Publication number: 20060137457Abstract: Implantable pressure sensors and methods for making and using the same are provided. A feature of embodiments of the subject pressure sensors is that they are low-drift sensors. The subject sensors find use in a variety of applications.Type: ApplicationFiled: December 28, 2004Publication date: June 29, 2006Applicant: Proteus Biomedical, Inc.Inventor: Mark Zdeblick
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Patent number: 7066031Abstract: Implantable pressure sensors and methods for making and using the same. A feature of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of at least one strain transducer that is fabricated from a stable gauge material. The subject pressure sensors find use in a variety of applications.Type: GrantFiled: December 28, 2004Date of Patent: June 27, 2006Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Benedict James Costello
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Patent number: 7063767Abstract: A method for producing a durable electromagnetic and radio frequency interference shield between two or more structural members of a wall or enclosure and a shielded shelter produced using the method. In one embodiment, joints between structural members are preferably filled with an electrically conductive filler. A base coat of a metal spray that adheres well to the filler and structural member is then applied. At least one layer of a metal spray with magnetic field attenuation properties such as steel, and at least one layer of a metal spray that has plane wave attenuation properties such as tin are applied to the base coat. Optionally, a coat of protective or conductive paint is then applied to the top surface of the metal spray layers. An enclosure with shielded joints according to the present invention has superior shielding capability and durability over the art.Type: GrantFiled: February 7, 2003Date of Patent: June 20, 2006Assignee: Proteus Technical Solutions, Inc.Inventors: Kenneth E. Tyson, Deborah S. Tyson, Theodore Marzan, Ronald B. Walker
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Patent number: 7033636Abstract: A low cholesterol protein composition derived from animal muscle tissue is provided. The low cholesterol protein composition is added to meat or fish prior to cooking to retain moisture during cooking in the fish or meat.Type: GrantFiled: April 19, 2004Date of Patent: April 25, 2006Assignee: Proteus Industries, Inc.Inventor: Stephen D. Kelleher
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Patent number: 7028550Abstract: Implantable pressure sensors and methods for making and using the same. A feature of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of at least one strain transducer that is fabricated from a stable gauge material. The subject pressure sensors find use in a variety of applications.Type: GrantFiled: December 28, 2004Date of Patent: April 18, 2006Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Benedict James Costello
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Patent number: 7013734Abstract: Implantable pressure sensors and methods for making and using the same. A feature of at least some of the subject pressure sensors is that they are low-drift sensors. Additional features of representative pressure sensors include the presence of at least one strain transducer that is fabricated from a stable gauge material. The subject pressure sensors find use in a variety of applications.Type: GrantFiled: December 28, 2004Date of Patent: March 21, 2006Assignee: Proteus Biomedical, Inc.Inventors: Mark Zdeblick, Benedict James Costello