Patents Assigned to Proteus
  • Communication System with Remote Activation
    Publication number: 20120007734
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 12, 2012
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventors: Jeffrey Berkman, Mark Zdeblick, Patricia Johnson, Hooman Hafezi, Jonathan Withrington
  • Communication System with Multiple Sources of Power
    Publication number: 20120004520
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 5, 2012
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventors: Adam Whitworth, Mark Zdeblick
  • Communication System Using an Implantable Device
    Publication number: 20120004527
    Abstract: The system of the present invention includes an implantable device that can detect high and low frequency current signature. The implantable device can communicate with a communication device that includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, the communication device is activated.
    Type: Application
    Filed: July 11, 2011
    Publication date: January 5, 2012
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventors: Todd Thompson, Mark Zdeblick, Yashar Behzadi, Benedict Costello, Timothy Robertson, Hooman Hafezi, George Savage
  • Shielded stimulation and sensing system and method
    Publication number: 20110282179
    Abstract: Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.
    Type: Application
    Filed: October 6, 2009
    Publication date: November 17, 2011
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventor: Mark Zdeblick
  • Low voltage oscillator for medical devices
    Patent number: 8054140
    Abstract: Low voltage oscillators that provide a stable output frequency with varying supply voltage are provided. The subject oscillators find use in a variety of different types of devices, e.g., medical devices, including both implantable and ex-vivo devices.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: November 8, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Robert Fleming, Cherie Kushner, Nilay Jani, Jonathan Withrington, Mark Zdeblick
  • Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same
    Patent number: 8055334
    Abstract: Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data processor configured to receive data from the body-associated receiver and generate and electroviscerogram from the received data. Also provided are methods of producing electroviscerograms using systems of the present invention.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: November 8, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: George Savage, Hooman Hafezi, Olivier Colliou, Mark Zdeblick, Angela Strand
  • Medical carriers comprising a low-impedance conductor, and methods of making and using the same
    Patent number: 8055353
    Abstract: Medical carriers that include a low-impedance conductor are provided. The low-impedance conductors are configured to provide electrical conductivity along a length of the medical carrier. An aspect of the low-impedance conductors is the presence of a longitudinally extended region configured as a non-coiled repetitive pattern that imparts fatigue resistance to the longitudinally extended region. Also provided are systems and methods of making the medical carriers, as well as methods of using the medical carriers.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: November 8, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Marc Kreidler, David Huynh, Marc Jensen
  • Self-referencing communication in implantable devices
    Patent number: 8055345
    Abstract: Various aspects of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Aspects of the invention include implantable integrated circuits that have self-referencing and self-clocking signal encoding, and are capable of bidirectional communication. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: November 8, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Haifeng Li, Mark Zdeblick, Lawrence Arne, Yafei Bi, Nilay Jani, Jonathan Withrington
  • Automated optimization of multi-electrode pacing for cardiac resynchronization
    Patent number: 8036743
    Abstract: One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads inserted in a patient. A pacing lead includes a plurality of pacing satellites, and a pacing satellite includes a plurality of electrodes that can be individually addressed and used for transmitting or detecting electric signals. The system then performs a second set of iterations to select one or more electrodes on the selected satellites. The system further performs a third set of iterations to select one or more timing configurations for pacing signals transmitted through one or more of the selected electrodes.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: October 11, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: George M. Savage, Todd Thompson, Mark J. Zdeblick, Lawrence W. Arne, Olivier Colliou, Benedict James Costello, Fataneh A. Omidvar
  • Ingestible therapy activator system and method
    Patent number: 8036748
    Abstract: An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The responder module may receive and process the effector instruction, resulting in a response by the therapeutic device. Examples of responses by therapeutic device include activating a therapy, deactivating a therapy, modulating a therapy, and discontinuing a therapy.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 11, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Mark Zdeblick, Marc Jensen, Olivier Colliou, Angela Strand
  • Method for detecting and/or quantifying a known function from a nucleic acid sample
    Patent number: 8017318
    Abstract: The invention concerns a method for detecting a known function, from nucleic acids present in a sample, characterized in that it comprises the following steps: (a) preparing, from the nucleic acids of the sample, nucleic acid molecules comprising the gene(s) coding for the protein(s) corresponding to said function, and the control elements required for the transcription and the translation of said gene(s); (b) in vitro transcription and translation of the nucleic acid molecule prepared in step (a); (c) detecting and/or measuring the function corresponding to the protein(s) produced in step (b).
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 13, 2011
    Assignee: Proteus S.A.
    Inventors: Jean François Bloch, Sandrine Dautel, Daniel Dupret, Jean-Michel Masson, Fabrice Lefevre
  • WAVE-POWERED ENERGY GENERATION APPARATUS
    Publication number: 20110192159
    Abstract: A wave-powered energy generation apparatus (10) comprises a plurality of pontoons (12) articulatingly connected to each other. A centre pontoon (12.2) is substantially curved. The apparatus (10) has a mooring point (19) for mooring the apparatus (10) in a body of water. The apparatus (10) also has a power generation system which is powered by articulating movement between the pontoons.
    Type: Application
    Filed: August 10, 2009
    Publication date: August 11, 2011
    Applicant: PROTEUS WAVE POWER PTY LTD.
    Inventors: Matthew Morgan, Andrew Horton
  • SENSING SYSTEM, DEVICE, AND METHOD FOR THERAPY MODULATION
    Publication number: 20110196454
    Abstract: Sensing system, device, and method for therapy modulation are provided. Various aspects include a receive module and a therapy-related action module. The receive module may receive a therapy parameter of an individual. The therapy-related action module may effectuate, based on the therapy parameter, a therapy-related action associated with a nervous system of the individual.
    Type: Application
    Filed: November 13, 2009
    Publication date: August 11, 2011
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventors: Angela Strand, Mark Zdeblick, George Savage, David O'reilly
  • Measuring conduction velocity using one or more satellite devices
    Patent number: 7983751
    Abstract: A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: July 19, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Mark J. Zdeblick, Timothy Robertson, George M. Savage
  • Method of determining the mutational load of a gene library obtained by random mutagenesis of a particular gene and means for implementing same
    Patent number: 7983849
    Abstract: The invention relates to methods of determining the mutational load of a gene bank obtained by random mutagenesis of a gene of interest by preparing a chart linking the mutational load of a gene bank obtained by random mutagenesis of a model gene with the fraction of mutated model genes observed in the bank; performing, in parallel, random mutagenesis of the model gene used for preparing the chart and the gene of interest to obtain the corresponding mutated gene banks; determining the mutational load of the gene bank obtained using the model gene on the basis of the chart plotted; and applying a correction factor to the mutational load of the mutated model gene bank to determine the mutational load in the gene bank of the mutated genes of interest.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: July 19, 2011
    Assignee: Proteus S.A.
    Inventors: Matthieu Chodorge, Laurent Fourage, Fabrice Lefevre, Jean-Michel Masson
  • Communication system with partial power source
    Patent number: 7978064
    Abstract: The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can be used in a variety of different applications, including as components of ingestible identifiers, such as may be found in ingestible event markers, e.g., pharma-informatics enabled pharmaceutical compositions.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: July 12, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Mark Zdeblick, Timothy Robertson, Aleksandr Pikelny, Hooman Hafezi
  • Multiplexed multi-electrode neurostimulation devices
    Patent number: 7974705
    Abstract: Implantable stimulation devices are provided. Aspects of the devices include a multiplexed multi-electrode component configured for neural stimulation. The multiplexed multi-electrode component includes two or more individually addressable satellite electrode structures electrically coupled to a common conductor. The satellite structures include a hermetically sealed integrated circuit controller operatively coupled to one or more electrodes. Also provided are systems that include the devices of the invention, as well as methods of using the systems and devices in a variety of different applications.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: July 5, 2011
    Assignee: Proteus Biomedical, Inc.
    Inventors: Mark Zdeblick, Todd Thompson, Marc Jensen, Olivier Colliou, Angela Strand
  • Optimal drive frequency selection in electrical tomography
    Patent number: 7969161
    Abstract: Electrical tomography drive frequency selection systems and methods are disclosed. One aspect of the present invention pertains to a system for optimally selecting a drive frequency of an electrical tomography which comprises a sensor electrode stably associated with a tissue site within an internal organ of a subject for generating an induced signal based on a noise signal over a range of frequency bands, wherein an electrical field for the electrical tomography is turned off. In addition, the system comprises a noise processing module for isolating the induced signal for each frequency band over the range of frequency bands. Furthermore, the system comprises a frequency select module for selecting a drive frequency of the electrical field for the electrical tomography by comparing the induced signal for each frequency band over the range of frequency bands.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: June 28, 2011
    Assignee: Proteus Bomedical, Inc.
    Inventors: Yashar Behzadi, Kenneth C. Crandall
  • Process for controlling protein to salt ratio in animal muscle protein composition and protein composition
    Patent number: 7956081
    Abstract: A low salt protein solution not capable of forming a gel is obtained from animal muscle tissue by forming an aqueous acidic protein solution which is filtered to remove salt and acid. The low salt protein solution can be formed into a gel by adding a physiologically acceptable salt to the low salt protein solution and heating the resultant protein solution with added salt.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: June 7, 2011
    Assignee: Proteus Industries, Inc.
    Inventor: Stephen D. Kelleher
  • Pacing and Stimulation Apparatus and Methods
    Publication number: 20110130809
    Abstract: System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.
    Type: Application
    Filed: November 13, 2009
    Publication date: June 2, 2011
    Applicant: PROTEUS BIOMEDICAL, INC.
    Inventor: Mark Zdeblick