Abstract: This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 0.01 nanoseconds at the full-width-at-half-maximum. This treatment may at least prevent growth of the lesion.

Abstract: A high-voltage coaxial cable with a hollow inner conductor is described. The hollow region can be filled with a non-conducting filler. The inner conductor is surrounded by a dielectric, which is surrounded by an outer conductor and jacket. Methods and systems for designing these very high voltage coaxial cables with matching system impedance and minimal cable cross sections are provided. Embodiments include coaxial cables, systems, and methods for designing coaxial cables with high standoff voltage capacity, greater flexibility than standard coaxial cable, and a given impedance. Embodiments provide setting the requirements for an insulator of a coaxial cable driving the dimensions of the other components of the coaxial cable.

Abstract: This disclosure relates to an in vivo treatment of a skin lesion of a mammal comprising application of electrical energy to the skin lesion in a form of electrical pulses. At least one electrical pulse is applied. The pulse duration may be at least 1 nanosecond at the full-width-half-maximum. Surface of a tissue surrounding the skin lesion may be marked to guide the device to deliver the electric pulses at substantially precise locations on the lesion surface. This treatment may prevent at least growth of the lesion.