Abstract: This invention relates to LAP-expressing probiotic bacteria and methods of use thereof to prevent and treat a pathogenic bacterial infection.
Abstract: Peptide aptamers and the methods to produce cassettes including the aptamers and manipulating them, are described. The peptide aptamer cassettes are useful to, e.g., inhibit protein function such as proteins necessary for the transformation of plants, or to replicate cells.
Abstract: Protein phosphorylation is a major post-translational modification and it plays a pivotal role in numerous cellular functions. We present a composition that includes a soluble nanopolymer core functionalized with groups having an affinity for either metal ion or metal oxides which can be used for phosphopeptide enrichment. Exemplary compounds including PolyMAC-Zr, PolyMAC-Fe and PolyMAC-Ti demonstrate outstanding reproducibility, exceptional sensitivity, fast chelation time, and high phosphopeptide recovery from standard mixtures that include phosphorylated peptides. The composition can be used for phosphoproteome isolation from samples of medicinal, diagnostic or biological interest such as malignant breast cancer cells. Such compositions were used for the quantitative analysis of the changes in the tyrosine phosphoproteome in highly invasive breast cancer cells after induction of Syk kinase, a potent suppressor of tumor growth and metastasis.
Abstract: Compounds that inhibit proteolytic enzymes of Human Immunodeficiency Virus (HIV) are described. Preparation of the inhibitors, pharmaceutical compositions containing them, and uses of the compounds or compositions for the treatment of HIV infections are also described.
Abstract: A laser nanoforming system and method for forming three-dimensional nanostructures from a metallic surface. A laser beam is directed to hit and explode an ablative layer to generate a shockwave that exerts a force on the metallic surface to form an inverse nanostructure of an underlying mold. A dry lubricant can be located between the metallic surface and mold to reduce friction. A confinement layer substantially transparent to the laser beam can confine the shockwave. A cushion layer can protect the mold from damage. A flyer layer between the ablative layer and metallic surface can protect the metallic surface from thermal effects of the exploding ablative layer. The mold can have feature sizes less than 500 nm. The metallic surface can be aluminum film. The dry lubricant can be sputtered Au—Cr film, evaporated Au film or a dip-coated PVP film or other dry lubricant materials.
Type:
Grant
Filed:
May 23, 2011
Date of Patent:
August 6, 2013
Assignee:
Purdue Research Foundation
Inventors:
Gary J. Cheng, Huang Gao, Yingling Yang
Abstract: Improved methods for packing a chromatographic column and columns packed by these methods are provided. The methods include introducing a packing material into a chromatographic column, while simultaneously ultrasonicating and applying pressure to the packing material to form a packed column with radial homogeneity.
Type:
Application
Filed:
April 5, 2011
Publication date:
August 1, 2013
Applicant:
Purdue Research Foundation
Inventors:
Mary Jean Wirth, Sampath Ranasinghe Kodithuwakkuge, Charu Yerneni, Robert Birdsall, Tharanga Ranasinghe Kodituwakkuge
Abstract: An apparatus and method of generating a codebook. The codebook generation apparatus includes a matrix extender to generate a candidate matrix set by multiplying a base matrix and at least one diagonal matrix, wherein the at least one diagonal matrix includes elements of a constrained set as diagonal elements; and a codebook generator to generate the codebook where a minimum distance between the elements is maximized, based on the candidate matrix set. According to aspects of the present invention, it is possible to provide a precoding codebook that can reduce an amount of feedback from a terminal.
Type:
Grant
Filed:
March 27, 2008
Date of Patent:
July 30, 2013
Assignees:
Samsung Electronics Co., Ltd., Purdue Research Foundation
Inventors:
Bruno Clerckx, Yongxing Zhou, Sung Jin Kim, David J. Love, Il Han Kim
Abstract: Communication between a base station with multiple transmission antennas and a mobile station is provided. The base station and the mobile station may recognize or estimate, respectively, a channel between the base station and the mobile station, and update a previous codebook with a new codebook based on a variation of the channel. In this instance, the mobile station may provide feedback information to the base station using the new codebook, and the base station may generate a transmission signal for the mobile station using the new codebook and the feedback information.
Type:
Grant
Filed:
April 24, 2009
Date of Patent:
July 30, 2013
Assignees:
Samsung Electronics Co., Ltd., Purdue Research Foundation
Inventors:
Bruno Clerckx, Sung Jin Kim, Ki Il Kim, David J. Love, Taejoon Kim
Abstract: A system and method for decontamination of product is described. An object to be treated, which may be a food product or a medical device, is placed in a substantially closed dielectric container with a working gas. The container is placed in an apparatus capable of producing a controlled electrical discharge so as to create reactive ion species within the package. The object to be treated may be exposed either the immediate products of the electrical discharge or the long lasting reactive ion species, or both, so as to treat the object to reduce or eliminate specific contaminants, which may be biological pathogens or the cause of product spoilage, or inorganic contaminants. The reactive ion species may result from an atmospheric non-equilibrium plasma (ANEP) formed by the apparatus and the treatment may be performed without significantly increasing the bulk temperature of the object being treated.
Abstract: Methods and apparatuses for processing materials to enhancing the material's surface strength, improving the material's cyclic and thermal stability of microstructures, and extend the material's fatigue performance. Embodiments include laser shock peening at material temperatures that are moderately elevated (from the material's perspective) above room temperature. Alternate embodiments include laser shock peening at very cold (cryogenic) material temperatures. Still further embodiments include laser shock peening while covering the surface of the material being processed with an active agent that interacts with the laser energy and enhances the pressure exerted on the surface.
Abstract: The present invention relates to kinase inhibiting compositions and uses thereof. The invention further provides isolated kinase inhibiting peptides and uses thereof for inhibiting hyperplasia, for inhibiting the growth of neoplasms, and for inducing programmed cell death in a cell population.
Abstract: An object is disposed such that the apparatus is between the object and an observer. The appearance of the object is altered and, in the limit, the object cannot be observed, and the background appears unobstructed. The apparatus is formed of a metamaterial where the properties of the metamaterial are varied as a function of distance from the interfaces. The metamaterial may be fabricated as a composite material having a dielectric component and inclusions of particles of sub-wavelength size, and may also include a gain medium.
Type:
Grant
Filed:
October 5, 2009
Date of Patent:
July 16, 2013
Assignee:
Purdue Research Foundation
Inventors:
Wenshan Cai, Vladimir M. Shalaev, Uday K. Chettiar, Alexander V. Kildishev
Abstract: Human anti-human folate receptor beta antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FR?.
Type:
Application
Filed:
March 8, 2013
Publication date:
July 11, 2013
Applicants:
Purdue Research Foundation, Services
Inventors:
Purdue Research Foundation, The United States of America, as Represented by the Secretary Department of Health and Human Services
Abstract: A system is provided for monitoring intraocular pressure, the system comprising: a sensor package configured to be disposed in the suprachoroidal space of a patient's eye; a pressure sensor; a wireless transceiver disposed within the sensor package and coupled to the pressure sensor; an external transceiver, the external receiver being wirelessly coupled to the wireless transceiver when the transceiver is disposed proximate to the patient's eye.
Type:
Grant
Filed:
August 22, 2008
Date of Patent:
July 2, 2013
Assignee:
Purdue Research Foundation
Inventors:
Pedro P. Irazoqui, Eric Y. Chow, William J. Chappell, Chin-Lung Yang, Babak Ziaie
Abstract: A silicon carbide power MOSFET having a drain region of a first conductivity type, a base region of a second conductivity type above the drain region, and a source region of the first conductivity type adjacent an upper surface of the base region, the base region including a channel extending from the source region through the base region adjacent a gate interface surface thereof, the channel having a length less than approximately 0.6 ?m, and the base region having a doping concentration of the second conductivity type sufficiently high that the potential barrier at the source end of the channel is not lowered by the voltage applied to the drain. The MOSFET includes self-aligned base and source regions as well as self-aligned ohmic contacts to the base and source regions.
Abstract: A system and method for performing a floating function in an earthmoving implement of an earthmoving machine without physically connecting chambers within a hydraulic actuator that is adapted to raise and lower the earthmoving implement. The system includes a device for delivering a pressurized fluid to and receiving pressurized fluid from the actuator, a valve for compensating for differences in volume between chambers of the actuator, and an electronic control circuit that includes electronic sensors for sensing the pressures in the chambers of the actuator, and a controller for receiving outputs of the sensors. The controller calculates an amount of the pressurized fluid that, when delivered to or received from the actuator, achieves a substantially constant pressures in the chambers of the actuator and enables the earthmoving implement to float regardless of motion of the actuator.
Type:
Grant
Filed:
November 5, 2009
Date of Patent:
July 2, 2013
Assignee:
Purdue Research Foundation
Inventors:
Edward C. Hughes, IV, Christopher Alan Williamson, Joshua D. Zimmerman, Monika Marianne Ivantysynova
Abstract: A multiple input multiple output (MIMO) communication system and communication method of configuring a codebook are provided. A channel may be formed between a transmitter and a receiver, and a cross-polarization discrimination value (XPD) may be detected. The XPD may vary based on a location of the transmitter and the receiver, a mobility thereof, or a peripheral environment, among other factors. The codebook may be configured based on the XPD.
Type:
Grant
Filed:
June 1, 2010
Date of Patent:
July 2, 2013
Assignees:
Samsung Electronics Co., Ltd., Purdue Research Foundation
Inventors:
Bruno Clerckx, Ki Il Kim, Jun Il Choi, David J. Love, Taejoon Kim
Abstract: This present disclosure relates to folate mimetics and their use in therapeutic and diagnostic applications. More particularly, the disclosure relates to using des-glutamyl folic acid analogs recognized by and selectively bound by folate receptors and other folate binding proteins and the use of such analogs for targeted delivery of diagnostic or therapeutic agents to folate-receptor bearing cell populations.
Type:
Grant
Filed:
May 7, 2010
Date of Patent:
June 25, 2013
Assignees:
Purdue Research Foundation, Endocyte, Inc.
Inventors:
Mark A Green, Chun-Yen Ke, Christopher P Leamon
Abstract: This paper presents a microfluidic pumping approach using traveling-wave dielectrophoresis (tw-DEP) of microparticles. Flow is generated directly in the microfluidic devices by inducing electromechanical effects in the fluid using microelectrodes. The fluidic driving mechanisms due to the particle-fluid and particle-particle interactions under twDEP are analyzed, and the induced flow field is obtained from numerical simulations. Experimental measurements of the flow velocity in a prototype DEP micropumping device show satisfactory agreement with the numerical predications.
Abstract: A system and method are described for capturing and analyzing gamma rays from neutron excitation of a region in 3-space being analyzed for explosives. A processor analyzes the results, determining whether underground explosives are present in a particular region of the ground. In one embodiment, one gamma ray energy band is used to infer an amount of silicon in the region, while another indicates the combined amount of silicon and nitrogen. The concentration of nitrogen in the region is inferred and used to trigger an “explosive found” or a “no explosive found” signal. In other embodiments, the system or method uses inferences about other elemental constituents of the ground being examined, sometimes taking as input analyzes from prior scans, and providing output indicating the likelihood of the presence of explosives in the region.