Abstract: The present disclosure relates to novel thiophene monoamine based organic-inorganic hybrid perovskites, and the method of making and using the novel organic-inorganic hybrid perovskites.

Abstract: This present disclosure relates to sensors capable of sensing mass, stiffness, and chemical or biological substances. More specifically, this disclosure provides the design and implementation of a piecewise-linear resonator realized via diode- and integrated circuit-based feedback electronics and a quartz crystal resonator. The proposed system is fabricated and characterized, and the creation and selective placement of the bifurcation points of the overall electromechanical system is demonstrated by tuning the circuit gains. The demonstrated circuit operates around at least 1 MHz.

Abstract: An in silico screening method generated compounds that are against laminin receptor 37LR and their anti-cancer functions in prostate cancer cell lines are disclosed herein. A group of derivatives based on the hit compound from the in silico screening are synthesized and tested with improved IC50 value that can have relevant clinical use for prostate cancer or osteoarthritis.

Abstract: Trap and/or refuge crops and methods of use in managing corn rootworm and other insect pests of maize are provided. Some methods involve using trap crops comprising plants with enhanced susceptibility to one or more insect pests to lure and kill insect pests. Other methods involve using refuge crops comprising plants with enhanced susceptibility to one or more insect pests to monitor insect pest populations in an area or to promote mating between insecticide resistant and insecticide non-resistant insects.

Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

Abstract: Disclosed herein are nanoparticle-based plasmonic solutions to therapeutic applications employing titanium nitride (TiN) and other non-stoichiometric compounds as the plasmonic material. Current solutions are suboptimal because they require complex shapes, large particle sizes, and a narrow range of sizes, in order to achieve plasmonic resonances in the biological window. The nanoparticles discloses herein provide plasmonic resonances occurring in the biological window even with small sizes, simple shapes, and better size dispersion restrictions. Local heating efficiencies of such nanoparticles outperform currently used Au and transition metal nanoparticles. The use of smaller particles with simpler shapes and better heating efficiencies allows better diffusion properties into tumor regions, larger penetration depth of light into the biological tissue, and the ability to use excitation light of less power.

Abstract: A method of performing ordered statistics between at least two parties is disclosed which includes identifying a first dataset (xA) by a first node (A), identifying a second dataset (xB) by a second node (B), wherein xB is unknown to A and xA is unknown to B, and wherein A is in communication with B, and wherein A and B are in communication with a server (S), A and B each additively splitting each member of their respective datasets into corresponding shares, sharing the corresponding shares with one another, arranging the corresponding shares according to a mutually agreed predetermined order into corresponding ordered shares, shuffling the ordered shares into shuffled shares, re-splitting the shuffled shares into re-split shuffled shares, and performing an ordered statistical operation on the re-split shuffled shares, wherein the steps of shuffle and re-split is based on additions, subtractions but not multiplication and division.

Abstract: A single volume soft sensor capable of sensing real-time continuous contact and stretching. An electrical impedance tomography (EIT) technique with support vector machine (SVM) learning is employed to estimate changes of resistance distribution on the sensor caused by fingertip contact even during sensor deformation events. A deformation switch is incorporated to maintain the localization during deformation events.

Abstract: A rapid cooling system for processing food is disclosed which includes a heat exchanger adapted to receive a first coolant (Coolant-I) at a first temperature and eject Coolant-I at a second temperature, a cooling chamber disposed within the heat exchanger in thermal communication with the heat exchanger, the cooling chamber includes a first inlet adapted to receive a product at an elevated temperature (T1), a second inlet adapted to receive a second coolant (Coolant-II) at a low temperature (T2), and an outlet adapted to release a combination of the product and Coolant-II at a low temperature (Tout) and pressure (Pout), wherein cooling of the product from T1 to Tout does not cause a phase change in the product.

Abstract: Disclosed herein are fully synthetic polymer-based lung surfactant materials, for the first time, as next generation SRT. In vitro studies on these polymer lung surfactants show that the candidate materials effectively mimic the surface tension controlling properties of currently marketed natural lung surfactants. Further, the polymer lung surfactants have strong protein resistance, which makes this class of materials promising also for potential use in Acute Respiratory Distress Syndrome (ARDS) treatment.

Abstract: A method of determining moisture content in an emulsified asphalt-aggregate system is disclosed. The method includes: placing a first electrode in an emulsified asphalt-aggregate system (Mixture) at a first depth, placing a second electrode in the Mixture at a second depth, applying an alternating current (AC) signal between the first electrode and the second electrode, measuring impedance, determining the frequency which yields the minimum measured impedance, recording the minimum measured impedance, repeating the above steps at a predetermined time interval until the recorded minimum impedance is about 10 times of the first recorded minimum impedance, and alerting a user that the Mixture has sufficiently cured.

Abstract: A software architecture where the software architecture processes a method, wherein the method includes defining initial conditions for a set of Büttiker probes. The set of Büttiker probes include various interaction equations between one or several many-body systems. The method includes computing properties of particles with quantum transport methods. A quantum transport method of the quantum transport methods include a set of Büttiker probes. The particles include the particles of one or several many-body systems. Further, the method includes calculating a current for each Büttiker probe of the set of Büttiker probes. The current includes at least one of momentum current, particle current, energy current, spin current, color charge or chirality current. The method includes setting up a set of continuity equations such that for each continuity equation a calculated current of a Büttiker probe is in a particular relation with an another calculated current of an another Büttiker probe.

Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.

Abstract: Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.

Abstract: The invention generally relates to systems and methods for analyzing an extracted sample using an immiscible extraction solvent. In certain embodiments, the invention provides a system for analyzing an analyte in a sample. The system includes an ionization probe and a mass spectrometer. The ionization probe includes a hollow body that optionally includes a distal tip. The hollow body is configured such that there is no substrate within the body and no electrode disposed on a surface of the body. An electrode is at least partially disposed within the hollow body.

Abstract: The invention generally relates to mass spectrometry probes and systems for ionizing a sample. In certain embodiments, the invention provides a mass spectrometry probe including a substrate in which a portion of the substrate is coated with a material, a portion of which protrudes from the substrate.

Abstract: The present disclosure relates to novel sesquiterpenoid compounds as SHP2 and/or POLE3 inhibitors for potential treatment for cancers, and to methods of making and using the sesquiterpenoid compounds. The present invention therefore provides a method of using the disclosed compounds as chemosensitizations agent to a DNA damaging drugs for cancers.

Abstract: Laser-assisted micromachining methods and systems capable of providing flexible beam positioning and low incident angles. Such laser-assisted micromachining systems preferably include a laser beam source, a cutting tool, means for engaging a workpiece with the cutting tool, optical elements arranged to define a path of a laser beam emitted by the laser beam source wherein the optical elements include at least a first mirror mounted in fixed relation to the laser beam source, and means for adjustably mounting a second mirror to project the laser beam onto the workpiece in proximity to the cutting tool and at an incidence angle relative to a surface of the workpiece.

Abstract: A hypersonic refractory material, including a refractory leading edge portion for a hypersonic vehicle and a high emissivity oxide coating adhered to the refractory leading edge portion. The high emissivity oxide coating is ZrB2 doped with a cation dopant material selected from the group including Sm, Tm, and mixtures thereof. The cation dopant material is present in a concentration of between 3 mole percent and 8 mole percent.

Abstract: The present disclosure relates to adhesive compositions made from the reaction product of plant protein and phenolics, and method of making and using the adhesive compositions. A maximum bonding strength of 7.8±1.5 MPa was obtained using only 1 weight % tannic acid in a zein matrix of pH=7 and cured at 120° C.