Patents Assigned to Quantum-Si Incorporated
  • Patent number: 12366706
    Abstract: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.
    Type: Grant
    Filed: April 5, 2024
    Date of Patent: July 22, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Ali Kabiri, Bing Shen, Gerard Schmid, James Beach, Kyle Preston, Sharath Hosali
  • Patent number: 12360114
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: July 15, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Brian Reed, Jeremy Lackey, Haidong Huang
  • Publication number: 20250179123
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides amino acid recognition molecules, such as amino acid binding proteins and fusion polypeptides thereof. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Application
    Filed: July 12, 2024
    Publication date: June 5, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Manjula Pandey
  • Patent number: 12312377
    Abstract: Aspects of the disclosure provide biconjugatable labels, labeled biomolecules, and methods of using and making the same.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: May 27, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Jeremy Lackey, Roger Nani, David Dodd
  • Patent number: 12317615
    Abstract: Aspects of the technology described herein relate to improved semiconductor-based image sensor designs. In some aspects, an integrated circuit described herein may include a first pixel and a second pixel, wherein the first pixel is proximate the second pixel in a mirrored configuration. In some aspects, an integrated circuit described herein may include a first pixel and a second pixel that is proximate to the first pixel along a row direction, and a conductive line extending along a column direction that intersects with the row direction, wherein the conductive line is in electrical communication with a first component of the first pixel and a second component of the second pixel.
    Type: Grant
    Filed: April 8, 2022
    Date of Patent: May 27, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Xin Wang, Eric A. G. Webster, Todd Rearick
  • Patent number: 12297496
    Abstract: The present disclosure provides techniques for improving the rate and efficiency of charge transfer within an integrated circuit configured to receive incident photons. Some aspects of the present disclosure relate to integrated circuits that are configured to induce one or more intrinsic electric fields that increase the rate and efficiency of charge transfer within the integrated circuits. Some aspects of the present disclosure relate to integrated circuits configured to induce a charge carrier depletion in the photodetection region(s) of the integrated circuits. In some embodiments, the charge carrier depletion in the photodetection region(s) may be intrinsic, in that the depletion is induced even in the absence of external electric fields applied to the integrated circuit. Some aspects of the present disclosure relate to processes for operating and/or manufacturing integrated devices as described herein.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: May 13, 2025
    Assignee: Quantum-Si Incorporated
    Inventor: Eric A. G. Webster
  • Patent number: 12300711
    Abstract: Aspects of the technology described herein relate to improved semiconductor-based image sensor designs. In some embodiments, an integrated circuit may comprise a photodetection region and a drain region electrically coupled to the photodetection region, and the photodetection region may be configured to induce an intrinsic electric field in a direction from the photodetection region to the drain region(s). In some embodiments, a charge storage region and the drain region may be positioned on a same side of the photodetection region. In some embodiments, at least one drain layer may be configured to receive incident photons and/or charge carriers via the photodetection region. In some embodiments, an integrated circuit may comprise a plurality of pixels and a control circuit configured to control a transfer of charge carriers in the plurality of pixels.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: May 13, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Eric A.G. Webster, Changhoon Choi, Dajiang Yang, Xin Wang, Todd Rearick, Kyle Preston, Ali Kabiri, Gerard Schmid
  • Publication number: 20250147035
    Abstract: The disclosure provides methods and compositions that enable the identification of polypeptides having one or more post-translational modifications. In some embodiments, the disclosure provides a method (e.g., a single-molecule measurement method) comprising contacting a single polypeptide with one or more post-translational modification-specific (PTM-specific) affinity reagents; and identifying whether the single polypeptide comprises a post-translational modification (PTM) by determining a luminescence signature representative of the binding interaction(s) between the single polypeptide and the one or more PTM-specific affinity reagents.
    Type: Application
    Filed: November 6, 2024
    Publication date: May 8, 2025
    Applicant: Quantum-Si Incorporated
    Inventor: Brian Reed
  • Publication number: 20250130103
    Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit includes a charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers directly into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
    Type: Application
    Filed: September 20, 2024
    Publication date: April 24, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Thomas Raymond Thurston, Benjamin Cipriany, Joseph D. Clark, Kyle Rearick, Keith G. Fife
  • Publication number: 20250130238
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Application
    Filed: June 24, 2024
    Publication date: April 24, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Brian Reed, Jeremy Lackey, Haidong Huang
  • Patent number: 12259324
    Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
    Type: Grant
    Filed: July 20, 2023
    Date of Patent: March 25, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
  • Patent number: 12259323
    Abstract: System and methods for analyzing single molecules and performing nucleic acid sequencing. An integrated device may include multiple pixels with sample wells configured to receive a sample, which when excited, emits radiation. The integrated device includes a surface having a trench region recessed from a portion of the surface and an array of sample wells, disposed in the trench region. The integrated device also includes a waveguide configured to couple excitation energy to at least one sample well in the array and positioned at a first distance from a surface of the trench region and at a second distance from the surface in a region separate from the trench region. The first distance is smaller than the second distance. The system also includes an instrument that interfaces with the integrated device. The instrument may include an excitation energy source for providing excitation energy to the integrated device by coupling to an excitation energy coupling region of the integrated device.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: March 25, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Ali Kabiri, Gerard Schmid, Keith G. Fife, James Beach, Jason W. Sickler, Lawrence C. West, Paul E. Glenn, Kyle Preston, Farshid Ghasemi, Benjamin Cipriany, Jeremy Lackey
  • Patent number: 12259391
    Abstract: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules having a shielding element that enhances photostability in polypeptide sequencing reactions.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: March 25, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Brian Reed, Jeremy Lackey, Haidong Huang
  • Publication number: 20250093670
    Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
    Type: Application
    Filed: August 27, 2024
    Publication date: March 20, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Paul E. Glenn, Jonathan C. Schultz, Benjamin Cipriany
  • Publication number: 20250093264
    Abstract: Systems and methods for optical power distribution within an integrated device, in a substantially uniform manner, to a large number of sample wells and/or other photonic elements. The integrated device and related instruments and systems may be used to analyze samples in parallel. The integrated device may include a grating coupler configured to receive light from an excitation source and optically couple with multiple waveguides configured to couple with sample wells. Vertical extents of optical modes of individual waveguides may be modulated to adjust confinement of light within the waveguides. This modulation may enable more uniform distribution of excitation light to the sample wells, improve excitation efficiency, and prevent overpower on regions of the integrated device.
    Type: Application
    Filed: November 27, 2024
    Publication date: March 20, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Gerard Schmid, Sharath Hosali, James Beach, Kyle Preston, Ali Kabiri, Bing Shen
  • Patent number: 12235463
    Abstract: Apparatus and methods for coupling an optical beam from an optical source to a hi-tech system are described. A compact, low-cost beam-shaping and steering assembly may be located between the optical source and hi-tech system and provide automated adjustments to beam parameters such as beam position, beam rotation, and beam incident angles. The beam-shaping and steering assembly may be used to couple an elongated beam to a plurality of optical waveguides.
    Type: Grant
    Filed: December 31, 2021
    Date of Patent: February 25, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Paul E. Glenn, Jonathan C. Schultz, Benjamin Cipriany
  • Publication number: 20250035639
    Abstract: The present disclosure provides methods and compositions for protein quantification using peptide barcodes, sample preparation for protein quantification, protein quantification using error-resistant peptide barcodes, methods to manipulate barcoded proteins, methods to determine the binding affinities of many protein variants in a mixture of proteins by single molecule measurements.
    Type: Application
    Filed: July 24, 2024
    Publication date: January 30, 2025
    Applicant: Quantum-Si Incorporated
    Inventors: Marco Ribezzi-Crivellari, Sebastian Hutchinson, Brian Reed, Christian Francis LaPointe
  • Patent number: 12203855
    Abstract: Some aspects relate to integrated devices for obtaining timing and/or spectral information from incident light. In some embodiments, a pixel may include one or more charge storage regions configured to receive charge carriers generated responsive to incident photons from a light source, with charge carriers stored in the charge storage region(s) indicative of spectral and timing information. In some embodiments, a pixel may include regions having different depths, each configured to generate charge carriers responsive to incident photons. In some embodiments, a pixel may include multiple charge storage regions having different depths, and one or more of the charge storage regions may be configured to receive the incident photons and generate charge carriers therein. In some embodiments, a pixel may include an optical sorting element configured to direct at least some incident photons to one charge storage region and other incident photons to another charge storage region.
    Type: Grant
    Filed: December 13, 2023
    Date of Patent: January 21, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Gerard Schmid, Dajiang Yang, Eric A. G. Webster, Xin Wang, Todd Rearick, Changhoon Choi, Ali Kabiri, Kyle Preston
  • Patent number: 12203854
    Abstract: An integrated circuit includes a photodetection region configured to receive incident photons. The photodetection region is configured to produce a plurality of charge carriers in response to the incident photons. The integrated circuit also includes at least one charge carrier storage region. The integrated circuit also includes a charge carrier segregation structure configured to selectively direct charge carriers of the plurality of charge carriers into the at least one charge carrier storage region based upon times at which the charge carriers are produced.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: January 21, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David M. Boisvert
  • Patent number: 12203853
    Abstract: Apparatus and methods relating to photonic bandgap optical nanostructures are described. Such optical nanostructures may exhibit prohibited photonic bandgaps or allowed photonic bands, and may be used to reject (e.g., block or attenuate) radiation at a first wavelength while allowing transmission of radiation at a second wavelength. Examples of photonic bandgap optical nanostructures includes periodic and quasi-periodic structures, with periodicity or quasi-periodicity in one, two, or three dimensions and structural variations in at least two dimensions. Such photonic bandgap optical nanostructures may be formed in integrated devices that include photodiodes and CMOS circuitry arranged to analyze radiation received by the photodiodes.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: January 21, 2025
    Assignee: Quantum-Si Incorporated
    Inventors: Ali Kabiri, Bing Shen, James Beach, Kyle Preston, Gerard Schmid