Patents Assigned to Queens's University
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Patent number: 12286558Abstract: A UV-curable durable coating composition is described that forms a transparent, antismudge coating. The composition includes a photoinitiator, a di-, tri-, or multi-functional monomer that bears double bonds, epoxide groups, or a combination, and a graft copolymer that bears pendant double bonds, epoxide groups or a combination and bears PDMS, polyisobutyl or perfluorinated polyether side chains.Type: GrantFiled: July 6, 2018Date of Patent: April 29, 2025Assignee: Queen's University at KingstonInventors: Guojun Liu, Heng Hu, Chao Zheng, Kaka Zhang
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Patent number: 12282001Abstract: Methods and apparatus for electrochemical analysis of water include acid cleaning a quartz crystal microbalance (QCM), stabilizing a QCM in analyte solution, and analyzing the solution by chronoamperometry and measuring a frequency shift of the QCM. The method may further include cleaning the QCM in an acid solution prior to stabilizing the QCM in analyte solution. The apparatus may provide at least semi-automated electrochemical analysis of water including determining a concentration of an analyte in a water sample, and communicating the concentration of the analyte over a network. The analyte may be manganese.Type: GrantFiled: February 28, 2023Date of Patent: April 22, 2025Assignee: Queen's University at KingstonInventors: Yu Pei, Zhe She, Sarah Jane Odessa Payne
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Patent number: 12278555Abstract: A controller for an AC-DC converter including a rectifier circuit that converts AC input voltage into DC output voltage uses control logic to control the rectifier circuit according to two or more operating modes. Each operating mode determines a gain of the rectifier circuit. The controller selects an operating mode from the two or more operating modes based on at least one of an AC input voltage value and a required DC output voltage value. The AC-DC converter provides a wide range of DC output voltage with power factor correction. The controller may be used with AC-DC converter topologies such as boost converter, isolated boost converter, PWM converter, LLC resonant converter, and LCC resonant converter.Type: GrantFiled: October 26, 2022Date of Patent: April 15, 2025Assignee: Queen's University at KingstonInventors: Yan-Fei Liu, Binghui He, Yang Chen, Bo Sheng, Wenbo Liu
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Patent number: 12252506Abstract: Methods of preparing nicotinamide riboside and derivatives thereof.Type: GrantFiled: April 26, 2023Date of Patent: March 18, 2025Assignee: The Queen's University of BelfastInventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
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Patent number: 12245817Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.Type: GrantFiled: June 23, 2023Date of Patent: March 11, 2025Assignees: Queen's University at Kingston, Kingston Health Sciences CentreInventors: Yong Jun Lai, Kong Ying Xie, Robert James Campbell
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Patent number: 12245816Abstract: A device for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject includes a flexible lens that fits on the eye and changes curvature in response to a change in curvature of the eye. A microchannel disposed in or on the lens has one or more ends that are open to the atmosphere and an indicator solution is disposed in a portion of the 5 microchannel. The microchannel exhibits a change in volume in response to a change in curvature of the lens, which results in a change in position of the indicator solution in the microchannel. The change in position of the indicator solution in the microchannel is indicative of a change in IOP. The change in position of the indicator solution may be detected in digital images of the lens taken with a camera of a mobile electronic device such 0 as a smartphone or a camera worn by the subject.Type: GrantFiled: May 29, 2020Date of Patent: March 11, 2025Assignees: Queen's University at Kingston, Kingston Health Sciences CentreInventors: Angelica Campigotto, Yong Jun Lai, Robert J. Campbell, Stephane Leahy
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Patent number: 12239639Abstract: A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.Type: GrantFiled: June 27, 2022Date of Patent: March 4, 2025Assignee: Queen's University at KingstonInventors: Rebecca Grange, John Allingham, Andrew Craig, P. Andrew Evans, Madhu Aeluri
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Patent number: 12195494Abstract: The present disclosure provides methods of making nicotinoyl riboside compounds or derivatives of formula (I): wherein X?, Z1, Z2, n, R1, R2, R3, R4, R5, R6, R7, and R8 are described herein, reduced analogs thereof, modified derivatives thereof, phosphorylated analogs thereof, and adenylyl dinucleotide conjugates thereof, or salts, solvates, or prodrugs thereof, and novel crystalline forms thereof.Type: GrantFiled: August 24, 2023Date of Patent: January 14, 2025Assignees: The Queen's University of Belfast, ChromaDex Inc.Inventors: Marie Eugenie Migaud, Philip Redpath, Kerri Crossey, Richard Cunningham, Aron Erickson, Richard Nygaard, Amanda Storjohann
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Patent number: 12123894Abstract: Apparatus and methods for measuring velocity perturbation in a fluid include one or more sensor vehicle adapted to be deployed in the fluid and a device that obtains position and acceleration data of each sensor vehicle. A physical model of the one or more sensor vehicle behaviour is used to transform the obtained data into a velocity field of the fluid, and output a map of the velocity field in the fluid. Sensor vehicles may be adapted to move passively through the fluid and/or to be transported by the fluid. The apparatus and methods may be used in liquid and gaseous environments, and the velocity field map may be used to track movement of species and particulate matter of interest in the fluid in real time.Type: GrantFiled: May 1, 2020Date of Patent: October 22, 2024Assignee: Queen's University at KingstonInventors: David E. Rival, Joshua N. Galler
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Patent number: 12116399Abstract: A recombinant von Willebrand Factor (VWF) protein comprising one or more mutations and uses thereof are described. A recombinant protein complex comprising a von Willebrand factor sequence and one artificial Factor VIII sequence is described. A recombinant protein complex comprising a Factor VIII sequence and one artificial von Willebrand sequence is described. A recombinant protein complex is described that includes one artificial von Willebrand factor sequence and one artificial Factor VIII sequence. Also described are nucleic acid sequences and a vector encoding a VWF sequence and a pharmaceutical composition for inducing blood clotting that includes a VWF protein.Type: GrantFiled: November 1, 2018Date of Patent: October 15, 2024Assignees: Queen's University at Kingston, Kingston Health Sciences Centre, Emory University, Georgia Tech Research CorporationInventors: Philip Zakas, David Lillicrap, Christopher Doering, Eric Gaucher, Caelan Radford, Harold Trent Spencer
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Patent number: 12081023Abstract: A portable power station (PPS) unit includes a controller that receives AC current information of AC input current at an AC input port and produces a control signal that is used to control the PPS unit to operate as a voltage source or a current source, and to control an AC output current at substantially the same magnitude, frequency, and phase as the AC input current. A PPS apparatus includes two or more PPS units connected together such that the AC output power of one PPS unit is connected to the AC input port of a next PPS unit; wherein a first PPS unit is a voltage source and each of the second or more PPS units is a current source, and a total AC output power of the PPS apparatus is substantially a sum of the AC output power produced by the two or more PPS units.Type: GrantFiled: December 12, 2022Date of Patent: September 3, 2024Assignee: Queen's University at KingstonInventors: Yan-Fei Liu, Binghui He, Yang Chen, Bo Sheng
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Patent number: 12049519Abstract: Provided is a peptide including X-(Xaa1)a-(Xaa2)b-Y-(Xaa3)c-(Xaa4)d-Z, or a salt or amide thereof, in which each of X and Z is independently selected from Asn, Cys, Gln, Gly, Ser, Thr and Tyr; in which one of Xaa1 and Xaa2 is His and the other of Xaa1 and Xaa2 is Arg; in which one of Xaa3 and Xaa4 is His and the other of Xaa3 and Xaa4 is Arg; in which the amino functional group of X is, optionally, acylated; in which the carboxylate functional group of Z is, optionally, amidated; in which Y is selected from Ala and Trp; in which each of a and d is independently an integer from 2 to 4; and each of b and c is independently an integer from 2 to 4. The peptide may be used in therapeutic approaches.Type: GrantFiled: March 9, 2020Date of Patent: July 30, 2024Assignee: The Queen's University of BelfastInventors: Helen McCarthy, Nicholas Dunne, Tracy Robson, Emma McErlean, Eoghan Mulholland, Grace Cole
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Publication number: 20240239831Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.Type: ApplicationFiled: March 7, 2024Publication date: July 18, 2024Applicant: The Queen's University of BelfastInventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
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Publication number: 20240235636Abstract: A method of beamforming by which a signal can be received into an array of channels, each of which is split into a real-part sub-channel and an imaginary part sub-channel. In each sub-channel, optical waves are used to carry the signal via waveguides. Each channel includes a real-part sub-channel where an optical wave is scaled by the real part of a complex number, and an imaginary part sub-channel, where a complementary optical wave is scaled by the complex part of the same complex number. When the complementary optical waves are received at the channel's output, they can be shifted by the phase of the complex number having defined their scaling. By processing a signal with a system operative to perform such method, the application of a different phase to each channel can result in a beamforming of the signal.Type: ApplicationFiled: March 21, 2024Publication date: July 11, 2024Applicants: HUAWEI TECHNOLOGIES CANADA CO., LTD., The University of British Columbia, Queen's University at KingstonInventors: Armaghan ESHAGHI, Mahsa SALMANI, Enxiao LUAN, Mitchell NICHOLS, Lutz Hans-Joachim LAMPE
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Patent number: 12017263Abstract: A method for remediating PFAS-contaminated soil comprises measuring the initial moisture content of the PFAS-contaminated soil, optionally drying the PFAS-contaminated soil, and ball milling the PFAS-contaminated soil with or without the use of milling additives.Type: GrantFiled: April 9, 2020Date of Patent: June 25, 2024Assignees: Queen's University at Kingston, Her Majesty the Queen in Right of Canada, Minister of the Department of National Defence (DND)Inventors: Kela P. Weber, Lauren Turner, Nick Battye, Bernard Kueper, Andrew Jason Hendry
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Patent number: 11990843Abstract: A control circuit for an isolated power converter includes a first sensing circuit that senses a secondary side output voltage and produces a pulse width modulation (PWM) signal having a duty cycle that is proportional to a value of the secondary side output voltage. The PWM is transferred a cross the converter isolation barrier to the primary side, and a primary side circuit receives the PWM signal and outputs a control signal. A controller determines the value of the secondary side output voltage from the control signal and uses the value to control primary side power switching devices of the isolated power converter to regulate the secondary side output voltage at a selected value.Type: GrantFiled: July 24, 2023Date of Patent: May 21, 2024Assignee: Queen's University at KingstonInventors: Yan-Fei Liu, Yang Chen, Binghui He, Wenbo Liu, Bo Sheng
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Patent number: 11981698Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.Type: GrantFiled: May 4, 2022Date of Patent: May 14, 2024Assignee: The Queen's University of BelfastInventors: Marie Migaud, Philip Redpath, Kerri Crossey, Mark Doherty
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Patent number: 11965893Abstract: This invention relates to the use of biomarker LRG1 as a biomarker for preeclampsia for use from the first trimester. Elevated levels of leucine-rich alpha 2 glycoprotein 1 (LRG1) can predict risk for the future development of preeclampsia or other hypertensive disorders of pregnancy. The predictive test will comprise the measurement of LRG1 protein, peptide fragment, DNA or RNA, from either blood, plasma, serum, urine, saliva or amniotic fluid. The invention provides a method and a test kit to assess the risk of pre-eclampsia in pregnant woman. The method or test can utilise antibodies to measure levels of LGR1 in a sample.Type: GrantFiled: July 7, 2022Date of Patent: April 23, 2024Assignee: The Queen's University of BelfastInventors: Chris Watson, Timothy Lyons, Alice Cheung, Clare Kelly
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Patent number: 11936691Abstract: A cloud communication architecture addresses shortcomings of traditional security protocols (e.g., SSL/TLS) in cloud computing, providing security for data-in-transit and authenticity of cloud users (CUs) and cloud service providers (CSPs). The architecture also protects the communication channel against attacks such as man-in-the-middle (MITM) (including eavesdropping, sniffing, identity spoofing, data tampering), sensitive information disclosure, replay, compromised-key, repudiation and session hijacking attacks. The architecture includes a high-performance cloud-focussed security protocol. The protocol efficiently utilizes the strength and speed of features such as symmetric block encryption with Galois/Counter mode (GCM), cryptographic hash, public key cryptography, and ephemeral key-exchange, and provides faster reconnection facility for supporting frequent connectivity and dealing with connection trade-offs. Embodiments have enhanced security against the above-noted attacks, and are superior to TLSv1.Type: GrantFiled: June 4, 2021Date of Patent: March 19, 2024Assignee: Queen's University at KingstonInventors: Md. Abu Faisal, Mohammad Zulkernine
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Patent number: 11911095Abstract: A method for generating a propagation and velocity maps for cardiac wavefront propagation including cardiac arrhythmia, sinus rhythm, and paced rhythm. Activation time information is generated in the absence of any time alignment reference, wherein an estimated activation time is a weighted summation of potentially nonlinear and nonorthogonal candidate functions (CFs) selected from a bank of CFs. Time alignments between sequential recordings may be done by including binary level functions among selected CFs. Embodiments are applicable to single catheter mapping and sequential mapping, and are robust as confirmed by the ability to generate propagation maps and conduction velocity in the presence of multiple colliding wavefronts. The propagation and conduction velocity maps may be used for one or more of diagnosing cardiac arrhythmia, localizing cardiac arrhythmia, guiding catheter ablation therapy of cardiac arrhythmia, and guiding cardiac pacing therapy.Type: GrantFiled: September 25, 2020Date of Patent: February 27, 2024Assignees: Queen's University at Kingston, Kingston Health Sciences CentreInventors: Mohammad Hassan Shariat, Damian P. Redfearn