Abstract: The present invention relates to a method of diagnosing ovarian cancer, including fallopian tube and/or primary peritoneal cancer. Specifically, the present invention relates to a method of diagnosing high grade serous carcinoma. The invention involves measuring the nucleic acid methylation levels of one or more biomarkers in the sample; and diagnosing ovarian cancer in the patient based on the nucleic acid methylation levels.

Abstract: The invention provides devices and methods for non-invasive monitoring and measuring of intraocular pressure (IOP) of a subject. Embodiments include a lens that is adapted to fit on the subject's eye, a microstructure disposed in or on the lens, the microstructure having at least one feature that exhibits a change in shape and/or geometry and/or position on the lens in response to a change in curvature of the lens. When the curvature of the lens changes in response to a change in IOP, a corresponding change in shape and/or geometry and/or position of the feature may be used to determine the change in IOP. The change in the feature is detectable in digital images of the lens taken with a mobile electronic device such as a smartphone.

Abstract: The invention provides a pharmaceutical composition of hyaluronic acid comprising repeating units of a disaccharide comprising glucuronic acid and N-acetylglucosamine, wherein a portion of the N-acetyl groups of the N-acetylglucosamine have been independently replaced with a group of the formula —N—C(O)—(C2-C4)-alkyl for treating hyperuicemia and gouty arthritis. Studies show that this composition is promising as an anti-gout therapeutic agent, which combines both anti-inflammatory actions as well as anti uracemic effects.

Abstract: Disclosed are novel gene therapy constructs containing both HEXA and HEXB genes to treat GM2 gangliosidoses, including Sandhoff disease and Tay-Sach's disease. Also described are co-treatments using chaperone and anti-inflammatory agents to enhance the effects of gene therapy.

Abstract: Controllers and methods for controlling a resonant power converter output voltage include operating the power converter according to a control period comprising an on cycle operation mode for a duration T_on that produces a first voltage Vo1 and an off cycle operation mode for a duration T_off that produces a second voltage Vo2. Vo1 is produced using a first switching frequency for a first selected number of switching cycles corresponding to the on time T_on. The converter output voltage or the converter input and output voltages may be sensed and used to determine the switching frequency during the on cycle operation mode and the duration of the off cycle operation mode. The final output voltage of the power converter is regulated to a selected value based on a ration of (T_on):(T_on+T_off). The controllers and methods may be used with power converters in power delivery devices to accept wide input voltage ranges compatible with devices such as cell phones, tablet computers, and notebook computers.

Abstract: The invention provides a wellbore fluid which comprises an aqueous continuous phase and, dissolved in said aqueous continuous phase, at least one salt containing an imidazolium cation having at least 6 carbon atoms, and a method of carrying out a wellbore operation, which comprises introducing into a wellbore in a clay-containing formation, a wellbore fluid according to the invention. The described salts are effective shale inhibitors.

Abstract: Methods of preparing nicotinamide riboside and derivatives thereof.

Abstract: Bioluminescent biosensors useful for monitoring and/or quantifying, in vitro or in vivo, activity of the Hippo signaling pathway. The biosensors monitor LATS kinase activity or YAP-TEAD interaction. The biosensors may be used in methods for monitoring and/or quantifying in real-time, in vitro or in vivo, activity of the Hippo signaling pathway, wherein the activity may be LATS kinase activity and/or YAP-TEAD interaction. The biosensors may be provided in kits for monitoring and/or quantifying in real-time, in vitro or in vivo, activity of the Hippo signaling pathway, wherein the activity may be LATS kinase activity and/or YAP-TEAD interaction.

Abstract: This invention relates to a dispersion comprising porous particles dispersed in a liquid phase, wherein the porous particles comprise a zeolite and the liquid phase is a size-excluded liquid. The invention also relates to a method of adsorbing a gas into a liquid, comprising at least the step of bringing the gas into contact with the dispersion. In addition, the invention relates to an assemblage of the dispersion, the zeolite comprising a cavity and a gas contained within the cavity.

Abstract: The invention relates to dispersions of porous solids in liquids selected from deep eutectic solvents, liquid oligomers, bulky liquids, liquid polymers, silicone oils, halogenated oils, paraffin oils or triglyceride oils, as well as to their methods of preparation. In embodiments of the invention, the porous solids are metal organic framework materials (MOFs), zeolites, covalent organic frameworks (COFs), porous inorganic materials, Mobil Compositions of Matter (MCMs) or a porous carbon. The invention also relates to the use of porous materials to form dispersions, and to assemblages of such dispersions with a gas or gases. The dispersions can exhibit high gas capacities and selectivities.

Abstract: A method and apparatus for quantifying differences in human sensorimotor performance useful for diagnosing, assessing, and/or detecting brain injury and/or a neurological disorder, or identifying exceptional performance in a subject. In a task a subject's limb movement is restricted to a limited workspace and an object moves towards the limb. The objective of the task is for the subject to contact the object with the limb within a set time period. During the task a perturbation directed to the object and/or limb, or other feature of the environment, may occur on some trials, requiring a rapid motor correction in order to contact the object, or the subject may receive an alternative instruction on whether to interact with the object. Position data and/or motion data and/or kinetic data of the limb or portions thereof with respect to a presented object are obtained, and a data set is acquired for a plurality of trials.

Abstract: A biobased additive is provided that is both a nucleating and a reinforcing agent when added to thermoplastic polyester (e.g., biopolyesters). A composite material, which is an additive-reinforced biopolyester, was prepared and improved thermo-mechanical properties were quantified. This composite material is a new class of biobased material that offers a sustainable, environmentally-friendly solution for packaging and other applications.

Abstract: A transconductance amplifier (TCA) implemented with high electron mobility transistors (HEMTs) in a push-pull amplifier output stage provides a voltage controlled constant high output current to loads ranging from 10 m? to 1? with a bandwidth of 25 MHz. A driving stage for the HEMTs is implemented with variable gain amplifiers that amplify the input voltage signal and provide bias for the HEMTs. An automatic gain control may be connected between the TCA output and the variable gain amplifiers to ensure a constant current output for a varying load.

Abstract: Polyurethane-based and epoxy-based coating compositions are described that provide coatings and adhesives that are clear, amphiphobic and durable. Both water and hexadecane readily slide off these surfaces without leaving a residue. Coatings with thicknesses ranging from about 10 nm to about 10 ?m exhibited excellent transmittance properties. Such films exhibited durability against abrasion, ink-resistance, anti-graffiti, anti-fingerprint, and strong adhesion to glass surfaces. The coatings are applicable to electronic devices, fabrics, glass, etc. to prepare optically clear, stain-resistant, and smudge-resistant surfaces.

Abstract: The invention provides methods of making microparticle and nanoparticle ocular implants from a compositions comprising: 99 to 60% (w/w) of a photopolymerizable composition selected from the group of fragments or monomers consisting of polyalkylene glycol diacrylate and polyalkylene glycol dimethacrylate, wherein the photopolymerizable composition has a molecular weight in the range of 100 to 20,000 Dalton; a biodegradable polymer selected from the group consisting of aliphatic polyester-based polyurethanes, polylactides, polycaprolactones, polyorthoesters and mixtures, copolymers, and block copolymers thereof; a photoinitiator; and a therapeutic agent.

Abstract: In a method for spatially localizing mass-spectrometry analysis of an analyte derived from an energy event, an electrical device is used to deliver an energy event to a substrate, and the analyte produced is analyzed using mass spectrometry. Electrical signals sent to and received from the electrical device under different modes of operation are sensed and classified according to each different mode of operation. A location of the electrical device is tracked in three dimensions during the energy event, and a processor is used to perform spatial-temporal alignment of the mass-spectrometry, the determined modes of operation of the electrical device, and the tracked location of the electrical device, wherein mass spectrometry data corresponding to the determined modes of the electrical device are identified and localized within the site of the energy event. The substrate may be tissue in a surgical site, and the electrical device may be an electrocautery device.

Abstract: Three-phase single-stage AC-DC converters achieve power factor correction with low phase voltage switch stress. Direct input current sensing is performed to calculate the average input current of the AC-DC converter and implement power factor correction. Embodiments feature high power factor, single stage power conversion, and soft-switching of all switches, resulting in high conversion efficiency in a cost-effective single-stage three-phase structure. The converters have low output voltage ripple without a double line frequency component, which allows non-electrolytic capacitor implementation. The converters are particularly useful in high-power applications such as electric vehicle charging.

Abstract: This invention relates to a process for the preparation of a dispersion comprising coloured or black particles, such coloured or black particles prepared by the process, the use of the dispersion and the coloured or black particles in electrophoretic fluids, and electrophoretic display devices comprising such fluids.

Abstract: Methods of preparing nicotinamide riboside and derivatives thereof, are described. In an aspect, the invention relates to a method of making a compound of formula (II), or a salt, or solvate thereof: wherein n is 0 or 1; Y is O or S; m is 1; R1 is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted primary or secondary amino, and substituted or unsubstituted azido; and R2-R5 are each H.

Abstract: A method for extracting a rare earth metal from a mixture of one or more rare earth metals, said method comprising contacting an acidic solution of the rare earth metal with a composition which comprises an ionic liquid to form an aqueous phase and a non-aqueous phase into which the rare earth metal has been selectively extracted.