Patents Assigned to Quest Diagnostics
  • detection assay
    Patent number: 10465252
    Abstract: Disclosed herein are methods and compositions for detecting Bordetella pertussis and Bordetella parapertussis by detecting the presence of the IS481 and IS1001 genomic insertion sequences, respectively.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: November 5, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Michelle M. Tabb, Ming-Chou Lee, Lilly I. Kong, Ning Lu, Michael Aye, Fan Chen, Jules Chen
  • COMPOSITIONS AND METHODS FOR DETECTING CIRCULATING TUMOR DNA
    Publication number: 20190330704
    Abstract: The present technology provides polynucleotide compositions and methods of using the same to detect circulating tumor DNA (ctDNA) in a patient. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: December 27, 2017
    Publication date: October 31, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Suzzette Arnal, Taraneh Angeloni
  • Quantitation of insulin by tandem mass spectrometry of insulin B chain
    Patent number: 10436803
    Abstract: Methods are described for determining the amount of insulin in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying insulin in a biological sample utilizing purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: October 8, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Zhaohui Chen, Nigel Clarke
  • EML4-ALK translocations in lung cancer
    Patent number: 10435758
    Abstract: The present disclosure relates to methods for the diagnosis and evaluation of neoplastic disorders, particularly non-small cell lung cancer. Assays are described in which patient test samples are analyzed for the presence of one or more specific EML4-ALK fusion genes associated with neoplastic disorders.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: October 8, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Heather R. Sanders, Maher Albitar, Aurelia Meloni-Ehrig
  • METHODS FOR QUANTITATION OF INSULIN LEVELS BY MASS SPECTROMETRY
    Publication number: 20190302095
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric technique.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 3, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Stephen W. TAYLOR, Michael McPHAUL, Richard E. REITZ, Zhaohui CHEN, Nigel CLARKE
  • Vitamin D metabolite determination utilizing mass spectrometry following derivatization
    Patent number: 10429398
    Abstract: The invention relates to the detection of vitamin D metabolites. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D metabolites by mass spectrometry.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: October 1, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Brett Holmquist, Nigel J. Clarke, Richard E Reitz
  • Mass spectrometry assay for congenital adrenal hyperplasia
    Patent number: 10429396
    Abstract: Methods are provided for detecting the amount of one or more CAH panel analytes (i.e., pregnenolone, 17-OH pregnenolone, progesterone, 17-OH progesterone, dehydroepiandrosterone (DHEA), androstenedione, testosterone, deoxycorticosterone, 11-deoxycortisol, and cortisol) in a sample by mass spectrometry. The methods generally involve ionizing one or more CAH panel analytes in a sample and quantifying the generated ions to determine the amount of one or more CAH panel analytes in the sample. In methods where amounts of multiple CAH panel analytes are detected, the amounts of multiple analytes are detected in the same sample injection.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: October 1, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Amit Ghoshal, Nigel J. Clarke, Mildred M. Goldman
  • Methods for detecting estrone by mass spectrometry
    Patent number: 10422804
    Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: September 24, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Mildred M. Goldman, Richard E. Reitz
  • METHODS FOR DETECTING DNA MUTATIONS USING MITRA TIP EXTRACTION
    Publication number: 20190284639
    Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient exhibiting cancer symptoms, or at risk for hereditary cancers such as breast cancer, ovarian cancer, colon cancer, or skin cancer, will benefit from treatment with one or more therapeutic agents. These methods are based on detecting hereditary cancer-related mutations in small-volume dried biological fluid samples that are collected using a volumetric absorptive microsampling device (e.g., MITRA Tip). Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: November 13, 2017
    Publication date: September 19, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Nigel J. Clarke
  • METHODS FOR DETECTING CHROMOGRANIN A BY MASS SPECTROMETRY
    Publication number: 20190285594
    Abstract: Provided are methods for detecting chromogranin A by mass spectrometry. In another aspect, provided herein are methods for quantitating chromogranin A by mass spectrometry. In another aspect, provided herein are methods for prognosis of or measuring the size of neuroendocrine tumors by mass spectrometry.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Michael Caufield, Michael McPhaul, Scott Goldman, Nigel Clarke
  • MASS SPECTROMETRIC DETERMINATION OF TESTOSTERONE IN MULTIPLEXED PATIENT SAMPLES
    Publication number: 20190285654
    Abstract: Provided herein are methods for high throughput quantitation of testosterone utilizing at least two different derivatizing agents of different masses. In another aspect, provided herein are methods for determining the amount of testosterone in each of a plurality of human samples with a single mass spectrometric assay by subjecting each of a plurality of human samples to a different derivatizing agent to generate a differently derivatized testosterone in each of the plurality of samples; combining the plurality of samples to form a multiplex sample; and quantifying the amount of testosterone in each sample by mass spectrometry.
    Type: Application
    Filed: March 15, 2019
    Publication date: September 19, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Mildred M. Goldman, Scott Goldman, Juliet Coletti, Nigel Clarke
  • METHODS AND DEVICES FOR DETECTING HEPATITIS C VIRUS
    Publication number: 20190276904
    Abstract: The present disclosure provides rapid and non-invasive methods for determining whether a patient will benefit from treatment with therapeutic agents that inhibit Hepatitis C virus (HCV). These methods are based on detecting HCV RNA and/or anti-HCV antibodies in small-volume dried biological fluid samples that are collected using a microsampling device. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: November 13, 2017
    Publication date: September 12, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Amy Rogers, John Leake, Nigel J. Clarke, Russell E. Baumann
  • METHODS FOR DETECTING NOROVIRUS
    Publication number: 20190211408
    Abstract: The present disclosure provides methods and compositions for determining whether a patient exhibiting acute gastroenteritis will benefit from treatment with therapeutic agents that inhibit Norovirus genogroup I (GI) or Norovirus genogroup II (GII). The methods disclosed herein are based on detecting Norovirus genogroup I (GI) and Norovirus genogroup II (GII) in a stool sample without extracting viral nucleic acids from a clinical specimen prior to performing real-time reverse transcription PCR. Kits for use in practicing the methods are also provided.
    Type: Application
    Filed: June 2, 2017
    Publication date: July 11, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Peter Lee, Raymond Huang, Kristin Ramos, Jules Chen, Michelle Tabb
  • APOLIPOPROTEIN E ISOTYPE DETECTION BY MASS SPECTROMETRY
    Publication number: 20190206666
    Abstract: Provided are methods for determining the apolipoprotein E (ApoE) phenotype in a sample by mass spectrometry; wherein the ApoE allele(s) present in the sample is determined from the identity of the ions detected by mass spectrometry. In another aspect, provided herein are methods for diagnosis or prognosis of Alzheimer's disease or dementia.
    Type: Application
    Filed: July 31, 2018
    Publication date: July 4, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Darren Weber, Nigel Clarke
  • Methods for quantitation of insulin levels by mass spectrometry
    Patent number: 10324082
    Abstract: Methods are described for determining the amount of insulin in a sample. Provided herein are mass spectrometric methods for detecting and quantifying insulin and C-peptide in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques. Also provided herein are mass spectrometric methods for detecting and quantifying insulin and b-chain in a biological sample utilizing enrichment and/or purification methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: June 18, 2019
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Stephen W. Taylor, Michael McPhaul, Richard E. Reitz, Zhaohui Chen, Nigel Clarke
  • METHOD FOR DETECTING CYSTIC FIBROSIS
    Publication number: 20190177797
    Abstract: The present invention relates to methods for amplifying various regions of the cystic fibrosis transmembrane regulator (CFTR) gene. Methods are provided for amplifying one or all 27 exons of the CFTR gene and a portion of the CFTR promoter region in a single tube. The method can identify the presence or absence of CF deletions or insertions in a sample and assist in the diagnosis of a genetic predisposition to cystic fibrosis.
    Type: Application
    Filed: December 17, 2018
    Publication date: June 13, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Feras Hantash, Weimin Sun
  • METHODS OF DETECTING MLH1 METHYLATION
    Publication number: 20190177805
    Abstract: The present technology relates to methods for excluding Lynch syndrome as a possible diagnosis in patients suffering from colorectal cancers or endometrial cancers. These methods are based on detecting the methylation status of the MLH1 promoter ‘C’ region in colorectal and endometrial cancer patients using an improved and highly sensitive methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay.
    Type: Application
    Filed: August 9, 2017
    Publication date: June 13, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventors: Kevin Qu, Feras Hantash, Amber Donahue
  • DETECTION OF VITAMINS A AND E BY TANDEM MASS SPECTROMETRY
    Publication number: 20190170774
    Abstract: Methods are described for measuring the amount of one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying one or more of vitamin A, ?-tocopherol, and the combination of ?-tocopherol and ?-tocopherol in a sample.
    Type: Application
    Filed: February 8, 2019
    Publication date: June 6, 2019
    Applicant: Quest Diagnostics Investments Incorporated
    Inventors: Sum CHAN, Qibo JIANG
  • DETECTION AND QUANTITATION OF GUANIDINOACETATE, CREATINE, AND CREATININE BY MASS SPECTROMETRY
    Publication number: 20190170711
    Abstract: Provided are methods for detecting or determining the amount of guanidinoacetate (GAA), creatine, and creatinine by mass spectrometry.
    Type: Application
    Filed: August 6, 2018
    Publication date: June 6, 2019
    Applicant: Quest Diagnostics Investments LLC
    Inventor: Thomas C. Lynn
  • C peptide detection by mass spectrometry
    Patent number: 10309972
    Abstract: Methods are described for measuring the amount of C peptide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying C peptide in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric or high resolution/high accuracy mass spectrometric techniques.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: June 4, 2019
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Nigel Clarke, Zhaohui Chen