Patents Assigned to R.T. Alamo Ventures I, LLC
  • Stereospecific enrichment of heterocyclic enantiomers
    Patent number: 7084275
    Abstract: The present invention describes methods for the stereoselective synthesis of heterocyclic enantiomers. The methods of the present invention incorporate the stereo-preferred oxidation of quinolone thiomethyl intermediates by optically active camphor based oxaziridines to provide R(+) or S(?) quinolone methylsulfinyl derivatives.
    Type: Grant
    Filed: November 18, 2003
    Date of Patent: August 1, 2006
    Assignee: R. T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski, Joseph Kupper
  • Dichlorinated heterocyclic compounds and methods of synthesis
    Patent number: 7045627
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Grant
    Filed: May 17, 2005
    Date of Patent: May 16, 2006
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Use of monochloroflosequinan in the treatment of sexual dysfunction
    Patent number: 7041677
    Abstract: The present invention described the administration of halogenated flosequinan derivatives and the enantiomers of halogenated flosequinan derivatives for the treatment of sexual dysfunction (in males and females) and for the treatment of cardiovascular disease.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: May 9, 2006
    Assignee: R.T. Alamo Ventures I, LLC
    Inventor: Neal R. Cutler
  • Methods for the treatment of central nervous system disorders in certain patient groups
    Patent number: 6995173
    Abstract: Methods and compositions for treating specific patient groups for Central Nervous System disorders, including but not limited to Tourette Syndrome, are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions comprising quinolinones (and derivatives thereof) in patients with symptoms of a Central Nervous System Disorder who are otherwise free of cardiac disease and/or who have not been given organic nitrates.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: February 7, 2006
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Neal R. Cutler, John Sramek
  • Carboxylated heterocyclic compounds and methods of synthesis
    Patent number: 6872831
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: March 29, 2005
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Carboxylated heterocyclic compounds and methods of synthesis
    Patent number: 6861528
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: March 1, 2005
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Fluorinated heterocyclic compounds and methods of synthesis
    Publication number: 20050032833
    Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.
    Type: Application
    Filed: May 20, 2004
    Publication date: February 10, 2005
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Dichlorinated heterocyclic compounds and methods of synthesis
    Patent number: 6835836
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: December 28, 2004
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Dichlorinated heterocyclic compounds and methods of synthesis
    Publication number: 20040242630
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Application
    Filed: February 18, 2004
    Publication date: December 2, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • DICHLORINATED HETEROCYCLIC COMPOUNDS AND METHODS OF SYNTHESIS
    Publication number: 20040229906
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Application
    Filed: February 18, 2004
    Publication date: November 18, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Carboxylated heterocyclic compounds and methods of synthesis
    Publication number: 20040220219
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Application
    Filed: December 31, 2003
    Publication date: November 4, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Carboxylated heterocyclic compounds and methods of synthesis
    Publication number: 20040220217
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Application
    Filed: December 31, 2003
    Publication date: November 4, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Chlorinated heterocyclic compounds and methods of synthesis
    Publication number: 20040220218
    Abstract: Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.
    Type: Application
    Filed: December 31, 2003
    Publication date: November 4, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Stereospecific enrichment of heterocyclic enantiomers
    Publication number: 20040215016
    Abstract: The present invention describes methods for the stereoselective synthesis of heterocyclic enantiomers. The methods of the present invention incorporate the stereo-preferred oxidation of quinolone thiomethyl intermediates by optically active camphor based oxaziridines to provide R(+) or S(−) quinolone methylsulfinyl derivatives.
    Type: Application
    Filed: November 18, 2003
    Publication date: October 28, 2004
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski, Joseph Kupper
  • Fluorinated heterocyclic compounds and methods of synthesis
    Patent number: 6767914
    Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: July 27, 2004
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Chlorinated heterocyclic compounds and methods of synthesis
    Patent number: 6730790
    Abstract: Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: May 4, 2004
    Assignee: R.T. Alamo Ventures I. LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Dichlorinated heterocyclic compounds and methods of synthesis
    Patent number: 6727262
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: April 27, 2004
    Assignee: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Carboxylated heterocyclic compounds and methods of synthesis
    Patent number: 6689791
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: February 10, 2004
    Assignee: R. T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Stereospecific enrichment of heterocyclic enantiomers
    Patent number: 6649764
    Abstract: The present invention describes methods for the stereoselective synthesis of heterocyclic enantiomers. The methods of the present invention incorporate the stereo-preferred oxidation of quinolone thiomethyl intermediates by optically active camphor based oxaziridines to provide R(+) or S(−) quinolone methylsulfinyl derivatives.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: November 18, 2003
    Assignee: R. T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski, Joseph Kupper
  • Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
    Publication number: 20030198669
    Abstract: The present invention is an improvement in the treatment of migraine headaches. By administering dihydroergotamine alone (or a combination of DHE and caffeine) major limitations of past treatments are circumvented thereby allowing for higher efficacy and fewer side effects of treatment at lower doses.
    Type: Application
    Filed: November 25, 2002
    Publication date: October 23, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Neal R. Cutler, Anthony DiSanto