Patents Assigned to R.T. Alamo Ventures I, LLC
  • Use of halogenated heterocyclic compounds in the treatment of sexual dysfunction and cardiovascular disease
    Publication number: 20030191152
    Abstract: The present invention described the administration of halogenated flosequinan derivatives and the enantiomers of halogenated flosequinan derivatives for the treatment of sexual dysfunction (in males and females) and for the treatment of cardiovascular disease.
    Type: Application
    Filed: October 28, 2002
    Publication date: October 9, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventor: Neal R. Cutler
  • CHLORINATED HETEROCYCLIC COMPOUNDS AND METHODS OF SYNTHESIS
    Publication number: 20030166677
    Abstract: Compositions of the present invention comprise chlorinated heterocyclic compounds, including racemic monochloroflosequinan, purified enantiomers of monochloroflosequinan and the sulfone derivative of monochloroflosequinan. The methods of the present invention comprise the synthesis of racemic monochloroflosequinan and derivatives thereof, including the sulfone derivative. Intermediates in the synthesis are also provided. The methods further comprise the synthesis of enantiomers of monochloroflosequinan.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Carboxylated heterocyclic compounds and methods of synthesis
    Publication number: 20030166678
    Abstract: Compositions of the present invention comprise carboxylated heterocyclic compounds, including carboxyflosequinan. The methods of the present invention also comprise the synthesis of carboxyflosequinan.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Dichlorinated heterocyclic compounds and methods of synthesis
    Publication number: 20030166676
    Abstract: Compositions of the present invention comprise dichlorinated heterocyclic compounds, including dichloroflosequinan. The methods of the present invention also comprise the synthesis of dichloroflosequinan.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Fluorinated heterocyclic compounds and methods of synthesis
    Publication number: 20030166679
    Abstract: Compositions of the present invention comprise fluorinated heterocyclic compounds, including monofluoroflosequinan and difluoroflosequinan. The methods of the present invention comprise the synthesis of monofluoroflosequinan and difluoroflosequinan.
    Type: Application
    Filed: October 28, 2002
    Publication date: September 4, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Stefan Kwiatkowski, Miroslaw Golinski
  • Methods for the treatment of central nervous system disorders in certain patient groups
    Publication number: 20030130311
    Abstract: Methods and compositions for treating specific patient groups for Central Nervous System disorders, including but not limited to Tourette Syndrome, are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions comprising quinolinones (and derivatives thereof) in patients with symptoms of a Central Nervous System Disorder who are otherwise free of cardiac disease and/or who have not been given organic nitrates.
    Type: Application
    Filed: September 30, 2002
    Publication date: July 10, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventors: Neal R. Cutler, John Sramek
  • Treatment of sexual dysfunction in certain patient groups
    Publication number: 20030105128
    Abstract: Methods for treating specific patient groups for sexual dysfunction are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions in patients who are free of cardiac disease and/or who have not been given organic nitrates.
    Type: Application
    Filed: July 30, 2002
    Publication date: June 5, 2003
    Applicant: R.T. Alamo Ventures I, LLC
    Inventor: Neal R. Cutler
  • PDE III inhibitors for treating sexual dysfunction
    Patent number: 6541487
    Abstract: Compositions that are selective PDE III inhibitors and that are effective to treat sexual dysfunction in males and females, including, but not limited to, erectile dysfunction in males. The compositions comprise halogenated quinolines, isoquinolines, quinolones, thioquinolones and 2-oxoquinolones, including derivatives thereof. The compounds can be taken orally or by a number of different routes or can be used to coat the interior of a condom to induce erection.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: April 1, 2003
    Assignee: R.T. Alamo Ventures I, LLC
    Inventor: Neal R. Cutler
  • Treatment of gastroparesis in certain patient groups
    Patent number: 6451813
    Abstract: Methods for treating specific patient groups for gastroparesis are provided. The methods of the present invention comprise the utilization of pharmaceutical compositions comprising quinolinones (and derivatives) in patients with symptoms of gastroparesis who are otherwise free of cardiac disease and/or who have not been given organic nitrates.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: September 17, 2002
    Assignee: R. T. Alamo Ventures I, LLC
    Inventors: Neal R. Cutler, John Sramek
  • Method of synthesizing flosequinan from 4-fluoroanthranilic acid
    Patent number: 6307050
    Abstract: A high-yield, 4-step synthesis for flosequinan starting with 4-fluoroanthranilic acid comprising cyclization with phosgene to create an intermediate -A, followed by methylation to create an intermediate -B, then by reaction with dimsyl sodium to create an intermediate -C, then by reaction with triethyl orthoformate in the presence of piperdine and acetic acid to give flosequinan. The overall yield of the disclosed process is greater than about 16%.
    Type: Grant
    Filed: February 7, 2001
    Date of Patent: October 23, 2001
    Assignee: R. T. Alamo Venture I LLC
    Inventors: Stephan Kwiatkowski, Maya Siddidqui, Rodney Eisenberg, Sudarsan Mukhopadhyay, Lowell Jeffry Lawrence, Steven G. Mobley