Patents Assigned to R-Tech Ueno
  • SOFT-GELATIN CAPSULE FORMULATION
    Publication number: 20130078303
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Application
    Filed: November 16, 2012
    Publication date: March 28, 2013
    Applicants: R-TECH UENO, LTD., SUCAMPO AG
    Inventors: SUCAMPO AG, R-TECH UENO, LTD.
  • Method for preparing prostaglandin derivative
    Patent number: 8389748
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: March 5, 2013
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • METHOD FOR PREPARING A FATTY ACID DERIVATIVE
    Publication number: 20130005995
    Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Tatsuya MATSUKAWA, Noriyuki YAMAMOTO, Ryuji UENO, Hiroyuki KOTAJIMA, Shunsuke FUKUYA, Michiharu HANDA, Katsuya SAKATA
  • METHOD FOR PREPARING A FATTY ACID DERIVATIVE
    Publication number: 20130005996
    Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 and R4 are hydrogen atom, halogen atom, lower alkyl or lower alkoxy; when R3 and R4 are lower alkoxy, R3 and R4 may be linked together to form a ring structure; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1; with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicant: R-TECH UENO, LTD.
    Inventors: Tatsuya MATSUKAWA, Noriyuki YAMAMOTO
  • Soft-gelatin capsule formulation
    Patent number: 8338639
    Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: December 25, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • Eye drop composition containing isopropyl unoprostone
    Patent number: 8324271
    Abstract: An eye drop composition in which the degradation of isopropyl unoprostone in an eye drop is prevented by adding trometamol to the eye drop containing isopropyl unoprostone.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: December 4, 2012
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Hiroyuki Asada, Akio Kimura
  • Method for preparing prostaglandin derivative
    Patent number: 8304562
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: November 6, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • AQUEOUS OPHTHALMIC COMPOSITION
    Publication number: 20120263803
    Abstract: Disclosed is an aqueous ophthalmic composition comprising (a) a fatty acid derivative such as a prostaglandin derivative, (b) a polyoxyethylene sorbitan fatty acid ester, (c) an edetic acid compound, (d) a boric acid and a salt of a boric acid, (e) a pharmaceutically acceptable aqueous carrier, and (f) no more than 0.005 w/v % of benzalkonium chloride. The composition is stable and has good anti-microbial properties.
    Type: Application
    Filed: April 11, 2012
    Publication date: October 18, 2012
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko MASHIMA, Yashuhiro HARADA, Junichi KAWASAKI, Ryuji UENO
  • METHOD FOR SCREENING AN AGENT BEING USEFUL FOR THE TREATMENT OF DRY EYE AND / OR CORNEAL AND CONJUNCTIVAL LESION AND PHARMACEUTICAL COMPOSITION OBTAINED BY THE METHOD
    Publication number: 20120245090
    Abstract: The present invention provides a method for screening an agent being useful for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to the report of the International Dry Eye WorkShop (DEWS Report) (2007) and a pharmaceutical composition comprising the agent. The present invention further provides a method for the treatment of dry eye and/or corneal and conjunctival lesion of dry eye severity level 3 or more according to DEWS Report (2007) using the agent.
    Type: Application
    Filed: November 26, 2010
    Publication date: September 27, 2012
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko Mashima, Akio Siranita
  • Method for preparing prostaglandin derivative
    Patent number: 8236969
    Abstract: Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 7, 2012
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Tatsuya Matsukawa, Kazuhiro Masuzaki, Ryuji Ueno
  • COMPOSITION AND METHOD FOR SCALP AND HAIR TREATMENT
    Publication number: 20120088823
    Abstract: Provided is a composition for scalp and hair treatment, comprising a menthol derivative and a prostaglandin compound having two hetero atoms at the 15 position. The composition of the present invention is effective not only for preventing dandruff and itchy scalp but also for preventing or treating hair loss, baldness, or hair thinness.
    Type: Application
    Filed: December 19, 2011
    Publication date: April 12, 2012
    Applicant: R-TECH UENO, LTD.
    Inventors: Masato IINO, Satoshi YAMAKI, Satoshi NAKANISHI, Masahiro TAJIMA, Ryuji UENO
  • METHOD FOR DIAGNOSING AND/OR EVALUATING RETINAL DISEASE
    Publication number: 20120087864
    Abstract: The present application provides a method for diagnosing and/or evaluating the presence or absence, severity or degree of the improvement of a retinal disease in a subject, which comprises determining and/or evaluating circulatory parameters, retinal function, retina morphology and/or visual relating quality of life (QOL).
    Type: Application
    Filed: October 12, 2011
    Publication date: April 12, 2012
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko MASHIMA, Ryuji UENO
  • Enhanced Preservation of Processed Food
    Publication number: 20120064210
    Abstract: The present invention included compositions and methods for treating Listeria in foods. The compositions and methods include at least one first preservative, and a second preservative selected from the group consisting of a Carnobacterium species, Carnobacterium maltaromaticum, a fermentate, containing at least one bacteriocin, and combinations thereof.
    Type: Application
    Filed: March 23, 2007
    Publication date: March 15, 2012
    Applicant: R-Tech Ueno, Ltd.
    Inventors: Michael E. Stiles, Denise Carlson, David C. Smith, Lynn McMullen
  • SOFT-GELATIN CAPSULE FORMULATION
    Publication number: 20110300211
    Abstract: The present invention provides a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which includes: a soft gelatin capsule shell including gelatin and sugar alcohol as a plasticizer, and a mixture including a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 8, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Yukiko HASHITERA, Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • METHOD FOR TREATING RETINAL DISEASE
    Publication number: 20110275715
    Abstract: The present application provides a method for treating a retinal disease in a patient in need thereof, which comprises administering at least three drops of an ophthalmic composition comprising a fatty acid derivative as an active ingredient in an eye of the patient per day.
    Type: Application
    Filed: April 12, 2011
    Publication date: November 10, 2011
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko MASHIMA, Ryuji UENO
  • METHOD FOR TREATING MACULAR EDEMA
    Publication number: 20110275711
    Abstract: Provided is a method for treating macular edema in a mammalian subject, comprising administering an effective amount of a fatty acid derivative to the subject in need thereof. The method of the present invention can effectively treat macular edema in a non-invasive manner. In one embodiment of the present invention, the fatty acid derivative is isopropyl unoprostone.
    Type: Application
    Filed: April 12, 2011
    Publication date: November 10, 2011
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko MASHIMA, Ryuji UENO
  • PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
    Publication number: 20110244036
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • PHARMACEUTICAL COMPOSITION COMPRISING A BI-CYCLIC COMPOUND AND METHOD FOR STABILIZING THE BI-CYCLIC COMPOUND
    Publication number: 20110244037
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (I): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Application
    Filed: June 15, 2011
    Publication date: October 6, 2011
    Applicants: SUCAMPO AG, R-TECH UENO, LTD.
    Inventors: Ryu HIRATA, Yasuhiro HARADA, Ryuji UENO
  • Soft-gelatin capsule formulation
    Patent number: 8026393
    Abstract: The present invention discloses a soft gelatin capsule formulation of a 15-keto-prostaglandin compound, which comprises: a soft gelatin capsule shell comprising gelatin and sugar alcohol as a plasticizer, and a mixture comprising a 15-keto-prostaglandin compound and a pharmaceutically acceptable vehicle which is filled in the shell. By encapsulating the 15-keto-prostaglandin compound in the specified soft gelatin capsule shell, stability of the compound is significantly improved.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: September 27, 2011
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Yukiko Hashitera, Ryu Hirata, Yasuhiro Harada, Ryuji Ueno
  • Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
    Patent number: 7985770
    Abstract: Disclosed is a method for stabilizing a pharmaceutically active bi-cyclic compound of formula (i): comprising the step of: admixing the same with a polyol and/or a fatty acid ester other than glyceride and a composition obtained by the method. In addition a soft gelatin capsule formulation of the compound of formula (I) obtained by incorporating the compound in a soft gelatin capsule shell comprising gelatin and a polyol plasticizer.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: July 26, 2011
    Assignees: Sucampo AG, R-Tech Ueno, Ltd.
    Inventors: Ryu Hirata, Yasuhiro Harada, Ryuji Ueno