Patents Assigned to R-Tech Ueno
  • Treatment of ocular hypertension with a synergistic combination
    Patent number: 5547968
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of(a) a 15-ketoprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and(b) a carbonate dehydratase inhibitor in an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 20, 1996
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Stabilization of a prostanoic acid compound
    Patent number: 5523461
    Abstract: The present invention provides a method of stabilizing a prostanoic acid compound, wherein the prostanoic acid compound having at least one oxo group on the .omega. chain are stored in a hydrous condition.
    Type: Grant
    Filed: February 25, 1994
    Date of Patent: June 4, 1996
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuji Ueno, Ryu Hirata
  • Treatment of ocular hypertension
    Patent number: 5432174
    Abstract: A method for the treatment of ocular hypertension which comprises administering, to a subject in need of such treatment,(a) a .beta.-adrenergic blocker at the enhancement phase of aqueous humor production, and(b) a prostanoic acid compound at the suppression phase of aqueous humor production, andin an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: December 7, 1993
    Date of Patent: July 11, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuji Ueno, Sachiko Kuno
  • Treatment of ocular hypertension with a synergistic combination
    Patent number: 5405846
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an ocular-hypertension synergistic combination of(a) a 15-deoxy-prostaglandin compound, and(b) a .beta.-adrenergic blocker in an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: April 11, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Treatment of ocular hypertension with an ocular synergistic combination
    Patent number: 5397797
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, a oculo-hypotensively synergistic combination of(a) a 13,14-dihydro-15-ketoprostaglandin compound, and(b) a cholinergic agentin an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: March 16, 1993
    Date of Patent: March 14, 1995
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Treatment of inflammation with 15-keto-prostaglandin compounds
    Patent number: 5346921
    Abstract: A method of treatment of inflammatory diseases which comprises administering, to a subject in need of such treatment, an anti-inflammatorily effective amount of a 15-keto-prostaglandin compound.
    Type: Grant
    Filed: November 5, 1992
    Date of Patent: September 13, 1994
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno
  • Process for production of prostaglandin intermediates
    Patent number: 5274130
    Abstract: The isomer ratio of a cis-isomer against the corresponding trans-isomer with respect to the 5-6 double bond is improved in the production of prostaglandins, when a lactol is reacted with an ylide to cause simultaneously formation of the 5-double bond and an .alpha.-chain, whereby the ylide generated from a phosphonium salt with a potossium base, and a solvent which is liquid at the reaction temperature and has a dipole moment of 0.3 to 3.0D are used.
    Type: Grant
    Filed: September 1, 1992
    Date of Patent: December 28, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventors: Ryuji Ueno, Tomio Oda
  • Promotion of wound-healing with 15-keto-prostaglandin compounds
    Patent number: 5252605
    Abstract: A method for promoting healing of wound which comprises administering, to a subject in need of such treatment, a wound-healingly effective amount of a 15-ketoprostaglandin compound.
    Type: Grant
    Filed: March 12, 1992
    Date of Patent: October 12, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventor: Ryuji Ueno
  • Ocular hypotensive agents
    Patent number: 5236907
    Abstract: The present invention relates to an ocular hypotensive treatment of glaucoma which comprising employing 20-substituted-PGs or 20-substituted15-keto-PGs effective as an ocular hypotensive agent; these compounds exhibit no or little side effect such as transient ocular hypertensive response, hyperemia of conjunctiva or of iris, dacryops, lema, closed eye and the like.
    Type: Grant
    Filed: October 11, 1991
    Date of Patent: August 17, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Method of producing .alpha.,.beta.-unsaturated ketolactones
    Patent number: 5229529
    Abstract: The present invention provides a method of preparing .alpha.,.beta.-unsaturated ketolactones which are useful for production of prostaglandins having one or more halogen substituent(s) at the 16 or 17 portion in high yield, in which, a dimethyl (2-oxoalkyl) phosphonate having one or more halogen substituents, a starting material, is reacted with a bicyclolactone aldehyde under the presence of an alkali metal hydride and a zinc compound.
    Type: Grant
    Filed: April 1, 1992
    Date of Patent: July 20, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventors: Ryuji Ueno, Tomio Oda
  • Prostaglandins of the F series
    Patent number: 5221763
    Abstract: The present invention provides new compounds, 13,14-dihydro-15-keto-PGFs, and vassopressors containing them, which raise blood pressure without substantial ephemeral depression of blood pressure, trachea or enteron contraction effect inherent in usual PGFs.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: June 22, 1993
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuzo Ueno, Ryuji Ueno, Tomio Oda
  • Increasing the choroidal blood flow
    Patent number: 5221690
    Abstract: A method for increasing the choroidal blood flow which comprises administering to a subject in need of such increasing a 13,14-dihydro-15-keto-20-ethyl-prostaglandin F, a pharmaceutically acceptable salt thereof or a lower alkyl ester thereof.
    Type: Grant
    Filed: April 13, 1992
    Date of Patent: June 22, 1993
    Assignee: R-Tech Ueno Ltd.
    Inventors: Tetsuya Sugiyama, Satoru Tokuoka, Masayuki Nakajima, Ikuo Azuma
  • Ocular hypotensive agents
    Patent number: 5212200
    Abstract: The present invention relates to ocular hypotensive agents which contains 13,14-dihydro-15-keto-prostagrandins, which shows no transient ocular hypertensive response that PGs usually show.
    Type: Grant
    Filed: September 16, 1991
    Date of Patent: May 18, 1993
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Ryuzo Ueno, Ryuiji Ueno
  • Treatment of cataract with 15-keto-prostaglandin compounds
    Patent number: 5212324
    Abstract: A compound for treatment of a cataract which is a 15-ketoprostaglandin compound.
    Type: Grant
    Filed: April 3, 1991
    Date of Patent: May 18, 1993
    Assignee: R.-Tech Ueno Ltd.
    Inventor: Ryuji Ueno
  • Treatment of ocular hypertension with a synergistic combination for ocular administration
    Patent number: 5208256
    Abstract: A method for treatment of ocular hypertension which comprises ocularly administering, to a subject in need of such treatment, an oculo-hypotensively synergistic combination of(a) a 13,14-dihydro-15-keto-20-loweralkylprostaglandin or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable ester thereof, and(b) a polyoxyethylenesorbitan unsaturated higher aliphatic acid monoesterin an amount effective in treatment of ocular hypertension.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: May 4, 1993
    Assignee: R-Tech Ueno, Ltd.
    Inventor: Ryuji Ueno