Abstract: The invention relates to a multiple-use device (1), wherein a fluid sample, in particular a blood sample, may enter a measuring chamber (3) of the device (1) via an inlet (16), flow through the measuring chamber (3) and leave the measuring chamber (3) via an outlet (17). The device (1) comprises an inner wall surface (9) defining an outer limit of the measuring chamber (3) The inner wall surface (9) comprises a surface structure (13) which is adapted to control a propagation of a flow front (6) of the fluid sample (4) in a direction (x) while the fluid sample (4) enters into the measuring chamber (3) via the inlet (16), while the fluid sample (4) flows through the measuring chamber (3), and while the fluid sample (4) leaves the measuring chamber (3) via the outlet (17).

Abstract: Magnesium ion selective electrode membranes and the preparation thereof. The membranes are rendered highly selective for magnesium ions by the addition of acidic groups to the preferably PVC membrane, either by introducing a lipophilic compound comprising an acidic group covalently linked to a C4-C18 alkyl-substituted phenyl group (e.g. bis-4-octylphenyl phosphoric acid) into the membrane comprising the magnesium selective ionophore (e.g. a neutral ionophore 1,10-phenanthroline derivative) or by covalently linking an acidic (e.g. a carboxylic) group to the ionophore (e.g. a 1,10-phenanthroline derivative).

Abstract: Processes for preparing ion selective membranes are presented which have selectivity for a primary analyte (in particular magnesium) as well as another ion (in particular calcium), wherein said process comprises addition of a) an ionophore (in particular 1,10-phenanthroline), b) a lipophilic salt containing said primary analyte (in particular hemi-magnesium bis[4-octylphenyl]phosphate) and c) a lipophilic salt containing said other ion (in particular hemi-calcium bis[4-octylphenyl]phosphate). Also, ion selective membranes are presented which are prepared using said processes, in particular to membranes selective for magnesium ions. In further aspects, electrodes and potentiometric sensors are presented comprising such membranes and the use thereof for determining ion concentrations in samples.

Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.

Abstract: Ion selective membranes and the preparation thereof, such as magnesium ion selective membranes and the preparation thereof. In particular, the invention describes improved PVC polymer blends for use in ion selective membranes. The invention furthermore relates to electrodes and potentiometric sensors comprising such membranes and the use thereof for determining ion concentrations in samples.

Abstract: The invention relates to a sealed bag containing a reference fluid for the calibration or quality control of a sensor element for measuring body fluid parameters, the bag comprising peripheral walls of a first layered material. The bag further comprises an access port formed by an opening in the first layered material, wherein the opening is sealed by a cover of a second layered material, wherein the second layered material is more resistant to oxidation by the reference fluid than the first layered material.

Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201).

Abstract: Disclosed is a method for transmitting data from an analyser system (1) comprising one or more analyser devices (5) to a remote server (3), wherein the one or more analyser devices (5) are configured to obtain data from samples and/or measurements taken of a patient. The method comprises determining data to be transmitted based on one or more rules associated with a geographical and/or an organizational location of the analyser system (1), and transmitting the determined data to the remote server (3). Corresponding computer program product, analyser system, remote server, and health care system are also disclosed.

Abstract: A system of medical devices, the system comprising: a medical device data management system; a plurality of medical devices communicatively connected to the medical device data management system; each medical device being operable to analyze one or more samples of biological material; and to communicate information about an operational state of the medical device to the medical device data management system; a plurality of portable electronic devices, each operable to be carried by an operator, each portable electronic device communicatively connectable to the medical device data management system and configured to receive, from the medical device data management system, information indicative of an operational state of respective medical devices and to display the received information in respect of one or more selected ones of the medical devices.

Abstract: The invention relates to a porous optical fiber for the detection of an analyte in a fluid by optical probing. The optical fiber has a first end and a second end opposite to the first end, as seen in a longitudinal direction, and a circumferential surface delimiting the optical fiber in radial directions perpendicular to the longitudinal direction. The optical fiber comprises a core adapted for supporting at least one optical mode propagating in the longitudinal direction, the core having a circumferential interface delimiting the core in the radial directions. The optical fiber further comprises pores penetrating from an opening at the circumferential surface through the circumferential interface into the core of the optical fiber, wherein a cross-sectional dimension of the openings is dimensioned so as to prevent a particulate fraction of the fluid from entering the pores, while allowing the analyte to enter the pores.

Abstract: The present application discloses a planar enzyme sensor for measuring the concentration of an analyte in a solution comprising a substrate of an electrically insulating material supporting an electrode layer of an electrically conductive material. The substrate and electrode layer have a plurality of layers disposed thereon which include an enzyme layer and a microporous outer layer covering the enzyme layer, wherein the outer layer comprises a continuous phase of a water-resistant polymer (e.g. a polyvinylacetate or an acrylate copolymer), a protein (e.g. an enzyme) embedded in the continuous phase, and possibly polytetrafluoroethylene particles. The enzyme and the polytetrafluoroethylene particles provide a controlled porosity to the outer membrane.

Abstract: The present invention relates to a sensor assembly (1) for body fluids.

Abstract: The present invention provides a syringe for obtaining a target volume of a liquid, in particular blood. The syringe provides a piston with a seal having a width that is identical to the volume line indicating the target full volume of the syringe. This offers a precise and an intuitive way for the end user to understand how much blood is recommended to be drawn from the patient. In exemplary embodiments these visual indicators have the same colour and a desired amount of interruptions of the line of the volume scale are provided.

Abstract: A system for time-resolved fluoroimmunoassay detection is disclosed. The system comprises a receptacle with a sample volume adapted for receiving a sample therein; a light source adapted to emit pulsed excitation light illumination optics adapted to collect the pulsed excitation light from the light source and to deliver the pulsed excitation light to the sample volume in the receptacle; a detection device adapted for gated detection of fluorescence radiation at least in a detection spectral range; detection optics adapted to collect fluorescence radiation from the receptacle at least in the detection spectral range and deliver the fluorescence radiation to the detection device; and an optical filter device configured for the separation of excitation light and detection light. A method for time-resolved fluoroimmunoassay detection is also provided.

Abstract: The disclosure relates to an apparatus for the analysis of biological liquid samples, the apparatus having a measurement chamber defining a sample volume with an inlet and an outlet; a fluid handling system adapted for feeding a liquid to the sample volume through the inlet and for removing the liquid through the outlet; a thermostatic sample heater device adapted for controlling a sample temperature of a liquid sample in the measurement chamber; and a processor unit. An analyte sensor output may be corrected on the basis of the initial temperature thus determined. A corresponding method for the analysis of biological liquid samples is provided. Furthermore, a method of performing a quality control procedure using the apparatus or the method is disclosed.

Abstract: The present invention relates in one aspect to a method of detecting a contaminant in a measurement chamber (201) of a sample analyzer (200). The sample analyzer (200) comprises an optical sensor with a sensor layer (205) comprising a luminophor (201), wherein the sensor layer (205) has a sensor surface (206) forming an interface to the measurement chamber (201).

Abstract: A planar waveguide device (PWD) for interacting with a fluid (FLD) is disclosed, the planar waveguide device (PWD) comprising a waveguide layer (WGL) for supporting optical confinement, a coupling arrangement (CPA) for in-coupling and out-coupling of light into and from the waveguide layer (WGL), a fluid zone (FZN) for accommodating the fluid (FLD), a filter layer (FTL) arranged between the fluid zone (FZN) and the waveguide layer (WGL) in an interaction region (IAR) of the waveguide layer (WGL), wherein the filter layer (FTL) comprises filter openings (FOP) arranged to allow the fluid (FLD) to interact with an evanescent field of light guided by the waveguide layer (WGL), wherein the filter openings (FOP) are adapted to prevent particles (PAR) larger than a predefined size from interacting with said evanescent field, wherein the filter openings (FOP) are arranged as line openings having their longitudinal direction in parallel with the direction of propagation (DOP) of light guided by the waveguide lay