Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g. selected from a calcium-selective ionophore, a potassium-selective ionophore, and a sodium-selective ionophore), and wherein the first ionophore is not present in any ion-selective electrode in the sensor array other than in the first ion-selective electrode.

Abstract: The present invention relates to a sensor assembly for body fluids. The sensor assembly includes a measurement chamber having side walls and top and bottom walls, each of the walls having a respective wall wettability for aqueous solutions; a first sensor adapted to measure a first parameter of body fluids, having a surface having a first wettability for aqueous solutions exposed to the measurement chamber at a first axial position, and a second sensor adapted to measure a second parameter of body fluids, having a surface having a second wettability for aqueous solutions higher than the first wettability exposed to the measurement chamber at a second axial position upstream or downstream from the first axial position. At the second axial position, the chamber width exceeds the width of the second sensor surface, and the measurement chamber has a widening in a horizontal direction as compared to the first axial position.

Abstract: A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.

Abstract: A sealed bag containing a reference fluid for the calibration and/or quality control of a creatine and/or creatinine sensor, the bag comprising: an inner polymer layer and an outer polymer layer; and an aluminium oxide gas barrier layer there between; and wherein the inner polymer layer is in contact with the reference fluid.

Abstract: A porous mirror (1) for detection of an analyte (96) in a fluid (99) by optical probing, comprising a translucent slab (2) with a front side (3), and a backside (4) facing away from the front side (3), wherein the front side (3) is adapted for being contacted with a fluid (99), and a reflective layer (5) at the front side (3) of the translucent slab (2), the reflective layer (5) being adapted to reflect light reaching the reflective layer from the backside (4) of the translucent slab (2), wherein the translucent slab (2) comprises pores (6), wherein the pores (6) are dead end pores (6) extending from respective openings (7) at the front side (3) into the translucent slab (2), through the reflective layer (5), wherein a cross-sectional dimension of the openings (7) of the pores (6) is dimensioned so as to prevent larger particles or debris, if any included the fluid, from entering the pores (6), while allowing the analyte (96) in the fluid (99) to enter the pores (6) via diffusion.

Abstract: The invention relates to a mutant polypeptide having creatine amidinohydrolase activity, where the polypeptide both retains thermostable activity in the presence of reagents that modify thiol groups. The invention further relates to methods for producing the mutant polypeptide; and to a sensor comprising the mutant polypeptide for use in the measurement of creatinine in samples of physiological fluids. Additionally, the invention teaches how to use the mutant polypeptide to enhance the life-time of a creatinine sensor, and a method for producing the sensor.

Abstract: A sealed bag containing a reference fluid for the calibration and/or quality control of a creatine and/or creatinine sensor, the bag comprising: an inner polymer layer and an outer polymer layer; and an aluminium oxide gas barrier layer there between; and wherein the inner polymer layer is in contact with the reference fluid.

Abstract: The invention relates to a method of detecting a clot in a measurement chamber of a liquid sample analyzer, wherein the liquid sample analyzer comprises at least two analyte sensors, a first analyte sensor, for measuring a first analyte in a liquid sample, and one or more second analyte sensors, for measuring one or more second analytes in the liquid sample in the measurement chamber, the method comprising the steps of, (a) at least partly filling the measurement chamber with a known solution having a composition comprising the first analyte at a pre-determined level, and the second one or more analytes at pre-determined levels, (b) obtaining a first sequence of measurement results by the first analyte sensor, and simultaneously obtaining a second sequence of measurement results by the second, one or more analyte sensors, (c) determining a change of the first sequence of measurement results, (d) determining a change of the second one or more sequence of measurement results, (e) comparing the change of the fir

Abstract: The present application discloses improved multiple-use sensor arrays for determining the content of various species in samples of biological origin, in particular in the area of point-of-care (POC) testing for blood gases. The multiple-use sensor array is arranged in a measuring chamber, and the sensor array comprises two or more different ion-selective electrodes including a first ion-selective electrode (e.g. an ammonium-selective electrode being part of a urea sensor), wherein the first ion-selective electrode includes a membrane comprising a polymer and (a) a first ionophore (e.g. an ammonium-selective ionophore) and (b) at least one further ionophore (e.g.

Abstract: A device for mounting an electrochemical sensor unit to a skin surface of a human being comprises a mounting member having a circumferential wall, an adhesive tape at a lower end of the circumferential wall for adhering the mounting member to the skin surface, and a sealing member. The sealing member provides a liquid tight seal between a lumen or measuring chamber defined between the skin surface, the mounting device and the sensor unit, the measuring chamber being normally filled with a contact liquid. Alternatively, the sealing member is provided on the sensor unit. The provision of the sealing member renders the system less vulnerable to force impacts and reduces the risk of flawed measurements due to atmospheric air in the measuring chamber. The electrochemical sensor unit may e.g. be suitable for transcutaneous measurement of partial carbon dioxide pressure (pCO2) or partial oxygen pressure (pO2).

Abstract: A CO2-sensitive planar sensing device is disclosed, which has an electrode with an ion-selective layer, an electrolyte layer and an outer layer. The electrolyte layer has osmotically active species in an amount of 0.8-6.0 milliosmol per m2 of electrolyte layer area, and has a hydrophilic osmolarity increasing component which does not add bicarbonate ions or chloride ions to the electrolyte layer.

Abstract: A method of calibrating a device for measuring the concentration of creatinine in a sample including one or more enzyme modulators, the device comprising an enzyme layer, the method comprising: determining sensitivities of the device for each of one or more calibration solutions; determining a degree of modulation for the sample to be measured, determining a degree of modulation for each calibration solution; wherein said determining of each of the degrees of modulation comprises estimating the concentration of an enzyme modulator in the enzyme layer of the device; and calculating the sensitivity of the device for the sample, wherein the said calculating comprises adjusting the sensitivity of the device for each calibration solution by a factor comprising the determined degrees of modulation of the sample and the calibration solution.

Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates changes in temperature of the calibration solutions from the initial time to the end time; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.

Abstract: An apparatus for detecting a first component in a sample, the first component being responsive to at least radiation of a first wavelength, the sample comprising the first component and a second component responsive to at least radiation of a second wavelength.

Abstract: An apparatus for detecting a first component in a sample, the first component being responsive to at least radiation of a first wavelength, the sample comprising the first component and a second component responsive to at least radiation of a second wavelength.

Abstract: The invention relates to a sealed oxygen reference fluid containing bag adapted for being pierced by an access probe for withdrawal of the oxygen reference fluid and including an access system comprising: a sealing element provided outside the bag and preventing any leakage between the bag and the access probe when the access probe has penetrated the bag, and a longitudinal support element provided inside the bag extending essentially parallel to an edge of the bag and being adapted to support the bag when the bag is penetrated by the access probe.

Abstract: An apparatus for hemolyzing a blood sample and for measuring at least one parameter thereof comprises a sample chamber for accommodation of the blood sample, the sample chamber having a first sidewall and an opposite second sidewall. The apparatus also comprises ultrasonic generator for generating ultrasonic waves in the first and second sidewalls so as to cause the blood sample provided between the first and second sidewall to be hemolyzed. Further, the apparatus comprises an optical measuring device for measuring the at least one parameter in the hemolyzed blood sample when the hemolyzed blood sample is provided between the first and second sidewalls. The ultrasonic generator of the apparatus comprises a first ultrasonic generator for generating ultrasonic waves in the first sidewall and a second ultrasonic generator for generating ultrasonic waves in the second sidewall.

Abstract: A reference solution is provided, which comprises, in a liquid phase, at least one of a first compound and a second compound which are mutually convertible into each other, and at least one catalyst, which catalyzes the conversion between the first compound and the second compound.