Abstract: Structures for response shaping in frequency and time domain, include an optical response shaper and/or a modulator device with multiple injection. The device comprises a resonator having an enclosed geometric structure, for example a ring or racetrack structure, at least two injecting optical waveguides approaching the resonator to define at least two coupling regions between the resonator and the injecting waveguides, and may define at least two Free Spectral Range states. One or both of the coupling regions has a coupling coefficient selected for a predetermined frequency or time response, and the coupling coefficient or other device parameters may be variable, in some case in real time to render the response programmably variable. In addition, the injection power at one of the optical waveguides serves to modify the response.

Abstract: Disclosed herein is a neural network based pre-decoder comprising a permutation embedding engine, a permutation classifier each comprising one or more trained neural networks and a selection unit. The permutation embedding engine is trained to compute a plurality of permutation embedding vectors each for a respective one of a plurality of permutations of a received codeword encoded using an error correction code and transmitted over a transmission channel subject to interference. The permutation classifier is trained to compute a decode score for each of the plurality of permutations expressing its probability to be successfully decoded based on classification of the plurality of permutation embedding vectors coupled with the plurality of permutations. The selection unit is configured to output one or more selected permutations having a highest decode score. One or more decoders may be then applied to recover the encoded codeword by decoding the one or more selected permutations.

Abstract: The present invention provides nanoparticle conjugates incorporating the self-assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanospheres. The present invention further provides nanoparticles formed by supramolecular co-assembly of the conjugates with a diphenylalanine (FF) dipeptide or analog thereof, to generate bioactive self-assembled nanostructures.

Abstract: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.

Abstract: Apparatus, including a set of N electrodes (22), configured to be located in proximity to an epidermis (24) of a subject, and to acquire signals generated by electric sources within the subject. The apparatus also includes a set of M channels, configured to transfer the signals, where M is less than N, and a switch (40), configured to select, repetitively and randomly, M signals from the N electrodes and to direct the M signals to the M channels. The apparatus further includes a processor (28), configured to activate the switch, and to receive and analyze the M signals from the M channels so as to determine respective positions of the electric sources within the subject.

Abstract: For example, an Electrostatically Formed Nanowire (EFN) may include a source region; at least one drain region; a wire region configured to drive a current between the source and drain regions via a conductive channel; a first lateral-gate area extending along a first surface of the wire region between the source and drain regions; a second lateral-gate area extending along a second surface of the wire region between the source and drain regions; and a sensing area in opening in a backside of a silicon substrate under the wire region and the first and second lateral-gate areas, the sensing area configured to, in reaction to a predefined substance, cause a change in a conductivity of the conductive channel.

Abstract: An effective therapeutic agent for the M2 channel comprising sulfonylamide or oxabicyclo structures effective for treating amantadine-resistant influenza A infections, and methods of treating amantadine-resistant influenza A infections through administration of the same.

Abstract: A piezoelectric transducer is provided herein, comprising a three-dimensional structure made of a plurality of peptides, the peptides being self-assembling and the structure being piezoelectric, wherein at least a portion, or each, of said plurality of peptides comprises peptides of 2 to 10 amino acid residues, provided that the plurality of peptides is not consisted of a plurality of Phe-Phe dipeptides. Further described herein are peptides having an amino acid sequence Hyp-Phe-Phe, Boc-Dip-Dip, (L)Trp-(D)Trp or (D)Trp-(L)Trp, as well as three-dimensional structures comprising such peptides.

Abstract: Provided is a patch including at least one pressure-absorbing member, the pressure absorbing member formed of a resilient material and having at least a first surface, the at least first surface is configured with a plurality of projections extending therefrom and a plurality of channels crossing one another at a plurality of intersections, an outermost surface of said plurality of projections lies along a projections plane of the pressure-absorbing member, the projections being deformable when subjected to pressure applied to the patch, so as to absorb at least some of the applied pressure.

Abstract: A method of mapping transverse relaxation in a magnetic resonance (MR) scan data, comprises receiving a multi-echo spin-echo MR scan protocol comprising a plurality of MR imaging parameters, and for each echo of the multi-echo spin-echo MR scan protocol: generating, based on the parameters, a simulated echo modulation curve using a set of refocusing coherence pathways, for each of a plurality of predetermined transverse relaxation times; calculating, for each transverse relaxation time, diffusion attenuation based on a respective subset of the refocusing coherence pathways; and correcting the echo modulation curve using the diffusion attenuation. The method can also comprise comparing the scan data to the corrected echo modulation curve for each of at least a portion of the transverse relaxation values, and generating a displayed output comprising a map of transverse relaxation based on the comparison.

Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.

Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.

Abstract: A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent.

Abstract: In a system for converting digital data into a modulated optical signal, an electrically controllable device having M actuating electrodes provides and optical signal that is modulated in response to binary voltages applied to the actuating electrodes. A digital-to-digital converter provides a mapping of input data words to binary actuation vectors for M bits and supplies the binary actuation vectors as M bits of binary actuation voltages to the M actuating electrodes, where M is larger than the number of bits in each input data word. The digital-to-digital converter maps each digital input data word to a binary actuation vector by selecting a binary actuation vector from a subset of binary actuation vectors available to represent each of the input data words.

Abstract: An isolated polynucleotide encoding a fusion protein which comprises a DNA targeting moiety linked to a catalytic domain of a plant DNA methyltransferase 3 (DNMT3) protein is disclosed. Uses thereof are also disclosed.

Abstract: Methods of treating diseases selected from the group consisting of an autoimmune disease, a neurodegenerative disease, triple negative breast cancer, head and neck cancer and an infectious disease are disclosed. The method comprises administering agents that bind to CD45.

Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.

Abstract: Apparatus for disaggregating a plurality of aggregated electrical devices that receive power via a same power node, the apparatus comprising: a memory having values of at least one power feature for each of the aggregated electrical devices that characterizes power consumption of the device; and a processor configured to: receive a measure of a value for the at least one power feature of node power distributed to the aggregated devices via the power node; determine an optimum probability mass function (PMF) based on the values for the at least one power feature for each of the electrical devices that is optimized to provide an optimum disaggregation state vector for the aggregated electrical devices that satisfies a predetermined criterion to provide a value for the at least one power feature that agrees with the received measure of the at least one power feature.

Abstract: A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle; (ii) at least one adjuvant; and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.

Abstract: A modulator comprises one or more resonators. Each resonator has a light confining closed loop structure, such as a ring structure, and two, three or more electrodes associated with the light-confining structure, and may be a micro-resonator. An optical signal is modulated by a digital signal using the resonator. The procedure comprises obtaining the digital signal, mapping the signal using a mapping function to produce a transformed digital signal, the transformed digital signal being selected to produce, say linear, output from the resonator, inputting the transformed digital signal via electrodes onto the resonator; and modulating the optical signal via coupling from the resonator. Suitable mapping produces 16 QAM and other modulation schemes.