Abstract: Compositions comprising a cell-derived particle associated with Cannabidiol (CBD), and uses thereof in treating medical conditions that can benefit from Cannabidiol (CBD) are provided.

Abstract: A method of diagnosing lung cancer in a subject-in-need thereof is provided. The method comprises: (a) providing a biological sample of the subject which comprises peripheral blood mononuclear cells (PBMCs); (b) in vitro contacting the PBMCs with a stimulant selected from the group consisting of the stimulants listed in Tables 3 and 4; and (c) measuring metabolic activity of the PBMCs having been contacted according to (b), wherein a statistically significant change in the metabolic activity of the PBMCs as compared to a control sample is indicative of lung cancer.

Abstract: A novel AI-driven drug-repurposing method, DeepDrug, is used to identify a lead combination of previously FDA-approved drugs to treat AD by targeting the upstream genetic markers along the AD pathology. A three-step methodology is used. First, a heterogeneous biomedical graph is constructed comprising complex and interconnected genes, proteins, and drug information to capture the network characteristics of the AD pathology, considering the expert known associations between different AD pathways and utilizing node weighting and edge weighting and direction. Second, the curated graph is taken as an input to an artificial intelligence (AI)-driven graphical neural network (GNN) framework, with embeddings of drug and gene nodes as the outputs. Third, a drug scoring and selection analysis is conduced to generate the drug-gene scores and identify a lead combination of repurposed AD drug candidates for clinical verification.

Abstract: Novel processes of preparing block polyester copolymers while precisely controlling the stereoconfiguration (e.g., tacticity), chemical composition and/or length of each unit (block) are provided. Block polyester copolymers featuring desirable combinations of two or more blocks featuring different stereoconfiguration (e.g., tacticity), chemical composition and/or length, including triblock, tetrablock and higher block copolymers are also provided. A novel family of organometallic magnesium complexes and uses thereof in preparing polyesters and block polyester copolymers are also provided.

Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.

Abstract: The present invention provides isolated monoclonal antibodies which bind to the MUC1 SEA domain. The invention also concerns the use of these antibodies in therapeutic and diagnostic methods.

Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.

Abstract: Isolated anti-IDE antibodies are provided. Each of the antibodies comprise an antigen recognition domain comprising the indicated CDR amino acid sequences. Methods of producing same, methods of using same, pharmaceutical compositions comprising same and articles of manufacture are also provided.

Abstract: Methods and arrays for identifying the cell or tissue origin of DNA are provided. Accordingly there is provided a method of identifying DNA having a methylation pattern distinctive of a cell or tissue type or state comprising: labeling an epigenetic modification of interest in a DNA sample with a label; contacting said sample on an array comprising a plurality of probes for said DNA under conditions which allow specific hybridization between said plurality of probes and said DNA; and detecting said hybridization, wherein an amount of said label is indicative of the cell or tissue type or state, wherein the method is effected in the absence of amplification of said DNA.

Abstract: A method for forming a 2-dimensional pattern or 3-dimensional object using an aluminum (Al) 5xxx series alloy includes providing a feedstock that includes the Al 5xxx alloy. The method further includes depositing, using an additive manufacturing process, the feedstock under thermal conditions that permit formation of the pattern or object. The method further includes adjusting a parameter of the additive manufacturing process during the depositing.

Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.

Abstract: A method of measuring signals from a surface. The method comprises: placing on the surface a flexible sensing device having an array of coated electrodes, wherein at least one electrode of the array is metallic and is at least partially coated by a polymer; and collecting signals from the sensing device.

Abstract: An apparatus includes a laser source and a scanner. The laser source is configured to generate electromagnetic radiation. The scanner scans at least part of a limbal area of an eye with the electromagnetic radiation generated by the laser source, thereby directing the electromagnetic radiation through an entire thickness of the limbal area of the eye without any contact with the eye and irradiating one or more regions of a trabecular meshwork of the eye with the electromagnetic radiation.

Abstract: The present disclosure relates to bacteria and bacteria-associated volatile organic compounds, and to their use in agriculture.

Abstract: A device and method are disclosed for regulated storage capacitor charging to high voltage. The device comprises an AC source configured to output an AC voltage, a voltage multiplier that constitutes a charging unit and a control unit. The control unit is configured to constantly sense the voltage on the storage capacitor and upon detecting that a predefined maximum charging voltage has been reached to react in at least one of the following ways: stop charging the storage capacitor, and closing an output switch so as to discharge of the storage capacitor through some load. The capacitance of each capacitor in the charging unit is substantially smaller than that of the storage capacitor so as achieve accurate maximum charging voltage as well as limited charging current.

Abstract: A system for determining muscle activation comprises a set of electrode adherable to a skin of a subject, and a processor in communication with the electrodes. The processor has a circuit configured for receiving locations of the electrodes and electrical signals detected by the electrodes, analyzing the signals to identify a section of an active muscle, identifying locations of at least a segment of active muscles and activation patterns of the active muscles based on the identified section, and constructing a displayable map of the locations and the activation patterns, wherein patterns corresponding to different active muscles are distinguishable on the map.

Abstract: Methods and systems for solving a linear system include setting resistances in an array of settable electrical resistances in accordance with values of an input matrix. A series of input vectors is applied to the array as voltages to generate a series of respective output vectors. Each input vector in the series of vectors is updated based on comparison of the respective output vectors to a target vector. A solution of a linear system is determined that includes the input matrix based on the updated input vectors.

Abstract: Techniques for generating and managing, including simulating and training, deep tensor neural networks are presented. A deep tensor neural network comprises a graph of nodes connected via weighted edges. A network management component (NMC) extracts features from tensor-formatted input data based on tensor-formatted parameters. NMC evolves tensor-formatted input data based on a defined tensor-tensor layer evolution rule, the network generating output data based on evolution of the tensor-formatted input data. The network is activated by non-linear activation functions, wherein the weighted edges and non-linear activation functions operate, based on tensor-tensor functions, to evolve tensor-formatted input data. NMC trains the network based on tensor-formatted training data, comparing output training data output from the network to simulated output data, based on a defined loss function, to determine an update.

Abstract: A new family of mononuclear organometallic complexes of a divalent metal bound to sequential tetradentate monoanionic {ONNN}-type ligands, and polymerization of cyclic esters such as lactides utilizing same are provided. Novel tetradentate monoanionic {ONNN}-type ligands usable for forming these complexes are also provided.

Abstract: A computer-implemented method is presented for performing matrix sketching by employing an analog crossbar architecture. The method includes low rank updating a first matrix for a first period of time, copying the first matrix into a dynamic correction computing device, switching to a second matrix to low rank update the second matrix for a second period of time, as the second matrix is low rank updated, feeding the first matrix with first stochastic pulses to reset the first matrix back to a first matrix symmetry point, copying the second matrix into the dynamic correction computing device, switching back to the first matrix to low rank update the first matrix for a third period of time, and as the first matrix is low rank updated, feeding the second matrix with second stochastic pulses to reset the second matrix back to a second matrix symmetry point.