Patents Assigned to RareCyte, Inc.
  • Patent number: 10962362
    Abstract: This disclosure is directed to a system and method for detecting a surface of a substrate within a scanner.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: March 30, 2021
    Assignee: RareCyte, Inc.
    Inventors: Paulina Varshavskaya, Edward Shafer, Steve Quarre, Ronald C. Seubert
  • Patent number: 10919034
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: February 16, 2021
    Assignee: RareCyte, Inc.
    Inventors: Lance U'ren, Ronald Seubert
  • Publication number: 20210025794
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.
    Type: Application
    Filed: January 8, 2017
    Publication date: January 28, 2021
    Applicant: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, Ronald Seubert, Jonathan Lundt, Lance U'Ren
  • Patent number: 10890748
    Abstract: This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: January 12, 2021
    Assignee: RareCyte, Inc.
    Inventors: Steve Quarre, Edward Shafer, David Stewart, Joel Smith
  • Patent number: 10871485
    Abstract: Kits, compositions, and methods for labeling target materials or target analytes are considered. The composition can include one or more affinity molecules indirectly conjugated to one or more detection moieties. The kit can be used to detect a single biomarker or multiple biomarkers. The kit can be used to perform a single round of labeling or multiple rounds of labeling.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: December 22, 2020
    Assignee: RareCyte, Inc.
    Inventors: Daniel E. Campton, Yao Sun
  • Patent number: 10802260
    Abstract: This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: October 13, 2020
    Assignee: RareCyte, Inc.
    Inventors: Steve Quarre, Edward Shafer, David Stewart, Joel Smith
  • Patent number: 10753875
    Abstract: This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties. A system and a process are disclosed by which individual detection moieties can be distinguished from a plurality of detection moieties (i.e., during multiplexing), such as by distinguishing the detection moieties orthogonally—in that there is no ambiguity as to which detection moiety is being detected and/or imaged. A feature of a signal of interest, such as from a detection moiety of interest, can be distinguished in the presence of a featureless signal (i.e., the signal has an unknown value and/or structure), such as from background, autofluorescence, or a non-desired detection moiety.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: August 25, 2020
    Assignee: RareCyte, Inc.
    Inventor: Jeremy Ryan Cooper
  • Patent number: 10416046
    Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: September 17, 2019
    Assignee: RareCyte, Inc.
    Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
  • Patent number: 10345237
    Abstract: This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: July 9, 2019
    Assignee: RareCyte, Inc.
    Inventor: Jeremy Ryan Cooper
  • Patent number: 10330684
    Abstract: This disclosure relates generally to detection and, in particular, to detecting objects within a sample or fraction thereof.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: June 25, 2019
    Assignee: RareCyte, Inc.
    Inventors: Daniel E. Campton, Arturo B. Ramirez, Melinda R. Duplessis
  • Patent number: 10274498
    Abstract: This disclosure relates generally to detection and, in particular, to detecting objects within a sample or fraction thereof.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 30, 2019
    Assignee: RareCyte, Inc.
    Inventors: Daniel E. Campton, Arturo B. Ramirez, Melinda R. Duplessis
  • Patent number: 10267805
    Abstract: This disclosure relates generally to detection and, in particular, to detecting objects within a sample or fraction thereof.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: April 23, 2019
    Assignee: RareCyte, Inc.
    Inventors: Daniel E. Campton, Arturo B. Ramirez
  • Patent number: 10222373
    Abstract: This disclosure is directed to methods for retrieving and using at least one lymphocyte. Additionally, cell receptor sequences identified with this strategy could be used for antibody development, TCR discovery, or appropriate therapeutics development or evaluation.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: March 5, 2019
    Assignee: RareCyte, Inc.
    Inventor: Lance U'Ren
  • Patent number: 10215169
    Abstract: This disclosure is directed to an apparatus, system and method for introducing a liquid into a vessel. A fluid layering system includes a pump connected to a line connected to a connector, such that the connector provides an air-tight fit with the vessel.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: February 26, 2019
    Assignee: RareCyte, Inc.
    Inventors: Steve Quarre, Edward Shafer, Lance U'Ren, Jennifer Chow
  • Patent number: 10101247
    Abstract: This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base, an anti-coagulant, and a nonsteroidal anti-inflammatory drug. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, or any combination thereof. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: October 16, 2018
    Assignee: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Ronald Seubert, Steve Quarre
  • Patent number: 10101248
    Abstract: This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base, an anti-coagulant, and a nonsteroidal anti-inflammatory drug. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, or any combination thereof. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: October 16, 2018
    Assignee: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Ronald Seubert
  • Patent number: 10088392
    Abstract: This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: October 2, 2018
    Assignee: RareCyte, Inc.
    Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
  • Patent number: 10072927
    Abstract: This disclosure is directed to a system and method for detecting a surface of a substrate within a scanner.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: September 11, 2018
    Assignee: RareCyte, Inc.
    Inventors: Paulina Varshavskaya, Edward Shafer, Steve Quarre, Ronald C. Seubert
  • Patent number: 10054524
    Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. An enrichment agent may be added to a vessel that contains the sample for positive selection, or, in other words, to select or aid in selecting the target material from amongst the remainder of the sample. The enrichment agent may be, for example, immunomagnetic beads, buoyant beads, high-density beads, chemicals to change the density of the target material, or the like.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: August 21, 2018
    Assignee: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Lundt, Lance U'Ren, Jennifer Chow
  • Publication number: 20180195935
    Abstract: This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.
    Type: Application
    Filed: April 11, 2017
    Publication date: July 12, 2018
    Applicant: RareCyte, Inc.
    Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert