Patents Assigned to RareCyte, Inc.
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Publication number: 20170322125Abstract: This disclosure is directed to solutions and methods of using the solutions. A first solution includes a polymer, a polyol, and a buffer. A second solution includes a polymer, a polyol, and an alcohol.Type: ApplicationFiled: April 20, 2017Publication date: November 9, 2017Applicant: RareCyte, Inc.Inventor: Daniel Campton
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Publication number: 20170322407Abstract: This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.Type: ApplicationFiled: May 23, 2017Publication date: November 9, 2017Applicant: RareCyte, Inc.Inventors: Steve Quarre, Edward Shafer, David Stewart, Joel Smith
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Patent number: 9810605Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a specimen. The magnetic gradient may be introduced by a magnet, such as a permanent magnet or an electromagnet, and the pressure gradient may be introduced by a pump which moves within a fluid-primed cannula to create the pressure gradient, thereby drawing the target analyte into the cannula. The picker may also expel the target analyte onto or into a substrate, such as a well plate, after the target analyte has been drawn into the picker by reversing the pressure gradient or removing the magnetic gradient.Type: GrantFiled: September 25, 2016Date of Patent: November 7, 2017Assignee: RareCyte, Inc.Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
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Publication number: 20170315340Abstract: This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.Type: ApplicationFiled: May 22, 2017Publication date: November 2, 2017Applicant: RareCyte, Inc.Inventors: Steve Quarre, Edward Shafer, David Stewart, Joel Smith
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Publication number: 20170276575Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.Type: ApplicationFiled: June 13, 2017Publication date: September 28, 2017Applicant: RareCyte, Inc.Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
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Publication number: 20170261735Abstract: This disclosure is directed to system for transferring a substrate, such as a microscope slide, and holding the substrate within at least one device. The system includes a holder for holding the substrate and a gripper for transferring the substrate, such as between a cassette or stack and the holder. A method is also discussed herein.Type: ApplicationFiled: May 24, 2017Publication date: September 14, 2017Applicant: RareCyte, Inc.Inventors: Steve Quarre, Edward Shafer, David Stewart, Joel Smith
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Publication number: 20170248600Abstract: This disclosure is directed to methods for retrieving and using at least one lymphocyte. Additionally, cell receptor sequences identified with this strategy could be used for antibody development, TCR discovery, or appropriate therapeutics development or evaluation.Type: ApplicationFiled: August 4, 2016Publication date: August 31, 2017Applicant: RareCyte, Inc.Inventor: Lance U'Ren
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Publication number: 20170219463Abstract: This disclosure is directed to a device and a system for aspirating and dispensing a target analyte, target material, or fluid. A picker may aspirate and dispense the desired material by introducing a pressure gradient. The picker may include a hydraulic fluid to hydraulically couple at least two components, such as a moveable pump component and a cannula.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Applicant: RareCyte, Inc.Inventors: Joshua Nordberg, Steve Quarre, Ronald Seubert
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Publication number: 20170199033Abstract: This disclosure is directed to a system and method for detecting a surface of a substrate within a scanner.Type: ApplicationFiled: January 7, 2016Publication date: July 13, 2017Applicant: RareCyte, Inc.Inventors: Paulina Varshavskaya, Edward Shafer, Steve Quarre
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Publication number: 20170191911Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.Type: ApplicationFiled: January 8, 2017Publication date: July 6, 2017Applicant: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, Ronald Seubert, Jonathan Lundt, Lance U'Ren
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Patent number: 9625360Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A fraction-density-altering solution may be added to a vessel that contains the sample to change the density of a first fraction of the sample without changing the density of the target material or the density of any other sample fraction. A collector may be inserted into the vessel to funnel the target material from the sample into the collector or into a processing receptacle included in the collector. In one implementation, the collector may include a cannula which extends from a funnel into a chamber to hold the processing receptacle. In another implementation, the processing receptacle may be inserted into a bore within the collector.Type: GrantFiled: October 14, 2015Date of Patent: April 18, 2017Assignee: RareCyte, Inc.Inventors: Lance U'Ren, Elizabeth Chang, Jennifer Chow
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Publication number: 20170074759Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. An enrichment agent may be added to a vessel that contains the sample for positive selection, or, in other words, to select or aid in selecting the target material from amongst the remainder of the sample. The enrichment agent may be, for example, immunomagnetic beads, buoyant beads, high-density beads, chemicals to change the density of the target material, or the like.Type: ApplicationFiled: November 2, 2016Publication date: March 16, 2017Applicant: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Lundt, Lance U'Ren, Jennifer Chow
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Publication number: 20170059552Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a displacement fluid, a collector, and a primary vessel. In another implementation, the system includes a processing vessel, a displacement fluid, a collector, and a primary vessel.Type: ApplicationFiled: November 14, 2016Publication date: March 2, 2017Applicant: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert
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Publication number: 20170014819Abstract: This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel.Type: ApplicationFiled: September 13, 2016Publication date: January 19, 2017Applicant: RareCyte, Inc.Inventors: Lance U'Ren, Ronald Seubert
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Publication number: 20170010188Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a specimen. The magnetic gradient may be introduced by a magnet, such as a permanent magnet or an electromagnet, and the pressure gradient may be introduced by a pump which moves within a fluid-primed cannula to create the pressure gradient, thereby drawing the target analyte into the cannula. The picker may also expel the target analyte onto or into a substrate, such as a well plate, after the target analyte has been drawn into the picker by reversing the pressure gradient or removing the magnetic gradient.Type: ApplicationFiled: September 25, 2016Publication date: January 12, 2017Applicant: RareCyte, Inc.Inventors: Joshua J. Nordberg, Steve Quarre
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Patent number: 9539570Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a plurality of processing vessels and a collector. The collector funnels portions of the target material from the suspension through a cannula and into the processing vessels. Sequential density fractionation is the division of a sample into fractions or of a fraction of a sample into sub-fractions by a step-wise or sequential process, such that each step or sequence results in the collection or separation of a different fraction or sub-fraction from the preceding and successive steps or sequences. In other words, sequential density fractionation provides individual sub-populations of a population or individual sub-sub-populations of a sub-population of a population through a series of steps.Type: GrantFiled: January 30, 2015Date of Patent: January 10, 2017Assignee: RareCyte, Inc.Inventors: Lance U'Ren, Daniel Campton, Joshua Nordberg, Steve Quarre, Jonathan Lundt
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Patent number: 9541481Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A first depletion agent may be added to a vessel that contains the sample to change the density of a non-target material.Type: GrantFiled: June 5, 2016Date of Patent: January 10, 2017Assignee: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Lundt, Lance U'Ren, Jennifer Chow
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Patent number: 9533303Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a primary vessel, such as a tube, a collector, and a two-part seal including an internal pliant part and an external constricting part. The internal pliant part may be a float and the external constricting part may be a sealing ring. The system may also include a processing vessel, such as an Eppendorf tube, a syringe or a test tube. The collector is sized and shaped to fit into a primary vessel and funnels the target material from the suspension through a cannula and into the processing vessel. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector.Type: GrantFiled: May 7, 2015Date of Patent: January 3, 2017Assignee: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Lundt, Lance U'Ren
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Patent number: 9519002Abstract: This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a specimen. The magnetic gradient may be introduced by a magnet, such as a permanent magnet or an electromagnet, and the pressure gradient may be introduced by a pump which moves within a fluid-primed cannula to create the pressure gradient, thereby drawing the target analyte into the cannula. The picker may also expel the target analyte onto or into a substrate, such as a well plate, after the target analyte has been drawn into the picker by reversing the pressure gradient or removing the magnetic gradient.Type: GrantFiled: April 9, 2014Date of Patent: December 13, 2016Assignee: RareCyte, Inc.Inventors: Joshua Nordberg, Steve Quarre
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Patent number: 9513291Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a sample. A density-altering agent may be added to a vessel that contains the sample to change the density of a non-target material.Type: GrantFiled: February 9, 2016Date of Patent: December 6, 2016Assignee: RareCyte, Inc.Inventors: Daniel Campton, Joshua Nordberg, Steve Quarre, David Stewart, Ronald Seubert, Jonathan Lundt, Lance U'Ren, Jennifer Chow