Patents Assigned to Regents of the University of California
  • Publication number: 20230307579
    Abstract: A method to fabricate micro-size III-nitride light emitting diodes (?LEDs) with an epitaxial tunnel junction comprised of a p+GaN layer, an InxAlyGazN insertion layer, and an n+GaN layer, grown using metalorganic chemical vapor deposition (MOCVD), wherein the ?LEDs have a low forward the GaN layers, which reduces a depletion width of the tunnel junction and increases the tunneling probability. The ?LEDs are fabricated with dimensions that vary from 25 to 10,000 ?m2. It was found that the InxAlyGazN insertion layer can reduce the forward voltage at 20 A/cm2 by at least 0.6 V. The tunnel junction ?LEDs with an n-type and p-type InxAlyGazN insertion layer had a low forward voltage at 20 A/cm2 that was very stable. At dimensions smaller than 1600 ?m2, the low forward voltage is less than 3.2 V.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 28, 2023
    Applicant: The Regents of the University of California
    Inventors: Panpan Li, Hongjian Li, Michael Iza, Shuji Nakamura, Steven P. DenBaars
  • Publication number: 20230305004
    Abstract: In various embodiments methods to improve the detection of a lateral-flow immunoassay for the sensitive detection of the SARS-CoV-2 nucleocapsid protein or other analytes, as well as devices that incorporate those methods are provided.
    Type: Application
    Filed: August 16, 2021
    Publication date: September 28, 2023
    Applicant: The Regents of the University of California
    Inventors: Daniel Takashi Kamei, Daniel William Bradbury, Ren Sun, Yushen Du, Benjamin Ming Wu, Jasmine Thanh Trinh, Milo Ryan, Cassandra Marie Cantu
  • Publication number: 20230305066
    Abstract: Disclosed is an analytic sensitivity expression for parameters of a battery electrochemical model, based on model reduction and reformulation techniques such as the single particle assumption, Padé approximation, and Laplace transform. The analytic expressions of sensitivity are in a compact form with explicit relationship to the current input, which enables the direct optimization of the input-dependent sensitivity. The current optimization with maximum sensitivity may be performed for several critical battery electrochemical parameters, namely a solid-phase lithium diffusion coefficient, a volume fraction of the electrode active material, and a reaction rate constant. The electrochemical parameter may be reliably identified using the optimal current profile.
    Type: Application
    Filed: August 4, 2021
    Publication date: September 28, 2023
    Applicants: LG ENERGY SOLUTION, LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION
    Inventors: Geum-Bee KIM, Hyoung Jun AHN, Won-Tae JOE, Qingzhi LAI, Xinfan LIN
  • Publication number: 20230303635
    Abstract: The present disclosure provides methods for the identification and quantitation of targets (e.g., biological targets such as cells and viruses) using molecules comprising a binding moiety that binds to the target and a fluorescent moiety whose fluorescence properties are altered when the binding moiety binds to the target. A plurality of said molecules are specifically arranged in structures that resemble the size and shape of a cell to maximize affinity and sensitivity.
    Type: Application
    Filed: August 19, 2021
    Publication date: September 28, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Victor Emilio MUÑOZ VAN DEN EYNDE
  • Publication number: 20230304799
    Abstract: A precision gyroscope which provides mode matching which is insensitive to rate input in response to continuously monitoring the split between the resonances of the drive and sense modes. A calibration signal, having at least one modulated term whose carrier is synchronous with the excitation in the drive resonator is utilized to modify the feedback signal in the sense resonator. The gyroscope thus does not suffer from corruption of, or from, the rate measurement; whereas the frequency of the calibration signal can be chosen independently of the bandwidth of the rate input.
    Type: Application
    Filed: April 5, 2023
    Publication date: September 28, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bernhard E. Boser, Burak Eminoglu
  • Publication number: 20230305322
    Abstract: Photonic pigments are disclosed, which include a plurality of magnetic nanorods assembled into tetragonal colloidal crystals.
    Type: Application
    Filed: March 13, 2023
    Publication date: September 28, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yadong Yin, Zhiwei Li
  • Publication number: 20230304166
    Abstract: An electrochemical method for producing calcium hydroxide includes dissolving a calcium precursor in a first solution in contact with a first electrode to produce Ca2+ ions, transporting the Ca2+ ions across a first membrane from the first solution into a second solution using a first electrochemical potential, producing hydroxide ions at a second electrode, transporting the hydroxide ions across a second membrane into the second solution using a second electrochemical potential, and precipitating calcium hydroxide from the second solution.
    Type: Application
    Filed: August 11, 2021
    Publication date: September 28, 2023
    Applicant: The Regents of the University of California
    Inventors: Iryna Zenyuk, Andrea Perego, Mo Li, Devashish S. Kulkarni
  • Publication number: 20230301767
    Abstract: An organ lengthening device comprising a spring-like structure, wherein the surface of the device is covered with micron-size anchors such as hooks, studs or wires made from a biodegradable polymer. The anchors are configured to engage the surface of the organ so that the device will be anchored to the organ. The device, which is inserted into the organ in a compressed position, gradually lengthens over time, thereby lengthening the organ, wherein the anchors are configured to degrade away and eventually allow the device to become disengaged from the organ.
    Type: Application
    Filed: April 3, 2023
    Publication date: September 28, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James Dunn, Benjamin Wu
  • Publication number: 20230303465
    Abstract: Catalytic dehydrogenation of a light alkane gas on a metal oxide catalyst is achieved by (a) pretreating the metal oxide catalyst with dimethylether (DME); and (b) reacting the alkane gas catalytically on the catalyst in a dehydrogenation reaction, under conditions wherein the pretreating improves product yield of the reaction.
    Type: Application
    Filed: May 18, 2023
    Publication date: September 28, 2023
    Applicant: The Regents of the University of California
    Inventors: Enrique Iglesia, Junnan Shangguan
  • Publication number: 20230293729
    Abstract: Methods and compositions are provided for activating transcription in a mammalian cell.
    Type: Application
    Filed: October 11, 2022
    Publication date: September 21, 2023
    Applicant: The Regents of the University of California
    Inventors: Nadav Ahituv, Navneet Matharu
  • Publication number: 20230295552
    Abstract: In various embodiments, a Laser-actuated Supercritical Injector (LASI) is provided. This device provides high-speed fluidic jet injection into biological samples, such as cells, organs, and tissues (including skin). In certain embodiments the LASI devices exploit high-speed fluidic jets that are pushed by rapid bubble expansion in a fluid. The bubbles are formed when liquid confined in microcavities or holes are heated up to above the supercritical temperature of the fluid. This leads to the formation of a short but ultra-high vapor pressure (supercritical) fluid that ejects the fluid (and any cargo contained therein) out through microchannels. This jet penetrates a cell, organ or tissue juxtaposed to a surface containing the microchannels and the jet provide sufficient force to penetrate into the cell, tissue, or organ leading to effective deliver of a cargo.
    Type: Application
    Filed: August 3, 2021
    Publication date: September 21, 2023
    Applicant: The Regents of the University of California
    Inventors: Pei-Yu E. Chiou, Tianxing Man
  • Publication number: 20230293438
    Abstract: A therapeutic microporous hydrogel scaffold for use in an animal is disclosed that releases one or more therapeutic agents or drugs. The scaffold uses a drug-releasing microporous annealed particle system that encapsulates drug-loaded nanoparticles into particle building blocks. By modulating nanoparticle hydrophilicity and pre-gel solution viscosity, the particle building blocks were generated with consistent and homogeneous encapsulation of nanoparticles. The scaffold may be used to treat myocardial infarction (MI) using, for example, the drugs forskolin (F) and Repsox (R). The intramyocardial injection of the pre-annealed hydrogel slurry of particles that formed the resultant scaffold improved left ventricular functions, which were further enhanced with increased angiogenesis and reduced fibrosis and inflammatory response.
    Type: Application
    Filed: July 15, 2021
    Publication date: September 21, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jun Fang, Song Li, Dino Di Carlo, Jaekyung Koh
  • Publication number: 20230284670
    Abstract: Systems and methods for additive manufacturing of biological matter with desired non-homogeneous and non-isotropic textures from deposited 2-D or 3-D printed elements. Desired textures, such as anisotropic structure at the microscale level, are achieved through a combination of controlled chemical, thermal and freezing steps producing crosslinked anisotropic structures by directional solidification. The apparatus has a movable printing platform associated with a heating module and a cooling module separated by a gap that creates a thermal gradient permitting directional solidification of a printed object as the platform moves over the modules.
    Type: Application
    Filed: February 10, 2023
    Publication date: September 14, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Boris Rubinsky, Dan Rubinsky, Gideon Ukpai
  • Publication number: 20230285291
    Abstract: This invention provides improved synthetic exosomes for delivery a one or more therapeutic agents to the central nervous system. In certain embodiments the synthetic exosome comprises a liposome formed from a lipid bilayer, where said lipid bilayer comprises: one or more phospholipids selected from the group consisting of phosphate lipids, phosphoglycerol lipids, phosphocholine lipids, and phosphoethanolamine lipids where the lipid carbon chain ranges from 3 to 24 carbon atoms; cholesterol, a cholesterol derivative (e.g., cholesterol hemicsuccinate), or a phytosterol; and a non-ionic surfactant; wherein the lipid bilayer does not contain an alcohol; and the liposome ranges in size from about 50 nm up to about 200 nm in diameter. Typically, the synthetic exosome is capable of crossing the blood brain barrier without substantially leaking said therapeutic moiety.
    Type: Application
    Filed: April 6, 2021
    Publication date: September 14, 2023
    Applicant: The Regents of the University of California
    Inventors: Jesus Campagna, Varghese John
  • Publication number: 20230285353
    Abstract: We have discovered a chemical cocktail that selectively induces a robust expansion of myogenic stem cells from readily-obtainable dermal cells and from muscle stromal cells. By differential plating and lineage tracing, we show that Pax7+ cells were the major source for chemical-induced myogenic stem cells (CiMCs). We further performed single-cell RNA sequencing (scRNA-seq) analysis to characterize the transcriptomic profile of CiMCs and demonstrate a specific expansion of myogenic cells from heterogeneous dermal cell population. Upon transplantation into the injured muscle, CiMCs were efficiently engrafted and improved functional muscle regeneration in both adult and aged mice. Furthermore, an in situ therapeutic modality using this cocktail was developed by loading the chemical cocktail into injectable nanoparticles, which enabled a sustained release of the cocktail in injured muscle and a local expansion of resident satellite cells for muscle regeneration in adult and aged mice.
    Type: Application
    Filed: July 27, 2021
    Publication date: September 14, 2023
    Applicant: The Regents of the University of California
    Inventors: Jun Fang, Junren Sia, Song Li
  • Publication number: 20230285559
    Abstract: A therapeutic hydrogel material is disclosed for the delivery of CAR-T cells that allows their distribution in the tumor resection recess, cavity, or void in combination with platelets decorated with the anti-programmed death-ligand 1 (PDL1) blocking antibody (aPDL1). The delivered hydrogel material acts as a reservoir for both CAR-T cells and platelet-bound aPDL1. Furthermore, inflammation occurring during the surgical wound healing triggers the release of platelet-derived microparticles containing the aPDL1. Cells delivered by the engineered hydrogel show significant control of local and distant tumor recurrence without causing toxic effects. In some embodiments, nanoparticles containing cytokines are also loaded in the therapeutic hydrogel material to maintain the activity and proliferation ability of CAR-T cells.
    Type: Application
    Filed: July 22, 2021
    Publication date: September 14, 2023
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, NORTH CAROLINA STATE UNIVERSITY
    Inventors: Zhen Gu, Quanyin Hu, Hongjun Li
  • Publication number: 20230287258
    Abstract: A solid state thermochromic polymer film comprising two or more separated solid phases with matched refractive indices, wherein the separated solid phases are transparent; and one of the phases undergoes a crystal melting above a threshold temperature resulting in significant reduction of its refractive index. The one of the phases undergoing the crystal melting becomes opaque when its temperature rises above said threshold temperature; and reverts to being transparent when its temperature lowers to an ambient temperature below said threshold temperature. In one example, the new thermochromic phase-changing copolymer with switchable optical transparency is fabricated via copolymerizing hydrophilic poly(hydroxyethyl acrylate) and hydrophobic poly(hexadecyl acrylate-tetradecyl acrylate). The polymer film is transparent due to matched refractive indices of the phase separated domains, but turns opaque when the long alkyl chains undergoes crystalline melting above 28-32° C.
    Type: Application
    Filed: July 12, 2021
    Publication date: September 14, 2023
    Applicant: The Regents of the University of California
    Inventor: Qibing Pei
  • Publication number: 20230285591
    Abstract: The present invention realtes to lentiviral particles which have been pseudotyped with Nipah virus (NiV) fusion (F) and attachment (G) glycoproteins (NiVpp-F/G). Additionally, the present invention relates to truncated NiV-F glyocproteins useful in producing such NiVpp lentiviral particles, as well as to additional variant peptides which enhance activity. Further, the present invention relates to methods of using such lentiviral particles or sequences, for example in the treatetment of cancer or CNS disorders.
    Type: Application
    Filed: January 6, 2023
    Publication date: September 14, 2023
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Benhur LEE, Karina PALOMARES, Olivier PERNET
  • Publication number: 20230288549
    Abstract: Systems and methods for simultaneously recovering and separate sounds from multiple sources using Impulse Radio Ultra-Wideband (IR-UWB) signals are described. In one embodiment, a device can be configured for generating an audio signal based on audio source ranging using ultrawideband signals. In an embodiment the device includes, a transmitter circuitry, a receiver circuitry, memory and a processor. The processor configured to generate a radio signal. The radio signal including an ultra-wideband Gaussian pulse modulated on a radio-frequency carrier. The processor further configured to transmit the radio signal using the transmitter circuitry, receive one or more backscattered signals at the receiver circuitry, demodulate the one or more backscattered signals to generate one or more baseband signals, and generate a set of data frames based on the one or more baseband signals.
    Type: Application
    Filed: November 15, 2022
    Publication date: September 14, 2023
    Applicants: The Regents of the University of California, Nanyang Technological University
    Inventors: Ziqi Wang, Mani Srivastava, Akash Deep Singh, Luis Garcia, Zhe Chen, Jun Luo
  • Publication number: 20230287072
    Abstract: The present disclosure provides a method of delivery, treatment, and prevention of neuropathy and/or pain associated with NGF treatment for an underline disease or condition with a NGF mutant, such as NGFR100W, that does not elicit pain. The present disclosure further provides a composition of micro- and/or nano-rods attached with the NGF mutant, such as NGFR100W, which are injectable or administered to a target for desired therapies.
    Type: Application
    Filed: August 2, 2021
    Publication date: September 14, 2023
    Applicants: The Regents of the University of California, The Steadman Clinic & Steadman Philippon Research Institute
    Inventors: Chengbiao WU, Kijung SUNG, Chelsea Shileds BAHNEY, Kevin RIVERA, Tejal DESAI