Patents Assigned to Regents of the University of California
  • Patent number: 11460395
    Abstract: A portable colorimetric assay system includes an opto-mechanical reader configured to be detachably mounted to a mobile phone having a camera or other camera-containing portable electronic device. The opto-mechanical reader includes one or more light sources configured to illuminate a test sample holder and control sample holder disposed in the opto-mechanical reader along an optical path aligned with a camera of the mobile phone or other camera-containing portable electronic device. One or more serum separation membranes are disposed in the opto-mechanical reader and define a sample receiving pad configured to receive a blood sample. A moveable serum collection membrane is membrane is also disposed in the reader and is configured to contact the sample receiving pad in a first position and moveable to a second position where the serum collection membrane is disposed inside the test sample holder.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Aydogan Ozcan, Aniruddha Ray, Hyouarm Joung, Derek Tseng, Isidro B. Salusky
  • Patent number: 11462677
    Abstract: A diaphragm for a piezoelectric micromachined ultrasonic transducer (PMUT) is presented having resonance frequency and bandwidth characteristics which are decoupled from one another into independent variables. Portions of at least the piezoelectric material layer and backside electrode layer are removed in a selected pattern to form structures, such as ribs, in the diaphragm which retains stiffness while reducing overall mass. The patterned structure can be formed by additive, or subtractive, fabrication processes.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bernhard Boser, David Horsley, Richard Przybyla, Ofer Rozen, Stefon Shelton
  • Patent number: 11461496
    Abstract: A system is provided for de-identifying electronic records. The system may be configured to tokenize an electronic record to produce a plurality of tokens including a first token. The system may determine whether the first token is part of one of a plurality of expressions known to include protected health information. In response to determining that the first token is not part of any one of the plurality of expressions, the system may determine, based on a blacklist of tokens known to include protected health information, whether the first token includes protected health information. In response to determining that the first token includes protected health information, the system may generate a de-identified electronic record by replacing the first token with a second token obfuscating the protected health information. Related methods and computer program products are also provided.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of California
    Inventors: Beau Norgeot, Atul Butte, Gundolf Schenk, Eugenia Rutenberg
  • Patent number: 11464031
    Abstract: Techniques include retrieving from storage a plurality of policies for sharing a shared channel among nodes in a data communications network. The plurality of polices define a tree of periodic schedules of variable periods, each policy defines a transmit time slot as a unique slot i of a modulus of a power m of a base b of a series of time slots, where m indicates a level of the tree of periodic schedules. The method also includes; observing at a first node the probabilities of empty time slots, successful time slots, and collision time slots on the shared channel; selecting at the first node a first policy among the plurality of policies based on the probabilities observed instead of a message received from a central authority; and transmitting a local data packet from the first node onto the shared channel at a transmit time based on the first policy.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of California
    Inventors: Jose Joaquin Garcia-Luna-Aceves, Luca de Alfaro, Molly Zhang
  • Patent number: 11458575
    Abstract: A device for shaping tissue includes a tip with an internal close-looped circulation system. The tip is configured to connect to tubes. One tube is configured to connect to a submersible cold-water pump. Another tube is an outlet. The tip has a sapphire window on one face and, on opposite face, a shaft with a laser fiber therein, and an opening for laser beam to shine through.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Brian Jet-Fei Wong, Guillermo Aguilar, Dmitry Protsenko, Lars Svaasand, Cara Chlebicki
  • Patent number: 11459385
    Abstract: The present invention provides antibodies, or antigen-binding portions thereof, which specifically bind to IL-2 and reduce the affinity of IL-2 binding to IL-2R? and IL-2R?. The invention further provides a method of obtaining such antibodies and nucleic acids encoding the same. The invention further relates to compositions and therapeutic methods for use of these antibodies for the treatment and/or prevention of autoimmune diseases, disorders or conditions and for immunosuppression, including, but not limited to, administering a complex comprising the antibody and IL-2.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 4, 2022
    Assignees: The Regents of the University of California, The Board of Trustees of the Leland Stanford Junior University, Pfizer, Inc.
    Inventors: Isaac J. Rondon, Natasha Crellin, Paul Bessette, Eleonora Trotta, Jeffrey A. Bluestone, Lauren K. Ely, Kenan C. Garcia
  • Patent number: 11458431
    Abstract: An adsorption material is disclosed that comprises a metal-organic framework and a plurality of ligands. The metal-organic framework comprising a plurality of metal ions. Each respective ligand in the plurality of ligands is amine appended to a respective metal ion in the plurality of metal ions of the metal-organic framework. Each respective ligand in the plurality of ligands comprises a substituted 1,3-propanediamine. The adsorbent has a CO2 adsorption capacity of greater than 2.50 mmol/g at 150 mbar CO2 at 40° C. Moreover, the adsorbent is configured to regenerate at less than 120° C. An example ligand is diamine 2,2-dimethyl-1,3-propanediamine. An example of the metal-organic framework is Mg2(dobpdc), where dobpdc4? is 4,4?-dioxidobiphenyl-3,3?-dicarboxylate. Example applications for the adsorption material are removal of carbon dioxide from flue gas and biogasses.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeffrey R. Long, Phillip J. Milner, Rebecca L. Siegelman
  • Patent number: 11459600
    Abstract: The present disclosure provides methods for detecting a single-stranded target RNA. The present disclosure provides methods of cleaving a precursor C2c2 guide RNA array into two or more C2c2 guide RNAs. The present disclosure provides a kit for detecting a target RNA in a sample.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Mitchell Ray O'Connell, Alexandra East-Seletsky, Spencer Charles Knight, James Harrison Doudna Cate
  • Patent number: 11458038
    Abstract: A heat exchange module having a heat transfer fluid channel and a heat transfer plate in heat transfer relation with fluid in the channel. The reference side of a thermoelectric cooler (TEC) is in thermal contact with the plate. A heat transfer tile is in thermal contact with a user side of the TEC. The module is configured to be operatively positionable with the tile in heat transfer relation with skin of a patient.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: October 4, 2022
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, HYPOTHERMIA DEVICES, INC.
    Inventors: Julio L. Vergara, Daniel M. Estrada, Mayank Kalra, Andrew Padula, Daniel E. Cuadra, Ryan C. Cohn
  • Patent number: 11458107
    Abstract: The present invention relates generally to compositions and methods comprising abiotic, synthetic polymers with affinity and specificity to proteins. The synthetic polymers are an improvement over biological agents by providing a simpler, less expensive, and customizable platform for binding to proteins. In one embodiment, the compositions and methods relate to synthetic polymers with affinity and specificity to vascular endothelial growth factor (VEGF). In one embodiment, the compositions are useful for treating diseases and disorders related to the overexpression of VEGF. In one embodiment, the compositions are useful for treating cancer. In one embodiment, the compositions are useful for detecting VEGF levels from biological samples. In one embodiment, the compositions are useful for detecting overexpression of VEGF from biological samples. In one embodiment, the compositions are used to diagnose cancer.
    Type: Grant
    Filed: August 25, 2017
    Date of Patent: October 4, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kenneth J. Shea, Hiroyuki Koide, Yoshiko Miura, Yu Hoshino, Yuri Nishimura, Naoto Oku
  • Patent number: 11459599
    Abstract: The present disclosure provides methods for detecting a single-stranded target RNA. The present disclosure provides methods of cleaving a precursor C2c2 guide RNA array into two or more C2c2 guide RNAs. The present disclosure provides a kit for detecting a target RNA in a sample.
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of California
    Inventors: Jennifer A. Doudna, Mitchell Ray O'Connell, Alexandra East-Seletsky, Spencer Charles Knight, James Harrison Doudna Cate
  • Patent number: 11457941
    Abstract: In one embodiment, an articulable endoscopic instrument including an articulable retractor configured to pass through a working channel of an endoscope, the articulable retractor including an end effector mounted to a distal end of the articulable retractor, and a handle to which the articulable retractor is mounted, the handle comprising controls that enable a user of the instrument to both articulate the retractor and actuate the end effector, wherein the retractor can be articulated using the controls to form two independent bends lying within one plane, the bends together forming a complex curve.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 4, 2022
    Assignee: The Regents of the University of California
    Inventors: Matthew Lin, Dillon Kwiat, Neil Ray, Stanley Rogers
  • Publication number: 20220304596
    Abstract: The disclosed embodiments relate to a system that performs ultra-fast tracer imaging on a subject using positron emission tomography. During operation, the system performs a high-temporal-resolution, total-body dynamic PET scan on the subject as an intravenously injected radioactive tracer propagates through the vascular system of the subject to produce PET projection data. Next, the system applies an image reconstruction technique to the PET projection data to produce subsecond temporal frames, which illustrate the dynamic propagation of the radioactive tracer through the vascular system of the subject. Finally, the system outputs the temporal frames through a display device.
    Type: Application
    Filed: July 16, 2020
    Publication date: September 29, 2022
    Applicant: The Regents of the University of California
    Inventors: Xuezhu Zhang, Jinyi Qi, Simon R. Cherry, Ramsey D. Badawi, Guobao Wang
  • Publication number: 20220305098
    Abstract: Angelman syndrome is a genetic neurological disorder with characteristics including delayed development, intellectual disability, severe speech impairment, and problems with movement and balance. Provided herein are polynucleotides, vectors, polypeptides, cells, compositions, kits and methods to treat Angelman syndrome.
    Type: Application
    Filed: August 21, 2020
    Publication date: September 29, 2022
    Applicant: The Regents of the University of California
    Inventor: Joseph Anderson
  • Publication number: 20220304928
    Abstract: Synthetic liposomal nanoparticles comprising a cell-free transcription and translation machinery, a plasmid encoding a cytokine, and a regulatable caged ATP molecule, as well as microparticles encasing the synthetic liposomal nanoparticles and methods of making and using the synthetic liposomal nanoparticles, are described herein. These liposomal nanoparticles may be used for the controlled release o a cytokine within a localized environment of, for example a tumor, as part of a therapeutic treatment of cancer, or for localized treatment at a focus of interest of an autoimmune disease, an allergic reaction or hypersensitivity reaction, a localized site of an infection or infectious disease, a localized site of an injury or other damage, a transplant or other surgical site, or a blood clot. Further, microparticles produced by encapsulating hundreds of liposomal nanoparticles, and their therapeutic uses, are also described.
    Type: Application
    Filed: September 18, 2020
    Publication date: September 29, 2022
    Applicant: The Regents of the University of California
    Inventors: Manish J. BUTTE, Mohammad Mahdi HASANI-SADRABADI, Fatemeh S. MAJEDI
  • Publication number: 20220304631
    Abstract: Systems and methods are provided for the non-invasive computation of Pulmonary Artery Pressure (and its components of mean, systolic and diastolic) (PAP) as well as Pulmonary Capillary Wedge Pressure (and its components of mean, A-Wave and V-Wave) (PCWP) using a wearable sensor device. Cardiac acoustic and electrocardiogram sensor signals are obtained and multiple temporal, amplitude-based, and spectral features are extracted from the signals. Extracted features from a subject are used as inputs for pre-trained classification, regression, or advanced machine learning models to provide an accurate computation of PAP and PCWP and their associated component values without surgery.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 29, 2022
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SENSYDIA CORPORATION
    Inventors: William J. Kaiser, Christopher Baek, Per Henrik Borgstrom, Aman Mahajan, Kanav Saraf, Michael Wasko, Xu Zhang, Yi Zheng
  • Publication number: 20220304766
    Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.
    Type: Application
    Filed: March 24, 2022
    Publication date: September 29, 2022
    Applicants: UROGEN PHARMA LTD., The Regents of the University of California
    Inventors: Ralph V. CLAYMAN, Pengbo Jiang, Mark Schoenberg, Omer Tsipori
  • Publication number: 20220307050
    Abstract: Provided herein are new compositions and methods for use in introducing transgenes into cells. The compositions are non-viral but achieve levels of transgene integration comparable to those obtained with viral-mediated methods, and can be used for targeted integration of a transgene at a specific genomic locus.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 29, 2022
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Chih-Wen NI, Chang-Ying CHIANG
  • Publication number: 20220308061
    Abstract: The disclosure provides methods and materials useful for obtaining novel TCR gene sequences that are useful in tumor-specific T cell receptor (TCR) gene transfer. Embodiments of the invention also include methods of crosslinking and permeabilizing mammalian cells that can, for example, be used in methods for obtaining novel TCR gene sequences. The disclosure further provides methods and materials useful for obtaining novel TCR gene sequences. Tumor-specific T cell receptor gene transfer enables specific and potent immune targeting of tumor and viral antigens, and for this reason is technology of significant interest to medical personnel.
    Type: Application
    Filed: September 2, 2020
    Publication date: September 29, 2022
    Applicant: The Regents of the University of California
    Inventors: Owen N. Witte, Pavlo A. Nesterenko, Jami McLaughlin Witte
  • Patent number: 11453891
    Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: September 27, 2022
    Assignee: The Regents of the University of California
    Inventors: Eugene Yeo, Kristopher Brannan, Ryan Marina, David Nelles