Patents Assigned to Regents of the University of California
  • Publication number: 20250145733
    Abstract: Disclosed herein are monospecific and bispecific antibodies that comprise a ALPPL2/ALPP-binding variable region. The bi-specific antibody is comprises of a monoclonal antibody targeting a tumor-specific cell surface antigen (ALPPL2/ALPP) with exquisite tissue specificity and a monoclonal antibody targeting a cell surface molecule (e.g., CD3) expressed by immune effector cells.
    Type: Application
    Filed: September 21, 2022
    Publication date: May 8, 2025
    Applicant: The Regents of the University of California
    Inventors: Bin Liu, Scott Bidlingmaier, Yang Su
  • Publication number: 20250147006
    Abstract: Fluidic systems, devices and methods are provided for separating and sequestering particles from a fluid flow within traps in a fluidic chip is provided. The fluidic platform is particularly suited for parallel live zebrafish embryo studies providing automated zebrafish embryo trapping and flow through culture as well as whole mount zebrafish antibody staining functions. The zebrafish on a chip testing platform uses a chaotic hydrodynamic trapping process to trap and retain zebrafish embryos in a consistent body orientation (i.e., head pointed inward) without any external adjustments. The system and apparatus can also be adapted to be a multifunctional concentration gradient generator (CGG) that can be used to automatically immobilize dechorionated zebrafish embryos and generate chemical gradients for acute fish embryo toxicity (FET) tests.
    Type: Application
    Filed: November 7, 2024
    Publication date: May 8, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Songtao Ye, Chih-Wen Ni
  • Publication number: 20250143596
    Abstract: The present embodiments relate generally to a soft system for producing a giant magnetoelastic effect. In some embodiments, the soft system is composed of platinum-catalyzed silicone polymer matrix and neodymium-iron-boron nanomagnets. The soft system shows up to four times more enhancement of the magnetomechanical coupling factor (T/Pa) than traditional rigid counterparts owing to a distinct physical mechanism. In embodiments, the giant magnetoelastic effect is coupled with magnetic induction to implement a soft magnetoelastic generator (MEG) as an approach to biomechanical energy conversion, a technology that was heretofore conventionally challenged by low current, high internal impedance, and low water/humidity resistance for decent operation stability. This new method of biomechanical-to-electrical conversion is intrinsically waterproof since the magnetic fields are able to penetrate water with negligible intensity loss.
    Type: Application
    Filed: September 23, 2022
    Publication date: May 8, 2025
    Applicant: The Regents of the University of California
    Inventor: Jun CHEN
  • Publication number: 20250145968
    Abstract: The present disclosure provides methods and compositions for modifying the genomes of bacteriophages, in particular by integrating a coding sequence for an anti-CRISPR protein into the bacteriophage genome together with a desired modification such as a deletion, insertion, or nucleotide substitution, and selecting for bacteriophages with the integrated anti-CRISPR coding sequence by introducing the phage into a counter selection strain comprising an RNA-targeting CRISPR-Cas system.
    Type: Application
    Filed: February 8, 2023
    Publication date: May 8, 2025
    Applicant: The Regents of the University of California
    Inventors: Joseph Bondy-Denomy, Jingwen Guan, Senen Mendoza
  • Publication number: 20250144147
    Abstract: Provided herein are compositions, systems, and methods to provide two gene editing-based approaches that can be used to correct the CD35 SCID-causing C202T mutation (TGA?CGA). In certain embodiments one approach involves CRISPR/Cas9 homology-directed repair (HDR)-mediated correction with a single-strand oligodeoxynucleotide (ssODN) homologous donor. In certain embodiments another approach comprises Adenine Base Editing (ABE)-correction, to precisely revert the CD35 SCID-causing C202T mutation (TGA?CGA).
    Type: Application
    Filed: January 27, 2023
    Publication date: May 8, 2025
    Applicant: The Regents of the University of California
    Inventors: Donald B. KOHN, Grace MCAULEY
  • Publication number: 20250144608
    Abstract: A method of upcycling polymers to useful hydrocarbon materials. A catalyst with nanoparticles on a substrate selectively docks and cleaves longer hydrocarbon chains over shorter hydrocarbon chains. The catalyst includes metal nanoparticles in an order array on a substrate.
    Type: Application
    Filed: January 6, 2025
    Publication date: May 8, 2025
    Applicants: UCHICAGO ARGONNE, LLC, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CORNELL UNIVERSITY, NORTHWESTERN UNIVERSITY, IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Massimiliano Delferro, Magali S. Ferrandon, Kenneth R. Poeppelmeier, Aaron D. Sadow, Susannah Scott, Anne M. LaPointe, Geoffrey Coates
  • Publication number: 20250143566
    Abstract: Phase-based optoretinography (ORG) is performed using tissue velocity obtained from a modified optical coherence tomography (OCT) system. A swept-source generated OCT A-scan is used to assemble a 2-dimensional profile of the retinal tissue (B-scan) by laterally scanning the imaging beam. These B-scans can be taken at multiple time-points and assembled into a M-scan, which displays motion of a particular cross-section of retinal tissue (after correction for bulk motion). The method captures the changes between each timestep of the M-scan to deduce tissue velocities of the COST, ROST, and IS/OS, among others. An initial contraction of outer segments is detected in outer segments, followed by an elongation shortly thereafter. The tissue velocity measurements can be used to infer retinal dysfunction without the need for costly and computationally expensive scans using adaptive optics.
    Type: Application
    Filed: November 7, 2024
    Publication date: May 8, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ravi S. Jonnal, Robert J. Zawadzki, Kari V. Vienola
  • Patent number: 12292046
    Abstract: A microfluidic tissue dissociation and filtration device simultaneously filters large tissue fragments and dissociates smaller aggregates into single cells, thereby improving single cell yield and purity. The device includes an inlet coupled to a first microfluidic channel at an upstream location and a first outlet at a downstream location. A first filter membrane is interposed between the first microfluidic channel and a second microfluidic channel, wherein the second microfluidic channel is in fluidic communication with the first microfluidic channel via the first filter membrane. The first filter membrane operates under a tangential flow format. A second outlet is coupled to a downstream location of the second microfluidic channel and includes a second filter membrane interposed between the second outlet and the second microfluidic channel. The dual membrane device increased single cell numbers by at least 3-fold for different tissue types.
    Type: Grant
    Filed: May 29, 2019
    Date of Patent: May 6, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jered Haun, Xiaolong Qiu, Marissa Noelani Pennell, Elliott E. Hui
  • Patent number: 12292445
    Abstract: Provided herein are methods for selecting a subject with a seizure disorder for treatment, as well as methods of treating the subject, determining the efficacy of the treatment, and adjusting the treatment dosage and frequency. In some aspects, provided herein are methods of treating seizures in a subject by administering to the subject a composition comprising bacteria of the Akkermansia (Akk) and Parabacteroides (Pb) genera.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: May 6, 2025
    Assignee: The Regents of the University of California
    Inventors: Elaine Y. Hsiao, Jessica Yano, Helen E. Vuong, Christine Olson
  • Patent number: 12290659
    Abstract: Systems and methods for Endovascular Perfusion Augmentation for Critical Care (EPACC) are provided. The system may include a catheter having an expandable aortic blood flow regulation device disposed on the distal end of the catheter for placement within an aorta of a patient. The system may also include a catheter controller unit that causes the expandable aortic blood flow regulation device to expand and contract to restrict blood flow through the aorta.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: May 6, 2025
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE
    Inventors: Michael Austin Johnson, Lucas Paul Neff, Timothy Williams
  • Patent number: 12290373
    Abstract: Fixational eye movement may be analyzed to determine one or more characteristics thereof. Exemplary characteristics include measurements of microsaccade and drift measurement. These measurements may be correlated to a value for a diagnostic indicator for a neurological disorder or disease. These correlations may be used to diagnose, monitor, and prognosticate neurological disorders without administration of traditionally used neurological function tests or analysis of biological samples by which the diagnostic indicators are typically determined.
    Type: Grant
    Filed: April 26, 2019
    Date of Patent: May 6, 2025
    Assignees: C. Light Technologies, Inc., The Regents of the University of California
    Inventors: Christy K. Sheehy, Ari Green, Zachary Helft
  • Publication number: 20250140893
    Abstract: A battery cell pressing system may include a sealed case having an internal chamber, the sealed case including at least one window to allow visual inspection of the internal chamber; a pouch-type battery cell disposed within the internal chamber of the sealed case; a fluid filling the internal chamber and surrounding the pouch-type battery cell; a fluid entrance in fluid communication with the internal chamber; a pressing member configured to adjust a pressure of the fluid within the internal chamber such that the pressure at which the fluid presses the pouch-type battery cell is approximately 1 MPa to 10 MPa; a heater configured to heat the fluid within the internal chamber; and a pressure measuring member configured to measure the pressure within the internal chamber. The fluid isotropically presses the pouch-type battery cell during at least one of charging and discharging of the pouch-type battery cell.
    Type: Application
    Filed: October 29, 2024
    Publication date: May 1, 2025
    Applicants: LG ENERGY SOLUTION, LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeongbeom LEE, Min-Sang SONG, Yu-Ting CHEN, Ying Shirley MENG
  • Publication number: 20250140894
    Abstract: A method of controlling a cycling pressure of a secondary battery can include assembling the secondary battery by stacking a cathode, a separator, and an anode in order; activating the secondary battery by applying a pressure of about 5 MPa or less; and cycling the secondary battery by applying the pressure of about 5 MPa or less.
    Type: Application
    Filed: October 29, 2024
    Publication date: May 1, 2025
    Applicants: LG ENERGY SOLUTION, LTD., THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jeongbeom LEE, Min-Sang SONG, Yu-Ting CHEN, Ying Shirley MENG
  • Publication number: 20250136441
    Abstract: Systems, processes and devices are provided for wafer-level fabrication of a resonator. A process is provided that includes chemical etching of glass and silicon, high-temperature glassblowing, controlling assembly of at least one YIG sphere relative to a nest structure, and plasma assisted wafer bonding. The process can include formation of loop coils and spherical coils defined by the glassblowing process including inner and outer hemispherical structures. The inner hemispherical structure may provide loops to drive and detect resonance in YIG spheres. Processes discussed herein allow for placement of loops in close proximity (e.g., few microns) to ferrimagnetic elements. The outer hemisphere may provide harmonic magnetic coils for frequency tuning. Embodiments are also directed to a resonator including first and second wafer-level glass blown wafer stacks each with inner hemisphere and outer hemispheres.
    Type: Application
    Filed: January 19, 2023
    Publication date: May 1, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Andrei M. SHKEL, Danmeng WANG, Austin R. PARRISH
  • Publication number: 20250139446
    Abstract: A system for automatically self-labeling a digital dataset includes a first sensor for generating a first data stream, a second sensor for collecting information to generate a second data stream, and a causal model manager (CMM). The CMM is configured to determine a first causal event from a first data segment of the first data stream, and a causal relation between the first causal event and a second data segment selected from the second data stream. The system further includes (a) an interactive time model for determining an interaction time between the first and second data segments, and (b) a self-labeling subsystem configured to derive a label from the second data segment, associate the first data segment with the derived label, form a self-labeled data pair from the associated first data segment and the derived label, and automatically annotate the self-labeled data pair with the interaction time.
    Type: Application
    Filed: October 24, 2024
    Publication date: May 1, 2025
    Applicant: The Regents of The University of California
    Inventors: Guann Pyng Li, Yutian Ren
  • Publication number: 20250137050
    Abstract: Described are methods for identifying an ASD risk gene, NHIP, and methods for determining the risk of an offspring for developing an ASD. A common structural variant disrupting the proximity of NHIP to a fetal brain enhancer was associated with NHIP expression and methylation levels and ASD risk, demonstrating a common genetic influence. NHIP is a novel environmentally-responsive ASD risk gene relevant to brain development in a previously under characterized region of the human genome.
    Type: Application
    Filed: June 17, 2022
    Publication date: May 1, 2025
    Applicant: The Regents of the University of California
    Inventor: Janine M. LaSalle
  • Publication number: 20250138296
    Abstract: Quantitative phase imaging (QPI) is a label-free computational imaging technique that provides optical path length information of objects. Here, a diffractive QPI network architecture is disclosed that can synthesize the quantitative phase image of an object by converting the input phase information of a scene or object(s) into intensity variations at the output plane. A diffractive QPI network is a specialized all-optical device designed to perform a quantitative phase-to-intensity transformation through passive diffractive/reflective surfaces that are spatially engineered using deep learning and image data. Forming a compact, all-optical network that axially extends only ˜200-300? (?=illumination wavelength), this framework replaces traditional QPI systems and related digital computational burdens with a set of passive substrate layers.
    Type: Application
    Filed: January 13, 2023
    Publication date: May 1, 2025
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Aydogan Ozcan, Deniz Mengu
  • Patent number: 12285472
    Abstract: The invention provides a composition, and method of use thereof, comprising self-antigen displaying nanoparticles to target auto-reactive immune components for treating and/or preventing the autoimmune diseases associated therewith. The nanoparticles can also be loaded with cytotoxic drugs for targeted cell killing or with immune-tolerizing compounds to normalize the immune regulation.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: April 29, 2025
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Liangfang Zhang, Che-Ming Jack Hu, Jonathan Copp, Ronnie H. Fang, Brian T. Luk
  • Patent number: 12287325
    Abstract: In certain embodiments methods of identifying T cell receptors that respond to specific target cell antigens are provided, where the methods comprise providing a substrate bearing a plurality of target cells (e.g., mammalian cells); contacting the target cells on the substrate with CD8+ T cells; and using label-free optical imaging to identify an increase in mass of a T-cell and/or a decrease in mass of a target cell, where an increase in mass of a T cell and/or a decrease in mass of a target cell is an indicator that said T cell bears a T cell receptor activated by antigens presented on said target cell.
    Type: Grant
    Filed: December 17, 2020
    Date of Patent: April 29, 2025
    Assignee: The Regents of the University of California
    Inventors: Michael A. Teitell, Thomas A. Zangle, Owen M. Witte, Daina Burnes Linton
  • Patent number: 12285404
    Abstract: The disclosure demonstrates the role of mast cell stabilizers in treating rosacea. The disclosure also shows the role of mast cells, cathelicidin, serine protease and/or vitamin D3 in rosacea pathology and the use of antagonists and inhibitors thereof to treat rosacea.
    Type: Grant
    Filed: June 7, 2022
    Date of Patent: April 29, 2025
    Assignee: The Regents of the University of California
    Inventors: Richard L. Gallo, Anna Di Nardo, Yumiko Muto