Abstract: The present disclosure arises at least in part from the seminal recognition that a combination treatment regimen including one or more cycles and/or doses of a checkpoint inhibitor and a therapeutic, either sequentially, in either order, or substantially simultaneously, can be more effective in treating cancer in some subjects and/or can initiate, enable, increase, enhance or prolong the activity and/or number of immune cells, or a medically beneficial response by a tumor.

Abstract: The present embodiments provide a solution for clock delivery, distribution to an entire waferscale system composed of many chiplets. A clock distribution scheme according to embodiments is also fault tolerant, i.e., the clock distribution network can avoid faulty chiplets on the substrate and reliably distribute clock to all the functional chiplets which are accessible by the network.

Abstract: Methods for utilizing a nucleic acid-based multilevel perceptron are provided.

Abstract: The present disclosure relates to techniques for developing artificial intelligence algorithms by distributing analytics to multiple sources of privacy protected, harmonized data. Particularly, aspects are directed to a computer implemented method that includes receiving an algorithm and input data requirements associated with the algorithm, identifying data assets as being available from a data host based on the input data requirements, curating the data assets within a data storage structure that is within infrastructure of the data host, and integrating the algorithm into a secure capsule computing framework. The secure capsule computing framework serves the algorithm to the data assets within the data storage structure in a secure manner that preserves privacy of the data assets and the algorithm. The computer implemented method further includes running the data assets through the algorithm to obtain an inference.

Abstract: Provided are methods and yeast cultures for producing polyol lipids and polyol lipid compositions.

Abstract: A gas diffusion air-cathode is made with a non-reacting metal as the supporting conducting substrate, such as in the form of a stainless steel mesh.

Abstract: A bioorthogonal catalytic patch integrates TiO2 nanosheets populated with metallic nanoparticles into polyvinyl alcohol-based microneedles arranged in an array. This bioorthogonal patch-based device is robust, removable and can effectively mediate the conversion of caged substrates into their active states once placed at the site of application. The capacity of the patch in executing bioorthogonal catalysis in high-level living systems was demonstrated by localized dealkylation of a caged doxorubicin prodrug at the melanoma tumor site and restoration of its pharmacological properties for cancer therapy. This in situ applied patch facilitated to enhance the local treatment efficacy and eliminate off-targeted prodrug activation or dose-dependent side effect towards healthy organs or tissues located away from the application site.

Abstract: Two approaches for on-chip ESD detection include variable dielectric width capacitor, and vertical metal-oxide-semiconductor (MOS) capacitor MOSCAP array. The variable dielectric width capacitor approach employs metal plates terminated with sharp corners to enhance local electric field and facilitate ready breakdown of a thin dielectric between the metal plates. The vertical MOSCAP array is composed of a capacitor array connected in series. Both approaches are incorporated in an example 22 nm fully depleted silicon-on-insulator. Vertical MOSCAP arrays detect ESD events starting from about 6 V with about 6 V granularity, while the variable dielectric width capacitor is suitable for detection of high ESD voltage from about 40 V and above.

Abstract: The application relates to phthalazine derivatives of formula (I) which are inhibitors of PARP1, PARP2 and/or tubulin and thus useful for the treatment of cancer. Also disclosed are pharmaceutical formulations containing such compounds, as well as combinations of these compounds with at least one additional therapeutic agent.

Abstract: A method for obtaining a smooth surface of an epi-layer with epitaxial lateral overgrowth. The method does not use mis-cut orientations and does not suppress the occurrence of pyramidal hillocks, but instead embeds the pyramidal hillocks in the epi-layer. A growth restrict mask is used to limit the expansion of the pyramidal hillocks in a lateral direction. The surface of the epi-layer becomes extremely smooth due to the disappearance of the pyramidal hillocks.

Abstract: Triazabicylodecene can effectively n-dope a variety of organic semiconductors, including PCBM, thus increasing in-plane conductivities. We synthesized a series of TBD-based n-dopants via an N-alkylation reaction and studied the effect of various alkyl chains on the physical and device properties of the dopants. Combining two TBD moieties on a long alky chain gave a solid dopant, 2TBD-C10, with high thermal stability above 250° C. PCBM films doped by 2TBD-C10 were the most tolerant to thermal annealing and reached in-plane conductivities of 6.5×10?2 S/cm. Furthermore, incorporating 2TBD-C10 doped PCBM as the electron transport layer (ETL) in methylammonium lead triiodide (MAPbI3) based photovoltaics led to a 23% increase in performance, from 11.8% to 14.5% PCE.

Abstract: Solid electrolyte compositions and solid-state batteries are disclosed, which comprise a solid electrolyte layer including a sulfide-containing solid-state electrolyte material and a compound of Chemical Formula 1. The sulfide-containing solid-state electrolyte material includes but is not limited to Li6PS5Cl (“LPSC”), an LPS-based glass or glass ceramic of formula xLi2S·yP2S5, wherein x+y=1, or an argyrodite-based sulfide-based solid electrolyte or formula Li6PS5X, wherein X=Cl, Br, or I) or Li6?yPS5?yCl1+y, where y is <1. In some aspects, the compound of Chemical Formula 1 is sodium 3-mercapto-1-propanesulfonate (3M1P).

Abstract: Methods are provided for treating a subject for an EGFRvIII expressing glioblastoma. The methods of the present disclosure involve administering to the subject a molecular circuit that is primed by EGFRvIII to induce one or more encoded therapeutics specific for one or more antigens expressed by the glioblastoma. Nucleic acids containing sequences encoding all or portions of such circuits are also provided, as well as cells, expression cassettes and vectors that contain such nucleic acids. Also provided are kits for practicing the described methods.

Abstract: Proteins are labeled by contacting the protein with a thiophosphorodichloridate reagent under conditions to effect chemoselective histidine conjugation.

Abstract: The present invention discloses methods and compositions for treating or ameliorating a condition associated with increased or decreased myofibroblast activities and use thereof.

Abstract: Filtering visible radiation from thermal radiation is valuable in decreasing noise in thermal imaging applications. The present disclosure relates to filter for filtering thermal radiation from a beam including both thermal radiation and visible radiation. A film made of particles with an average size and an average pore size is formed on a substrate. The average size and average pore size are greater than or equal to the wavelength of visible radiation but less than the wavelength of thermal or infrared radiation. Thus, in some cases, the film may be substantially transparent infrared radiation and substantially reflective or substantially absorptive to visible radiation. In other cases, the film may be substantially reflective to infrared radiation and substantially transparent or substantially absorptive to visible radiation.

Abstract: According to one aspect, a variable friction shoe sole includes a midsole body, one or more compressible portions comprised of a compressible material, one or more low-friction portions vertically aligned with the one or more compressible portions, and one or more intermediate layers located between the one or more low-friction portions and the one or more compressible portions. The one or more low-friction portions are prominent of the midsole body when vertical ground reaction forces (GRFs) applied to the variable friction shoe sole are low, and wherein an increase in GRFs compresses the one or more compressible portions and causes the one or more low-friction portions to retract inwards.

Abstract: In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

Abstract: A cathode for a high voltage lithium-ion secondary battery is described, including: an electrode layer having an electrode composition containing cathode active particles, fluoropolymer binder and conductive carbon. The cathode active particles are high voltage lithium transition metal oxides, the fluoropolymer binder is a fibrillated tetrafluoroethylene polymer having high melt creep viscosity, and the conductive carbon is carbon fibers having a specific surface area of about 50 m2/g or less. The carbon fibers and the fluoropolymer binder form a conducting structural web electronically connecting the cathode active particles, enabling electronic conductivity through the electrode layer. The electrode layer is adhered to a current collector comprising aluminum having surface roughness and substantially no carbon surface coating other than the conductive carbon of the electrode layer.

Abstract: Systems and methods for performing optical coherence tomography (OCT) on a target using microcomb lasers in accordance with embodiments of the invention are illustrated. One embodiment includes an OCT system that includes a laser generator configured to generate a laser beam, and an optical amplifier configured to amplify the laser beam, a microresonator configured to receive the amplified laser beam and couple the received laser beam into the microresonator to generate a microcomb laser, a grating configured to filter the generated microcomb laser, an interferometer configured to split the generated microcomb laser into a sample arm and a reference arm, an OCT probe configured to generate tomograms of a target using the sample arm, and a spectrometer configured to obtain depth information from the interferogram and generate cross-sectional images of the target based on the obtained depth information.