Abstract: A method of diagnosis of Ménière's disease (MD) by performing genetic testing using a panel of gene mutations, including single nucleotide polymorphisms (SNPs), insertions and/or deletions (IN/DELs), in Ménière's disease-associated genes, providing genetic basis for MD. A method of treatment of MD by targeting the SNPs and/or IN/DELs gene mutations in Ménière's disease-associated genes, and/or by CRISPR or gene therapy or editing on the SNPs and/or IN/DELs gene mutations in Ménière's disease-associated genes.

Abstract: Disclosed herein are methods, probes, and kits for diagnosing the presence of cancer and/or a cancer type in a subject.

Abstract: The invention disclosed herein provides methods and materials designed to improve organ transplantation outcomes. Embodiments of the invention include methods for administering the drug belumosudil to patients who have undergone an organ or other tissue transplantation (e.g., transplantation of a solid donor organ such as a kidney and/or receiving an infusion of donor stem cells such as CD34+ cells). In these methods, transplantation patients to whom belumosudil is administered are selected to be those not suffering from graft versus host disease (GVHD).

Abstract: A power amplifier (amp) includes a first transistor configured in the common source (CS) amplification mode, wherein the gate terminal of the first transistor is the input port of the power amp; and a second transistor configured in the common gate (CG) amplification mode, wherein the drain terminal of the second transistor is the output port of the power amp. The power amp also includes a first inductive component coupled between the drain terminal of the first transistor and the ground to increase the impedance between the drain terminal of the first transistor and the ground, thereby increasing an output power at the output port. The power amp additionally includes a second inductive component coupled between the drain terminal of the first transistor and the source terminal of the second transistor to increase the conductance in the output admittance at the output port, thereby further increasing the output power.

Abstract: The disclosure relates to methods and compositions to treat an eosinophilic disease or disorder. More particularly, the disclosure provides methods and compositions for treating eosinophilic esophagitis.

Abstract: The present disclosure provides a method for preparing an aerogel or a foam, the method comprising: forming a reaction mixture comprising a cellulose nanofibril gel, a first solvent, and one or more crosslinking agents under conditions sufficient to crosslink the gel; and contacting the crosslinked gel with a second solvent under conditions sufficient to dry the crosslinked gel, thereby forming an aerogel or foam.

Abstract: Supercooled water or solutions can be destabilized by the nucleation of ice. Constraining water in a constant-volume (isochoric) container minimizes destabilization through thermodynamic, kinetic, and fluid dynamic means, significantly enhancing supercooling stability. Methods and devices are used for stable and transportable supercooling of aqueous solutions or suspensions, and the stable and long-term preservation of biological matter that may be stored therein.

Abstract: Biocompatible and biodegradable polymers are provided herein as compositions, methods, and systems for making the compositions. These polymers can be adjustably stable and used in medical applications as adhesives and sealants, and in non-medical applications. Radical polymerization protocols, and two-step cationic and radical polymerization protocols, are provided for the creation of stable, polydisulfide polymers, which can be done in aqueous solution and at ambient and in vivo temperatures ranging, for example, from 0° C. to 37° C. The compositions are biocompatible and can be used as fast curing, biocompatible and biodegradable adhesives and sealants suitable for use in the consumer, industrial, military and medical arts, namely as a functional biomaterial, sustainable plastic, surgical superglue, bone adhesive, pressure-sensitive adhesive, structural adhesive, and other relevant sustainable materials with closed-loop recycling.

Abstract: Provided herein are pharmaceutical formulations comprising a 1,2-HOPO chelating agent and/or a 3,2-HOPO chelating agent.

Abstract: Methods, apparatus and systems are described that relate to uncooled long-wave infrared (LWIR) photodetectors capable of operating at room temperature and having a simple structure that can be manufactured at low cost. One example LWIR photodetector includes a layer of amorphous silicon (a-Si) disposed on a silicon substrate and a layer of amorphous germanium (a-Ge) disposed on the a-Si layer, wherein the a-Ge layer is operable to absorb infrared light and provide photoconductive gain, and the a-Si layer is operable to produce carrier multiplication via cycling excitation process.

Abstract: Disclosed herein are apparatus for a cooler device includes a manifold constructed at least partially of silicon oxide. The manifold includes an array of inlet channels and an array of outlet channels. Each inlet channel has a first depth. The array of outlet channels are interlaced with the array of inlet channels, Each outlet channel has a second depth that is larger than the first depth. Each of the array of outlet channels has a pair of sidewalls separating each outlet channel from adjacent inlet channels of the array of inlet channels.

Abstract: Disclosed herein are small molecule inhibitors of platelet function, and methods of using the small molecules to treat diseases, such as platelet hemostasis and thrombosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

Abstract: A method of activating heteromeric KCNQ2/3, KCNQ3/5, or KCNQ4/5 voltage-gated potassium channels in a cell membrane is described, as are compositions for use with same, as well as methods of reducing neuronal excitability and of ameliorating symptoms of epilepsy, anxiety, neuropathic pain, hypertension, cardiovascular disease, a neurodegenerative disorder, alcohol withdrawal, cancer, inflammation, or ophthalmic disease in a subject. These KCNQ2/3 (or KCNQ3/5 or KCNQ4/5) channels are heteromers that comprise KCNQ2 (or KCNQ5) subunits and KCNQ3 (or KCNQ4) subunits. In one embodiment, the method comprises: (a) contacting the cell membrane with a first agent that binds a KCNQ2 (or KCNQ5) subunit; and (b) contacting the cell membrane with a second agent that binds a KCNQ3 (or KCNQ4) subunit.

Abstract: Described herein is an implantable device configured to detect impedance characteristic of a tissue.

Abstract: A system for the detection and classification of live microorganisms in a sample includes a light source and an incubator holding one or more sample-containing growth plates. A translation stage moves the image sensor and/or the growth plate(s) along one or more dimensions to capture time-lapse holographic images of microorganisms. Image processing software executed by a computing device captures time-lapse holographic images of the microorganisms or clusters of microorganisms on the one or more growth plates. The image processing software is configured to detect candidate microorganism colonies in reconstructed, time-lapse holographic images based on differential image analysis. The image processing software includes one or more trained deep neural networks that process the time-lapsed image(s) of candidate microorganism colonies to detect true microorganism colonies and/or output a species associated with each true microorganism colony.

Abstract: In one aspect, the present disclosure provides a method for identifying treatment targets relating to tumors. In another aspect, the present disclosure provides a method for identifying biomarkers and molecular features of normal and cancer cells.

Abstract: Disclosure provides antimicrobial fiber, comprising: a cationic or polycationic moiety grafted onto a cellulosic fiber and an anionic photosensitizer. Exposing the antimicrobial cotton fiber to light generates reactive oxygen species (ROS) and induces a biocidal function.

Abstract: Disclosed is an analytic sensitivity expression for parameters of a battery electrochemical model, based on model reduction and reformulation techniques such as the single particle assumption, Padé approximation, and Laplace transform. The analytic expressions of sensitivity are in a compact form with explicit relationship to the current input, which enables the direct optimization of the input-dependent sensitivity. The current optimization with maximum sensitivity may be performed for several critical battery electrochemical parameters, namely a solid-phase lithium diffusion coefficient, a volume fraction of the electrode active material, and a reaction rate constant. The electrochemical parameter may be reliably identified using the optimal current profile.

Abstract: A reaction system for carrying out a process for production of chemicals from liquid feedstocks includes a reactor containing one or more liquid reactants, an assembly with two or more electrodes within the reactor configured to generate a high voltage discharge within the one or more liquid reactants, an electrical power supply electrically coupled to the electrodes, inlets and outlets to the reactor for delivering reactants and removing products, and a pressure controller configured to control a pressure of the liquid reactants.

Abstract: A polarization-sensitive encoder, a polarimetric camera, and a method for polarimetric imaging in which the encoder includes a two-dimensional (2D) polycrystalline photonic-crystal film with nanofiber, multi-scale, self-assembled structures.