Abstract: In one aspect the present disclosure relates to a system for forming a three dimensional (3D) object from a volume of photo-responsive material contained within a material container. A plurality of optical projection subsystems are adapted to be arranged at least partially circumferentially around a material container containing the volume of photo-responsive material, and are controlled by a controller. The optical projection subsystems direct optical projections at a plurality of angles ? through the volume of photo-responsive material. The optical projections are further directed about a z axis extending through the volume of photo-responsive material.

Abstract: Provided are methods of modulating gene expression of a target RNA in a cell comprising (a) recruiting a modulation unit, wherein the modulation unit comprises an RNA binding protein (RBP), an exogenous RNA binding moiety, and a gene-editing agent; (b) delivering the modulation unit into the cell; and (c) detecting change in the target RNA translation, wherein the modulation unit modulates gene expression of the target RNA in the cell.

Abstract: Disclosed herein, inter alia, are trioxolane compounds and methods of using the same for treatment and detection of diseases.

Abstract: Methods, agents, and compositions for promoting milk production in a mammal are provided. Agents useful for promoting milk production may include an agent that inhibits NOTCH4 activity. The agent may inhibit NOTCH4 activity by binding to ROBO2 and/or by binding to NOTCH4. The agent may inhibit NOTCH4 by competing with ROBO1 for binding to ROBO2, thereby making ROBO1 available to inhibit NOTCH4 activity. The agent may be a soluble ROBO1 extracellular domain or an anti-NOTCH4 antibody that inhibits NOTCH4 activity. The agent may be an RNAi construct that inhibits expression of NOTCH4 or an RNAi construct that inhibits expression of ROBO2. Also provided herein are transgenic mammals genetically modified for expression of a soluble ROBO1 extracellular domain; inhibition of expression of ROBO2; and/or inhibition of expression of NOTCH4. Methods for promoting milk production in such transgenic mammals by administering one or more of the agents disclosed herein are also provided.

Abstract: Systems and methods are provided for controlling heat stress and accumulations in livestock using the application of water sprays onto the animal in conjunction with fan induced airflow. The system has a controller with sensor inputs of the ambient environment including temperature, humidity, wind speed, and surrounding surface temperature sensors and fan and spray control outputs. To achieve savings in water and electricity, a transient, one-dimensional simultaneous heat and mass transfer model of evaporation within the wetted fur layer of a dairy cow is used to estimate drying time and heat rejection rate based on ambient conditions along with a control algorithm to predict the fan speed and sprinkler operation frequency needed to meet specified cooling load thresholds given the outdoor conditions. Estimated savings demonstrated that the model-based controller could reduce annual electricity and water consumption by 20% and 40%, respectively.

Abstract: A system for detecting high-frequency radiation that offers near-quantum-limited sensitivity, broad spectral bandwidth, and high spectral resolution while operating at room temperature. The system can include an antenna assembly configured to receive at least a high-frequency radiation and a substrate comprising a semiconductor material with a contact-semiconductor interface connected to the antenna assembly. The system also includes an optical pump configured to produce an optical beam that has a high-frequency beat frequency, the optical beam contacting the contact-semiconductor interface to create an intermediate frequency signal by combining the optical beam with the high-frequency radiation. The system further includes a detector configured to detect the intermediate frequency and generate at least one report indicating the received, high-frequency radiation.

Abstract: A dendrite resistant battery may include a first electrode, a second electrode, and an electrolyte interposed between the first electrode and the second electrode. The dendrite resistant battery may further include at least one acoustic wave device configured to generate a plurality of acoustic waves during a charging of the battery. The charging of the battery may trigger cations from the first electrode to travel through the electrolyte and deposit on the second electrode. The plurality of acoustic waves may agitate the electrolyte to at least homogenize a distribution of cations in the electrolyte. The homogenization of the distribution of cations may prevent a formation of dendrites on the second electrode by at least increasing a uniformity of the deposit of cations on the second electrode. Related methods and systems for battery management are also provided.

Abstract: The disclosure provides compositions and methods for treating traumatic brain injury (TBI). The compositions comprise CDK4/CDK6 inhibitors. The methods comprise administering a composition comprising a CDK4/CDK6 inhibitor to a subject in an amount sufficient to reduce one or more symptoms of TBI.

Abstract: A system including a data-driven controller configured to output signals controlling a dose of therapy to a treatment site and in response to feedback comprising data representing a healing state of the treatment site measured by a sensor; and a pumping system coupled to the controller, the pumping system pumping the therapy to the treatment site.

Abstract: Described are agents and methods for modulating an immune response. More particularly, described are various agents and methods for selectively regulating expression of the gene Il12b in live animals, including human patients. Aberrant expression of Il12b is associated with autoinflammatory diseases including psoriasis, chronic eczema, vitiligo, lichen planus, systemic lupus erythematosus, Behçet's disease, and alopecia. Selective modulation of Il12b offers a new avenue for treatment of such diseases.

Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.

Abstract: The disclosure relates to radioimmunotherapy for prostate cancer using an antibody or antibody fragment that specifically binds CUB domain-containing protein 1 (CDCP1). The disclosure further related to use of a diagnostic radioisotope-labeled anti-CDCP1 antibody or CDCP1-binding fragment thereof for radionuclide imaging of CDCP1 expression in vivo. in prostate cancer patients.

Abstract: In some aspects, the disclosure is directed to methods and systems for artificial intelligence-based evaluation of pharmaceutical drug efficacy. Disclosed are implementations of deep learning that may be used to analyze histological images, study the differentiation of induced pluripotent stem cells, and perform binary classifications (live or dead, drug treated or untreated) on cancer cells or other target cells. Various type of classifiers or deep learning machines may be used in implementations, along with pre-processing in many implementations to further enhance distinctions between affected and unaffected cells.

Abstract: The disclosure relates to radioimmunotherapy for bladder cancer using an antibody or antibody fragment that specifically binds CUB domain-containing protein 1 (CDCP1). The disclosure also relates to use of a diagnostic radioisotope-labeled anti-CDCP1 antibody or CDCP1-binding fragment thereof for radionuclide imaging of CDCP1 expression in vivo in bladder cancer patients.

Abstract: Methods and compositions for silica gel encapsulation of plant growth-promoting bacteria are disclosed. Aspects of the disclosure include silica gel microbeads comprising one or more plant growth-promoting bacteria. Also disclosed are methods for generating bacteria-containing silica gel microbeads. Further described are methods for promoting plant growth comprising providing a bacteria-containing silica based solution (e.g., droplets) to a plant seed. Plant seeds coated with bacteria-containing silica gel microbeads are disclosed herein.

Abstract: The present disclosure provides a “double tap” method to improve genome editing efficiencies that takes advantage of the reproducible nature of indel sequences. The “double tap” method uses multiple gRNAs: a primary gRNA that targets the wild-type genomic sequence, and one or more secondary or tertiary or subsequent gRNAs that target the most common indel sequence(s), which provides a “second/third chance” at editing. The “double tap” method also improves gene drive efficiency by recycling resistance alleles. The “double tap” method can be readily implemented in any CRISPR-based gene drive and in a subject that has HDR as a DNA repair mechanism and/or a system suffering from low HDR frequencies to improve performance by boosting efficient gene editing.

Abstract: Provided is a method of preparing mesopore Y zeolite catalysts with larger mesopore sizes. The method employs swelling agents, and optionally cosolvents. The larger mesopores improve accessibility for mass transport of bulky reactants. In the preparation a swelling agent is used in combination with cetyltrimethylammonium bromide (CTAB). Cosolvents can also be used to affect a strong swelling effect.

Abstract: Some aspects are directed to an all-on-chip, optoelectronic device for sampling arbitrary, low-energy, near-infrared waveforms under ambient conditions. This solid-state integrated detector uses optical-field-driven electron emission from resonant nanoantennas to achieve petahertz-level switching speeds by generating on-chip attosecond electron burst. Also disclosed is a cross-correlation technique based on perturbation of local electron field emission rates that allows for the full characterization of arbitrary electric fields down to 1 femtojoule, and/or on the order of 500 kV/m, using plasmonic nanoantennas.

Abstract: A method of fabricating a plurality of monolithic, cascaded, multiple color III-nitride light-emitting diodes (LEDs) with independent junction control, wherein: each of the LEDs is comprised of at least an n-type III-nitride layer, a III-nitride emitting layer, and a p-type III-nitride layer; at least two of the LEDs are separated by an n-type tunnel junction (TJ) insertion layer grown by selective area growth on or above the p-type III-nitride layer of one of the LEDs; the p-type III-nitride layer of one of the LEDs and the n-type tunnel junction insertion layer form a tunnel junction; and the p-type III-nitride layer of one of the LEDs is at least partially covered by the n-type tunnel junction insertion layer.

Abstract: An electromagnetic interface (EMI) shielding material and method for producing the electromagnetic interface (EMI) shielding material. The EMI shielding material including a polymer matrix and a van der Waals material embedded in the polymer matrix and forming quasi-one-dimensional atomic threads, and wherein the van der Waals material is a trichalcogenide compound.