Abstract: Siderocalin-metal chelator combinations that bind metallic radioisotopes used in nuclear medicine with high affinity are described. The high affinity siderocalin-metal chelator combinations include a number of chelator backbone arrangements with functional groups that coordinate with metals. The siderocalin-metal chelator combinations can be used to deliver radionuclides for imaging and therapeutic purposes.

Abstract: Ferrocene (Fc)-substituted organometallic complexes are described. In one example, an Fc-substituted organometallic complex has a structure represented by formula IV: where M is a Group 13 metal, R1 is H or a substituted phenyl, and R2 is 4-ferrocenylphenyl. Non-aqueous redox flow batteries and electrical energy storage systems comprising the Fe-substituted organometallic complexes and methods of storing energy using the Fe-substituted organometallic complexes are provided.

Abstract: Provided herein are methods for in-vivo assessment of intraventricular flow shear stress, risk of hemolysis, also the location and extent of blood flow stasis regions and inside a cardiac chamber or blood vessel. Also provided herein are systems for performing such methods. Also provided herein are methods for assessing hemolysis and/or thrombosis risk in patients implanted with an LVAD. LVAD positioning and/or speed may be adjusted based on the results obtained by using methods described herein, and the risk for hemolysis and/or thrombosis can be minimized.

Abstract: A method and system for automated correction of phase error in MRI-based flow evaluation employs a computer processor programmed to execute a trained convolutional neural network (CNN) to receive and process image data comprising flow velocity data in three directions and magnitude data collected from a region of interest over a scan period from magnetic resonance imaging instrumentation. The image data is processed using the trained CNN to generate three output channels with pixelwise inferred corrections for the flow velocity data which are further smoothed using a regression algorithm. The smoothed corrections are added to the original image data to generate corrected flow data, which may be used for flow visualization and quantization.

Abstract: Techniques for patient pressure injury prevention (PPIP) include receiving, from a plurality of pressure sensors configured to be disposed in a spatial arrangement in contact with a patient, samples that indicate pressure measurements by the plurality of sensors at each of a plurality of different times. At each of the plurality of different times an angular orientation of the pressure is determined based on the samples. A change in the angular orientation of the pressure is determined at each successive time of the plurality of different times. A value of a patient movement parameter is determined based on the change in angular orientation of the pressure. A pressure injury category for the patient based on the value of the patient movement parameter is presented on a display device for a caregiver. Treatment of the patient by the caregiver is based on the pressure injury category.

Abstract: Compositions comprise statistically random heteropolymers complexed with active proteins, and are formulated and used in stimuli-responsive materials and nanoreactors composed of proteins and synthetic materials.

Abstract: The present disclosure provides CasY proteins, nucleic acids encoding the CasY proteins, and modified host cells comprising the CasY proteins and/or nucleic acids encoding same. CasY proteins are useful in a variety of applications, which are provided. The present disclosure provides CasY guide RNAs that bind to and provide sequence specificity to the CasY proteins, nucleic acids encoding the CasY guide RNAs, and modified host cells comprising the CasY guide RNAs and/or nucleic acids encoding same. CasY guide RNAs are useful in a variety of applications, which are provided. The present disclosure provides methods of identifying a CRISPR RNA-guided endonuclease.

Abstract: Methods and compositions for nuclear delivery and transcriptional repression employ a cell-penetrant MeCP2 fusion protein.

Abstract: Compounds, pharmaceutical compositions, kits, and methods for treating gut motility disorders are herein. Examples of gut motility disorders to which the compounds, pharmaceutical compositions, kits, and methods are directed include achalasia, Hirschspmng's disease, an intestinal pseudo-obstruction, gastroesophageal reflux disease (GERD), functional dysphagia, functional dyspepsia, irritable bowel syndrome (IBS), gastroparesis, functional constipations, functional diarrhea, and fecal incontinence. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In some embodiments of the invention, a millimeter wave (mmWave) backscatter network node includes a frequency scanning antenna (FSA) having at least one port, the FSA including an array of emitting elements such that, given an incoming signal resulting in emitting signal from the emitting elements, the direction in which emitting signals combine constructively changes with the frequency of the incoming signal, and a radio frequency (RF) signal processing unit configured to measure strength and determine frequency of a received signal that is received by a first port of the FSA.

Abstract: Systems, processes and devices are provided for laser-based manufacturing of resonators and MEMS devices from bulk material including optically transparent material. Processes include digital marking of resonator structures in bulk material through non-linear interaction of ultrafast laser beam inscribing and material. The resonator structure may be defined and released through selective wet etching of the laser-modified areas, utilizing a combination of basic and acidic aqueous solutions. Processes can also include hydrofluoric thinning prior to wet etching to prevent laser surface damages. Systems and processes can pattern and fabricate resonator structures and concentricring structures. Embodiments provide miniaturized vibratory sensors from low loss material, such as fused silica and quartz, with an improved resolution and accuracy of measurements for inertial sensing, time referencing, bio-sensing and acoustic sensing.

Abstract: The present disclosure provides methods and systems for systematic elimination of background DNA in a DNA mixture sample. Often, the DNA of interest is in a heavy background of DNAs from other tissues. For example, a majority of DNA in plasma cell-free DNA originates from white blood cells. The present disclosure exploits genome-wide background DNA methylation to systematically eliminate DNA from white blood cells and normal tissue(s), therefore enriching non-background DNA for diagnostics, for example, the diagnostics of cancer and infectious diseases. The methods and systems may comprise the selection of targeted regions to generate one or more hybrid capture panels, digest nucleic acid molecules of specific methylation status with one or more restriction enzymes, retrieve the remaining DNA using the hybrid capture panel, sequence the captured DNA, analyze the sequencing data of the captured DNA, and diagnose diseases.

Abstract: Natural killer (NK) cells are innate lymphocytes that possess traits of adaptive immunity, such as memory formation. However, the molecular mechanisms by which NK cells persist to form memory cells are not well understood. Using single cell RNA sequencing, we identified two distinct effector NK cell (NKeff) populations following mouse cytomegalovirus (MCMV) infection. Ly6C? memory precursor (MP) NK cells displayed enhanced survival during the contraction phase in a Bcl2-dependent manner, and differentiated into Ly6C+ memory NK cells. Our studies show that a NK cell-intrinsic checkpoint is controlled by the transcription factor Fli1 which limits MP NK formation by regulating early effector NK cell fitness during viral infection. Building upon this discovery, we have designed methods and materials for modulating the molecular mechanisms that regulate memory cell fate in NK cells, such as genetically modified NK cells having a deletion in the gene for the transcription factor Fli1.

Abstract: A method and system device to generate and deliver an electric field to a target a peripheral nerve with customized electric fields according to the nerve of interest, which may be superficial or deep in the human body, to elicits action potentials of the target nerve. The system utilizes a stimulator circuit which receives parameters of a stimulation protocol from an external control device, and assembles basic building waveforms, counters, and timers which when combined are directed to a current/voltage driver hardware (CDC) that generates the stimulation protocol.

Abstract: Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.

Abstract: Provided are methods of preventing, delaying, mitigating, reducing and/or inhibiting alpha-synuclein aggregates in the brains of a subject at risk of developing or suffering a cognitive disease associated with, caused and/or mediated at least in part by alpha-synuclein aggregates, for example, Parkinson's Disease or Dementia with Lewy Bodies (DLB).

Abstract: Provided herein are catalyst materials comprising a catalyst support; and PtM? nanowires affixed to the catalyst support, wherein the PtM? nanowires include single atomic species of M? at exterior surfaces of the PtM? nanowires, and M? represents at least one metal, e.g., a metal different from Pt. Also disclosed are manufacturing methods comprising: providing initial MM? nanowires having an initial molar ratio of M:M?, wherein M is a noble metal, and M? is a metal different from M; subjecting the initial MM? nanowires to electrochemical dealloying to partially remove M? and form partially dealloyed MM? nanowires having a subsequent molar ratio of M:M?, wherein the subsequent molar ratio of M:M? is greater than the initial molar ratio of M:M?; and affixing the partially dealloyed MM? nanowires to a catalyst support.

Abstract: Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groove of FZD inhibits TcdB entry into cells, and/or inhibits Wnt signaling. Methods of treating Clostridium difficile infection (CDI) and methods of treating cancer are also provided.

Abstract: Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome these and other limitations, the present embodiments include a flexible field-effect transistor (FET) biosensor array that exploits a new cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples.