Abstract: Provided herein are, inter alia, methods of identifying agents that are capable of inhibiting the binding (e.g., coupling) between a ROR1 protein and a ROR2 protein. By interfering with ROR1-ROR2 coupling (binding) the agents identified using the methods provided herein inhibit non-canonical Wnt5a signaling. Thus, the agents identified by the methods provided herein may, inter alia, be useful for cancer diagnosis and therapy.

Abstract: In one aspect, the present disclosure provides a method for identifying treatment targets relating to tumors. In another aspect, the present disclosure provides a method for identifying biomarkers and molecular features of normal and cancer cells.

Abstract: Methods and compositions are provided for activating transcription in a mammalian cell.

Abstract: Some aspects are directed to an all-on-chip, optoelectronic device for sampling arbitrary, low-energy, near-infrared waveforms under ambient conditions. This solid-state integrated detector uses optical-field-driven electron emission from resonant nanoantennas to achieve petahertz-level switching speeds by generating on-chip attosecond electron burst. Also disclosed is a cross-correlation technique based on perturbation of local electron field emission rates that allows for the full characterization of arbitrary electric fields down to 1 femtojoule, and/or on the order of 500 kV/m, using plasmonic nanoantennas.

Abstract: A transcutaneous magnetic stimulation (tMS) device is provided for modulating nerve function and chronic pain management, and includes a tMS stimulator, a control module in wired and powered communication with the tMS stimulator, and a portable electronic device in wireless communication with the control module to receive, generate and transmit feedback and control settings relating to a treatment session. The tMS stimulator may be a flexible figure-of-eight coil configured in different sizes and shapes to provide varying pulse and magnetic field strengths for mobile, home, or clinical uses, and also include guidance tools and measurement sensors to aid in positioning and directing the tMS stimulator to a target area for treatment.

Abstract: Microfluidic sensing devices utilizing microfluidic sensing electrodes are provided. In one embodiment, a method for fabrication of a microfluidic sensing electrode device for detection of analyte(s) in a fluid is provided, the method comprising: generating a chamber comprising: a tube hole configured to receive a tube, wherein the tube hole extends from a first end of the chamber to a second end of the chamber; and a plurality of electrode holes configured to receive a plurality of electrodes, wherein each of the plurality of electrode holes is in contact with the tube hole; inserting the tube into the tube hole; inserting the plurality of electrodes into the plurality of electrode holes; applying a resin to the chamber; removing the tube from the tube hole, wherein removing the tube from the tube hole exposes a sensing zone that allows the plurality of electrodes to be in contact with the fluid.

Abstract: In one aspect, there is provided a system including at least one processor, and at least one memory including program code which when executed by the at least one processor causes operations including capturing an image of at least a portion of a surface of an object; generating, from the captured image, pixel intensity data; in response to generating the pixel intensity data, determining, based on a height error model, height error data, wherein the height error data indicates an uncertainty of at least one height measurement of the object; and determining, based on the height error data, whether the object satisfies a threshold criteria for acceptance of the object. Related system, methods, and articles of manufacture are also disclosed.

Abstract: Systems and methods are described herein that create discrete volumes associated with solid-phase particles (e.g., drop-carrier particles) suspended in an immiscible phase (e.g., dropicles). One embodiment of the system includes a plurality of hydrogel-based drop-carrier particles containing a microscale voids or cavities that hold an aqueous phase droplet of fluid within each drop-carrier particle. The plurality of hydrogel drop-carrier particles associated with aqueous drops are suspended as individual elements in an immiscible oil phase. The microscale hydrogel drop-carrier particles containing the voids or cavities may be manufactured using microfluidic droplet generators. The dropicles may be used to analyze single-entities (e.g., single-molecules and single-cells) and analytes.

Abstract: A method of growing III-nitride-based devices, such as light emitting diodes (LEDs) and laser diodes (LDs) on or above a strain relaxed template (SRT). The SRT uses a thin, thermally decomposed, InGaN underlayer, which is referred to as a decomposition layer (DL). Above the DL is a n-type GaN or low composition InGaN decomposition stop layer (DSL). A buffer layer comprising an n-type InGaN/GaN superlattice (SL) is then grown. For an LD structure. an n-type waveguide layer comprising a second n-type InGaN/GaN SL is then grown. followed by an active region, a p-type electron blocking layer (EBL), a p-type waveguide layer comprising a p-type InGaN/GaN SL, and p-type GaN or p-type InGaN layers. For an LED structure, the waveguide layers may be omitted. In this disclosure, AlGaN means AlxGa(1-x)N with 1?x?0 and InGaN means InxGa(1-x)N with 1?x?0.

Abstract: Techniques, systems and apparatus are described for magnetic resonance imaging. A method includes generating an MRI image by processing a first image obtained by applying a first order of modules including at least a first control module at a first time point and a first labeling module at a second time point to a target object, wherein the first control module inverts a magnetization of the target object and a second image obtained by applying a second order of modules including at least a second labeling module at a third time and a second control module at a fourth time to the target object, wherein the second labeling module inverts the magnetization of the target object.

Abstract: Carbamoyl phosphate synthetase 1 (CPS1) deficiency is a metabolic disorder of the liver that results m abnormal nitrogen metabolism. To illustrate the ability of gene therapy to treat CPS1 deficiency, two adeno-associated viruses encoding portions of a codon optimized CPS1 were generated and tested in a conditional CPS1 knock out mouse model. When administered to mice having knocked out endogenous CPS1 expression, mice from this model demonstrate homologous recombination and reconstitution of the codon optimized CPS1 gene, expression of the CPS1 protein and the associated control of plasma ammonia following the administered AAVs comprising the CPS1 gene sequences. While all control mice perish, the mice in this model live and have normal behavior. As there is no effective therapy for human patients with the CPS1 disorder, this invention can address this unmet need for these patients.

Abstract: A method of forming an electrode material includes: (1) loading an electrochemically active material onto graphene sheets; (2) combining the electrochemically active material-loaded graphene sheets with holey graphene oxide sheets to form a mixture; and (3) treating the mixture under reducing conditions to form a composite including a graphene framework loaded with the electrochemically active material.

Abstract: Disclosed is a negative electrode for an all-solid-state battery and an all-solid-state battery including the negative electrode. More specifically, disclosed is a pre-lithiated silicon negative electrode, and an all-solid-state battery comprising the same.

Abstract: Nanoscopic dispersion of trace enzymes and random heteropolymers in plastics provides to fully functional plastics with eco-friendly microplastic elimination and programmable degradation.

Abstract: An everting vine robot intubation device capable of automatically and autonomously intubating the trachea and producing a lumen through which artificial ventilation may be conducted. The device includes an everting primary vine robot attached to a mouthpiece and a smaller diameter everting intubation vine robot associated with the primary everting vine robot. The primary vine robot is shaped and sized to extend to the back of a patient's laryngopharynx when fully actuated and the intubation everting vine robot is shaped and sized to extend from the primary vine robot into the patient's trachea when fully actuated.

Abstract: A method, a system, and a computer program product for localization of wireless devices. At least one of mapping and wireless data describing a physical environment is received. The physical environment includes one or more wireless access points. Using the received mapping and/or wireless data, a location of each of the wireless access points is determined. Using the determined location of the wireless access points, one or more wireless devices positioned in the physical environment are located.

Abstract: A monitoring apparatus for a human body includes a node network with at least one motion sensor and at least one acoustic sensor. A processor is coupled to the node network, and receives motion information and acoustic information from the node network. The processor determines from the motion information and the acoustic information a source of acoustic emissions within the human body by analyzing the acoustic information in the time domain to identify an event envelope representing an acoustic event, determining a feature vector related to the event envelope, calculating a distance between the feature vector and each of a set of predetermined event silhouettes, and identifying one of the predetermined event silhouettes for which the distance is a minimum.

Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.

Abstract: A method of making boron oxide nanoparticles. The method can comprise sonochemically treating a composition comprising a boron oxide to form boron oxide nanoparticles. The method allows for the formation of these nanoparticles from non-toxic, inexpensive reagents and ambient reaction conditions. Additionally, the nanoparticles produced by the teachings described herein can be easily surface functionalized.

Abstract: Methods and compositions for increasing one or more plant growth characteristics in a plant are disclosed. The compositions comprise one or more microbial isolates that promote plant growth. Methods include providing an effective amount of a composition comprising one or more microbial isolates that promote one or more plant growth characteristics.