Abstract: The disclosure provides biocatalysts that halogenate complex chemical compounds in specific and predictable ways. Also disclosed are halogenated complex organic compounds. The disclosure further provides methods for the halogenation of complex chemical compounds and methods of inhibiting the contraction of smooth muscle in mammals.

Abstract: A multi-modal biosensor system includes a vibrating plate orientated along a plane. An actuator is interfaced with the vibrating plate and operable to vibrate the vibrating plate along the plane. The actuator includes two electrodes rigidly affixed to the vibrating plate. An optical support structure is rigidly affixed to the vibrating plate, and provides an outwardly facing surface to receive a measurement sample. A light source is configured to project light onto the outwardly facing surface of the optical support structure. A light detector is configured to capture light reflected from the outwardly facing surface of the optical support structure. A controller interfaces with the two electrodes and the light detector. The controller operates to detect changes in the vibrating motion of the vibrating plate concurrently with detecting changes in the light captured by the light detector.

Abstract: The present invention relates to the field of (bio-)medicine, and more particularly to the treatment of copper-related diseases. Novel means and methods for depleting (excess) copper from organs and/or the circulation are provided. Agents with a high copper binding affinity and stabilized forms thereof are provided, as well as a novel treatment regimen. The means and methods of the present invention are particularly useful for treatment of Wilson Disease, but also for treatment of other conditions.

Abstract: The disclosure relates to microspheres comprising a core and a shell. More particularly the disclosure relates to microspheres for extended, controlled release of a poorly water-soluble therapeutic agent having a solubility in water of 50 ?g/mL or less, the microsphere having a core comprising the therapeutic agent, and a substantially impermeable shell surrounding the core. Methods of making and using the microspheres are also provided.

Abstract: A multi-functional water quality sensor assembly includes an electrically non-conductive substrate carrying electrically conductive traces that comprise one or more electrodes configured to sense at least one of oxidation reduction potential (ORP) or acidity (pH) of water. The electrodes are configured to be operated according to a dynamic mode, which includes establishing constant potentials or constant currents between the electrodes and documenting potentials between the electrodes as a measure of ORP and/or pH, and/or determining a differential in the potentials between first and second times as a measure of pH of the water, wherein the dynamic mode may be carried out without use of a silver chloride reference electrode.

Abstract: A vaneless ventilation system includes a rigid duct and a vent assembly in fluid communication with the duct. The vent assembly includes a rigid housing defining an outlet, a bendable duct disposed inside the rigid housing, a linkage assembly coupled to the bendable duct to allow deflection of the bendable duct upon movement of the linkage assembly, and an actuation mechanism coupled to the linkage assembly, wherein actuation of the actuation mechanism causes the linkage assembly to move, thereby deflecting the bendable duct.

Abstract: People use their mobile devices anywhere and anytime to run various apps, and the information shown on their device screens can be seen by nearby unauthorized parties, referred to as shoulder surfers. To mitigate this privacy threat, techniques have been developed utilizing human vision and optical system properties to hide the users' on-screen information from the shoulder surfers. Specifically, the proposed techniques discretize the device screen into grid patterns to neutralize the low-frequency components so that the on-screen information will “blend into” the background when viewed from the outside of the designed visible range.

Abstract: An important new vulnerability was discovered and is applicable to several in-vehicle networks including Control Area Network (CAN), the de facto standard in-vehicle network protocol. Specifically, a bus-off attack exploits the safe mode of CAN to disconnect or shut down uncompromised (healthy) ECUs. This is an important attack that must be thwarted, since once the attacker compromises an ECU, it is easy to mount the attack on safety-critical ECUs while its prevention/detection is very difficult. Based on analysis and experimental results, a mechanism to detect and/or prevent a bus-off attack is proposed and evaluated.

Abstract: A fluidic logic and actuator system for outputting a displacement having a fluidic logic circuitry layer including a fluidic control input and a plurality of fluidic latching memory units. At least some of the plurality of fluidic latching memory units are configured to perform combinatorial and sequential logic functions and output a fluid response. A fluid actuator layer is provided having a plurality of fluid actuators, wherein each of the plurality of fluid actuators being movable in response to the fluid response of a corresponding one of the plurality of fluidic latching memory units.

Abstract: A transceiver includes a receive circuit configured to receive an incoming signal and recover a reference signal at a reference frequency from the incoming signal. The incoming signal is a wireless packet. A first oscillator generates a signal at a set of predetermined frequencies. A first phase lock loop (PLL) interfaced with the first oscillator. The first PLL is configured to adjust a first oscillator frequency of the first oscillator based on an incoming frequency of the incoming signal using the reference frequency. A transmit circuit includes a second oscillator configured to generate a carrier signal at a predetermined frequency and a modulator configured to modulate data over the carrier signal at the predetermined frequency. The transmit circuit includes a second PLL interfaced with the second oscillator that sets the second oscillator to generate the carrier signal at the predetermined frequency using the reference signal. The transmit circuit transmits the modulated carrier signal.

Abstract: Components, for example, nanoparticles for detecting and/or treating one or more active carious lesions or microcavities in teeth of a subject are provided. The component or nanoparticle may comprise a biocompatible and biodegradable polymer (e.g., a starch) bearing at least one cationic region and/or having a net positive charge and thereby capable of associating with one or more active and/or early carious lesions on a tooth in an oral cavity of a subject. The components or nanoparticles are optionally water soluble or dispersible. The components or nanoparticle also comprises an imaging agent (e.g., a fluorophore or dye) bonded to the biocompatible and biodegradable polymer. The component or nanoparticle is thus capable of indicating the presence of one or more active carious lesions when the component or nanoparticle is associated therewith. Oral care compositions comprising such compounds/nanoparticles and methods of making and using the same are also provided.

Abstract: The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R1c, R1d, R1e, R2, R3, R8a, R8b, L, X, Z1, and Z2 are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to menin inhibition such as cancer.

Abstract: Material-Sensing Light Imaging, Detection, And Ranging (LIDAR) systems optionally include a laser configured to generate a light pulse, a beam steerer configured to produce a polarization-adjusted light pulse emitted towards an object, at least one polarizer configured to polarize reflected, scattered, or emitted light returned from the object, and a processor configured to detect at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object. The beam steerer may include a kirigami nanocomposite. Methods are also provided, including, for example, generating a light pulse, adjusting a polarization of the light pulse to produce a polarization-adjusted light pulse emitted towards an object, polarizing reflected, scattered, or emitted light returned from the object, and detecting at least one material of the object based on an intensity and polarization of the polarized reflected, scattered or emitted light from the object.

Abstract: An energy harvester coupled to a vibration source includes a housing, a transducer, and an amplifier. The transducer may have a first part and a second part. The first part and the second part may move relative to each other along a central axis in response to a motion from the vibration source. The amplifier is coupled to the housing and operable to amplify an amplitude of the motion received from the vibration source. The amplifier has an input member coupled to the vibration source and an output member coupled to the first part of the transducer. The input member moves at a distance D1 in response to the motion from the vibration source. The output member moves the first part of the transducer in response to the input member moving. The first part of the transducer moves along the central axis by a distance D2, where D2>D1.

Abstract: A thermoelectric composition is provided that includes a nanocomposite comprising a copper selenide (Cu2Se) matrix having a plurality of nanoinclusions comprising copper metal selenide (CuMSe2) distributed therein. M may be selected from the group consisting of: indium (In), aluminum (Al), gallium (Ga), antimony (Sb), bismuth (Bi), and combinations thereof. The thermoelectric composition has an average figure of merit (ZT) of greater than or equal to about 1.5 at a temperature of less than or equal to about 850K (about 577° C.). Methods of making such a thermoelectric nanocomposite material by a sequential solid-state transformation of a CuSe2 precursor are also provided.

Abstract: Disclosed herein are organic photosensitive optoelectronic devices, such as organic photovoltaics, including a photoactive region, wherein the photoactive region contains an energy-cascading multilayer donor region. The energy-cascading multilayer donor region may drive exciton transfer from an anode to a dissociating interface while reducing exciton quenching, improving overlap with the solar spectrum, and minimizing polaron pair recombination, resulting in improved device performance.

Abstract: The present disclosure provides compounds represented by Formula I: I, and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2a, R2b, R3, R4, Ar, L, X, Y, and B are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat a condition or disorder responsive to degradation of BET bromodomains such as cancer.

Abstract: A pixel circuit that includes: a substrate body having a channel influenced by an electric field; an aperture in communication with the channel for receiving a fluorescent light input and moving electrons through the substrate body; and a plurality of sampling devices adapted to be switched on simultaneously to sample the moving electrons.

Abstract: A fastener and method for joining dissimilar materials. The fastener has a metal body and a hollow portion. The method includes the steps of: layering a thermoplastic first component with a second component such that the first component covers an opening formed through the second component; pressing the metal fastener against the first component through the opening in the second component; and heating the thermoplastic at an interface of the metal fastener and the first component so that the thermoplastic flows into the hollow portion of the metal fastener during the step of pressing. A portion of the metal fastener is thus embedded in the thermoplastic and a joint is formed that attaches the first and second components together when the thermoplastic is cooled.

Abstract: A heating and/or cooling device having one or more thermoelectric threads. The thermoelectric thread includes a plurality of individual thermoelectric elements, each thermoelectric element having a first side and a second side. A set of first side electrodes connects at least some of the thermoelectric elements at the first side, and a set of second side electrodes connects at least some of the thermoelectric elements at the second side. An electrically insulative covering at least partially surrounds the plurality of individual thermoelectric elements. The electrically insulative covering is configured to be woven into or otherwise integrated with a fabric.