Abstract: Various implementations of sorting networks are described that utilize time-encoded data signals having encoded values. In some examples, an electrical circuit device includes a sorting network configured to receive a plurality of time-encoded signals. Each time-encoded signal of the plurality of time-encoded signals encodes a data value based on a duty cycle of the respective time-encoded signal or based on a proportion of data bits in the respective time-encoded signal that are high relative to the total data bits in the respective time-encoded signal. The sorting network is also configured to sort the plurality of time-encoded signals based on the encoded data values of the plurality of time-encoded signals.

Abstract: The present disclosure provides a method for using a magnetic resonance system to measure magnetization data from a region of interest in a subject having a spin system that includes at least a first labile spin species and a second labile spin species experiencing chemical exchange. The method includes applying periodic radiofrequency irradiation to the spin system using a frequency swept pulse sequence having frequency and amplitude modulation functions, wherein sweeping a frequency of the RF irradiation together with amplitude modulation generates a magnetic field component having an effective field. The method further includes generating off resonance side bands in a frequency domain positioned adjacent the resonant frequency of the first labile spin species or the second labile spin species by applying the periodic RF irradiation to induce the instantaneous flip of the effective field with periodicity of RF irradiation tuned to the chemical shift difference of the exchanging sites.

Abstract: The present disclosure provides engineered SARS-CoV-2 spike ectodomain polypeptides and cells for producing such a polypeptide, as well as compositions and methods thereof.

Abstract: Systems and methods for digital signal processing using a sliding windowed infinite Fourier transform (“SWIFT”) algorithm are described. A discrete-time Fourier transform (“DTFT”) of an input signal is computed over an infinite-length temporal window that is slid from one sample in the input signal to the next. The DTFT with the temporal window at a given sample point is effectively calculated by phase shifting and decaying the DTFT calculated when the temporal window was positioned at the previous sample point and adding the current sample to the result.

Abstract: The invention provides a compound of formula I: or a salt thereof, wherein R1, R2, R3, A and n have any of the values described in the specification, as well as compositions comprising a compound of formula I, and methods of preparing and use thereof. The compounds are useful as vaccine adjuvant potentiators.

Abstract: Disclosed are mutated phosphotriesterase enzymes with improved stability and activity, as well as their use in particular for degrading organophosphorus compounds.

Abstract: A vision-aided inertial navigation system (VINS) implements a square-root multi-state constraint Kalman filter (SR-MSCKF) for navigation. In one example, a processor of a VINS receives image data and motion data for a plurality of poses of a frame of reference along a trajectory. The processor executes an Extended Kalman Filter (EKF)-based estimator to compute estimates for a position and orientation for each of the plurality of poses of the frame of reference along the trajectory. For features observed from multiple poses along the trajectory, the estimator computes constraints that geometrically relate the multiple poses of the respective feature. Using the motion data and the computed constraints, the estimator computes state estimates for the position and orientation of the frame of reference. Further, the estimator determines uncertainty data for the state estimates and maintains the uncertainty data as a square root factor of a covariance matrix.

Abstract: A magnetic device may include a layer stack including a work function structure, a dielectric layer, and a ferromagnetic layer, where the ferromagnetic layer is positioned between the work function structure and the dielectric layer. The work function structure is configured to deplete electrons from the ferromagnetic layer or accumulate electrons in the ferromagnetic layer. A magnetization orientation of the ferromagnetic layer is configured to be switched by a voltage applied across the layer stack or by a voltage applied across or through the work function structure.

Abstract: This disclosure describes example techniques and systems for identifying the presence and/or composition of nucleic acids in the blood of a host organism of a model species harboring tissue of a donor organism of another species. For example, the technique may involve identifying the presence and composition of nucleic acids in the blood of a mouse harboring tissue of a human or another companion animal. These cell-free nucleic acids that are identified can be used as biomarkers to determine the presence of a disease, its biological behavior, its rate of progression, and/or the response of the disease to one or more unique therapies. In other examples, the cell-free nucleic acids may be used as biomarkers to determine a response of the host species to the tissue of the donor organism or a response of tissue derived from the second organism to transplantation within the first organism of the first species.

Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.

Abstract: A dual-mode ultrasound system provides real-time imaging and therapy delivery using a transducer array. The system may use various imaging modes to provide image data that may be used to select control points within an imaging field of view. The control points along with the image data may be used to solve an optimization problem to achieve desired focusing gains at one or more of the control points. The optimized solution may be used to produce excitation waveforms to generate new image data. The focusing gains may be evaluated and the optimization problem may be iterated until desired focusing gains are achieved. Virtual arrays may be defined and cascaded to provide flexibility in solving the optimization problem.

Abstract: An example composition includes a therapeutically effective amount of a histidine kinase inhibitor. The histidine kinase inhibitor includes at least one of a 6-benzo[d]thiazol-2-amine derivative, a purine derivative, an adenine derivative, an adenine-sulfonyl fluoride derivative, a riluzole analog, a riluzole-sulfonyl fluoride derivative, a 6-benzo[d]thiazol-2-amine-sulfonyl fluoride derivative, a 6,6?-oxybis(benzo[d]thiazol-2-amine) derivative, or a 6,6?-oxybis(benzo[d]thiazol-2-amine)-sulfonyl fluoride derivative. An example technique for treating a bacterial infection includes administering a composition comprising a histidine kinase inhibitor to a patient.

Abstract: A system includes an imager, a processor, and an output module. The imager is configured to provide a plurality of tissue images. The processor is coupled to the imager and is configured to receive the plurality of images. The processor is coupled to a memory. The memory has instructions for determining classification of a region of tissue associated with the plurality of tissue images. Determining classification includes fusing discriminator outputs from a region covariance descriptor and from a normalized color histogram discriminator. The output module is coupled to the processor. The output module is configured to provide a three dimensional representation of the tissue.

Abstract: A multi-planar intraoral radio frequency (RF) coil apparatus for use in a magnetic resonance imaging system can include a housing having a shape configured to be positioned in an occlusal plane between an upper jaw and a lower jaw of a subject and a plurality of coil elements disposed within the housing. The plurality of coil elements includes a first coil element positioned in a first plane and a second coil element positioned in a second plane different from the first plane and substantially parallel to the first plane. The coil elements can be loop coil elements or dipole coil elements.

Abstract: Magnetic resonance imaging (“MRI”) data are corrected from corruptions due to physiological changes using a self-navigated phase correction technique. Unlike motion correction techniques, the effects of physiological changes (e.g., breathing and respiration) are corrected by making the MRI data self-consistent relative to an absolute uncorrupted phase reference. This phase correction information can be extracted from the acquisition itself, thereby eliminating the need for a separate navigator scan, and establishing an accelerated acquisition. This absolute reference can be computed in a data segmented space, and the subsequent data can be corrected relative to this absolute reference with low-resolution phases.

Abstract: The invention provides a compound of formula (I): wherein R1, R2, and R3 have any of the values described in the specification, as well as compositions comprising a compound of formula (I), methods for preparing compounds of formula (I), and methods for detecting the presence of an amine in a sample. The compounds are useful as pigments.

Abstract: The invention provides the compound: or a salt thereof, as well as pharmaceutical compositions comprising the compound or a pharmaceutically acceptable salt thereof and methods for treating a pathological condition in an animal with the compound or with a pharmaceutically acceptable salt thereof.

Abstract: A method for treating a cancer involving one or more translocations generating an oncogenic fusion transcription factor that requires p300/CBP for activity in an animal, comprising administering a compound of formula (I): or a pharmaceutically acceptable salt thereof to the animal.

Abstract: A device includes a substrate, an electrode, an electrical pad, and a signal line. The signal line is coupled to the substrate and covered by an insulation layer. The signal line is coupled to the electrical pad and the electrode. At least one of the electrode and the signal line includes a diamagnetic material and paramagnetic material, wherein a ratio of the diamagnetic material and the paramagnetic material is selected based on the susceptibility properties of a physiological tissue. The term paramagnetic herein refers to magnetic susceptibility greater than that of the surrounding tissue and diamagnetic refers to magnetic susceptibility lower than that of the tissue.

Abstract: Embodiments herein include a method for detecting a brain condition in a subject. The method can include obtaining a breath sample from the subject and contacting it with a chemical sensor element, where the chemical sensor element includes a plurality of discrete graphene varactors. The method can include sensing and storing capacitance of the discrete graphene varactors to obtain a sample data set and classifying the sample data set into one or more preestablished brain condition classifications. Other embodiments are also included herein.