Abstract: In certain embodiments, the present invention provides methods of identifying and treating a transplant recipient patient having transplantation tolerance induced by apoptotic donor leukocytes infused under cover of transient immunotherapy.

Abstract: The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stem cells but can differentiate into cell types of at least two of ectodermal, endodermal, and mesodermal embryonic germ layers, e.g., stem cells.

Abstract: The techniques and systems described herein relate to manufacturing, characterizing, and/or identifying one or more types of magnetic nanowires (MNWs). One or more types of MNWs may be associated with different objects, and a system may identify the objects based on the magnetic nanowires associated with the objects. For example, such techniques may involve characterizing the types of MNWs based on magnetic field transmission characteristics and ferromagnetic resonance characteristics of each type of MNW. In some examples, the techniques described herein may enable the identification of each of a plurality of types of MNWs present in a sample or object based on a combined transmission value of the sample. Such techniques may enable the development and use of barcode-like systems of different types of MNWs for labeling and identifying objects of interest.

Abstract: The present disclosure provides an acousto-optic device comprising an acousto-optic layer, an electromagnetic radiation source, and an acoustic source. In an embodiment, the acousto-optic layer has a substantially planar shape defining an x-y plane and functions as an optical waveguide to optical waves and as an acoustic waveguide to acoustic waves propagating in the x-y plane. In an embodiment, the electromagnetic radiation source is optically coupled to the acousto-optic layer and configured to deliver electromagnetic radiation therein. In an embodiment, the acoustic source is acoustically coupled to the acousto-optic layer and configured to deliver acoustic energy therein and is configured to adjust a wavelength of the acoustic energy. In an embodiment, the electromagnetic radiation source and the acoustic energy source are positioned to provide an intersection between the electromagnetic radiation and the acoustic energy, which at least partially scatters light from the intersection out of the x-y plane.

Abstract: An apparatus includes a first feed-forward PUF, a second feed-forward PUF and an exclusive-or circuit configured to perform an exclusive-or operation of an output of the first feed-forward PUF and an output of the second feed-forward PUF.

Abstract: This disclosure describes, generally, a modified form of CD16, genetically-modified cells that express the modified CD16, and methods that involve the genetically-modified cells. The modified form of CD16 can exhibit increased anti-tumor and/or anti-viral activity due, at least in part, to reduced susceptibility to ADAM17-mediated shedding upon NK cell stimulation.

Abstract: Methods of curtain coating substrates are disclosed. In some embodiments, the methods include applying two or more liquid layers simultaneously to a substrate, wherein the multiple layers include a bottom liquid layer comprising a shear thinning liquid, and another liquid layer comprising a viscoelastic liquid. In some embodiments, the disclosed methods include formulating a bottom layer liquid comprising a shear thinning liquid, formulating another layer liquid comprising a viscoelastic liquid, pumping the bottom layer liquid and the other layer liquid through coating dies simultaneously and onto a moving substrate such that the bottom layer liquid impinges on the substrate thereby forming a bottom layer, and the other layer liquid forms another liquid layer above the bottom liquid layer. The inclusion of a bottom liquid layer comprising a shear thinning liquid and other layer comprising a viscoelastic liquid provides for enlargement of the curtain coating window.

Abstract: One example is directed to an end effector position estimation system for an off-road vehicle, which includes at least one inertial measurement unit (IMU) configured to be positioned on at least one of actuators and links of the vehicle that together move the end effector of the vehicle, and configured to generate measurement signals. The position estimation system includes at least one other IMU configured to be positioned on a base of the vehicle, and configured to generate other measurement signals. The position estimation system includes an estimation unit to estimate a position of the end effector of the vehicle based at least in part on the measurement signals and the other measurement signals, wherein the estimation unit is configured to perform an estimation method that removes an influence of terrain-induced vibrations and terrain slope in the measurement signals based on the other measurement signals.

Abstract: Pharmaceutical formulations comprising ketamine, propofol, and a lipid are provided. Methods of making the formulations and methods of using the formulations to provide sedation, amnesia, analgesia, anxiolysis, and/or stable hemodynamics are also provided.

Abstract: Genonie-edited primary B cells, methods of making genome-edited primary B cells, a therapeutic cassette that can be introduced into primary B cells, and methods of using the genome-edited primary B cells and the therapeutic cassette.

Abstract: A trans-disciplinary system for cell-free biosynthesis includes a cell-free transcription-translation (TX-TL) tool and modular, generalizable microfluidic architectures. Both components of the system are independently functional and are combinable into a cell-free biosynthesis platform. In the first component, modular plasmid libraries are used to program bacterial cell-free TX-TL systems. Each plasmid holds one gene or operon, and all the genes are controlled by the same promoter, so that the stoichiometry of enzyme synthesis is determined by the stoichiometry of plasmids in the reaction. In the second part, in order to facilitate high throughput mixing and matching of gene units from the modular plasmid libraries, a modular, reconfigurable, flexible, and scalable microfluidic architecture is employed.

Abstract: This document relates to materials and methods for generating early flowering oilseed (e.g., pennycress) plants. For example, oilseed plants (e.g., modified oilseed plants) having one or more modifications in a polypeptide involved in early flowering (e.g., early flowering six (ELF6)), as well as materials and methods for making and using early flowering oilseed plants are provided.

Abstract: A non-pneumatic tire defining axial, radial, and circumferential directions. The tire includes an annular lattice structure extending radially between an inner circumferential edge and an outer circumferential edge. The lattice structure exhibits topological polarization, with the inner circumferential edge being stiffer than the outer circumferential edge. The topological polarization includes asymmetry in mechanical response to opposing forces applied to the inner and outer circumferential edges. The lattice structure which provides topological polarization endows the tire with localized softness along the outer radius, which enables extreme absorption of asperities, without transferring significant forces to the axle. In some embodiments, the lattice structure further exhibits topological protection, including the topological polarization characteristics being maintained upon experiencing wear at the outer circumferential edge.

Abstract: Real-time systems for monitoring base editing in living cells, including base editing by APOBEC-Cas9 fusions, is provided herein.

Abstract: Certain embodiments of the invention provide a cyclic compound of formula I: wherein: Pro is a residue of L-proline; X1 is a residue of Arg or DArg; X2 is a residue of Phe or DPhe; X3 is a residue of Phe, DPhe or hPhe; X4 is a residue of a natural or unnatural amino acid; X5 is a residue of Ala, Asp, Glu, Lys, His, Phe, Ser, Leu or Gly; X6 is a residue of Phe, Ala, Gly, Ser, Lys, Asp, Leu, Nle, Trp, Tyr, Cha or hPhe; and DPro is a residue of D-proline; or a salt thereof. Certain embodiments also provide compositions comprising such compounds, as well as methods of using such compounds and compositions.

Abstract: A system and method for cardiac activation imaging includes non-invasively or minimally invasively acquiring data about an electrical activation of a heart of a subject using at least one sensor. An activation image of the heart of the subject is reconstructed using a weighted sparse constrained reconstruction.

Abstract: In some examples, a device includes a dielectric material, a ferromagnetic material, and a topological material positioned between the dielectric material and the ferromagnetic material. The device is configured to trap electric charge inside the dielectric material or at an interface of the dielectric material and the topological material. The device is configured to switch a magnetization state of the ferromagnetic material based on a current through the topological material or based on a voltage in the topological material.

Abstract: Described here is a deep brain stimulation (“DBS”) approach that targets several relevant nodes within brain circuitry, while monitoring multiple symptoms for efficacy. This approach to multi-symptom monitoring and stimulation therapy may be used as an extra stimulation setting in extant DBS devices, particularly those equipped for both stimulation and sensing. The therapeutic efficacy of DBS devices is extended by optimizing them for multiple symptoms (such as sleep disturbance in addition to movement disorders), thus increasing quality of life for patients.

Abstract: Techniques are described for additive manufacturing, e.g., 3D printing, stretchable tactile sensors. As described, the techniques may allow the stretchable tactile sensors to be 3D printed under ambient conditions via nanocomposite inks. In various embodiments, sinter-free inks are described with adjustable viscosities and electrical conductivities. Moreover, conductive compositions are described in which micron or submicron-sized silver particles are dispersed in a highly stretchable silicone elastomer. Techniques are described herein in which the inks are used 3D printing process to form tactile sensing platforms and integrated arrays.

Abstract: Systems, methods, and computer-readable media are provided for simulating the coupled axial/torsional dynamics of drilling systems.