Patents Assigned to Renovis, Inc.
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Patent number: 8093265
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 10, 2012
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Bicycloheteroaryl compounds as P2Xmodulators and uses thereof
    Patent number: 7816371
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: October 19, 2010
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Yunfeng Fang, Jianhua He, legal representative, Yeyu Cao, Carl Kaub, Sumithra Gowlugari, Zhan Wang
  • Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
    Patent number: 7745451
    Abstract: Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4?, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: June 29, 2010
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Carl J. Kaub
  • Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
    Publication number: 20100004222
    Abstract: Compounds are disclosed that have a formula represented by the following: Formula (I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: February 22, 2007
    Publication date: January 7, 2010
    Applicant: Renovis, Inc.
    Inventors: Michael G. Kelly, Carl J. Kaub, John Kincaid, Satyanarayana Janagani, Guoxian Wu, Zhi-Liang Wei, Kiran Sahasrabudhe, Matthew Duncton, Ravindra B. Upasani, Yunfeng Fang, Matthew Cox, Jianhua He
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7576099
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: August 18, 2009
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satyanarayana Janagani, Ravindra B. Upasani, Guoxian Wu, Jianhua He, legal representative, Zhi-Liang Wei, Carl Kaub, YunFeng Fang
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7432281
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: October 7, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Ravindra B. Upasani
  • Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
    Patent number: 7414131
    Abstract: Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: August 19, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid, David Lonergan, YunFeng Fang, Zhi-Liang Wei
  • Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
    Patent number: 7402596
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: July 22, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid
  • Amide compounds as ion channel ligands and uses thereof
    Patent number: 7338950
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: March 4, 2008
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid
  • Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
    Patent number: 7312330
    Abstract: Amine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: December 25, 2007
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, Satyanarayana Janagani, Guoxian Wu, John Kincaid, David Lonergan, YunFeng Fang, Zhi-Liang Wei
  • Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
    Patent number: 7312233
    Abstract: Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 14, 2006
    Date of Patent: December 25, 2007
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid, Satyanarayana Janagani, Matthew Duncton
  • Bicycloheteroaryl compounds as P2X modulators and uses thereof
    Patent number: 7297700
    Abstract: Bicycloheteroaryl compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Grant
    Filed: March 17, 2006
    Date of Patent: November 20, 2007
    Assignee: Renovis, Inc.
    Inventors: Michael G. Kelly, John Kincaid
  • Nitrone compounds, pharmaceutical compositions containing the same and methods for treating inflammation and neuropathic pain
    Patent number: 7115666
    Abstract: Disclosed are nitrone compounds and pharmaceutical compositions containing such compounds. The nitrone compounds have one to six additional carbons bridging between the nitrone functionality and the nitrone aryl ring. The disclosed compositions are useful as therapeutics for inflammation-related conditions and analgesia in mammals, such as arthritis, and for neuropathic pain and traumatic injuries such as traumatic brain injury and acute spinal cord injury.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: October 3, 2006
    Assignee: Renovis, Inc.
    Inventors: M. Amin Khan, Ravindra B. Upasani, Paul L. Wood
  • Acetamidobenzamide compounds for neurodegenerative disorders
    Patent number: 7005546
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: June 22, 2004
    Date of Patent: February 28, 2006
    Assignee: Renovis, Inc.
    Inventors: William Flitter, William Garland, Richard Paylor, Allan Wilcox
  • 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
    Patent number: 6998419
    Abstract: Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1–R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: February 14, 2006
    Assignee: Renovis, Inc.
    Inventors: L. David Waterbury, Allan L. Wilcox, John M. Carney, Farah Mavandadi, Albert Danielzadeh
  • AMIDE DERIVATIVES AS ION CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME
    Publication number: 20050222200
    Abstract: Abstract of the Disclosure Compounds are disclosed that have a formula represented by Formula I herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
    Type: Application
    Filed: October 7, 2004
    Publication date: October 6, 2005
    Applicant: Renovis, Inc.
    Inventor: Michael Kelly
  • Use of aryl nitrone compounds in methods for treating neuropathic pain
    Patent number: 6835754
    Abstract: 3,4,5-trisubstituted aryl nitrone compounds having the formula: where R1-R4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: December 28, 2004
    Assignee: Renovis, Inc.
    Inventors: L. David Waterbury, Paul L. Wood, M. Amin Khan, Ravindra B. Upasani
  • Acetamidobenzamide compounds for neurodegenerative disorders
    Patent number: 6759433
    Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: July 6, 2004
    Assignee: Renovis, Inc.
    Inventors: William Flitter, William Garland, Richard Paylor, Allan Wilcox
  • 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
    Patent number: 6730700
    Abstract: Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: May 4, 2004
    Assignee: Renovis, Inc.
    Inventors: L. David Waterbury, Allan L. Wilcox, John M. Carney, Farah Mavandadi, Albert Danielzadeh