Abstract: 3,4,5-trisubstituted aryl nitrone compounds having the formula:
where R1-R4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.
Type:
Grant
Filed:
January 8, 2002
Date of Patent:
December 28, 2004
Assignee:
Renovis, Inc.
Inventors:
L. David Waterbury, Paul L. Wood, M. Amin Khan, Ravindra B. Upasani
Abstract: Disclosed are 3,4,5-trisubstituted aryl nitrone compoundsd and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
Type:
Application
Filed:
January 12, 2004
Publication date:
October 7, 2004
Applicant:
RENOVIS, INC.
Inventors:
L. David Waterbury, Allan L. Wilcox, John M. Carney, Farah Mavandadi, Albert Danielzadeh
Abstract: A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.
Type:
Grant
Filed:
December 12, 2002
Date of Patent:
July 6, 2004
Assignee:
Renovis, Inc.
Inventors:
William Flitter, William Garland, Richard Paylor, Allan Wilcox
Abstract: Disclosed are 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing such compounds. The 3,4,5-trisubstituted aryl nitrone compounds have formula (I); where R1-R4 are as defined in the specification. The disclosed compositions are useful as therapeutics for inflammation-related conditions in mammals, such as arthritis, and as analytical reagents for detecting free radicals.
Type:
Grant
Filed:
July 15, 2002
Date of Patent:
May 4, 2004
Assignee:
Renovis, Inc.
Inventors:
L. David Waterbury, Allan L. Wilcox, John M. Carney, Farah Mavandadi, Albert Danielzadeh