Abstract: Disclosed herein are novel microbial polycultures of two or more cell strains, capable of producing flavanones, flavonoids, and anthocyanidin-3-O-glucosides, and methods of use thereof. Also disclosed is a microbial cell capable of producing phenylpropanoic acids, and methods of use thereof.

Abstract: A detection scheme for temporary overvoltages and/or ground fault overvoltages in electric power systems is described. Current passing through a surge arrestor component of the power system is monitored. An algorithm for identifying one or more frequency components of the measured current signal is performed to screen out unwanted harmonics. In some embodiments, this is a frequency domain analysis. The frequency component(s) of the current signal is then compared to a calculated pickup current or pickup voltage of the system to determine if system protection steps should be undertaken.

Abstract: A detection scheme for x-ray small angle scattering is described. An x-ray small angle scattering apparatus may include a first grating and a complementary second grating. The first grating includes a plurality of first grating cells. The complementarity second grating includes a plurality of second grating cells. The second grating is positioned relative to the first grating. A configuration of the first grating, a configuration of the second grating and the relative positioning of the gratings are configured to pass one or more small angle scattered photons and to block one or more Compton scattered photons and one or more main x-ray photons.

Abstract: A force measuring apparatus is described. The apparatus includes a force concentrator. The force concentrator is configured to attach to a loadbearing medical device and to produce a transverse force related to an eccentric axial force applied to the loadbearing medical device. A bending stiffness of the force concentrator is different from a bending stiffness of the loadbearing medical device.

Abstract: A high absorption photovoltaic material and method of making the material for use in a solar cell are disclosed. The photovoltaic material includes a surface modified with a layer of repeating photonic crystal structures. The photonic crystal structures are approximately inverse conically shaped and have a curved sidewall that has an approximately Gaussian shape. The photonic crystal structures generally have a high vertical depth and sidewall angle. The structures also have a gradient refractive index profile and exhibit the parallel-to-interface refraction light trapping effect. An anti-reflective coating is disposed over the photonic crystal structure layer. The photovoltaic material exhibits near unity light absorption over a broad range of visible and near infrared wavelengths and incidence angles, even at reduced thicknesses.

Abstract: The technology is a securing device for electrical wiring and other mechanical components to the frame or other wire bundles without the use of metallic hardware.

Abstract: A method of prolonging service life of an energy storage device such as a lithium-ion battery includes temporarily operating the battery at an elevated current density. Cycling of lithium-ion batteries at regular current densities results in the generation of lithium-metal dendrites at the surface of the anode, particularly in batteries where the anode is lithium metal. The lithium metal dendrites pose a threat to damage other components of the battery, such as separators, as well as causing an electrical short. Operating the battery in bursts at the elevated current density results in self-heating at the anode surface that merges adjacent lithium-metal dendrites and an overall smoothing of the anode surface. This method is also applicable to other alkali-metal-based batteries and chemistries.

Abstract: In some embodiments, a method of machine learning includes identifying, by an auto encoder network, a simulator feature based, at least in part, on a received first simulator data set and an emulator feature based, at least in part, on a received first emulator data set. The method further includes determining, by a synthesis control circuitry, a synthesized feature based, at least in part, on the simulator feature and based, at least in part, on the emulator feature; and generating, by the auto encoder network, an intermediate data set based, at least in part, on a second simulator data set and including the synthesized feature. Some embodiments of the method further include determining, by a generative artificial neural network, a synthesized data set based, at least in part, on the intermediate data set and based, at least in part, on an objective function.

Abstract: Methods, systems, and assemblies for cooling an electronic component are disclosed. A heat sink assembly includes first and second substrates. The first substrate is in thermal contact with the electronic component. A primary channel is formed in the second surface of the first substrate. The primary channel is configured to direct cooling fluid for cooling the electronic component. An array of primary cooling fluid fins is positioned within the primary channel. The array of primary cooling fluid fins includes upstream solid fins and downstream open fins each having an upstream opening and downstream sidewalls. The secondary channel is formed within the second surface of the second substrate and is configured to direct partially heated cooling fluid away from the electronic component. An array of secondary cooling fluid fins is positioned within the secondary channel downstream. An enclosing layer seals the secondary channel.

Abstract: Methods and systems for controlling a fluid flow field near a surface are disclosed. In some embodiments, the system includes an array of oscillating bodies disposed on the surface to provide physical modification to the flow field. Fluid jets are also emitted from an outlet in the oscillating body to provide virtual modification of the flow field through momentum addition. Fluid jet sources, including synthetic jet generators such as piezoelectric drivers and sources of compressed fluids such as air or water, are positioned to be in fluid communication with the outlet at intervals during the oscillation of the oscillating body. Controlling the oscillation amplitude and frequency of the body, as well as the location of oscillating body outlets and frequency of fluid jet emission, have advantageous effects for the surface such as improved heat transfer properties and reduction in structural vibration and noise.

Abstract: A cross-connect switch architecture is described. A cross-connect switch device includes a cross-point switch array, a plurality of photo detectors and a plurality of amplifiers. The cross-point switch array includes a plurality of switches. Each switch is coupled between a respective photo detector and a respective amplifier and is configured to couple the respective photo detector to the respective amplifier when the switch is selected.

Abstract: Method, system and computer program product are provided for estimating a circadian phase of a subject by: obtaining a sensed biological signal for the subject; and using, by one or more processors, adaptive frequency tracking to adaptively estimate the circadian phase of the subject from the sensed biological signal. Circadian phase estimation may be accelerated by providing a feedback loop for the adaptive frequency tracking, which utilizes, in part, a circadian phase model in automatically ascertaining a phase correction for the adaptive frequency tracking. The circadian phase estimation may be used in automatically constructing a light-based circadian rhythm model for the subject using a linear parameter-varying (LPV) formulation, and once constructed, the circadian rhythm model for the subject may be used to provide light-based circadian rhythm regulation.

Abstract: A deep neural network for metal artifact reduction is described. A method for computed tomography (CT) metal artifact reduction (MAR) includes generating, by a projection completion circuitry, an intermediate CT image data based, at least in part, on input CT projection data. The intermediate CT image data is configured to include relatively fewer artifacts than an uncorrected CT image reconstructed from the input CT projection data. The method further includes generating, by an artificial neural network (ANN), CT output image data based, at least in part, on the intermediate CT image data. The CT output image data is configured to include relatively fewer artifacts compared to the intermediate CT image data. The method may further include generating, by detail image circuitry, detail CT image data based, at least in part, on input CT image data. The CT output image data is generated based, at least in part, on the detail CT image data.

Abstract: Provided are a conjugate including a core and sialic acids or derivatives thereof bound to the surface of the core, and use thereof. The conjugate provided in the present invention binds with hemagglutinin on the surface of influenza virus to inhibit the course of infection of influenza virus, thereby preventing or treating infection of influenza virus and also preventing or treating infection of influenza virus resistant to antiviral agents. Accordingly, the conjugate may be widely used in the development of prophylactic or therapeutic agents for influenza virus infection.

Abstract: The invention relates, in part, to nanoparticles, methods for preparing nanoparticles and methods of administering nanoparticles for immune stimulation. An immune-stimulating nanoparticle of the invention may include, at least in part, a polymer substrate comprising a biodegradable polymer and may include at least one antigen and/or at least one adjuvant.

Abstract: Compositions of the present disclosure include a first dCas9-FokI-sgRNA complex and a second dCas9-FokI-sgRNA complex. The first sgRNA is configured to target a first side of a genomic fusion site and the second sgRNA is configured to target a second side of the genomic fusion site. The first and second complexes only cut DNA upon dimerization. Thus, upon binding of both first dCas9-FokI-sgRNA complex and second dCas9-FokI-sgRNA complex, the dimer is produced and DNA cleavage proceeds at the genomic fusion site. The dCas9-FokI-sgRNA complexes are loaded on a folded-DNA shell for transport across the cellular membrane. The shell has a viral-mimic structure that maximizes cell entry, is non-cytotoxic, has low-to-nonimmunogenicity, and provides excellent capacity to enclose and protect the complexes. These systems exhibit both cellular (via the shell) and molecular (via the complexes) specificity, significantly reducing off-target activity and the associated harmful side-effects.

Abstract: A neural network based corrector for photon counting detectors is described. A method for photon count correction includes receiving, by a trained artificial neural network (ANN), a detected photon count from a photon counting detector. The detected photon count corresponds to an attenuated energy spectrum. The attenuated energy spectrum is related to characteristics of an imaging object and is based, at least in part, on an incident energy spectrum. The method further includes correcting, by the trained ANN, the detected photon count to produce a corrected photon count. The method may include reconstructing, by image reconstruction circuitry, an image based, at least in part, on the corrected photon count.

Abstract: Systems for the production of graphene oxide sheets are provided. The systems include electro-deposition and spray deposition techniques. The graphene oxide sheets may be used as pre-cursors for the formation of porous graphene network (PGN) anodes and lithiated porous graphene (Li-PGN) cathodes. The method of making PGN electrodes includes thermally reducing a pre-cursor sheet of graphene oxide to provide a PGN anode and exposing the sheet to lithium or a lithium-containing compound to produce a Li-PGN cathode. The Li-PGN cathode and PGN anode may be combined with an electrolyte to provide an “all-carbon” battery that is useful in various applications, such as automotive applications.

Abstract: Methods and devices including a light display transceiver device are disclosed. Disclosed methods and devices include a light source array including at least one pixel unit, the at least one pixel unit including one of a single pixel, a plurality of groups of cooperating single pixels, a combination of singles pixels and groups of cooperating single pixels, and a single group of cooperating single pixels. Control wires are joined with each of the at least one pixel units. A controller is joined with the control wires for controlling each of the at least one pixel unit. The light source array is configured to operate in at least one of three modes, a full-space-division-duplex (FSDD) mode, a half-space-division-duplex (HSDD) mode, and a time-division-duplex (TDD) mode. The controller causes the light source array to operate in one of the three modes.

Abstract: A heparin structure with increased anticoagulant activity and method of making the same are disclosed. A heparin sample is provided and treated with a heparan sulfate sulfotransferase in an enzymatic reaction to add sulfuryl groups from a sulfuryl group source to the heparin sample, resulting in a heparin structure having above about 8% more 3-O-sulfo groups relative to wild-type bovine intestinal heparin. The added sulfuryl groups modify the heparin structure and increase the sample's binding to antithrombin III and its anticoagulant activity to be more similar and a viable alternative to porcine intestinal heparin. The modified heparin exhibits an anti-FXa activity and an anti-FIIa activity greater than about 180 U/mg, and a ratio of the anti-FXa activity to the anti-FIIa activity of about 0.9 to about 1.1, consistent with U.S. Pharmacopeia (USP) heparin activity specifications.