Abstract: Systems and methods for generating and evaluating candidate sequences of partitioning steps to partition at least one biologically produced product from at least one impurity. In some embodiments, a plurality of candidate sequences of partitioning steps may be generated, wherein at least one candidate sequence of the plurality of candidate sequences comprises a plurality of partitioning steps in a specified order. The plurality of candidate sequences may be evaluated. For instance, a data set associated with the at least one partitioning step may be accessed, the data set comprising: first data indicative of a behavior of the at least one biologically produced product with respect to the at least one partitioning step; and second data indicative of a behavior of the at least one impurity with respect to the at least one partitioning step. The at least one candidate sequence may be scored based at least in part on the data set.

Abstract: A magnetically coupled piston pump includes a piston, a pump body, and a set of drive magnets. The piston includes a set of piston magnets. Each piston magnet has poles arranged along a longitudinal axis of the piston, and each piston magnet is arranged in the piston so that the orientation of the poles of each piston magnet is the opposite of the orientation of each adjacent piston magnet. The piston is disposed in and permitted to move within the pump body. The set of drive magnets is arranged outside the pump body. Each drive magnet corresponds to a piston magnet, has poles arranged along the longitudinal axis, and is arranged so that the orientation of the poles is opposite the orientation of the poles of the corresponding piston magnet. A drive unit is coupled to the drive magnets for moving the drive magnets along the longitudinal axis.

Abstract: The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.

Abstract: Novel and advantageous systems and methods for performing X-ray imaging by using an X-ray source with source grating functionality incorporated therein are provided. An electron beam can be electromagnetically manipulated such that the X-ray source emits radiation in a pattern that is the same as if the radiation had already passed through a source grating.

Abstract: Aspects of the present disclosure relate to systems and methods for manufacturing biologically-produced pharmaceutical products. Some of the systems described herein comprise an upstream component comprising a bioreactor and at least one filter (e.g., a filter probe) integrated with a downstream component comprising a purification module comprising at least a first partitioning unit and a second partitioning unit. In some embodiments, these integrated biomanufacturing systems may be operated under continuous or conditions and may be capable of efficiently producing pure, high-quality pharmaceutical products.

Abstract: The electrochemical energy conversion system of the present disclosure includes an anode, a cathode, and an ion exchange membrane including a polymer having an aromatic polymer chain and an alkylated substrate including an alkyl chain, and at least one ionic group. The alkylated substrate is bound to at least one aromatic group in the polymer chain via Friedel-Crafts alkylation of the at least one aromatic group. The alkylation reaction utilizes a haloalkylated tertiary alcohol or a haloalkylated alkene as a precursor. In the presence of an acid catalyst, a carbocation is generated in the precursor which reacts with the aromatic rings of the polymer chain. The at least one ionic group is then replaced with a desired cationic or anionic group using a substitution reaction. The membranes exhibit advantageous stability achieved through a simplified and scalable reaction scheme.

Abstract: Advantageous machines, such as flux-switching machines (FSMs) are provided. An FSM can be yokeless and can have two rotors, which can be displaced from one another (e.g., by half a pole pitch). An FSM can be a flux-switching permanent magnet machine (FSPMM), and all magnets can be magnetized in the same circumferential direction. FSMs of the subject invention are cost-effective, have high torque density, and can operate well even under fault conditions.

Abstract: Novel and advantageous lighting modules and systems are provided. Lighting modules and systems according to embodiments of the subject invention can be low-luminance, high-efficiency, low-glare lighting modules. For example, a lighting system can utilize multiple layers of efficient optics to spread light from multiple light sources (e.g., a grid of point sources) over a larger luminous surface. The larger luminous surface can maintain the controllability, directionality, and efficiency of a single point source, while significantly reducing the glare. The surface can appear uniformly lit, or substantially uniformly lit, and no dark boundaries may be present between the individual light sources.

Abstract: The present disclosure relates to, inter alia, a modified surface comprising an optically active monomer, a polymeric material having a surface onto which the optically active monomer is covalently bound. In one aspect, a membrane comprising an optically active monomer, a poly(aryl sulfone) membrane having a surface onto which the optically active monomer is covalently bound. The present disclosure also relates to a method of modifying a surface, the method comprising applying sufficient energy to a surface to induce covalent bonding with an optically active monomer, and contacting the optically active monomer with the surface. In one aspect, a method of modifying a surface of a poly(aryl sulfone) membrane is disclosed. In another aspect, a method of synthesizing an optically active monomer is disclosed. In one aspect, a method of filtration of chiral compounds is disclosed.

Abstract: Embodiments of the invention relate generally to graphene fibers and, more particularly, to graphene fibers comprising intercalated large-sized graphene oxide (LGGO)/graphene sheets and small-sized graphene oxide (SMGO)/graphene sheets having high thermal and electrical conductivities and high mechanical strength. In one embodiment, the invention provides a graphene fiber comprising: a plurality of intercalated graphene sheets including: a plurality of large-sized graphene sheets; and a plurality of small-sized graphene sheets, wherein at least one of the plurality of small-sized graphene sheets is disposed between at least two of the plurality of large-sized graphene sheets.

Abstract: Systems, methods, and kits for reducing structural vibrations on wind turbine blades are provided. The actual dynamic structural conditions of a wind turbine blade can be used as a feedback mechanism. A flow control device and a sensor can be installed on a wind turbine blade, and a closed loop control system in operable communication with the flow control device and the sensor can be used to provide closed loop control.

Abstract: An improved nanoparticle for transfecting cells is provided. The nanoparticle includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide. Also provided is an improved method of modifying intracellular polynucleotides. The method includes contacting a cell with a nanoparticle that includes a core polyplex and a silica coating on the core polyplex and, optionally, a polymer attached to an outer surface of the silica coating, where the polyplex includes an anionic polymer, a cationic polymer, a cationic polypeptide, and a polynucleotide.

Abstract: Embodiments of the invention relate to a novel class of polymers with superior mechanical properties and chemical stability, as compared to known polymers. These polymers are particularly well suited for use in anion exchange membranes (AEMs), including those employed in fuel cells. Novel methods for the manufacture of these polymers are also described.

Abstract: A system, method and program product for generating sound masking in an open-plan space. A method is disclosed that includes: establishing a set of acoustic criteria for the space that specifies minimum output levels at a set of specified frequencies; mixing sound samples to create an audio output stream for use as sound masking when broadcast over at least one speaker using a power amplifier; and processing the audio output stream, wherein the processing includes: analyzing the audio output stream with a spectrum analyzer to determine if the minimum output levels at the set of specified frequencies are met; and level adjusting the audio output stream with an equalizer to ensure that minimum output levels at the set of specified frequencies are met but do not exceed a given threshold above the minimum level.

Abstract: Multipurpose lighting systems and methods of providing controllable lighting are provided. A lighting system includes a sheet of flexible material, a plurality of light sources and a controller. The plurality of light sources are attached to the sheet of flexible material and configured to emit diffused light. The controller is coupled to the plurality of light sources and is configured to control one or more of the plurality of light sources according to one of a plurality of prescribed lighting characteristics associated with a respective plurality of different lighting tasks. In some examples, the lighting system includes a camera coupled to the sheet of flexible material configured to capture at least one image of an object synchronously with the light emitted by the plurality of light sources.

Abstract: The present invention relates to synthetic membranes and use of these synthetic membranes for isolation of volatile organic compounds and purification of water. The synthetic membrane includes a hydrophobic polymer layer located on a polymeric membrane support layer. The invention includes a method of isolating volatile organic compounds with the synthetic membrane by contacting a volatile organic mixture with the hydrophobic polymer layer of the synthetic membrane and removing volatile organic compounds from the polymeric membrane support layer of the synthetic membrane by a process of pervaporation. The invention also includes a method of purifying water with the synthetic membrane by contacting an ionic solution with the hydrophobic polymer layer of the synthetic membrane and removing water from the polymeric membrane support layer of the synthetic membrane by a process of reverse osmosis. The invention also relates to methods of isolating non-polar gases by gas fractionation.

Abstract: Systems and methods for geometric calibration and image reconstruction in computed tomography (CT) scanning using iterative reconstruction algorithms are provided. An iterative reconstruction algorithm can be used to reconstruct an improved image, and then the improved image can be used to adjust inaccurate parameters by using a Locally Linear Embedding (LLE) method. Adjusted parameters can then be used to reconstruct new images, which can then be used to further adjust the parameters. The steps of this iterative process can be repeated until a quality threshold is met.

Abstract: A heparin structure with increased anticoagulant activity and method of making the same are disclosed. A heparin sample is provided and treated with a heparan sulfate sulfotransferase in an enzymatic reaction to add sulfuryl groups from a sulfuryl group source to the heparin sample, resulting in a heparin structure having above about 8% more 3-O-sulfo groups relative to wild-type bovine intestinal heparin. The added sulfuryl groups modify the heparin structure and increase the sample's binding to antithrombin III and its anticoagulant activity to be more similar and a viable alternative to porcine intestinal heparin. The modified heparin exhibits an anti-FXa activity and an anti-FIIa activity greater than about 180 U/mg, and a ratio of the anti-FXa activity to the anti-FIIa activity of about 0.9 to about 1.1, consistent with U.S. Pharmacopeia (USP) heparin activity specifications.

Abstract: A system for generating a high resolution (HR) computed tomography (CT) image from a low resolution (LR) CT image is described. The system includes a first generative adversarial network (GAN) and a second GAN. The first GAN includes a first generative neural network (G) configured to receive a training LR image dataset and to generate a corresponding estimated HR image dataset, and a first discriminative neural network (DY) configured to compare a training HR image dataset and the estimated HR image dataset. The second GAN includes a second generative neural network (F) configured to receive the training HR image dataset and to generate a corresponding estimated LR image dataset, and a second discriminative neural network (DX) configured to compare the training LR image dataset and the estimated LR image dataset.

Abstract: Embodiments of the invention relate generally to anion exchange membranes and, more particularly, to anion exchange membranes comprising a styrene block copolymer and methods for their manufacture. In one embodiment, the invention provides a polymer according to formula IV, wherein x and y are mol %, QA is or each of R1 and R2 is, independently, a linear alkyl chain or a cyclic alkyl chain, and Z is selected from a group consisting of: a linear alkyl chain, a cyclic alkyl chain, and an alkylene ether chain.