Patents Assigned to Research Development Foundation
  • Publication number: 20220380832
    Abstract: Provided are methods for the identification of mutant kinases that are resistant to inhibition by a kinase inhibitor. In some embodiments, the methods may be used to assess a test compound or kinase inhibitor for the risk of the development of resistance in vivo, e.g., during clinical administration to treat a disease such as a cancer.
    Type: Application
    Filed: January 3, 2022
    Publication date: December 1, 2022
    Applicant: Research Development Foundation
    Inventors: Brent IVERSON, George GEORGIOU, Joseph DESAUTELLE, Joseph TAFT
  • Patent number: 11512283
    Abstract: Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: November 29, 2022
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Michal Amit, Joseph Itskovitz-Eldor
  • Patent number: 11513533
    Abstract: Methods and systems are provided for belief space planning for multiple robots at an initial belief state, for reducing belief space uncertainty, including receiving multiple, candidate, multi-robot paths, each including one or more pose constraints; generating a candidate factor graph for each candidate multi-robot path, and generating from each candidate factor graph a topology graph; calculating a signature metric from each topology graph, wherein the signature metric is one of a Von Neumann (VN) metric and a spanning tree (ST) metric; selecting a multi-robot path having the greatest signature metric from among the candidate, multi-robot paths; and instructing the multiple robots to proceed according to the selected multi-robot path.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: November 29, 2022
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Andrej Kitanov, Vadim Indelman
  • Patent number: 11505336
    Abstract: A vacuum arc thruster device having a cathode rod disposed within a concentric insulator tube, and an anode electrode located at the distal edge of the insulator tube, separated from the cathode rod by the insulator tube. A controlled feeding mechanism moves the cathode towards the distal exit plane in a helical motion, the cathode rotating as it moves forward. The cathode rod is fixed in the center of a headless screw segment, which is rotated within a screw thread on the internal surface of a cylindrical wall of the device. As the erosion rate is concentrated at the exit plane, the screw action path enables uniform erosion around the cathode circumference, and cathode linear motion that can be matched to the radial erosion rate. The feeding rate and hence the thrust are proportional to the input power, which can be regulated by the pulse frequency.
    Type: Grant
    Filed: June 15, 2017
    Date of Patent: November 22, 2022
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventor: Igal Kronhaus
  • Publication number: 20220356216
    Abstract: A composition of matter comprising a fusion protein attached to the outer surface of a substrate is disclosed. The fusion protein comprises a light-generating protein and a light-transducing protein. Uses of the composition of matter are disclosed.
    Type: Application
    Filed: May 5, 2022
    Publication date: November 10, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Avraham SCHROEDER, Omer ADIR
  • Publication number: 20220356231
    Abstract: Provided herein are immunogenic compositions that may be used, in some aspects, to induce an immune response against an Ehrlichia such as Ehrlichia cams. In some embodiments, the immunogenic composition comprises an E. canis bacterin and/or adjuvant, such as for example an emulsion or liposomal adjuvant. Related methods such as for diagnosis of or vaccination against ehrlichiosis are also provided.
    Type: Application
    Filed: July 13, 2020
    Publication date: November 10, 2022
    Applicants: Research Development Foundation, Zoetis Services LLC
    Inventors: Jere W. McBRIDE, Paul J. DOMINOWSKI, Suman MAHAN, Jason J. MILLERSHIP, Duncan M. MWANGI, Sharath RAI, Sharon M. WAPPEL
  • Publication number: 20220351079
    Abstract: Disclosed embodiments are a computing system and a computer-implemented method for distributed training of a machine learning model over a plurality of computing nodes, in a plurality of iterations, characterized by gradient gap based mitigation of the gradient staleness problem. The disclosed method evaluates the staleness of the gradient based on the difference in gradients between a central point, for example an iteration's common starting point, and the points reached by the respective computing node during one or more iterations, and aggregates the update steps from the plurality of computing nodes, while giving more weight to computing nodes having a lesser change in the gradient.
    Type: Application
    Filed: November 5, 2020
    Publication date: November 3, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Assaf SCHUSTER, Saar BARKAI, Ido HAKIMI
  • Publication number: 20220349067
    Abstract: Provided are electrochemical cells and methods for generating hydrogen gas and oxygen gas.
    Type: Application
    Filed: July 6, 2022
    Publication date: November 3, 2022
    Applicant: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Gideon GRADER, Gennady SHTER, Hen DOTAN, Avner ROTHSCHILD, Avigail LANDMAN
  • Publication number: 20220340764
    Abstract: A methodology is provided for generating hydrophobic superhydrophobic, oleophobic and/or superoleophobic surfaces. Compositions of matter made of a substrate having deposited on a surface thereof (e.g., by thermal evaporation) hydrocarbon waxes, including fluorinated waxes, are disclosed. Process of preparing such compositions of matter and articles of manufacturing incorporating such compositions are also disclosed. Further disclosed are articles of manufacturing and methods which are useful in inhibiting, reducing and/or retarding biofilm formation, and which include applying waxes (e.g., by thermal evaporation) on a surface of the articles.
    Type: Application
    Filed: July 5, 2022
    Publication date: October 27, 2022
    Applicants: Technion Research & Development Foundation Limited, The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Boaz POKROY, Sasha PECHOOK, Moshe SHEMESH
  • Publication number: 20220333066
    Abstract: Provided are novel serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3 and ascorbic acid at a concentration of at least about 50 microgram/ml; ascorbic acid at a concentration range of about 400-600 microgram/ml, bFGF at a concentration range of about 50-200 ng/ml, xeno-free serum replacement and a lipid mixture; the IL6RIL6 chimera at a concentration range of about 50-200 picogram per milliliter (pg/ml); or leukemia inhibitory factor (LIF) at a concentration of at least 2000 units/ml; cell cultures comprising same with pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems; and methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation.
    Type: Application
    Filed: June 16, 2022
    Publication date: October 20, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Michal AMIT, Joseph ITSKOVITZ-ELDOR
  • Patent number: 11474954
    Abstract: A cache unit that is configured to retain: a plurality of cache blocks; a plurality of owner indicators, and a plurality of validity marks. For each cache block of the plurality of cache blocks exists a corresponding owner indicator in the plurality of owner indicators. An owner indicator corresponding to a cache block is capable of identifying an entity that caused the cache block to be fetched to the cache unit. For each cache block of the plurality of cache blocks exists a corresponding validity mark in the plurality of validity marks. A validity mark corresponding to the cache block indicates whether a validation process performed on the cache block upon fetching thereof was successful. The cache unit may be useful for secure execution.
    Type: Grant
    Filed: June 3, 2018
    Date of Patent: October 18, 2022
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Ofir Shwartz, Yitzhak Birk
  • Patent number: 11471453
    Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.
    Type: Grant
    Filed: March 30, 2020
    Date of Patent: October 18, 2022
    Assignees: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, HEALTH CORPORATION - RAMBAM
    Inventors: Asya Rolls, Tamar Ben Shannan, Hilla Azulay-Debbie, Fahed Hakim, Maya Schiller, Shai Shen-Orr, Elina Starosvetsky
  • Publication number: 20220319656
    Abstract: Provided herein are methods and systems for automated generation of hypothesis based on sets of search terms, and scoring of said automatically generated hypothesis to determine novelty, reasonability and/or feasibility thereof. Further provided are methods of utilizing said generated hypothesis for determination of personalized treatment regime of various health conditions.
    Type: Application
    Filed: August 16, 2020
    Publication date: October 6, 2022
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION
    Inventors: Yosef Shamay, David Dobreen
  • Patent number: 11459379
    Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: October 4, 2022
    Assignee: Research Development Foundation
    Inventors: Jere W. McBride, Christopher K. Doyle
  • Publication number: 20220308054
    Abstract: Provided are methods of determining prognosis of a subject diagnosed with sepsis, by determining the baseline levels of T-cell senescence in the subject. Also provided are methods of treating a subject diagnosed with sepsis, by monitoring the subject diagnosed with sepsis and treating the subject which exhibits high baseline levels of T-cell senescence.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 29, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Shai S. SHEN-ORR, Ayelet ALPERT, Elina STAROSVETSKY, Ashham MANSUR
  • Patent number: 11452759
    Abstract: The invention provides a method for treating cancer comprising the step of administering a therapeutically effective amount of KPC1, a peptide which is at least about 70% homologous to the KPC1 or an agent which up-regulates KPC1. In some embodiments, there is also provided a method for treating cancer comprising the step of administering a therapeutically effective amount of p50, a peptide which is at least about 70% homologous to the p50 or an agent which up-regulates p50.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: September 27, 2022
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Aaron Ciechanover, Yelena Kravtsova, Inna Shomer, Victoria Cohen
  • Publication number: 20220296321
    Abstract: A compact robotic device for driving movement of two or more elongate surgical tools configured for a telescopic arrangement when said two or more elongate surgical tools are at least partially received within said device, the device comprising: a housing comprising walls which define an inner volume including at least two inner pathways for accommodating the two or more elongate surgical tools; the housing encasing: a plurality of motors, and two or more tool actuation assemblies configured at a position of each of the two or more inner pathways; the actuation assemblies driven by the plurality of motors and configured to operably contact an elongate surgical tool at least partially received in the inner pathway to at least one of advance, retract and/or roll said elongate surgical tool.
    Type: Application
    Filed: February 23, 2022
    Publication date: September 22, 2022
    Applicants: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon SHARON, Idan BOADER, Evgeny KOFMAN, Moshe SHOHAM, Eran COHEN, Eyal MORAG
  • Publication number: 20220300610
    Abstract: A system and method for protecting a speculative execution processor, from side channel attacks, are disclosed. The system comprises a processing circuitry, adapted to: in a first time period performing an execution of a code segment by storing speculative instructions in an internal cache memory which is inaccessible to read actions of an external processing unit; in a second time period copying only a committed portion of the executed code segment into another memory component which is accessible to read actions of the external processing unit. The first and second time periods are different and independent.
    Type: Application
    Filed: June 19, 2020
    Publication date: September 22, 2022
    Applicant: Technion Research & Development Foundation Limited
    Inventor: Abraham MENDELSON
  • Patent number: 11450744
    Abstract: The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of tungsten trioxide, rhenium trioxide, or chromium oxide coating said hydrogen-terminated surface. Such conducting materials are useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.
    Type: Grant
    Filed: September 2, 2018
    Date of Patent: September 20, 2022
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Rafi Kalish, Moshe Tordjman
  • Publication number: 20220290637
    Abstract: A thermochemical recuperation (TCR) system that may use a water-alcohol mixture as an engine liquid coolant; that may include a TCR reformer configured to output a TCR product at pressure no less than twenty bars; a pressure regulator; and an TCR product accumulator configured to separate an outputting of the TCR product by the TCR reformer from a provision of the TCR product to the pressure regulator; wherein the pressure regulator is configured to provide the TCR product to a direct injector of an engine, thereby enabling the direct injector to inject the TCR product at a high pressure level—for example at a pressure level that exceeds twenty bars.
    Type: Application
    Filed: July 7, 2020
    Publication date: September 15, 2022
    Applicant: Technion Research and Development Foundation Ltd.
    Inventors: Leonid Tartakovsky, Moshe Sheintuch, Mark Veinblat, Andy Thawko