Abstract: A modular robotic surgical system comprising: a base; a plurality of tool-receivers arranged as separate units, each tool-receiver unit operable to move an elongate surgical tool received therein; a plurality of interface coupling pairs, each coupling pair comprising a first coupler as part of the base and a second coupler as part of each of the tool-receiver units; wherein each of the tool-receiver units is independently and interchangeably attachable to the base via the coupling pair.

Abstract: Modified aminoglycoside compounds represented by Formula I as defined and described in the specification are provided. The modified aminoglycosides feature a diamine-containing functional moiety at one or more of positions 3?, 4? and 6?. Uses of the modified aminoglycosides as antimicrobial (e.g., antibacterial) agents, and in treating medical conditions associated with microorganisms, are also provided.

Abstract: There is provided a method of computing lineage, comprising: managing a dataset of records, each record associated with set(s) of vectors of real numbers that encode an approximation of lineage of the respective record, the set(s) of vectors computed by an encoding process, obtaining result record(s) in response to executing a query on the dataset, computing set(s) of vectors for the result record(s), searching the set(s) of vectors on the records of the dataset to identify a record associated with a subset of vectors that are statistically similar to the set(s) of vectors for the result record(s), and providing a subset of the records corresponding to the identified subset of records, the subset of the records having a likelihood of contributing to the existence of the result record(s) in response to execution of the query.

Abstract: An electronic memory block comprises phase change memory cells for memory storage and further phase change memory cells forming logic gates, to provide in-memory data processing.

Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: A method for providing an architectural component, the method includes (i) receiving, by a computerized system, a request to design a manufacturing process of an architectural component; (ii) determining, by the computerized process, the manufacturing process by applying an interactive design process that takes into account interactions between (a) material composition parameters, (b) architectural design parameters, and (c) manufacturing parameters; wherein the manufacturing process is an additive three dimensional printing process; and (iii) responding to the designed manufacturing process.

Abstract: Patterning a substrate can be provided. A substrate is covered by an immersion liquid and a microfluidic probe head is positioned in proximity with the surface of the substrate, so as to immerse a processing surface of the probe head in the immersion liquid. Liquid flows are generated between the processing surface of the probe head and the surface of the substrate, via the probe head. The liquid flows generated include an etching flow of an etching liquid (e.g., an acid or solvent) and a processing flow of a processing liquid (e.g., a solution or suspension).

Abstract: Immunoreactive engineered polypeptides are provided. The engineered polypeptides can be used to diagnose or induce an immune response against E. chaffeensis or E. canis.

Abstract: Provided herein are composite conductors, characterized by having copper deposits inside the bulk rather than on the outer surface of a non-metallic conductive porous matrix, such as CNT fabric, as well as a process for obtaining the same. The composite conductors provided herein are also characterized by a low specific weight and a high ampacity compared to metal conductors of similar size and shape.

Abstract: The present invention relates to an heparanase-binding and heparanase-neutralizing monoclonal antibody (IgG-1 mAb A54), including its epitope (HBD-II) and mode of interaction with heparanase, pharmaceutical composition comprising same, and uses thereof e.g. for inhibiting or treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, viral infection, diabetes and related complications. The present invention further provides combinatorial cancer therapies, comprising the heparanase-neutralizing mAb and an additional anti-cancer treatment such as chemotherapy or radiation.

Abstract: A direct gaseous reformate injector that includes an inlet for receiving a gaseous reformate; a plunger; and an outward-opening valve that comprises a valve body and a needle that is movable, by the plunger, in relation to the valve body, between a (a) closed position in which the gaseous reformate is not outputted from the direct gaseous reformate injector, and (b) an open position in which the gaseous reformate is outputted from the direct gaseous reformate injector.

Abstract: A method of treating a disease or disorder for which an increase in immune cells in the brain is therapeutic in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which specifically binds and increases activity of a receptor selected from the group consisting of a 5HT2C receptor, a 5HT2A receptor and a 5HT2B receptor in the postcentral gyrus and/or the choroid plexus (CP) of the brain of the subject. Compositions for treating these diseases are also disclosed.

Abstract: A method of preparing a composition comprising mycelium along with a cellulose and/or plurality of nanoparticles is described herein. The method comprises inoculating a liquid medium with fungus, the liquid medium comprising nutrients and the cellulose and/or nanoparticles. Further described herein are compositions comprising mycelium along with a cellulose and/or plurality of nanoparticles, as well as articles-of-manufacture comprising such a composition, wherein at least 10% of the cellulose and/or nanoparticles in the composition is incorporated within the mycelium. A method of enhancing fungal growth is also described, comprising contacting the fungus with a liquid medium comprising a polymer which comprises carboxylic acid groups.

Abstract: A method for quantitative magnetic resonance imaging (MRI), the method includes (a) receiving a sequence of MRI images of an in vivo tissue, by an image registration deep neural network (DNN) module that was trained, by a training process, to impose one or more MRI signal related physical constraints on a content of the sequence of MRI images; and (b) extracting one or more quantitative map from the sequence of MRI images.

Abstract: Immunoreactive engineered polypeptides are provided. The engineered polypeptides can be used to diagnose or induce an immune response against E. chaffeensis or E. canis.

Abstract: Mechanophoric compounds featuring one or more, or two or more, clickable group(s), which are capable of being coupled to naturally occurring, synthetic and/or metallic substrates via Click chemistry, method of preparing mechanophoric matrices using the mechanophoric compounds, and mechanophoric matrices obtainable thereby, and uses thereof for detecting force-induced damage in the matrices by a colorimetric change are provided.

Abstract: Exemplary embodiments of the present disclosure include apparatus and methods to classify the plaque tissue present in the coronary artery using intravascular optical coherence tomography (IVOCT) images.

Abstract: An atomic interferometer system comprises optical tweezers each configured to trap at least one atom therein, an atom source system configured to release atoms, and a controller configured to control the optical tweezers to trap at least one atom released by the atom source system in one of the tweezers, to spatially split a wave function of the trapped atom between at least two of the tweezers, and to at least partially recombine the split atomic wave function in at least one of the tweezers. The atomic interferometer system can also comprise a measuring system configured to measure wavefunction population in each of the tweezers and to display an output pertaining to the wavefunction populations.

Abstract: Systems and methods for performing minimally invasive surgical procedures, especially for removal of tumors, and especially for brain tumors, using a robotically inserted therapeutic probe, which first detects tumorous tissue on a pre-planned path through the patient's tissue, before performing therapeutic procedures on the tissue, such as ablation. This pre-treatment detection procedure is thus able to avoid the destruction of healthy tissue. This also ensures that the therapeutic process indicated in a preoperative surgical plan is only performed on tumorous tissue, without sole reliance on preoperative image indications. This is important for neurosurgical operations performed on the brain, since preoperative images may not be accurate due to brain shift occurring during the procedure. Detection can be performed optically or ultrasonically, and treatment by laser or RF ablation. The probe insertion can be performed at 90° to the insertion axis of the device, thus minimizing passage through healthy tissue.

Abstract: A scaffold comprising electrospun decellularized ECM of an organ, wherein the decellularized ECM has a similar protein composition to native ECM of the organ. Methods of generating same are also disclosed as well as uses of same.