Abstract: An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.

Abstract: Provided are methods for diagnosing or selecting a mammal in need of a stimulant ADHD drug, conducting a non-specific electro-dermal responses (EDAs) analysis and/or an auditory sustained attention (ASAT) analysis on the mammal and administering or adjusting the dose of a stimulant ADHD drug to be administered to the mammal.

Abstract: A self-healing field-effect transistor (FET) device is disclosed in this application, the self-healing FET has a self-healing substrate, a self-healing dielectric layer, a gate electrode, at least one source electrode, at least one drain electrode, and at least one channel. The self-healing substrate and the self-healing dielectric layer have a disulfide-containing poly(urea-urethane) (PUU) polymer. The self-healing dielectric layer has a thickness of less than about 10 ?m. The electrodes have electrically conductive elongated nanostructures. The at least one channel has semi-conducting elongated nanostructures.

Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.

Abstract: Provided herein is a porous ?-cyclodextrin-containing monolith having a microstructure templated by the external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.

Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.

Abstract: A method for reconstructing spatial information, the method includes: (i) Obtaining an under-sampled frequency domain representation (FDR) of the spatial information. The under-sampled FDR was obtained by sampling an FDR of the spatial information with a sampling mask. (ii) Feeding the under-sampled FDR and the sampling mask to a machine learning process. (iii) Reconstructing the spatial information by the machine learning process. The machine learning process was trained using a training data set that includes training under-sampled FRDs of training spatial information, and one or more training sampling masks that were used to sample FDRs of training spatial information.

Abstract: An assembly for driving movement of an elongate surgical tool, comprising: a plurality of adjacent pairs of driving wheels, each pair of driving wheels having a space therebetween such that spaces of the plurality of pairs of driving wheels are axially aligned to form a channel for the elongate surgical tool to extend through; wherein at least one pair of driving wheels out of the plurality of pairs is arranged to lie on a plane different than a plane on which at least one other pair of driving wheels lies.

Abstract: A surface-emitting light source system for generating coherent light having two spin modes comprises a two-dimensional material exhibiting a direct band gap. The two-dimensional material is coupled to a planar heterostructure cavity having an inversion asymmetric core region at least partially surrounded by an inversion symmetric cladding region.

Abstract: Disclosed are methods and probiotic compositions for the treatment of a metabolic disease or disorder such as, e.g., obesity, type 2 diabetes, or fatty liver. In some embodiments, heat-inactivated Parabacteroides goldsteinii is enterically administered to a subject, such as a human patient, to treat the metabolic disease or disorder or to promote the development of warm microbiota to treat the metabolic disease or disorder. In some aspects, spermine or spermidine may be administered to a subject or used in vitro to promote the growth of microbiota that can be used for the treatment of a metabolic disease or disorder.

Abstract: Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, or an anion conducting polymer, and may further be used in electrochemical devices such as alkaline fuel cells, and alkaline redox-flow batteries.

Abstract: Apparatus, systems and methods for ultrasound and photoacoustic guidance of coronary procedures are disclosed herein. Certain embodiments include a first catheter comprising an ultrasound transceiver, and a second catheter comprising a proximal end and a distal end, with a photoacoustic excitation light transmitter positioned at the distal end of the second catheter. The photoacoustic excitation light transmitter can be configured to emit excitation light in a conical pattern and at a specific pulse duration. The second catheter can be configured to detect photoacoustic signals resulting from the absorption of excitation light emitted by the photoacoustic excitation light transmitter.

Abstract: A system for generating light, comprises a spectral light source, characterized by a spectral line shape described by a visibility function; and a multimode waveguide, characterized by an optical path difference distribution described by a standard deviation. The standard deviation typically matches, within a predetermined tolerance, a location of a zero point of the visibility function at which a contrast of the visibility function is less than 0.1.

Abstract: Provided herein are chimeric polypeptides that may be used, e.g., for the diagnosis of or vaccination against Ehrlichia chaffeensis and/or Ehrlichia canis.

Abstract: A method of analyzing the therapeutic efficacy of a therapeutic agent for treating an immune-related disorder is disclosed. The method comprises contacting blood cells of the subject with the agent, measuring the expression of at least 20 genes in the blood cells of the subject; obtaining an immune age value based on the expression of the at least 20 genes, and comparing the immune age value with an immune age value of the subject calculated on the basis of expression of the at least 20 genes in blood cells of the subject, in the absence of the agent.

Abstract: A system comprising: at least one hardware processor; and a non-transitory computer-readable storage medium having stored thereon program instructions, the program instructions executable by the at least one hardware processor to: receive a data stream representing events; receive a plurality of complex event patterns (CEPs) comprising (a) a set of conditions reflecting relations among said events, and (b) a set of attributes associated with each of said events; and calculate an optimal multi-pattern evaluation plan corresponding to said CEPs by: (i) generating an initial evaluation plan, (ii) applying a search method to calculate modified versions of said initial evaluation plan, (iii) assigning a score to each of said modified versions based on a cost function, and (iv) selecting one of said modified versions having a highest said score as said optimal multi-pattern evaluation plan.

Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.

Abstract: A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5? position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

Abstract: The present invention relates to products and methods for modulating cardiac function.

Abstract: A method for locating a vessel, the method comprising illuminating at least a portion of the vessel with a background light having a substantially high susceptibility to absorption by particles in said portion of the vessel; detecting backscattered light from said illuminated portion of the vessel; reproducing an image from said backscattered light; and identifying dark regions within said reproduced image.