Abstract: Methods and systems are provided for belief space planning for multiple robots at an initial belief state, for reducing belief space uncertainty, including receiving multiple, candidate, multi-robot paths, each including one or more pose constraints; generating a candidate factor graph for each candidate multi-robot path, and generating from each candidate factor graph a topology graph; calculating a signature metric from each topology graph, wherein the signature metric is one of a Von Neumann (VN) metric and a spanning tree (ST) metric; selecting a multi-robot path having the greatest signature metric from among the candidate, multi-robot paths; and instructing the multiple robots to proceed according to the selected multi-robot path.
Type:
Grant
Filed:
February 24, 2020
Date of Patent:
November 29, 2022
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Abstract: A vacuum arc thruster device having a cathode rod disposed within a concentric insulator tube, and an anode electrode located at the distal edge of the insulator tube, separated from the cathode rod by the insulator tube. A controlled feeding mechanism moves the cathode towards the distal exit plane in a helical motion, the cathode rotating as it moves forward. The cathode rod is fixed in the center of a headless screw segment, which is rotated within a screw thread on the internal surface of a cylindrical wall of the device. As the erosion rate is concentrated at the exit plane, the screw action path enables uniform erosion around the cathode circumference, and cathode linear motion that can be matched to the radial erosion rate. The feeding rate and hence the thrust are proportional to the input power, which can be regulated by the pulse frequency.
Type:
Grant
Filed:
June 15, 2017
Date of Patent:
November 22, 2022
Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
Abstract: Provided herein are immunogenic compositions that may be used, in some aspects, to induce an immune response against an Ehrlichia such as Ehrlichia cams. In some embodiments, the immunogenic composition comprises an E. canis bacterin and/or adjuvant, such as for example an emulsion or liposomal adjuvant. Related methods such as for diagnosis of or vaccination against ehrlichiosis are also provided.
Type:
Application
Filed:
July 13, 2020
Publication date:
November 10, 2022
Applicants:
Research Development Foundation, Zoetis Services LLC
Inventors:
Jere W. McBRIDE, Paul J. DOMINOWSKI, Suman MAHAN, Jason J. MILLERSHIP, Duncan M. MWANGI, Sharath RAI, Sharon M. WAPPEL
Abstract: A composition of matter comprising a fusion protein attached to the outer surface of a substrate is disclosed. The fusion protein comprises a light-generating protein and a light-transducing protein. Uses of the composition of matter are disclosed.
Type:
Application
Filed:
May 5, 2022
Publication date:
November 10, 2022
Applicant:
Technion Research & Development Foundation Limited
Abstract: Disclosed embodiments are a computing system and a computer-implemented method for distributed training of a machine learning model over a plurality of computing nodes, in a plurality of iterations, characterized by gradient gap based mitigation of the gradient staleness problem. The disclosed method evaluates the staleness of the gradient based on the difference in gradients between a central point, for example an iteration's common starting point, and the points reached by the respective computing node during one or more iterations, and aggregates the update steps from the plurality of computing nodes, while giving more weight to computing nodes having a lesser change in the gradient.
Type:
Application
Filed:
November 5, 2020
Publication date:
November 3, 2022
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Assaf SCHUSTER, Saar BARKAI, Ido HAKIMI
Abstract: A methodology is provided for generating hydrophobic superhydrophobic, oleophobic and/or superoleophobic surfaces. Compositions of matter made of a substrate having deposited on a surface thereof (e.g., by thermal evaporation) hydrocarbon waxes, including fluorinated waxes, are disclosed. Process of preparing such compositions of matter and articles of manufacturing incorporating such compositions are also disclosed. Further disclosed are articles of manufacturing and methods which are useful in inhibiting, reducing and/or retarding biofilm formation, and which include applying waxes (e.g., by thermal evaporation) on a surface of the articles.
Type:
Application
Filed:
July 5, 2022
Publication date:
October 27, 2022
Applicants:
Technion Research & Development Foundation Limited, The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
Abstract: Provided are novel serum-free culture media which comprise basic fibroblast growth factor (bFGF), transforming growth factor beta-3 and ascorbic acid at a concentration of at least about 50 microgram/ml; ascorbic acid at a concentration range of about 400-600 microgram/ml, bFGF at a concentration range of about 50-200 ng/ml, xeno-free serum replacement and a lipid mixture; the IL6RIL6 chimera at a concentration range of about 50-200 picogram per milliliter (pg/ml); or leukemia inhibitory factor (LIF) at a concentration of at least 2000 units/ml; cell cultures comprising same with pluripotent stem cells such as human embryonic stem cells and induced pluripotent stem (iPS) cells, and methods of using same for expanding pluripotent stem cells in an undifferentiated state using two-dimensional or three-dimensional culture systems; and methods of expanding iPS cells in a suspension culture devoid of substrate adherence and cell encapsulation.
Type:
Application
Filed:
June 16, 2022
Publication date:
October 20, 2022
Applicant:
Technion Research & Development Foundation Limited
Abstract: A method for modulating an immune response by activating or inhibiting dopaminergic neurons in the Ventral Tegmental Area (VTA) is provided. Modulation is achieved by modulating the activity, the abundance or both of: a natural killer cell, a CD8 T-cell, a CD4 T-cell, a B-cell, a dendritic cell, a macrophage, a granulocyte, or their combination.
Type:
Grant
Filed:
March 30, 2020
Date of Patent:
October 18, 2022
Assignees:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED, HEALTH CORPORATION - RAMBAM
Inventors:
Asya Rolls, Tamar Ben Shannan, Hilla Azulay-Debbie, Fahed Hakim, Maya Schiller, Shai Shen-Orr, Elina Starosvetsky
Abstract: A cache unit that is configured to retain: a plurality of cache blocks; a plurality of owner indicators, and a plurality of validity marks. For each cache block of the plurality of cache blocks exists a corresponding owner indicator in the plurality of owner indicators. An owner indicator corresponding to a cache block is capable of identifying an entity that caused the cache block to be fetched to the cache unit. For each cache block of the plurality of cache blocks exists a corresponding validity mark in the plurality of validity marks. A validity mark corresponding to the cache block indicates whether a validation process performed on the cache block upon fetching thereof was successful. The cache unit may be useful for secure execution.
Type:
Grant
Filed:
June 3, 2018
Date of Patent:
October 18, 2022
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
Abstract: Provided herein are methods and systems for automated generation of hypothesis based on sets of search terms, and scoring of said automatically generated hypothesis to determine novelty, reasonability and/or feasibility thereof. Further provided are methods of utilizing said generated hypothesis for determination of personalized treatment regime of various health conditions.
Type:
Application
Filed:
August 16, 2020
Publication date:
October 6, 2022
Applicant:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION
Abstract: The present invention concerns gp36 immunoreactive compositions for E. canis and gp 47 immunoreactive compositions for E. chaffeensis. In particular, epitopes for E. canis gp36 and E. chaffeensis gp 47 are disclosed. In certain embodiments, the immunoreactive compositions comprise tandem repeats having carbohydrate moieties.
Abstract: Provided are methods of determining prognosis of a subject diagnosed with sepsis, by determining the baseline levels of T-cell senescence in the subject. Also provided are methods of treating a subject diagnosed with sepsis, by monitoring the subject diagnosed with sepsis and treating the subject which exhibits high baseline levels of T-cell senescence.
Type:
Application
Filed:
May 26, 2022
Publication date:
September 29, 2022
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Shai S. SHEN-ORR, Ayelet ALPERT, Elina STAROSVETSKY, Ashham MANSUR
Abstract: The invention provides a method for treating cancer comprising the step of administering a therapeutically effective amount of KPC1, a peptide which is at least about 70% homologous to the KPC1 or an agent which up-regulates KPC1. In some embodiments, there is also provided a method for treating cancer comprising the step of administering a therapeutically effective amount of p50, a peptide which is at least about 70% homologous to the p50 or an agent which up-regulates p50.
Type:
Grant
Filed:
January 5, 2016
Date of Patent:
September 27, 2022
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
Inventors:
Aaron Ciechanover, Yelena Kravtsova, Inna Shomer, Victoria Cohen
Abstract: A system and method for protecting a speculative execution processor, from side channel attacks, are disclosed. The system comprises a processing circuitry, adapted to: in a first time period performing an execution of a code segment by storing speculative instructions in an internal cache memory which is inaccessible to read actions of an external processing unit; in a second time period copying only a committed portion of the executed code segment into another memory component which is accessible to read actions of the external processing unit. The first and second time periods are different and independent.
Type:
Application
Filed:
June 19, 2020
Publication date:
September 22, 2022
Applicant:
Technion Research & Development Foundation Limited
Abstract: A compact robotic device for driving movement of two or more elongate surgical tools configured for a telescopic arrangement when said two or more elongate surgical tools are at least partially received within said device, the device comprising: a housing comprising walls which define an inner volume including at least two inner pathways for accommodating the two or more elongate surgical tools; the housing encasing: a plurality of motors, and two or more tool actuation assemblies configured at a position of each of the two or more inner pathways; the actuation assemblies driven by the plurality of motors and configured to operably contact an elongate surgical tool at least partially received in the inner pathway to at least one of advance, retract and/or roll said elongate surgical tool.
Type:
Application
Filed:
February 23, 2022
Publication date:
September 22, 2022
Applicants:
Microbot Medical Ltd., Technion Research & Development Foundation Limited
Inventors:
Simon SHARON, Idan BOADER, Evgeny KOFMAN, Moshe SHOHAM, Eran COHEN, Eyal MORAG
Abstract: The present invention provides a conducting material comprising a carbon-based material selected from a diamond or an insulating diamond-like carbon, having a hydrogen-terminated surface and a layer of tungsten trioxide, rhenium trioxide, or chromium oxide coating said hydrogen-terminated surface. Such conducting materials are useful in the fabrication of electronic components, electrodes, sensors, diodes, field effect transistors, and field emission electron sources.
Type:
Grant
Filed:
September 2, 2018
Date of Patent:
September 20, 2022
Assignee:
Technion Research & Development Foundation Ltd.
Abstract: A thermochemical recuperation (TCR) system that may use a water-alcohol mixture as an engine liquid coolant; that may include a TCR reformer configured to output a TCR product at pressure no less than twenty bars; a pressure regulator; and an TCR product accumulator configured to separate an outputting of the TCR product by the TCR reformer from a provision of the TCR product to the pressure regulator; wherein the pressure regulator is configured to provide the TCR product to a direct injector of an engine, thereby enabling the direct injector to inject the TCR product at a high pressure level—for example at a pressure level that exceeds twenty bars.
Type:
Application
Filed:
July 7, 2020
Publication date:
September 15, 2022
Applicant:
Technion Research and Development Foundation Ltd.
Inventors:
Leonid Tartakovsky, Moshe Sheintuch, Mark Veinblat, Andy Thawko
Abstract: An aspect of the invention relates to methods and implants comprising acoustic-sensitive material and at least one additional component within said acoustic-sensitive material. In some embodiments, the at least one additional component is one or more of at least one releasable drug within said acoustic-sensitive material and/or a plurality of cells within said acoustic-sensitive material. In some embodiments, the implant comprises a dedicated form, which is provided inside the body of the patient.
Type:
Application
Filed:
March 3, 2022
Publication date:
September 15, 2022
Applicant:
Technion Research & Development Foundation Limited
Inventors:
Shulamit LEVENBERG, Lior DEBBI, Majd MACHOUR, Haim AZHARI, Daniel DAHIS
Abstract: A method comprising: prior to performing a planned i-th data movement in a distributed data system comprising a plurality of storage sites, generating (i) a first map of current locations of data item replicas following an immediately-preceding (i?1)-th data movement, (b) a first timestamp associated with a completion of said (i?1)-th data movement, and (c) a second map of expected locations of data item replicas following said i-th data movement; implementing said i-th data movement; generating, upon performing said i-th data movement, a second timestamp associated with a completion of said i-th data movement, wherein said second timestamp is indexed as i; and if a failure occurs with respect to at least one of said storage sites during said i-th data movement, determining a completion status of said i-th data movement, based on a comparison between said indexing of said second map and said indexing of said second timestamp.
Type:
Grant
Filed:
July 23, 2019
Date of Patent:
September 13, 2022
Assignee:
TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED