Patents Assigned to Research Development Foundation
  • RNAI NANOPARTICLES AND METHODS OF USING SAME IN AGRICULTURE
    Publication number: 20240090512
    Abstract: The present invention provides a nanoparticle including: (a) an amphiphilic co-polymer including an ionizable polymer covalently bound to a hydrophobic domain; and a polynucleotide comprising 60 to 500 nucleobases. Further provided are compositions including the nanoparticle of the invention, and methods of using same.
    Type: Application
    Filed: January 20, 2022
    Publication date: March 21, 2024
    Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Oded SHOSEYOV, Avi SCHROEDER, Aviram AVITAL, Noy SADOT MUZIKA, Zohar Lily PERSKY
  • RECONSTRUCTION OF INFORMATION STORED IN A DNA STROAGE SYSTEM
    Publication number: 20240095543
    Abstract: A method for estimating an information unit represented by DNA strands, the method includes (a) sequencing the DNA strands to provide noisy copies of an encoded version of the information unit; wherein the information unit comprises information unit elements; (b) neural network (NN) processing the multiple noisy copies by one or more NNs to provide a soft estimate of the encoded information unit; wherein the soft estimate comprises estimated encoded information unit elements and an encoded information unit elements estimated confidence parameter; and (c) decoding the soft estimate of the encoded information unit to provide a prediction of the information unit.
    Type: Application
    Filed: August 14, 2023
    Publication date: March 21, 2024
    Applicants: Technion Research & Development Foundation Limited, BAR-ILAN UNIVERSITY
    Inventors: Daniella Bar-Lev, Itai Orr, Omer Sabary, Tuvi Etzion, Eitan Yaakobi
  • LOW MOLECULAR WEIGHT CORROLE COMPOSITIONS
    Publication number: 20240083920
    Abstract: Embodiments of the invention relate to a corrole according to formula [I]; wherein R1, R2, and R3 are each independently H, —COOH, CF3, or a halide selected from the group consisting of F—, Cl—, Br— and I, with the proviso that R1, R2, and R3 can not all be CF3, and when the compound is of Formula II, wherein M is a metallic ion or an elemental ion selected from the group consisting of an elemental ion of group 13-16 in row 3 or above and boron, preferably selected from the group consisting of: Fe, Mn, Ga, P, Mo, Re, Co and Cu, or a salt thereof. Methods for treatment, catalysis, and detection using the compounds are also described.
    Type: Application
    Filed: January 11, 2022
    Publication date: March 14, 2024
    Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD
    Inventors: Zeev GROSS, Atif MAHAMMED
  • Heat engine
    Patent number: 11927117
    Abstract: A method for converting heat to mechanical work including providing incoming heat transfer fluid (HTF) at a first temperature to a mixing chamber, providing incoming compressed gas at a second temperature to the mixing chamber, enabling the gas and the HTF to mix, producing a gas-and-HTF mix, enabling the HTF in the gas-and-HTF mix to heat the gas and isothermal expansion of the gas in the gas-and-HTF mix, limiting volume of the gas-and-HTF mix, thereby increasing pressure of the gas and causing acceleration of a flow of the gas-and-HTF mix, causing the gas-and-HTF mix to eject through a nozzle, thereby converting the heat of the HTF to kinetic energy, and using the kinetic energy to produce mechanical work. Related apparatus and methods are also described.
    Type: Grant
    Filed: August 30, 2021
    Date of Patent: March 12, 2024
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Carmel Rotschild, Joseph Cassell
  • METAL-CONTAINING POLYMERIC ION CONDUCTORS
    Publication number: 20240079622
    Abstract: Polymeric ion conductors composed of a polymeric or co-polymeric backbone which comprises a plurality of backbone units, a metal ligand attached to at least a portion of the backbone units, and a metal ion attached to the metal ligand are provided. The metal ligand can be an N-heterocyclic carbene ligand and the metal can feature low oxophilicity. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor or the ion exchange membrane are also provided.
    Type: Application
    Filed: December 31, 2021
    Publication date: March 7, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Charles Eliezer DIESENDRUCK, Dario R. DEKEL
  • AURICULAR RECONSTRUCTION USING 3D PRINTED AUTOLOGOUS CARTILAGE TISSUE
    Publication number: 20240065829
    Abstract: An aspect of some embodiments of the invention relates to methods of manufacturing a 3D printed implant, comprising printing a mold of a scaffold, generating said scaffold from said mold, seeding cells on said scaffold, where said generating said scaffold comprises generating parts of said scaffold with different levels of stiffness.
    Type: Application
    Filed: January 4, 2022
    Publication date: February 29, 2024
    Applicants: Technion Research & Development Foundation Limited, Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Shulamit LEVENBERG, Shira LANDAU, Shay DUVDEVANI
  • Multi-functional field effect transistor with intrinsic self-healing properties
    Patent number: 11916148
    Abstract: A self-healing field-effect transistor (FET) device is disclosed in this application, the self-healing FET has a self-healing substrate, a self-healing dielectric layer, a gate electrode, at least one source electrode, at least one drain electrode, and at least one channel. The self-healing substrate and the self-healing dielectric layer have a disulfide-containing poly(urea-urethane) (PUU) polymer. The self-healing dielectric layer has a thickness of less than about 10 ?m. The electrodes have electrically conductive elongated nanostructures. The at least one channel has semi-conducting elongated nanostructures.
    Type: Grant
    Filed: December 17, 2022
    Date of Patent: February 27, 2024
    Assignee: TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
    Inventors: Hossam Haick, Muhammad Khatib
  • Attention evaluation and methods for medicating
    Patent number: 11911373
    Abstract: Provided are methods for diagnosing or selecting a mammal in need of a stimulant ADHD drug, conducting a non-specific electro-dermal responses (EDAs) analysis and/or an auditory sustained attention (ASAT) analysis on the mammal and administering or adjusting the dose of a stimulant ADHD drug to be administered to the mammal.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: February 27, 2024
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventors: Avraham Avital, Zev Brand
  • Beta-cyclodextrin-based monoliths through emulsion templating
    Patent number: 11911745
    Abstract: Provided herein is a porous ?-cyclodextrin-containing monolith having a microstructure templated by the external phase of a HIPE, as well as processes of manufacturing the same and uses thereof.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: February 27, 2024
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Rajashekharayya A. Sanguramath, Inna Berezovska, Michael S. Silverstein
  • Cell-targeted cytotoxic constructs
    Patent number: 11913043
    Abstract: The invention is directed to cell-targeted cytotoxic agents, including sortase serine protease constructs. Methods for targeted cell killing for treatment of proliferative diseases, for example, cancer, are provided. Exemplary embodiments comprise an R-spondin ligand for targeting the cytotoxic agents to effect the cell killing.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: February 27, 2024
    Assignee: Research Development Foundation
    Inventors: Xinjian Lin, Xiying Shang, Stephen B. Howell
  • Swab composition for detection of molecules/explosives on a surface
    Patent number: 11906498
    Abstract: Compositions comprising electrospun fibers and colorimetric detection encapsulated thereto are provided. Further, methods of use of said composition, including, but not limited to in-situ detection of molecules of interest, such as explosive compounds, are provided.
    Type: Grant
    Filed: October 19, 2020
    Date of Patent: February 20, 2024
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.
    Inventors: Eyal Zussman, Yuval Eshed, Reshef Gal-Oz
  • PHYSICALLY-PRIMED DEEP-NEURAL-NETWORKS FOR GENERALIZED UNDERSAMPLED MRI RECONSTRUCTION
    Publication number: 20240054699
    Abstract: A method for reconstructing spatial information, the method includes: (i) Obtaining an under-sampled frequency domain representation (FDR) of the spatial information. The under-sampled FDR was obtained by sampling an FDR of the spatial information with a sampling mask. (ii) Feeding the under-sampled FDR and the sampling mask to a machine learning process. (iii) Reconstructing the spatial information by the machine learning process. The machine learning process was trained using a training data set that includes training under-sampled FRDs of training spatial information, and one or more training sampling masks that were used to sample FDRs of training spatial information.
    Type: Application
    Filed: August 14, 2023
    Publication date: February 15, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Mordechay Pinchas Freiman, Nitzan Avidan
  • COMPACT ROBOTIC DEVICE AND ASSEMBLIES FOR MANIPULATION OF ELONGATE SURGICAL TOOLS
    Publication number: 20240041543
    Abstract: An assembly for driving movement of an elongate surgical tool, comprising: a plurality of adjacent pairs of driving wheels, each pair of driving wheels having a space therebetween such that spaces of the plurality of pairs of driving wheels are axially aligned to form a channel for the elongate surgical tool to extend through; wherein at least one pair of driving wheels out of the plurality of pairs is arranged to lie on a plane different than a plane on which at least one other pair of driving wheels lies.
    Type: Application
    Filed: October 19, 2023
    Publication date: February 8, 2024
    Applicants: Microbot Medical Ltd., Technion Research & Development Foundation Limited
    Inventors: Simon SHARON, Idan BOADER, Evgeny KOFMAN, Zev SOHN, Moshe SHOHAM, Eran COHEN, Eyal MORAG
  • METHOD AND SYSTEM FOR GENERATING COHERENT LIGHT HAVING TWO SPIN MODES
    Publication number: 20240039246
    Abstract: A surface-emitting light source system for generating coherent light having two spin modes comprises a two-dimensional material exhibiting a direct band gap. The two-dimensional material is coupled to a planar heterostructure cavity having an inversion asymmetric core region at least partially surrounded by an inversion symmetric cladding region.
    Type: Application
    Filed: July 27, 2023
    Publication date: February 1, 2024
    Applicant: Technion Research & Development Foundation Limited
    Inventors: Erez HASMAN, Kexiu RONG
  • Carbazolium salt and use thereof in anion exchange membranes
    Patent number: 11883813
    Abstract: Compositions comprising a tetraaryl ammonium salt, a tetraaryl ammonium salt covalently bound to a polymer and methods for manufacturing the same are disclosed. The disclosed compositions are useful e.g., for an anion exchange membrane, or an anion conducting polymer, and may further be used in electrochemical devices such as alkaline fuel cells, and alkaline redox-flow batteries.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: January 30, 2024
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Charles Eliezer Diesendruck, Dario Dekel
  • Methods and probiotic compositions for the treatment of metabolic diseases and disorders
    Patent number: 11883447
    Abstract: Disclosed are methods and probiotic compositions for the treatment of a metabolic disease or disorder such as, e.g., obesity, type 2 diabetes, or fatty liver. In some embodiments, heat-inactivated Parabacteroides goldsteinii is enterically administered to a subject, such as a human patient, to treat the metabolic disease or disorder or to promote the development of warm microbiota to treat the metabolic disease or disorder. In some aspects, spermine or spermidine may be administered to a subject or used in vitro to promote the growth of microbiota that can be used for the treatment of a metabolic disease or disorder.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: January 30, 2024
    Assignee: Research Development Foundation
    Inventors: Mirko Trajkovski, Claire Chevalier, Melis Çolako{hacek over (g)}lu
  • SYSTEMS AND METHODS FOR ULTRASOUND AND PHOTOACOUSTIC GUIDANCE OF CORONARY PROCEDURES
    Publication number: 20240023813
    Abstract: Apparatus, systems and methods for ultrasound and photoacoustic guidance of coronary procedures are disclosed herein. Certain embodiments include a first catheter comprising an ultrasound transceiver, and a second catheter comprising a proximal end and a distal end, with a photoacoustic excitation light transmitter positioned at the distal end of the second catheter. The photoacoustic excitation light transmitter can be configured to emit excitation light in a conical pattern and at a specific pulse duration. The second catheter can be configured to detect photoacoustic signals resulting from the absorption of excitation light emitted by the photoacoustic excitation light transmitter.
    Type: Application
    Filed: September 14, 2021
    Publication date: January 25, 2024
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventors: Thomas E. MILNER, Marc D. FELDMAN, Nitesh KATTA
  • System and method for generating light
    Patent number: 11879632
    Abstract: A system for generating light, comprises a spectral light source, characterized by a spectral line shape described by a visibility function; and a multimode waveguide, characterized by an optical path difference distribution described by a standard deviation. The standard deviation typically matches, within a predetermined tolerance, a location of a zero point of the visibility function at which a contrast of the visibility function is less than 0.1.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: January 23, 2024
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Carmel Rotschild, Daria Negri, Michal Shimanovich, Matej Kurtulik
  • CHIMERIC IMMUNOGENIC POLYPEPTIDES
    Publication number: 20240018195
    Abstract: Provided herein are chimeric polypeptides that may be used, e.g., for the diagnosis of or vaccination against Ehrlichia chaffeensis and/or Ehrlichia canis.
    Type: Application
    Filed: September 5, 2023
    Publication date: January 18, 2024
    Applicant: Research Development Foundation
    Inventors: Jere W. McBRIDE, David H. WALKER
  • METHODS OF ASSESSING THE THERAPEUTIC ACTIVITY OF AGENTS FOR THE TREATMENT OF IMMUNE DISORDERS
    Publication number: 20240018592
    Abstract: A method of analyzing the therapeutic efficacy of a therapeutic agent for treating an immune-related disorder is disclosed. The method comprises contacting blood cells of the subject with the agent, measuring the expression of at least 20 genes in the blood cells of the subject; obtaining an immune age value based on the expression of the at least 20 genes, and comparing the immune age value with an immune age value of the subject calculated on the basis of expression of the at least 20 genes in blood cells of the subject, in the absence of the agent.
    Type: Application
    Filed: October 26, 2021
    Publication date: January 18, 2024
    Applicants: Technion Research & Development Foundation Limited, Rambam Med-Tech Ltd.
    Inventors: Shai S. SHEN-ORR, Yehuda CHOWERS, Ayelet ALPERT, Shiran GERASSY-VAINBERG, Erik FELDMAN